Interleukin-6 causes myocardial failure and skeletal muscle atrophy in rats

Circulation

Volumn 111, Issue 8, 2005, Pages 996-1005

  Janssen, Sofie P M ^a   Gayan Ramirez, Ghislaine ^a   Van Den Bergh, An ^a   Herijgers, Paul ^a   Maes, Karen ^a   Verbeken, Erik ^a   Decramer, Marc ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Blood flow; Cardiomyopathy; Contractility; Interleukins; Muscles

Indexed keywords

INTERLEUKIN 6;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIAPHRAGM; GASTROCNEMIUS MUSCLE; HEART DILATATION; HEART FAILURE; HEART MUSCLE CONTRACTILITY; LUNG EDEMA; MALE; MUSCLE ATROPHY; MUSCLE CELL; MUSCLE CONTRACTILITY; NONHUMAN; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE;

ANIMALS; BODY WEIGHT; CARDIOMYOPATHIES; CARDIOVASCULAR SYSTEM; CORONARY VESSELS; DIAPHRAGM; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; HEART FAILURE, CONGESTIVE; INTERLEUKIN-6; LIVER; LUNG; MALE; MOTOR ACTIVITY; MUSCLE CONTRACTION; MUSCLE, SKELETAL; MUSCULAR ATROPHY; MYOCARDIAL CONTRACTION; MYOCARDIUM; ORGAN SIZE; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; REGIONAL BLOOD FLOW;

EID: 14844361274     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000156469.96135.0D     Document Type: Article

References (40)

1. TorreAmione G, Kapadia S, Benedict C, Oral H, Young JB, Mann DL. Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the studies of left ventricular dysfunction (SOLVD). J Am Coll Cardiol. 1996;27:1201-1206.
2. Kragsbjerg P, Holmberg H, Vikerfors T. Dynamics of blood cytokine concentrations in patients with bacteremic infections. Scand J Infect Dis. 1996;28:391-398.
3. Yamada Y, Endo S, Inada K. Plasma cytokine levels in patients with severe burn injury: with reference to the relationship between infection and prognosis. Burns. 1996;22:587-593.
4. Schutte H, Lohmeyer J, Rosseau S, Ziegler S, Siebert C, Kielisch H, Pralle H, Grimminger F, Morr H, Seeger W. Bronchoalveolar and systemic cytokine profiles in patients with ARDS, severe pneumonia and cardiogenic pulmonary oedema. Eur Respir J. 1996;9:1858-1867.
5. Wedzicha JA, Seemungal TA, MacCallum PK, Paul EA, Donaldson GC, Bhowmik A, Jeffries DJ, Meade TW. Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels. Thromb Haemost. 2000;84:210-215.
6. Stassijns G, Gayan-Ramirez G, De Leyn P, Verhoeven G, Herijgers P, de Bock V, Dom R, Lysens R, Decramer M. Systolic ventricular dysfunction causes selective diaphragm atrophy in tats. Am J Respir Crit Care Med. 1998;158:1963-1967.
7. Vassilakopoulos T, Zakynthinos E, Roussos C, Zakynthinos S. Respiratory muscles in heart failure. Monaldi Arch Chest Dis. 1999;54:150-153.
8. Bolton CF. Sepsis and the systemic inflammatory response syndrome: neuromuscular manifestations. Crit Care Med. 1996;24:1408-1416.
9. Yasuhara S, Kanakubo E, Perez ME, Kaneki M, Fujita T, Okamoto T, Martyn JA. The 1999 Moyer Award: burn injury induces skeletal muscle apoptosis and the activation of caspase pathways in rats. J Burn Care Rehabil. 1999;20:462-470.
10. American Thoracic Society/European Respiratory Society. Skeletal muscle dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1999;159:S1-S40.
11. Herridge MS, Cheung AM, Tansey CM, Matte-Martyn A, Diaz-Granados N, Al Saidi F, Cooper AB, Guest CB, Mazer CD, Mehta S, Stewart TE, Barr A, Cook D, Slutsky AS. One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med. 2003;348:683-693.
12. Fujita J, Tsujinaka T, Ebisui C, Yano M, Shiozaki H, Katsume A, Ohsugi Y, Monden M. Role of interleukin-6 in skeletal muscle protein breakdown and cathepsin activity in vivo. Eur Surg Res. 1996;28:361-366.
13. Tsujinaka T, Fujita J, Ebisui C, Yano M, Kominami E, Suzuki K, Tanaka K, Katsume A, Ohsugi Y, Shiozaki H, Monden M. Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice. J Clin Invest. 1996;97:244-249.
14. Goodman MN. Interleukin-6 induces skeletal muscle protein breakdown in rats. Proc Soc Exp Biol Med. 1994;205:182-185.
15. Okazaki S, Kawai H, Arii Y, Yamaguchi H, Saito S. Effects of calcitonin gene-related peptide and interleukin 6 on myoblast differentiation. Cell Prolif. 1996;29:173-182.
16. Hirota H, Yoshida K, Kishimoto T, Taga T. Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice. Proc Natl Acad Sci U S A. 1995;92:4862-4866.
17. Jin H, Yang R, Keller GA, Ryan A, Ko A, Finkle D, Swanson TA, Li W, Pennica D, Wood WI, Paoni NF. In vivo effects of cardiotrophin-1. Cytokine. 1996;8:920-926.
18. Jin H, Yang R, Ko A, Pennica D, Wood WI, Paoni NF. Effects of cardiotrophin-1 on haemodynamics and cardiac function in conscious rats. Cytokine. 1998;10:19-25.
19. Pennica D, King KL, Shaw KJ, Luis E, Rullamas J, Luoh SM, Darbonne WC, Knutzon DS, Yen R, Chien KR. Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. Proc Natl Acad Sci U S A. 1995;92:1142-1146.
20. Finkel MS, Oddis CV, Jacob TD, Watkins SC, Hattler BG, Simmons RL. Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science. 1992;257:387-389.
21. 2+ ATPase (SERCA2) in cardiac myocytes. Basic Res Cardiol. 2000;95:47-54.
22. Patten M, Kramer E, Bunemann J, Wenck C, Thoenes M, Wieland T, Long C. Endotoxin and cytokines alter contractile protein expression in cardiac myocytes in vivo. Pflügers Arch. 2001;442:920-927.
23. Dekhuijzen PN, Gayan-Ramirez G, de Bock V, Dom R, Decramer M. Triamcinolone and prednisolone affect contractile properties and histopathology of rat diaphragm differently. J Clin Invest. 1993;92:1534-1542.
24. Moore BJ, Miller MJ, Feldman HA, Reid MB. Diaphragm atrophy and weakness in cortisone-treated rats. J Appl Physiol. 1989;67:2420-2426.
25. Dubowitz V. Muscle Biopsy: A Practical Approach. London, England: Balliere Tindall; 1985.
26. Herijgers P, Leunens V, Tjandra-Maga TB, Mubagwa K, Flameng W. Changes in organ perfusion after brain death in the rat and its relation to circulating catecholamines. Transplantation. 1996;62:330-335.
27. Bloemen H, Aerts JM, Berckmans D, Goedseels V. Image analysis to measure activity index of animals. Equine Vet J Suppl. 1997;23:16-19.
28. Lindsay DC, Lovegrove CA, Dunn MJ, Bennett JG, Pepper JR, Yacoub MH, Poole-Wilson PA. Histological abnormalities of muscle from limb, thorax and diaphragm in chronic heart failure. Eur Heart J. 1996;17:1239-1250.
29. McParland C, Resch EF, Krishnan B, Wang Y, Cujec B, Gallagher CG. Inspiratory muscle weakness in chronic heart failure: role of nutrition and electrolyte status and systemic myopathy. Am J Respir Crit Care Med. 1995;151:1101-1107.
30. Hammond MD, Bauer KA, Sharp JT, Rocha RD. Respiratory muscle strength in congestive heart failure. Chest. 1990;98:1091-1094.
31. Howell S, Maarek JM, Fournier M, Sullivan K, Zhan WZ, Sieck GC. Congestive heart failure: differential adaptation of the diaphragm and latissimus dorsi. J Appl Physiol. 1995;79:389-397.
32. Lipkin DP, Jones DA, Round JM, Poole-Wilson PA. Abnormalities of skeletal muscle in patients with chronic heart failure. Int J Cardiol. 1988;18:187-195.
33. Nava S, Gayan-Ramirez G, Rollier H, Bisschop A, Dom R, de Bock V, Decramer M. Effects of acute steroid administration on ventilatory and peripheral muscles in rats. Am J Respir Crit Care Med. 1996;153:1888-1896.
34. Klover PJ, Zimmers TA, Koniaris LG, Mooney RA. Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes. 2003;52:2784-2789.
35. Hussain SN, Roussos C, Magder S. Effects of tension, duty cycle, and arterial pressure on diaphragmatic blood flow in dogs. J Appl Physiol. 1989;66:968-976.
36. Olencki T, Finke J, Tubbs R, Elson P, McLain D, Herzog P, Budd GT, Gunn H, Bukowski RM. Phase 1 trial of subcutaneous IL-6 in patients with refractory cancer: clinical and biologic effects. J Immunother. 2000;23:549-556.
37. Roth-Isigkeit A, Hasselbach L, Ocklitz E, Bruckner S, Ros A, Gehring H, Schmucker P, Rink L, Seyfarth M. Inter-individual differences in cytokine release in patients undergoing cardiac surgery with cardiopulmonary bypass. Clin Exp Immunol. 2001;125:80-88.
38. Gwechenberger M, Hulsmann M, Berger R, Graf S, Springer C, Stanek B, Pacher R. Interleukin-6 and B-type natriuretic peptide are independent predictors for worsening of heart failure in patients with progressive congestive heart failure. J Heart Lung Transplant. 2004;23:839-844.
39. Millar AB, Armstrong L, van der Linden J, Moat N, Ekroth R, Westwick J, Scallan M, Lincoln C. Cytokine production and hemofiltration in children undergoing cardiopulmonary bypass. Ann Thorac Surg. 1993;56:1499-1502.
40. Metrangolo L, Fiorillo M, Friedman G, Silance PG, Kahn RJ, Novelli GP, Vincent JL. Early hemodynamic course of septic shock. Crit Care Med. 1995;23:1971-1975.