Chapter 5 Metabolic modifiers in animal nutrition: potential benefits and risks

Biology of Growing Animals

Volumn 4, Issue C, 2006, Pages 135-178

  Murdoch, G K ^a   Okine, E K ^a   Christopherson, R J ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 56949093591     PISSN: 18771823     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1877-1823(09)70092-X     Document Type: Article

References (290)

1. Adams T.E., Baker L., Fiddes R.J., and Brandon M.R. The sheep growth hormone receptor: Molecular cloning and ontogeny of mRNA expression in the liver. Mol. Cell. Endocrinol. 73 (1990) 135-145
2. Adeola O., Ram J.I., Maenz D.D., and Classen H.L. Transport of putrescine across duodenal, jejunal and ileal brush border membrane of chicks (Gallus domesticus). Comp. J. Biochem. Physiol. C 135 3 (2003) 235-247
3. Alhonen J.J., Pietela M., and Keinanen T.A. Genetic approaches to the cellular functions of polyamines in mammals. Eur. J. Biochem. 27 5 (2004) 877-894
4. Argetsinger L.S., and Carter-Su C. Mechanisms of signaling by growth hormone receptor. Physiol. Rev. 76 (1996) 1089-1107
5. Asakawa A., Inui A., Kaga T., Yuzuriha H., Nagata T., Ueno N., Makino S., Fujimiya M., Niijima A., Fujino M.A., and Kasuga M. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 120 2 (2001) 337-345
6. Bachman E.S., Dhillon H., Zhang C.Y., Cinti S., Bianco A.C., Kobilka B.K., and Lowell B.B. βAR signaling required for diet-induced thermogenesis and obesity resistance. Science 279 (2002) 843-845
7. Bado A., Levasseur S., Attoub S., Kermorgant S., Laigneau J., Bortolluzzi M., Miozo L., Lehy T., Guerre-Millo M., Marchand-Brustel Y., and Lewin M.J.M. The stomach is a source of leptin. Nature 394 (1998) 790-793
8. Baldwin R.L., Calvert C.C., and Oberbauer A.M. Growth control in the future. In: Pearson A.M., and Dutson T.R. (Eds). Growth Regulation in Farm Animals. Advances in Meat Research 7 (1991), Elsevier Press, New York 609-629
9. Banks W.A., Kastin A.J., Huang W., Jaspan J.B., and Maness L.M. Leptin enters the brain by a saturable system independent of insulin. Peptides 17 (1996) 305-311
10. Barnes D.M., Kirby Y.K., and Oliver K.G. Effects of biogenic amines on growth and the incidence of proventricular lesions in broiler chickens. Poult. Sci. 80 7 (2001) 906-911
11. Bauman D.E., and Vernon R.G. Effects of exogenous bovine somatotropin on lactation. Annu. Rev. Nutr. 13 (1993) 437-461
12. Bauman D.E., Degeeter M.J., Peel C.J., Lanza G.M., Gorewit R.C., and Hammond R.W. Effect of recombinantly derived bovine growth hormone (bGH) on lactational performance of high yielding dairy cows. J. Dairy Sci. 65 Suppl. 1 (1982) 121
13. Bednarek M.A., Feighner S.D., Pong S.S., McKee K.K., Hreniuk D.L., Silva M.V., Warren V.A., Howard A.D., Van der Ploeg L.H.Y., and Heck J.V. Structure-function studies on the new growth hormone-releasing peptide, ghrelin: Minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. J. Med. Chem. 43 23 (2000) 4370-4376
14. Beermann D.H. Status of current strategies for growth regulation. In: Campion D.R., Hausman G.J., and Martin R.J. (Eds). Animal Growth Regulation (1989), Plenum, New York 377-400
15. Beermann D.H. Beta-adrenergic receptor agonist modulation of skeletal muscle growth. J. Anim. Sci. 80 Suppl. E. (2002) E18-E23
16. Beermann D.H., and DeVol D.L. Effects of somatotropin, somatotropin releasing factor and somatostatin on growth. In: Pearson A.M., and Dutson T.R. (Eds). Growth Regulation in Farm Animals, Vol. 17: Advances in Meat Research (1991), Elsevier, Essex, UK 373
17. Bell A.W., Bauman D.E., Beermann D.H., and Harrell R.J. The Roles of Nutrition, Development and Hormone Sensitivity in the Regulation of Protein Metabolism. J. Nutr. 128 (1998) 360S-363S Nutrition, development and efficacy of growth modifiers in livestock species. In:Davis, T.A. (Ed.)
18. Bergen W.G., Johnson S.E., Skjaerlund D.M., Babiker A.S., Ames N.K., Merkel R.A., and Anderson D.B. Muscle protein metabolism in finishing pigs fed ractopamine. J. Anim. Sci. 67 (1989) 2255-2265
19. Bierring E., and Nielsen E. The composition of the tissues of albino rats treated with alkaline anterior pituitary extracts. Biochem. J. 26 (1932) 1015-1021
20. Bohorov O., Buttery P.J., Correia J.H.R.D., and Soar J.B. The effect of the beta-2-adrenergic agonist clenbuterol or implantation with oestradiol plus trenbolone acetate on protein metabolism in wether lambs. Brit. J. Nutr. 57 (1987) 99-107
21. Boisclair Y.R., Bauman D.E., Bell A.W., Dunshea F., and Harkins M. Nutrient utilization and protein turnover in the hindlimb of cattle treated with bovine somatotropin. J. Nutr. 124 (1994) 664-673
22. Boisclair Y.R., Johnston K.B., Bauman D.E., Crooker B.A., Dunshea F.R., and Bell A.W. Paradoxical increases of circulating nonesterified fatty acids in somatotropin treated cattle undergoing mild disturbances. Domest. Anim. Endocrinol. 14 (1997) 251-262
23. Boleman S.L., Boleman S.J., Bidner T.D., Southern L.L., Ward T.L., Pontif J.E., and Pike M.M. Effect of chromium picolinate on growth, body composition, and tissue accretion in pigs. J. Anim. Sci. 73 7 (1995) 2033-2042
24. Boyd R.D., and Bauman D.E. Mechanisms of action for somatotropin in growth. In: Campion R., Hausman G.J., and Martin R.J. (Eds). Current Concepts of Animal Growth Regulation (1989), Plenum, New York 257-293
25. Boyd R.D., Bauman D.E., Fox D.G., and Scanes C. Impact of metabolism modifiers on protein accretion and protein and energy requirements of livestock. J. Anim. Sci. 69 Suppl. 2 (1991) 56-75
26. Brambilla G., Cenci T., Franconi F., Galarini R., Macri A., Rondoni F., Strozzi M., and Liozzo A. Clinical and pharmacological profile in a clenbuterol epidemic poisoning of contaminated beef meat in Italy. Toxicol. Lett. 114 (2000) 47-53
27. Buchanan F.C., Fitzsimmons C.J., van Kessel A.G., Thue T.D., Wimkelman-Sim D.C., and Schmutz S.M. Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels. Genet. Sel. Evol. 34 (2002) 105-116
28. Burton J.L., McBride B.W., Block E., Glimm D.R., and Kennelly J.J. A review of bovine growth hormone. Can. J. Anim. Sci. 74 (1994) 167-201
29. Burton J.L., Mallard B.A., and Mowat D.N. Effects of supplemental chromium on antibody responses of newly weaned feedlot calves to immunization with infectious bovine rhinotracheitis and parainfluenza 3 virus. Can. J. Vet. Res. 58 2 (1994) 148-151
30. Burton J.L., Nonnecke B.J., Elsasser T.H., Mallard B.A., Yang W.Z., and Mowat D.N. Immunomodulatory activity of blood serum from chromium-supplemented periparturient dairy cows. Vet. Immunol. Immunopathol. 49 1-32 (1995) 29-38
31. Buttery P.J., and Sinnett-Smith P.A. The mode of action of anabolic agents with special reference to their effects on protein metabolism - some speculation in manipulation of growth. In: Roche J.F., and O'Callaghan D. (Eds). Farm Animals. Martinus Nijhoff (1984), Boston, Mass 211-232
32. Buttery P.J., and Dawson J.M. The mode of action of beta-agonists as manipulators of carcass composition. In: Hanrahan J.P. (Ed). Beta-Agonists and Their Effects on Animal Growth and Carcass Quality (1987), Elsevier Applied Science, London 29-43
33. Campbell R.G., Steele N.C., Caperna T.J., McMurtry J.P., Solomon M.B., and Mitchell A.D. Interrelationships between energy intake and exogenous porcine growth hormone administration on the performance, body composition and protein and energy metabolism of growing pigs weighing 25-32 kilograms body weight. J. Anim. Sci. 66 (1988) 1643-1655
34. Campfeild A.L., Smith F.J., Gulserz Y., Devos R., and Burn P. Mouse OB protein: evidence for a peripheral signal linking adibosity and central neural networks. Science 269 (1995) 546-549
35. Carr D., and Friesen H.G. Growth hormone and insulin binding to human liver. J. Clin. Endocrinol. Metab. 42 (1976) 484-493
36. Chang G.X., Mallard B.A., and Mowat D.N. Effects of chromium on health status, blood neutrophil phagocytosis and in vitro lymphocyte blastogenesis of dairy cows. Vet. Immunol. Immunopathol. 52 1-32 (1996) 37-52
37. Chang G.X., Mallard B.A., Mowat D.N., and Gallo G.F. Effect of supplemental chromium on antibody responses of newly arrived feeder calves to vaccines and ovalbumin. Can. J. Vet. Res. 60 2 (1996) 140-144
38. Chen X.B., Samaraweera L., Kyle D.J., Ørskov E.R., and Abeygunawardene H. Urinary excretion of purine derivatives and tissue xanthine oxidase (EC1.2.3.2) activity in buffaloes and Bos taurus cattle. Brit. J. Nutr. 75 (1996) 397-407
39. Chowdhury S.R., and Smith T.K. Effects of dietary 1,4-diaminobutane (putrescine) on eggshell quality and laying performance of hens laying thin-shelled eggs. Poult. Sci. 80 12 (2001) 1702-1709
40. Christopherson R.J. Effects of prolonged cold and the outdoor winter environment on apparent digestibility in sheep and cattle. Can. J. Anim. Sci. 56 (1976) 201-212
41. Christopherson R.J., Ekpe E.D., Moibi J.A., and Li B.T. Roles of adrenergic receptors in regulating metabolism in ruminants. In: Ivan M. (Ed). Animal Science Research and Development: Moving Toward a New Century (1995), Canadian Society of Animal Science 205-223
42. Claeys M.C., Mulvaney D.R., and McCarthy F.D. Skeletal muscle protein synthesis and growth-hormone secretion in young lambs treated with clenbuterol. J. Anim. Sci. 67 (1989) 2245-2254
43. Clancy M., Wangness P.J., and Baumgardt B.R. Effect of silage extract on voluntary intake, rumen fluid constituents, and rumen motility. J. Dairy Sci. 60 (1977) 580-590
44. Cochard A., Guilhermet R., and Bonneau M. Plasma growth hormone (GB), insulin and amino acid responses to arginine with or without aspartic acid in pigs. Effect of the dose. Reprod. Nutr. Dev. 38 3 (1998) 331-343
45. Collins S., Caron M.G., and Leftkowitz R.J. Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. Annu. Rev. Physiol. 53 (1991) 497-508
46. Considine R.V., Sinha M., Heiman M., Kraiuciunas A., Stephens T., Nyce M., Ohannesian J., and Marco C. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334 (1996) 292-295
47. Cosgrove S.J., Mosenthin R., and Christopherson R.J. Thermogenic and digestive responses of ad libitum fed pigs to alpha-2-adrenergic stimulation with guanfacin in different thermal environments. Can. J. Anim. Sci. 82 (2002) 79-86
48. Cummings D.E., Purnell J.Q., Frayo R.S., Schmidova K., Wisse B.E., and Weigle D.S. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50 8 (2001) 1714-1719
49. Cusin I., Zarzewska K.E., Boss O., Muzzin P., and Giacobino J.-P. Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favours the expression of uncoupling proteins. Diabetes 47 (1998) 1014-1019
50. Date Y., Kojima M., Hosoda H., Sawaguchi A., Mondal M.S., Suganuma T., Matsukura S., Kangawa K., and Nakazato M. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141 11 (2000) 4255-4261
51. Dawson J.M., Buttery P.J., Lammiman M.J., Soar J.B., Essex C.P., Gill M., and Beever D.E. Nutritional and endocrinologic manipulation of lean deposition in forage fed steers. Brit. J. Nutr. 66 (1991) 171-185
52. De Vos A.M., Utsch M., and Kossiakoff A.A. Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex. Science 255 (1992) 306-312
53. De Vos P., Lefebvre A.M., Shrivo I., Fruchart J.C., and Auwerx J. Glucocorticoids induce the expression of the leptin gene through a non-classical mechanism of transcriptional activation. Eur. J. Biochem. 253 (1998) 619-626
54. Delavaud C., Ferlay A., Faulconnier Y., Bocquier F., Kann G., and Chillard Y. Plasma leptin concentration in adult cattle: effects of breed, adiposity, feeding levels, and meal intake. J. Anim. Sci. 80 (2002) 1317-1328
55. Depreux F.F.S., Grant A.L., Anderson D.B., and Gerrard D.E. Paylean alters myosin heavy chain isoform content in pig muscle. J. Anim. Sci. 80 7 (2002) 1888-1894
56. Donkin S.S., Chiu P.Y., Yin D., Louveau I., Swencki B., Vockroth J., Evock-Clover C.M., Peters J.L., and Etherton T.D. Porcine somatotropin differentially down-regulates expression of the GLUT4 and fatty acid synthase genes in pig adipose tissue. J. Nutr. 126 (1996) 2568-2577
57. Dorhout B., Faassen A., van Beusekom C.M., Kingma A.W., Hoog E., de Nagel G.T., Karrenbeld A., Boersma E.R., and Muskiet F.A.J. Oral administration of deuterium-labelled polyamines to suckling rat pups: luminal uptake, metabolic fate and effects on gastrointestinal maturation. Br. J. Nutr. 78 4 (1997) 639-654
58. Downs W.G. An experimental study of the growth effects of the anterior lobe of the hypophysis on the teeth and other tissues and organs. J. Dent. Res. 10 (1930) 601-654
59. Duckett S.K., Wagner D.G., Owens F.N., Dolezal H.G., and Gill D.R. Effects of estrogenic and/or androgenic implants on performance, carcass traits, and meat tenderness in feedlot steers: A review. Prof. Anim. Sci. 12 (1996) 205-214
60. Dunshea F.R., Harris D.M., Bauman D.E., Boyd R.D., and Bell A.W. Effect of porcine somatotropin on in vivo glucose kinetics and lipogenesis in growing pigs. J. Anim. Sci. 70 (1992) 141-151
61. Dunshea F.R., King R.H., and Campbell R.G. Interrelationships between dietary protein and ractopamine on protein and lipid deposition in finishing gilts. J. Anim. Sci. 71 (1993) 931-941
62. Dyer C.J., Simmons J.M., Matteri R.L., and Keisler D.H. Leptin receptor mRNA is expressed in ewe anterior pituitary and adipose tissues and is differentially expressed in hypothalamic regions of well-fed and fed restricted ewes. Anim. Endocrinol. 14 (1997) 119-128
63. Eisemann J.H., Tyrrell H.F., Hammond A.C., Reynolds P.J., Bauman D.E., Haaland G.L., Mcmurry J.P., and Varga G.A. Effect of bovine growth hormone administration on metabolism of growing Hereford heifers: dietary digestibility, energy, and nitrogen balance. J. Nutr. 116 (1986) 157-163
64. Eisemann J.H., Hammond A.C., Rumsey T.S., and Bauman D.E. Nitrogen and protein metabolism and metabolites in plasma and urine of beef steers treated with somatotropin. J. Anim. Sci. 67 (1989) 105-115
65. Ekpe E.D., Moibi J.A., and Christopherson R.J. Beta-adrenergic receptors in skeletal muscles of ruminants: Effects of temperature and feed intake. Can. J. Anim. Sci. 80 (2000) 79-86
66. Ekpe E.D., Moibi J.A., and Christopherson R.J. Effects of temperature and plane of nutrition on beta adrenergic receptors in heart, kidney and liver of lambs. J. Anim. Sci. 78 (2000) 1907-1916
67. Elbers J.M.H., Asscheman H., Seidell J.C., Frolich M., Meinder A.E., and Gooren L.J.G. Reversal of the sex difference in serum leptin levels upon cross-sex hormone administration in transsexuals. J. Clin. Endocrinol. Metab. 82 (1997) 3267-3270
68. Eliassen K.A. Formation of polyamines in the rumen of goats during growth. Acta. Vet. Scand. 23 (1982) 275-294
69. Eliassen K.A., and Sjaastad O.V. Polyamines in the gastrointestinal tract of goat kids and in the regenerating ruminal epithelium of sheep. J. Vet. Med. A, Physiol. Pathol. Clin. Med. 47 5 (2000) 297-310
70. Elsasser T.H., Kahl S., Steele N.C., and Rumsey T.S. Nutritional modulation of somatotropin axiscytokine relationships in cattle: a brief review. Comp. Biochem. Physiol. A Physiol. 116 (1997) 209-221
71. Emilsson V., O'Dowd J., Wang S., Liu Y.-L., Sennit M., Heyman R., and Cawthorne M.A. The effects of rexinoids and rosiglitazone on body weight and uncoupling protein isoform expression in the zucker fa/fa rats. Metabolism 49 12 (2000) 1610-1615
72. Emilsson V., O'Dowd J., Nolan A.L., and Cawthorne M.A. Hexosamines and nutrient excess induce leptin production and leptin receptor activation in pancreatic islets and clonal beta-cells. Endocrinology 142 10 (2001) 4414-4419
73. Enright W.J. Effects of administration of somatotropin on growth, feed efficiency and carcass composition of ruminants: A review. In: Sejrsen K., Vestergaard M., and Neimann-Sørensen A. (Eds). Use of Somatotropin in Livestock Production (1989), Elsevier Applied Science, New York 132-156
74. Eppard P.J., White T.C., Birmingham B.K., Hintz R.L., Bentle L.A., Wood D.C., Salsgiver W.J., Rowold E., Miller M.A., Ganguli S., Hale M.D., Krivi G.G., Collier R.J., and Lanza G.M. Pharmacokinetic and galactopoietic response to recombinant variants of bovine growth hormone. J. Endocrinol. 139 (1993) 441-450
75. Erickson J.C., Clegg K.E., and Palmiter R.D. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381 (1996) 415-418
76. Etherton T.D., and Bauman D.E. Biology of somatotropin in growth and lacatation of domestic animals. Physiol. Rev. 78 (1998) 745-761
77. Etherton T.D., and Louveau I. Manipulation of adiposity by somatotropin and beta-adrenergic agonists: a comparison of their mechanisms of action. Proc. Nutr. Soc. 51 (1992) 419-431
78. Etherton T.D., and Walton P.E. Hormonal and metabolic regulation of lipid metabolism in domestic livestock. J. Anim. Sci. 63 Suppl. 2 (1986) 76-88
79. Etherton T.D., Louveau I., Sørensen M.T., and Chaudhuri S. Mechanisms by which somatotropin decreases adipose tissue growth. Am. J. Clin. Nutr. 58 Suppl. (1993) 287S-295S
80. Evans H.M., and Simpson M.E. Hormones of the anterior hypophysis. Am. J. Physiol. 98 (1931) 511-546
81. Ewtushik A.L., Bertolo R.F.P., and Ball R.O. Intestinal development of early weaned piglets receiving diets supplemented with selected amino acids or polyamines. Can. J. Anim. Sci. 80 4 (2000) 653-662
82. Fain J.N., Coronel E.C., Beauchamp M.J., and Bahouth S.W. Expression of leptin and beta(2)-adrenergic receptors in rat adipose tissue in altered thyroid states. Biochem. J. 322 (1997) 145-150
83. Florini J.R., Ewton D.Z., and Collican S.A. Growth hormone and the insulin-like growth factor system in myogenesis. Endocr. Rev. 17 (1996) 481-517
84. Forbes T.D.A., Carpenter B.B., Randel R.O., and Tolleson D.R. Effect of phenolic monoamines on release of luteinizing hormone stimulated by gonadotropin-releasing hormone and plasma adrenocorticotropic hormone: Norepinephrine and cortisol concentrations in wethers. J. Anim. Sci. 72 (1994) 464-469
85. Forrest R.H., Hickford J.G., Hogan A., and Frampton C. Polymorphism at the ovine beta3-adrener-gic receptor locus: associations with birth weight, growth rate, carcass composition and cold survival. Anim. Genet. 34 1 (2003) 19-25
86. Galbraith H., and Topps J.H. Effects of hormones on the growth and body composition of animals. Nutr. Abstr. Rev. Ser. B 52 (1981) 521
87. Garlick P.J. Assessment of the safety of glutamine and other amino acids. J. Nutr. 131 (2001) 2556S-2561S
88. Gazzola C. Alpha2-adrenoceptor-mediated effects on resting energy expenditure. Int. J. Obesity 17 (1993) 637-641
89. Ge W., Davis M.E., Hines H.C., Irvin K.M., and Simmen R.C.M. Association of single nucleotide plymorphisms in the growth hormone and growth hormone receptor genes with blood serum insulinlike growth factor I concentration and growth traits in Angus cattle. J. Anim. Sci. 81 (2003) 641-648
90. Geary T.W., McFadin E.L., MacNeil M.D., Grings E.E., Short R.E., Funston R.N., and Keisler D.H. Leptin as a predictor of carcass composition in beef cattle. J. Anim. Sci. 81 (2003) 1-8
91. Giacobino J.P. Beta(3)-adrenoceptor - an update. Eur. J. Endocrinol. 132 4 (1995) 377-385
92. Glasow A., Kiess K., Anderegg U., Berthold A., Bottner A., and Kratzsch J. Expression of leptin (Ob) and leptin receptor (Ob-R) in human fibroblasts: regulation of leptin secretion by insulin. J. Clin. Endocrinol. Metab. 86 9 (2001) 4472-4479
93. Gondo R.G., Aguiar-Oliveira M.H., Hayashida C.Y., Toledo S.P., Abelin N., Levine M.A., Bowers C.Y., Souza A.H., Pereira R.M., Santos N.L., and Salvatori R. Growth hormone-releasing peptide-2 stimulates GH secretion in GH-deficient patients with mutated GH-releasing hormone receptor. J. Clin. Endocrinol. Metab. 86 7 (2001) 3279-3283
94. Gonzalez P., Fente C.A., Franco C., Vazquez B., Quinto E., and Cepeda A. Determination of residues of the beta-agonist clenbuterol in liver of medicated farm animals by gas chromatography-mass spectroscopy using diphasic dialysis as an extraction procedure. J. Chromatogr. B. Biomed. Sci. Appl. 693 (1997) 321-326
95. Gopinath R., and Etherton T.D. Effects of porcine growth hormone on glucose metabolism of pigs. II. Glucose tolerance, peripheral tissue insulin sensitivity and glucose kinetics. J. Anim. Sci. 67 (1989) 689-697
96. Grant A.L., Holland R.E., Thomas J.W., King J.K., and Liesman J.S. Effects of dietary amines on the small intestine in calves fed soybean protein. J. Nutr. 119 7 (1989) 1034-1041
97. Grant A.L., Thomas J.W., King J.K., and Liesman J.S. Effects of dietary amines on small intestinal variables in neonatal pigs fed soy protein isolate. J. Anim. Sci. 68 2 (1990) 363-371
98. Greco S., Niepceron E., Hugueny I., George P., Louisot P., and Biol M.C. Dietary spermidine and spermine participate in maturation of galactosyltransferase activity and glycoprotein galactosylation in rat small intestine. J. Nutr. 131 7 (2001) 1890-1897
99. Groot M.J., Schilt R., Ossenkoppele J.S., Berende P.L., and Haasnoot W. Combinations of growth promoters in veal calves: consequences for screening and confirmation methods. Zentralbl. Veterinärmed. A. 45 (1998) 425-440
100. Grunfeld C., Zhoa C., Fuller J., Pollock A., Moser A., Freidman J., and Feingold K.R. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters - a role for leptin in anorexia infection. J. Clin. Invest. 97 (1996) 2151-2157
101. Guerra C., Roncero C., Porras A., Fernandez M., and Benito M. Triiodothyronine induces the transcription of the uncoupling protein gene and stabilizes its mRNA in fetal rat brown adipocyte primary cultures. J. Biol. Chem. 271 4 (1996) 2076-2081
102. Hadcock J.R., and Malbon C.C. Down-regulation of beta-adrenergic receptors agonist-induced reduction in receptor mRNA levels. Proc. Natl. Acad. Sci. USA. 85 (1988) 5021-5025
103. Halaas J.L., Gajiwala K.S., Maffei M., Cohen S.L., Chait B.T., Rabinowitz D., Lallone R.L., Burley S.K., and Freidman J.M. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269 (1995) 543-546
104. Hancock D.L., Wagner J.F., and Anderson D.B. Effects of estrogen and androgens on animal growth. In: Pearson A.M., and Dutson T.R. (Eds). Growth Regulation in Farm Animals: Advances in Meat Research 7 (1991), Elsevier Applied Science, London 255-297
105. In: Hanrahan J.R. (Ed). Beta-agonist and their Adrenergic Receptors Effects on Animal Growth and Carcass Quality (1987), Comm. Eur. Commun, Elsevier Appl., Science, London, U.K.
106. Hashizume T., Horiuchi M., Tate N., Nonaka S., Kojima M., Hosoda H., and Kangawa K. Effects of ghrelin on growth hormone secretion from cultured adenohypophysial cells in cattle. Endocr. J. 50 3 (2003) 289-295
107. Hashizume T., Horiuchi M., Tate N., Nonaka S., Mikami U., and Kojima M. Effects of Ghrelin on growth hormone secretion from cultured adenohypophysial cells in pigs. Domest. Anim. Endocrinol. 24 3 (2003) 209-218
108. Hauser S.D., Mcgrath M.F., Collier R.J., and Krivi G.G. Cloning and in vivo expression of bovine growth hormone receptor mRNA. Mol. Cell. Endocrinol. 72 (1990) 187-200
109. Hayashida T., Murakami K., Mogi K., Nishihara M., Nakazato M., Mondal M.S., Horii Y., Kojima M., Kangawa K., and Murakami N. Ghrelin in domestic animals: distribution in stomach and its possible role. Domest. Anim. Endocrinol. 21 (2001) 17-24
110. Hayden J.M., Bergen W.G., and Merkel R.A. Skeletal muscle protein metabolism and serum growth hormone, insulin, and cortisol concentrations in growing steers implanted with estradiol-17β, trenbolone acetate, or estradiol-17β plus trenbolone acetate. J. Anim. Sci. 70 (1992) 2109-2119
111. th Symposium on Energy Metabolism of Farm Animals
112. Hill R.A., Hoey A.J., and Sillence M.N. Functional activity of antibodies at the bovine beta-2-adrenoceptor. J. Anim. Sci. 76 (1998) 1651-1661
113. Hollenberg A.N., Susulic V.S., Madura J.P., Zhang B., Moller D.E., Tontonoz P., Sarraf P., Spiegelman B.M., and Lowell B.B. Functional antagonism between CCAAT/enhancer binding protein-α and peroxisome proliferator-activated receptor-γ on the leptin promotor. J. Biol. Chem. 272 (1997) 5283-5290
114. Holst B., and Schwartz T.W. Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation. Trends Pharmacol. Sci. 25 3 (2004) 113-117
115. Holzer Z., Aharoni Y., Brosh A., Orlov A., Veenhuizen J.J., and Kasser T.R. The effects of long term administration of recombinant bovine somatotropin (posilac) and Synovex on performance, plasma hormone and amino acid concentration and muscle and subcutaneous fat fatty acid composition in Holstein-Friesian bull calves. J. Anim. Sci. 77 (1999) 1422-1430
116. Holzer Z., Aharoni Y., Brosh A., Orlov A., and Buonomo F. The influence of recombinant bovine somatotropin on dietary energy level-related growth of Holstein-Friesian bull calves. J. Anim. Sci. 78 (2000) 621-628
117. Hopfner M., Berger A., Folsch U.R., and Loser C. Effects of insulin-like growth factor I on growth and polyamine metabolism in various organs in rats. Digestion 65 2 (2002) 103-111
118. Houseknecht K.L., and Bauman D.E. Regulation of lipolysis by somatotropin: functional alteration of adrenergic and adenosine signaling in bovine adipose tissue. J. Endocrinol. 152 (1997) 465-475
119. Houseknecht K.L., Baile C.A., Matteri R.L., and Spurlock M.E. The biology of leptin: A review. J. Anim. Sci. 76 5 (1998) 1405-1420
120. Houseknecht K.L., Portocarrero C.P., Ji S., Lemenager R., and Spurlock M.E. Growth hormone regulates leptin gene expression in bovine adipose tissue: correlation with adipose IGF-1 expression. J. Endocrinol. 164 1 (2000) 51-57
121. Howard A.D., Feighner S.D., Cully D.F., Arena J.P., Liberator P.A., Rosenblum C.I., Hamelin M., Hreniuk D.L., Palyha O.C., Anderson J., Paress P.S., Diaz C., Chou M., Liu K.K., McKee K.K., Pong S.S., Chaung L.Y., Elbrecht A., Dashkevicz M., Heavens R., Rigby M., Sirinathsinghji D.J., Dean D.C., Melillo D.G., Patchett A.A., Nargund R., Griffin P.R., DeMartino J.A., Gupta S.K., Schaeffer J.A., Smith R.G., and Van der Ploeg L.H.T. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273 (1996) 974-977
122. Hunter R.A. The effect of alpha-2 adrenergic agonist, guanfacin on the energy metabolism of steers fed on low quality roughage diets. Br. J. Nutr. 67 (1992) 337-347
123. Hunter R.A., Sillence M.N., Gazzola C., and Speirs W.J. Increasing annual growth rate of cattle by reducing maintenance energy requirements. Aust. J. Agric. Res. 44 (1993) 579-595
124. Igareshi K., and Kashiwagi K. Polyamines: Mysterious modulators of cellular functions. Biochem. Biophys. Res. Commun. 271 (2000) 559-564
125. Jekabsons M.B., Gregoire F.M., Schonfeld-Warden N.A., Warden C.H., and Horwitz B.A. T3 stimulates resting metabolism and UCP-2 and UCP-3 mRNA but not non-phosphorylating respiration in mice. Endocrin. Metab. 277 2 (1999) E380-E389
126. Johnson, K.A., Michal, J.J., 2001. The role of diet composition on ruminal and gastrointestinal growth. In: Chwalibog, A., Jakobsen, K., (Eds.), Energy Metabolism in Animals. Proceedings of the 15th Symposium on Energy Metabolism in Animals, pp. 223-32.
127. Johnson L.R. Regulation of gastrointestinal mucosal growth. Physiol. Rev. 68 (1988) 456-502
128. Johnson L.R., and McCormack S.A. Healing of gastrointestinal mucosa: involvement of polyamines. News Physiol. Sci. 14 (1999) 12-17
129. Kennedy A.D., and Belluk B.M. Growth and carcass composition of ram lambs treated with clonidine. Can. J. Anim. Sci. 67 (1987) 417-425
130. Kennedy P.M., Young B.A., and Christopherson R.J. Studies on the relationship between thyroid function, cold acclimation and retention time of digesta in sheep. J. Anim. Sci. 45 5 (1977) 1084-1090
131. Kim Y.S., Sainz R.D., Summers R.I., and Molenaar P. Cimetrol reduces beta-adrenergic receptor density in rat skeletal muscles. J. Anim. Sci. 70 (1992) 115-122
132. Knerr I., Groschl M., Rascher W., and Rauh M. Endocrine effects of food intake: Insulin, ghrelin, and leptin responses to a single bolus of essential amino acids in humans. Ann. Nutr. Metab. 47 6 (2003) 312-318
133. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
134. Korbonits M., Kojima M., Kangawa K., and Grossman A.B. Presence of ghrelin in normal and adenomatous human pituitary. Endocrine 14 1 (2001) 101-104
135. Kornegay E.T., Wang Z., Wood C.M., and Lindemann M.D. Supplemental chromium picolinate influences nitrogen balance, dry matter digestibility, and carcass traits in growing-finishing pigs. J. Anim. Sci. 75 5 (1997) 1319-1323
136. Kwon H., Wu G., Bazer F.W., and Spencer T.E. Development changes in polyamine levels and synthesis in the ovine conceptus. Biol. Reprod. 69 5 (2003) 1626-1634
137. Landis M.D., Carstens G.E., McPhail E.G., Randel R.D., Green K.K., Slay L., and Smith S.B. Ontogenic development of brown adipose tissue in Angus and Brahman fetal calves. J. Anim. Sci. 80 (2002) 591-601
138. Landsberg L., Saville M.E., and Young J.B. Sympathoadrenal system and regulation of thermogenesis. Am. J. Physiol. Endocrinol. Metab. 247 (1984) 181-189
139. Lee H.M., Wang G., Englander E.W., Kojima M., and Greeley G.H. Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations. Endocrinology 143 1 (2002) 185-190
140. Lesniak M.A., Gorden P., and Roth J. Reactivity of non-primate growth hormones and prolactins with human growth hormone receptors on cultured human lymphocytes. J. Clin. Endocrinol. Metab. 44 (1977) 838-849
141. Levin N., Nelson C., Gurney A., Vbanelen R., and DeSauvage F. Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proc. Natl. Acad. Sci. USA 93 (1996) 1726-1730
142. Li C.H., Evans H.M., and Simpson M.E. Isolation and properties of the anterior hypophysial growth hormone. J. Biol. Chem. 159 (1945) 353-366
143. Li Y., Christopherson R.J., Li B.T., and Moibi J.A. Effects of a beta-adrenergic agonist (L-644,969) on performance and carcass traits of growing lambs in a cold environment. Can. J. Anim. Sci. 80 (2000) 459-465
144. Lien T.F., Wu C.P., Wang B.J., Shiao T.Y., Lin B.H., Lu J.J., and Hu C.Y. Effect of supplemental levels of chromium picolinate on the growth performance, serum traits, carcass characteristics and lipid metabolism of growing-finishing pigs. Anim. Sci. 72 (2001) 289-296
145. Lindemann M.D. Chromium picolinate for the enhancement of muscle development and nutrient management. In: Kornegay E.T. (Ed). Nutrient Management of Food Animals to Enhance and Protect the Environment (1996), CRC Press. Inc, Boca Raton 303-314
146. Lindemann M.D., Wood C.M., Harper A.F., Kornegay E.T., and Anderson R.A. Dietary chromium picolinate additions improve gain: feed and carcass characteristics in growing-finishing pigs and increase litter size in reproducing sows. J. Anim. Sci. 73 2 (1995) 457-465
147. Lindsay D.B., Hunter R.A., Gazzola C., Spiers W.G., and Sillence M.N. Energy and growth. Aust. J. Agric. Res. 44 (1993) 875-899
148. Lobely G.E., Hoskin S.O., and McNeil C.J. Glutamine in animal science and production. J. Nutr. 131 (2001) 2525S-2531S
149. Lohrke B., Derno M., Matthes H.D., and Jenstsch W. Metabolic response of different breeds of cattle to varying nutritional and environmental conditions. In: Jung H.-J.G., and Fahey Jr. G.C. (Eds). Nutritional Ecology of Herbivores. American Society of Animal Science (1999), Savoy, Ill 505-549
150. Lollmann B., Gruninger S., Stricker-Krangad A., and Chiesi M. Detection and quantification of the leptin receptor splice variants Ob-Ra, b and e in different mouse tissues. Biochem. Biophys. Res. Commun. 232 2 (1997) 648-652
151. Loret S., Brolet P., Pierzynowski S., Gouders I., Klimek M., Danielason V., Rosted A., Lesniewska V., and Dandrifosse G. Pancreatic secretions as a source of luminal polyamine in pigs. Exp. Physiol. 85 3 (2000) 301-308
152. Loser C. Polyamines in human and animal milk. Br. J. Nutr. 84 Suppl. 1 (2000) S55-S58
153. Lowell B.B., Susulic V.S., Grujic D., and Ito M. Using transgenic and gene knockout techniques to assess beta 3 adrenoceptor function. In: Strosberg A.D. (Ed). The Beta-3 Adrenoceptor (2000), Taylor and Francis, London 36-47
154. Machlin L. Effect of porcine growth hormone on growth and carcass composition of the pig. J. Anim. Sci. 35 (1972) 794-800
155. Magri K.A., Adamo M., Leroith D., and Etherton T.D. The inhibition of insulin action and glucose metabolism by porcine growth hormone in porcine adipocytes is not the result of any decrease in insulin binding or insulin receptor kinase activity. Biochem. J. 266 (1990) 107-113
156. Martinez-Navarro J.F. Food poisoning related to consumption of illicit beta-agonist in liver. Lancet 336 (1990) 1311
157. Masaki T., Yoshimatsu H., Chiba S., Hidaka S., Tajima D., Kakuma T., Kurokawa M., and Sakata T. Tumor necrosis factor α regulates in vivo expression of the rat ucp family differentially. Biochem. Biophys. Acta 1436 (1999) 585-592
158. Masaki T., Yoshimatsu H., Chiba S., Watanabe T., and Sakata T. Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice. Diabetes 50 2 (2001) 376-384
159. Matthews J.O., Southern L.L., Fernandez J.M., Pontif J.E., Bidner T.D., and Odgaard R.L. Effect of chromium picolinate and chromium propionate on glucose and insulin kinetics of growing barrows and on growth and carcass traits of growing-finishing barrows. J. Anim. Sci. 79 8 (2001) 2172-2178
160. Mazannti G., Daniele C., Boatto G., Manca G., Brambilla G., and Loizzo A. New beta-adrenergic agonists used illicitly as growth promoters in animal breeding: chemical and pharmacodynamic studies. Toxicology 187 (2003) 91-100
161. McDaneld T.G., Hancock D.L., and Moody D.E. Altered mRNA abundance of ASB15 and four other genes in skeletal muscle following administration of beta-adrenergic receptor agonists. Physiol. Genomics 16 (2004) 275-283
162. Mcdowell G.H., Hart I.C., and Kirby A.C. Local intra-arterial infusion of growth hormone into the mammary glands of sheep and goats: effects on milk yield and composition, plasma hormones and metabolites. Aust. J. Biol. Sci. 40 (1987) 181-189
163. Mersmann H.J. Overview of the effects of beta-adrenergic receptor agonists on animal growth including mechanisms of action. J. Anim. Sci. 76 (1998) 160-172
164. Mersmann H.J. Beta-adrenergic receptor modulation of adipocyte metabolism and growth. J. Anim. Sci. 80 Suppl. E (2002) E24-E29
165. Mertz W. Chromium occurrence and function in biological systems. Physiol. Rev. 49 (1969) 163-239
166. Meyer A.A., and Webster A.J.F. Cold induced vasodilation in the sheep. Can. J. Physiol. Pharmacol. 49 (1971) 901-908
167. Meyer H.H. Biochemistry and physiology of anabolic hormones used for improvement of meat production. APMIS 109 (2001) 1-8
168. Meyer H.H.D., and Rapp M. Estrogen receptor in bovine skeletal muscle. J. Anim. Sci. 60 (1985) 294-300
169. Miaron J.O.O., and Christopherson R.J. Metabolic responses of the whole body, portal-drained viscera and hind quarter to adrenaline infusion: Effects of nonselective and selective beta adrenoceptor blockade. Can. J. Anim. Sci. 77 (1997) 307-316
170. Miaron J.O.O., Christopherson R.J., Hardin R.T., Mosenthin R., and Cosgrove S. The effect of alpha-2 adrenoceptor stimulation with guanfacin on heat production of restricted fed steers kept at -9, 11 or 28°C and on ad libitum fed steers acclimated to -19 and 22°C. J. Therm. Biol. 20 (1995) 291-298
171. 2-adrenoceptor stimulation with guanfacin on thermogenesis in fasted and fed sheep. Can. J. Anim. Sci. 75 (1995) 537-541
172. Mildner A.M., and Clarke S.D. Porcine fatty acid synthase: cloning of complementary DNA, tissue distribution of its mRNA and suppression of expression by somatotropin and dietary protein. J. Nutr. 121 (1991) 900-907
173. Mills S.E., Kissel J., Bidwell C.A., and Smith D.J. Stereoselectivity of porcine beta adrenergic receptors for ractopamine stereoisomers. J. Anim. Sci. 81 1 (2003) 122-129
174. Minokoshi Y., Kim Y.-B., Peroni O.D., Fryer L.G.D., Muller C., Carling D., and Kahn B.B. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415 (2002) 339-343
175. Mix H., Widjaja A., Jandl O., Cornberg M., Kaul A., Goke M., Beil W., Kuske M., Brabant G., Manns M.P., and Wagner S. Isoforms in the human stomach. Gut 47 (2000) 481-486
176. Mogridge J.L., Smith T.K., and Sousadias M.G. Effect of feeding raw soybeans on polyamine metabolism in chicks and the therapeutic effect of exogenous putrescine. J. Anim. Sci. 74 8 (1996) 1897-1904
177. Moibi J.A., Christopherson R.J., and Li Y. Effect of beta-adrenergic agonist L-644,969 on the impact of the thermal environment on in vitro fatty acid synthesis and the lipogenic enzymes in sheep. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 125 (2000) 251-263
178. Moloney A.P., Allen P., Joseph R.L., Tarrant P.V., and Convey E.M. Carcass and meat quality of finishing Friesian steers fed the beta-adrenergic agonist, L-644.9.69. Meat Sci. 38 (1994) 419-432
179. Mooney K.W., and Cromwell G.L. Efficacy of chromium picolinate and chromium chloride as potential carcass modifiers in swine. J. Anim. Sci. 75 10 (1997) 2661-2671
180. Moore W.V., Draper S., and Hung C.H. Species variation in the binding of hGH to hepatic membranes. Horm. Res. 21 (1985) 33-45
181. Mori K., Yoshimoto A., Takaya K., Hosoda K., Ariyasu H., Yahata K., Mukoyama M., Sugawara A., Hosoda H., Kojima M., Kangawa K., and Nakao K. Kidney produces a novel acylated peptide, ghrelin. FEBS Lett. 486 3 (2000) 213-216
182. Moseley W.M., Paulissen J.B., Goodwin M.C., Alaniz G.R., and Claflin W.H. Recombinant bovine somatotropin improves growth performance in finishing beef steers. J. Anim. Sci. 70 (1992) 412-425
183. Muoio D.M., Dohm G.L., Fiedorek Jr. F.T., Tapscott E.B., Coleman R.A., and Dohn G.L. Leptin directly alters lipid partitioning in skeletal muscle. Diabetes 46 8 (1997) 1360-1363
184. Muzzin P., Revelli J.P., Kuhne F., Gocayne J.D., McCombie W.R., Venter J.C., Giacobino J.P., and Fraser C.M. An adipose tissue-specific beta-adrenergic-receptor - molecular-cloning and down-regulation in obesity. J. Biol. Chem. 266 35 (1991) 24053-24058
185. Myers M.J., Farrell D.E., Evock-Clover C.M., Cope C.V., Henderson M., and Steele N.C. Effect of recombinant growth hormone and chromium picolinate on cytokine production and growth performance in swine. Pathobiology 63 5 (1995) 283-287
186. Nakazato M., Murakami N., Date Y., Kojima M., Matsuo H., Kangawa K., and Matsukura S. A role for ghrelin in the central regulation of feeding. Nature 409 6817 (2001) 194-198
187. Nash J.E., Rocha H.J.G., Buchan V., Calder G.A., Milne E., Quirke J.F., and Lobeley G.E. The effect of acute and chronic administration of the beta agonist, cimaterol, on protein synthesis in ovine skin and muscle. Brit. J. Nutr. 71 (1994) 501-513
188. National Research Council. Metabolic Modifiers. Effects on the Nutrient Requirements of Food Producing Animals (1994), National Academy Press, Washington, DC
189. Newsholme P. Why is glutamine metabolism important to cells of the immune system in health, post-injury, surgery or infection?. J. Nutr. 131 (2001) 2515S-2522S
190. O'Connor R.M., Butler W.R., Finnerty K.D., Hogue D.E., and Beerman D.H. Acute and chronic hormone and metabolite changes in lambs fed the beta-agonist, cimaterol. Domest. Anim. Endocrinol. 8 (1991) 537-548
191. Obregon M.J., Calvo R., Hernandez A., Escobar del Rey F., and Morreale de Escobar G. Regulation of uncoupling protein messenger ribonucleic acid and 5' deiodinase activity by thyroid hormones in fetal brown adipose tissue. Endocrinology 137 11 (1996) 4721-4729
192. Olszewski P.K., Li D., Grace M.K., Billington C.J., Kotz C.M., and Levine A.S. Neural basis of orexigenic effects of ghrelin acting within lateral hypothalamus. Peptides 24 4 (2003) 597-602
193. Onal E.E., Cinaz P., Atalay Y., Turkyilmaz C., Bideci A., Akturk A., Okumus N., Unal S., Koc E., and Ergenekon E. Umbilical cord ghrelin concentrations in small- and appropriate-for-gestational age newborn infants: relationship to anthropometric markers. J. Endocrinol. 180 2 (2004) 267-271
194. Ono Y., Solomon M.B., Evock-Clover C.M., Steele N.C., and Maruyama K. Effects of porcine somatotropin administration on porcine muscles located within different regions of the body. J. Anim. Sci. 73 (1995) 2282-2288
195. Page K.A., Hartzell D.L., Li C., Westby A.L., Della-Fera M.A., Azain M.J., Pringle T.D., and Baile C.A. Beta-Adrenergic receptor agonists increase apoptosis of adipose tissue in mice. Domest. Anim. Endocrinol. 26 (2004) 23-31
196. Page M.D., Diequez C., and Scalon M.F. Neuro-regulation of growth hormone secretion. In: Heap R.B., Prosser C.G., and Lamming G.E. (Eds). Biotechnology in Growth Regulation (1989), Butterworths, Toronto, ON 47
197. Pell J.M., and Bates P.C. Collagen and non-collagen protein turnover in skeletal muscle of growth hormone-treated lambs. J. Endocrinol. 115 (1987) R1-R4
198. Pelleymounter M.A., Cullen M.J., Baker M.B., Hecht R., Winter D., Boone T., and Collinc F. Effects of obese gene product on body weight regulation in ob/ob mice. Science 269 5223 (1995) 540-543
199. Perez-Llamas F., Lopez J.A., and Zamora S. The digestive and metabolic utilization of the dietary protein: effect of clenbuterol and protein level. Arch. Int. Phys. Biochem. Biophys. 100 1 (1992) 27-31
200. Peters J.P. Consequences of accelerated gain and growth hormone administration for lipid metabolism in growing beef steers. J. Nutr. 116 (1986) 2490-2503
201. Peulen O., Deloyer P., Grandfils C., Loret S., and Dandrifosse G. Intestinal maturation induced by spermine in young animals. Livest. Prod. Sci. 66 2 (2000) 109-120
202. Pringle T.D., Calkins C.R., Koohmaraie M., and Jones S.J. Effects over time of feeding a beta adrenergic agonist to wether lambs on animal performance, muscle growth, endogenous muscle proteinase activities, and meat tenderness. J. Anim. Sci. 71 (1993) 636-644
203. Pulce C., Lamaison D., Keck G., Bostvironnois C., Nicholas J., and Descotes J. Collective human food poisonings by clenbuterol residues in veal liver. Vet. Hum. Toxicol. 33 (1991) 480-481
204. Qian H., Hartzell D.L., Baile C.A., Azain M.J., Compton M.M., and Hausman G.J. Brain administration of leptin causes deletion of adipocytes by apoptosis. Endocrinology 139 (1998) 791-794
205. Ramsay T.G., Yan X., and Morrison C. The obesity gene in swine: Sequence and expression of porcine leptin. J. Anim. Sci. 76 (1998) 484-490
206. Rausch M.I., Tripp M.W., Govoni K.E., Zang W., Weber W.J., Crooker B.A., Hoagland T.A., and Zinn S.A. The influence of level of feeding on growth and serum insulin-like growth factor I and insulin-like growth factor-binding proteins in growing beef cattle supplemented with somatotropin. J. Anim. Sci. 80 (2002) 94-100
207. Rawlings S.R., and Mason W.T. Modulation of growth hormone release: from CNS to the secretory event. In: Heap R.B., Prosser C.G., and Lamming G.E. (Eds). Biotechnology in Growth Regulation (1989), Butterworths, Toronto, ON 35
208. Rechler M.M., and Nissley S.P. Insulin-like growth factors. Handb. Exp. Pharmacol. 95 (1990) 263-367
209. Reeds P.J., and Burrin D.G. Glutamine and the bowel. J. Nutr. 131 (2001) 2505S-2508S
210. Reiling B.A., and Johnson D.D. Effects of implant regimes (trebolone acetate-estradiol administered alone or in combination with zeranol) and Vitamin D3 on fresh beef color and quality. J. Anim. Sci. 81 (2003) 135-142
211. Reitman M.L., Bi S., Marcus-Samuels B., and Gavrilova O. Leptin and its role in pregnancy and fetal development - an overview. Biochem. Soc. Trans. 29 2 (2001) 68-72
212. Revelli J.P., Preitner F., Samec S., Muniesa P., Kuehne F., Boss O., Vassalli J.D., Dulloo A., Seydoux J., Giacobino J.P., Huarte J., and Ody C. Targeted gene disruption reveals a leptin-independent role for the mouse beta (3)-adrenoceptor in the regulation of body composition. J. Clin. Invest. 100 5 (1997) 1098-1106
213. Robert C., Palin M.-F., Coulombe N., Roberge C., Silversides F.G., Benkel B.F., McKay R.M., and Pelletier G. Backfat thickness in pigs is positively associated with leptin mRNA levels. Can. J. Anim. Sci. 78 (1998) 473-482
214. Roche J.F., and Quirke J.F. The effects of steroid hormones and xenobiotics on growth of farm animals. In: Buttery P.J., Haynes N.B., and Lindsay D.B. (Eds). Control and Manipulation of Animal Growth (1986), Butterworths, London 35-51
215. 1-acetyltransferase during peri-implantation. Biol. Reprod. 65 2 (2001) 587-594
216. Rosenbloom A.L., Rosenfeld R.G., and Guevara-Aguirre J. Growth hormone insensitivity. Pediatr. Clin. N. Am. 44 (1997) 423-442
217. Rotwein P., Gronowski A.M., and Thomas M.J. Rapid nuclear actions of growth hormone. Horm. Res. 42 (1994) 170-175
218. Ruffolo R.R., and Hieble J.P. Alpha-adrenoceptors. Pharmacol. Ther. 61 (1994) 1-64
219. Rumsey T.S., McLeod K., Elsasser T.H., Kahl S., and Baldwin R.L. Performance and carcass merit of growing beef steers with chlortetracycline-modified sensitivity to pituitary releasing hormones and fed two dietary protein levels. J. Anim. Sci. 78 (2000) 2765-2770
220. Sacks G.S. Glutamine supplementation in catabolic patients. Ann. Pharmacol. 33 (1999) 348-354
221. Sainz R.D., Kim Y.S., Dunshea F.R., and Campbell R.G. Effects of ractopamine on pig muscle histology, calpains and beta-adrenergic receptors. Aust. J. Agric. Res. 44 (1993) 1441-1448
222. Saladin R., De Vos P., Guerre-Millo M., Leturque A., Girard J., Staels B., and Auwerx J. Transient increases in obese gene expression after food intake or insulin administration. Nature 377 (1995) 527-529
223. Salleras L., Dominguez A., Mata E., Taberner J.L., Moro I., and Salva P. Epidemiologic study of an outbreak of clenbuterol poisoning in Catalonia, Spain. Public Health Rep. 110 (1995) 338-342
224. Scarpace P.J., Matheny M., Pollock B.H., and Tumer N. Leptin increases uncoupling protein expression and energy expenditure. Am. J. Physiol. 273 (1997) E226-E230
225. Scarpace P.J., Nicolson M., and Matheny M. UCP2, UCP3 and leptin gene expression: modulation by food restriction and leptin. J. Endocrinol. 159 (1998) 349-357
226. Schaefer A.L., Jones S.D.M., Kennedy A.D., Tong A.K.W., and Onischuk L.A. The effects of the alpha adrenergic agonist clonidine on the growth carcass yield meat quality and physiological endocrinological response in steers. Can. J. Anim. Sci. 70 (1990) 857-866
227. Schwartz M.W., Seeley R.J., Campfield L.A., Burn P., and Baskin D.G. Identification of targets of leptin action in rat hypothalamus. J. Clin. Invest. 98 (1996) 1101-1106
228. Sechen S.J., Bauman D.E., Tyrrell H.F., and Reynolds P.J. Effect of somatotropin on kinetics of nonesterified fatty acids and partition of energy, carbon, and nitrogen in lactating dairy cows. J. Dairy Sci. 72 (1989) 59-67
229. Sechen S.J., Dunshea F.R., and Bauman D.E. Somatotropin in lactating cows: Effect on response to epinephrine and insulin. Am. J. Physiol. 258 (1990) E582-E588
230. Shackelford S.D., Wheeler T.L., and Koohmaraie M. The effects of in utero exposure of lambs to a beta-adrenergic agonist on prenatal and postnatal muscle growth, carcass cutability, and meat tenderness. J. Anim. Sci. 73 (1995) 2986-2993
231. Shimada M., Date Y., Mondal M.S., Toshinai K., Shimbara T., Fukunaga K., Murakami N., Miyazato M., Kangawa K., Yoshimatsu H., Matsuo H., and Nakazato M. Somatostatin suppresses ghrelin secretion from the rat stomach. Biochem. Biophys. Res. Commun. 302 3 (2003) 520-525
232. Sillence M.N. Evaluation of new technologies for the improvement of nitrogen utilization in ruminants. In: Kornegay E.T. (Ed). Nutrient Management of Food Animals to Enhance and Protect the Environment (1996), CRC Press. Inc, Boca Raton 105-133
233. Sillence M.N., Tudor G.D., Mathews M.L., and Lindsay D.B. Effects of the alpha-2 adrenoceptor agonist guanfacin on growth and thermogenesis in mice. J. Anim. Sci. 70 (1992) 3429-3434
234. Smith D.J. The pharmacokinetics, metabolism, and tissue residues of beta-adrenergic agonists in livestock. J. Anim. Sci. 76 (1998) 173-194
235. Smith R.G.L., Van der Ploeg H.T., Howard A.D., Feighner S.D., Cheng K., Hickey G.J., Wyvratt Jr. M.J., Fisher M.H., Nargund R.P., and Patchett A.A. Peptidomimetic regulation of growth hormone secretion. Endocr. Rev. 18 (1997) 621-645
236. Smith S.B., Davis S.K., Wilson J.J., Stone R.T., Wu F.Y., Garcia D.K., Lunt D.K., and Schiavetta A.M. Bovine fast-twitch myosin light chain 1: cloning and mRNA amount in muscle of cattle treated with clenbuterol. Am. J. Physiol. - Endocrinol. Metab. 268 5 (1995) E858-E865
237. Smith T.K. Effect of dietary putrescine on whole body growth and polyamine metabolism. Proc. Soc. Exp. Biol. Med. 194 4 (1990) 332-337
238. Smith T.K., Mogrodge J.L., and Sousadias M.G. Growth promoting potential and toxicity of spermidine, a polyamine and biogenic amine found in foods and feedstuffs. J. Agric. Food Chem. 44 2 (1996) 518-521
239. Sobhani I., Bado A., Vissuzaine C., Buyse M., Kermorgant S., Laigneau J.-P., Attoub S., Lehy T., Henin D., Mignon M., and Lewin M.J.M. Leptin secretion and leptin receptor in the human stomach. Gut 47 (2000) 178-183
240. Sorensen A., Adam C.L., Findaly P.A., Marie M., Thomas L., Travers M.T., and Vernon R.G. Leptin secretion and hypothalamic neuropeptide and receptor gene expression in sheep. Am. J. Physiol. 282 (2002) R1227-R1235
241. Stephens T.W., Basinski M., Bristov P.K., Bue-Valleskey J.M., Burgett S.G., Craft L., Hale J., Hoffmann J., Hsiung H.M., Kriaucinas A., MacKellar W., Rostteck P.R., Schooner B., Smith P., Tinsky F.C., Zhang X.-Y., and Helman M. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377 (1995) 530-532
242. Strosberg A.D. The association with obesity and diabetes in beta-adrenoceptors and other proteins. J. Mol. Med. 78 3 (2000) 24
243. Subiyatno A., Mowat D.N., and Yang W.Z. Metabolite and hormonal responses to glucose or propionate infusions in periparturient dairy cows supplemented with chromium. J. Dairy Sci. 79 8 (1996) 1436-1445
244. Sugino T., Yamaura J., Yamagishi M., Ogura A., Hayashi R., Kurose Y., Kojima M., Kangawa K., Hasegawa Y., and Terashima Y. A transient surge of ghrelin secretion before feeding is modified by different feeding regimens in sheep. Biochem. Biophys. Res. Commun. 298 5 (2002) 785-788
245. Sugino T., Hasegawa Y., Kikkawa Y., Yamaura J., Yamagishi M., Kurose Y., Kojima M., Kangawa K., and Terashima Y. A transient ghrelin surge occurs just before feeding in a scheduled meal-fed sheep. Biochem. Biophys. Res. Commun. 295 2 (2002) 255-260
246. Sugino T., Yamaura J., Yamagishi M., Kurose Y., Kojima M., Kangawa K., Hasegawa Y., and Terashima Y. Involvement of cholinergic neurons in the regulation of the ghrelin secretory response to feeding in sheep. Biochem. Biophys. Res. Commun. 304 2 (2003) 308-312
247. Susulic V.S., Frederich R.C., Lawitts J., Tozzo E., Kahn B.B., Harper M.E., Himms-Hagen J., Flier J.S., and Lowell B.B. Targeted disruption of the beta(3)-adrenergic receptor gene. J. Biol. Chem. 270 49 (1995) 29483-29492
248. Tannenbaum G.S., and Bowers C.Y. Interactions of growth hormone secretagogues and growth hormone-releasing hormone/somatostatin. Endocrine 14 1 (2001) 21-27
249. Thompson D.A., Penicayd L., and Welle S.L. Alpha-2 adrenoceptor stimulation inhibits thermogenesis and food intake during glucoprivation in humans. Am. J Physiol. 247 (1984) R560-R566
250. Thompson N.M., Gill D.A.S., Davies R., Loveridge N., Houston P.A., Robinson I.C.A.F., and Wells T. Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor. Endocrinology 145 1 (2004) 234-242
251. Thompson S.H., Boxhorn L.K., Kong W., and Allen R.E. Trenbolone alters the responsiveness of skeletal muscle satellite cells to fibroblast growth factor and insulin-like growth factor I. Endocrinology 124 (1989) 2110-2117
252. Tomas F.M., Campbell R.G., King R.H., Johnson R.J., Chandler C.S., and Taverner M.R. Growth hormone increases whole-body protein turnover in growing pigs. J. Anim. Sci. 70 (1996) 3138-3143
253. Toshinai K., Mondal M.S., Nakazato M., Date Y., Murakami N., Kojima M., Kangawa K., and Matsukura S. Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochem. Biophys. Res. Commun. 281 5 (2001) 1220-1225
254. Trayhurn P., Duncan J.S., and Rayner D.V. Acute cold-induced supression of ob (obese) gene expression in white adipose tissue of mice: mediation by the sympathetic system. Biochem. J. 311 (1995) 729-733
255. Trayhurn P., Duncan J.S., Rayner D.V., and Hardie L.J. Rapid inhibition of ob gene expression and circulating leptin levels in lean mice by the beta3-adrenoceptor agonists BRL 35135A and ZD2079. Biochem. Biophys. Res. Commun. 228 (1996) 605-610
256. Trayhurn P., Hoggard N., Mercer J.G., and Rayner D.V. Hormonal and neuroendocrine regulation of energy balance - the role of leptin. Arch. Tierernähr. 51 (1998) 177-185
257. Tschop M., Lahner H., Feldmeier H., Grasberger H., Morrison K.M., Janssen O.E., Attanasio A.F., and Strasburger C.J. Effects of growth hormone replacement therapy on levels of cortisol and cortisol-binding globulin in hypopituitary adults. Eur. J. Endocrinol. 143 6 (2000) 769-773
258. Tschop M., Wawarta R., Riepl R.L., Friedrich S., Bidlingmaier M., Landgraf R., and Folwaczny C. Post-prandial decrease of circulating human ghrelin levels. J. Endocrinol. Invest. 24 6 (2001) RC19-RC21
259. Tschop M., Weyer C., Tataranni P.A., Devanarayan V., Ravussin E., and Heiman M.L. Circulating ghrelin levels are decreased in human obesity. Diabetes 50 4 (2001) 707-709
260. Tuggle C.K., and Trenkle A. Control of growth hormone synthesis. Domest. Anim. Endocrinol. 13 (1996) 1-33
261. Uda K., Tsujikawa T., Ihara T., Fujiyama Y., and Bamba T. Luminal polyamines upregulate transmural glucose transport in the rat small intestine. J. Gastroenterol. 37 6 (2002) 434-441
262. Uda K., Tsujikawa T., Fujiyama Y., and Bamba T. Rapid absorption of luminal polyamines in a rat small intestine ex vivo model. J. Gastroenterol. Hepatol. 18 5 (2003) 554-559
263. Ultsch M., de Vos A.M., and Kossiakoff A.A. Crystals of the complex between human growth hormone and the extracellular domain of its receptor. J. Mol. Biol. 222 (1991) 865-868
264. Vernon R.G. Influence of somatotropin on metabolism. In: Sejrsen K., Vestergaard M., and Neimann-Sørensen A. (Eds). Use of Somatotropin in Livestock Production (1989), Elsevier Applied Science, New York 31-50
265. Vernon R.G., Barber M.C., and Finley E. Modulation of the activity of acetyl-CoA carboxylase and other lipogenic enzymes by growth hormone, insulin and dexamethasone in sheep adipose tissue and relationship to adaptations to lactation. Biochem. J. 274 (1991) 543-548
266. Verstegen M.W., Van der Hel W., Henken A.M., Huisman J., Kanis E., Van der Wal P., and van Weerden E.J. Effect of exogenous porcine somatotropin administration on nitrogen and energy metabolism in three genotypes of pigs. J. Anim. Sci. 68 (1990) 1008-1016
267. Vestergaard M., Henckel P., Oksbierg N., and Seirsen K. The effects of cimetrol on muscle fiber characteristics, capillary supply, and metabolic potentials of longissimus and semitendinosus muscles from young Friesian bulls. J. Anim. Sci. 72 (1994) 2298-2306
268. Vincent J.B. The potential value and toxicity of chromium picolinate as a nutritional supplement, weight loss agent and muscle development agent. Sports Med. 33 3 (2003) 213-230
269. Wabitsch M., Blum W.F., Muche R., Braun M., Hube F., Rascher W., Heinze E., Teller W., and Hauner H. Contribution of androgens to the gender differences in leptin production in obese children and adolescents. J. Clin. Invest. 100 (1997) 808-813
270. Walton P.E., and Etherton T.D. Stimulation of lipogenesis by insulin in swine adipose tissue: antagonism by porcine growth hormone. J. Anim. Sci. 62 (1986) 1584-1595
271. Walton P.E., Etherton T.D., and Chung C.S. Exogenous pituitary and recombinant growth hormones induce insulin and insulin-like growth factor I resistance in pig adipose tissue. Domest. Anim. Endocrinol. 4 (1987) 183-189
272. Wang H.J., Geller F., Dempfle A., Schauble N., Friedel S., Lichtner P., Fontenla-Horro F., Wudy S., Hagemann S., Gortner L., Huse K., Remschmidt H., Bettecken T., Meitinger T., Schafer H., Hebebrand J., and Hinney A. Ghrelin receptor gene: Identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal stature. J. Clin. Endocrinol. Metab. 89 1 (2004) 157-162
273. Wang J., Liu R., Hawkins M., Barilia N., and Rossetti L. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature 393 (1998) 684-688
274. Wang L.C.H. Effects of feeding on aminophylline induced supramaximal thermogenesis. Life. Sci. 29 (1981) 2459-2466
275. Warris P.D., Kestin S.C., and Brown S.N. The effect of beta adrenergic agonists on carcass and meat quality in sheep. Anim. Prod. 48 (1989) 385-392
276. Warris P.D., Brown S.N., Rolph T.P., and Kestin S.C. Interactions between the beta adrenergic agonist salbutamol and genotype on meat quality in pigs. J. Anim. Sci. 68 (1990) 3669-3676
277. Webb A.S., Rogers R.W., and Rude B.J. Review: Androgenic, estrogenic and combination implants: Production and meat quality in beef. Prof. Anim. Sci. 18 (2002) 103-106
278. Webster A.J.F. Adaptation to cold. In: Robertshaw D. (Ed). Environmental Physiology (1974), Butterworths University Park Press, Baltimore, USA 71-106
279. Webster A.J.F. The influence of the climatic environment on the metabolism in cattle. In: Swan H., and Broster W.H. (Eds). Principles of Cattle Production (1975), Butterworth & Co. Publishers, London
280. Witkamp R.F. Pharmacological and toxicological properties of beta-adrenergic agonists. In: Enne G., Kuiper H.A., and Valentini A. (Eds). Residues of Veterinary Drugs and Mycotoxins in Animal Products: New Methods for Risk Assessment and Quality Control (1996), Wagening Pers., Wageningen, The Netherlands 113-123
281. Witkamp R.F., and van Miert A. Pharmacology and therapeutic use of beta-2-agonists. In: Kuper H.A., and Hoogenboom L. (Eds). In Vitro Toxicological Studies and Real Time Analysis of Residues in Food (1992), RIKILT-DLO 75-88
282. Wray-Cahen D., Ross D.A., Bauman D.E., and Boyd R.D. Metabolic effects of porcine somatotropin: Nitrogen and energy balance and characterization of the temporal patterns of blood metabolites and hormones. J. Anim. Sci. 69 (1991) 1503-1514
283. Wren A.M., Seal L.J., Cohen M.A., Brynes A.E., Frost G.S., Murphy K.G., Dhillo W.S., Ghatei M.A., and Bloom S.R. Ghrelin enhances appetite and increases food intake in humans. J. Clin. Endocrinol. Metab. 86 12 (2001) 5992
284. Wright A.J., Mallard B.A., and Mowat D.N. The influence of supplemental chromium and vaccines on the acute phase response of newly arrived feeder calves. Can. J. Vet. Res. 59 4 (1995) 311-315
285. Wu G., Flynn N.E., and Knabe D.A. Enhanced intestinal synthesis of polyamines from proline in cortisol-treated piglets. Am. J. Physiol. Endocrinol. Metab. 279 (2000) E395-E402
286. Wu G., Meininger C.J., Knabe D.A., Bazer F.W., and Rhoads J.M. Arginine in development, health and disease. Curr. Opin. Clin. Nutr. Metab. Care 3 1 (2000) 59-66
287. Young F.G. Experimental stimulation (galactopoiesis) of lactation. Br. Med. Bull. 5 (1947) 155-160
288. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., and Friedman J.M. Positional cloning of the mouse obese gene and its human analogue. Nature 372 (1994) 425-432
289. Zhou Y.-T., Shimabukuro M., Koyama K., Lee Y., Wang M.-Y., Trieu F., Newgard C.B., and Unger R.H. Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. Proc. Natl. Acad. Sci. USA 94 (1997) 6386-6390
290. Zimmermann B., Diebold G., Galbraith J., Whitmore W., Okamoto M., Robinson J.B., Young B.A., Murdoch G., Mosenthin R., and Christopherson R.J. Effect of amonophylline on metabolic and thermoregulatory responses during hypothermia associated with cold-exposure in lambs. Can. J. Anim. Sci. 83 (2003) 739-748