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Volumn 253, Issue 3, 1998, Pages 619-626

Glucocorticoids induce the expression of the leptin gene through a non- classical mechanism of transcriptional activation

Author keywords

CCAAT enhancer binding protein; Gene expression; Glucocorticoid receptor; Nuclear receptors; Obesity

Indexed keywords

BINDING PROTEIN; GENE PRODUCT; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; LEPTIN; NUCLEAR FACTOR; TRANSCRIPTION FACTOR SP1;

EID: 0032080257     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1998.2530619.x     Document Type: Article
Times cited : (48)

References (57)
  • 1
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L. & Friedman, J. M. (1994) Positional cloning of the mouse obese gene and its human homologue, Nature 372, 425-432.
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 4
    • 0029739826 scopus 로고    scopus 로고
    • Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
    • Vaisse, C., Halaas, J. L., Horvath, C. M., Darnell, J. E., Stoffel, M. & Friedman, J. M. (1996) Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice, Nat. Genet. 14, 95-97.
    • (1996) Nat. Genet. , vol.14 , pp. 95-97
    • Vaisse, C.1    Halaas, J.L.2    Horvath, C.M.3    Darnell, J.E.4    Stoffel, M.5    Friedman, J.M.6
  • 8
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein; evidence for a peripheral signal linking adiposity and central neural networks
    • Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R. & Burn, P. (1995) Recombinant mouse OB protein; evidence for a peripheral signal linking adiposity and central neural networks, Science 269, 546-549.
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 11
    • 0029088115 scopus 로고
    • Recombinant ob gene product reduces food intake in fasted mice
    • Rentsch, J., Levens, N. & Chiesi, M. (1995) Recombinant ob gene product reduces food intake in fasted mice, Biochem. Biophys. Res. Commun. 214, 131-136.
    • (1995) Biochem. Biophys. Res. Commun. , vol.214 , pp. 131-136
    • Rentsch, J.1    Levens, N.2    Chiesi, M.3
  • 12
    • 0030010388 scopus 로고    scopus 로고
    • Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
    • Chehab, F. F., Lim, M. E. & Lu, R. (1996) Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin, Nature Genet. 12, 318-320.
    • (1996) Nature Genet. , vol.12 , pp. 318-320
    • Chehab, F.F.1    Lim, M.E.2    Lu, R.3
  • 15
    • 0029050937 scopus 로고
    • Overexpression of the obese (ob) gene in adipose tissue of human obese subjects
    • Lönnqvist, F., Arner, P., Nordfors, L. & Schalling, M. (1995) Overexpression of the obese (ob) gene in adipose tissue of human obese subjects, Nat. Med. 1, 950-953.
    • (1995) Nat. Med. , vol.1 , pp. 950-953
    • Lönnqvist, F.1    Arner, P.2    Nordfors, L.3    Schalling, M.4
  • 16
    • 0029083859 scopus 로고
    • Increased obese mRNA expression in omental fat cells from massively obese humans
    • Hamilton, B. S., Paglia, D., Kwan, A. Y. M. & Deitel, M. (1995) Increased obese mRNA expression in omental fat cells from massively obese humans, Nat. Med. 1, 954-956.
    • (1995) Nat. Med. , vol.1 , pp. 954-956
    • Hamilton, B.S.1    Paglia, D.2    Kwan, A.Y.M.3    Deitel, M.4
  • 18
    • 0030455364 scopus 로고    scopus 로고
    • Regulation of ob gene expression in rodents and humans
    • Saladin, R., Staels, B., Auwerx, J. & Briggs, M. (1996) Regulation of ob gene expression in rodents and humans, Horm. Metab. Res. 28, 638-641.
    • (1996) Horm. Metab. Res. , vol.28 , pp. 638-641
    • Saladin, R.1    Staels, B.2    Auwerx, J.3    Briggs, M.4
  • 19
    • 0029021599 scopus 로고
    • Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake
    • De Vos, P., Saladin, R., Auwerx, J. & Staels, B. (1995) Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake, J. Biol. Chem. 270, 15 958-15 961.
    • (1995) J. Biol. Chem. , vol.270 , pp. 15958-15961
    • De Vos, P.1    Saladin, R.2    Auwerx, J.3    Staels, B.4
  • 20
    • 0028972884 scopus 로고
    • Dexamethasone regulates obese expression in isolated rat adipocytes
    • Murakami, T., Iida, M. & Shima, K. (1995) Dexamethasone regulates obese expression in isolated rat adipocytes, Biochem. Biophys. Res. Commun. 214, 1260-1267.
    • (1995) Biochem. Biophys. Res. Commun. , vol.214 , pp. 1260-1267
    • Murakami, T.1    Iida, M.2    Shima, K.3
  • 22
    • 0029848687 scopus 로고    scopus 로고
    • Short-term dexamethasone treatment increases plasma leptin independently of changes in insulin sensitivity in healthy women
    • Larsson, H. & Ahren, B. (1996) Short-term dexamethasone treatment increases plasma leptin independently of changes in insulin sensitivity in healthy women, J. Clin. Endocrinol. Metab. 81, 4428-4432.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 4428-4432
    • Larsson, H.1    Ahren, B.2
  • 23
    • 0030452084 scopus 로고    scopus 로고
    • Dexamethasone induces an acute and sustained rise in circulating leptin levels in normal human subjects
    • Miell, J. P., Englaro, P. & Blum, W. F. (1996) Dexamethasone induces an acute and sustained rise in circulating leptin levels in normal human subjects. Horm. Metab. Res. 28, 704-707.
    • (1996) Horm. Metab. Res. , vol.28 , pp. 704-707
    • Miell, J.P.1    Englaro, P.2    Blum, W.F.3
  • 24
    • 0030481888 scopus 로고    scopus 로고
    • High leptin concentrations in serum of very obese children are further stimulated by dexamethasone
    • Kiess, W., Englaro, P., Hanitsch, S., Rascher, W., Attanasio, A. & Blum, W. F. (1996) High leptin concentrations in serum of very obese children are further stimulated by dexamethasone, Horm. Metab. Res. 28, 708-710.
    • (1996) Horm. Metab. Res. , vol.28 , pp. 708-710
    • Kiess, W.1    Englaro, P.2    Hanitsch, S.3    Rascher, W.4    Attanasio, A.5    Blum, W.F.6
  • 26
    • 0026654145 scopus 로고
    • Expression of glucose transporters (GLUT 1 and GLUT 4) in primary cultured rat adipocytes: Differential evolution with time and chronic insulin effect
    • Hajduch, E. J., Guerre-Millo, M., Hainault, I. A., Guichard, C. M. & Lavau, M. M. (1992) Expression of glucose transporters (GLUT 1 and GLUT 4) in primary cultured rat adipocytes: differential evolution with time and chronic insulin effect, J. Cell. Biochem. 49, 251-258.
    • (1992) J. Cell. Biochem. , vol.49 , pp. 251-258
    • Hajduch, E.J.1    Guerre-Millo, M.2    Hainault, I.A.3    Guichard, C.M.4    Lavau, M.M.5
  • 27
    • 0029157428 scopus 로고
    • Transient increase in obese gene expression after food intake and insulin administration
    • Saladin, R., De Vos, P., Guerre-Millo, M., Leturque, A., Girard, J., Staels, B. & Auwerx, J. (1995) Transient increase in obese gene expression after food intake and insulin administration. Nature 377, 527-529.
    • (1995) Nature , vol.377 , pp. 527-529
    • Saladin, R.1    De Vos, P.2    Guerre-Millo, M.3    Leturque, A.4    Girard, J.5    Staels, B.6    Auwerx, J.7
  • 28
    • 0018899345 scopus 로고
    • Number and evolutionary conservation of α- and β-tubulin and cytoplasmatic β- and γ-actin genes using specific cloned cDNA probes
    • Cleveland, D. W., Lopata, M. A., McDonald, R. J., Cowan, M. J., Rutter, W. J. & Kirschner, M. W. (1980) Number and evolutionary conservation of α- and β-tubulin and cytoplasmatic β- and γ-actin genes using specific cloned cDNA probes, Cell 20, 95-105.
    • (1980) Cell , vol.20 , pp. 95-105
    • Cleveland, D.W.1    Lopata, M.A.2    McDonald, R.J.3    Cowan, M.J.4    Rutter, W.J.5    Kirschner, M.W.6
  • 30
    • 0022453518 scopus 로고
    • Functional domains of the human glucocorticoid receptor
    • Giguère, V., Hollenberg, S. M., Rosenfeld, M. G. & Evans, R. M. (1986) Functional domains of the human glucocorticoid receptor, Cell 46, 645-652.
    • (1986) Cell , vol.46 , pp. 645-652
    • Giguère, V.1    Hollenberg, S.M.2    Rosenfeld, M.G.3    Evans, R.M.4
  • 32
    • 0024728988 scopus 로고
    • Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes
    • Christy, R. J., Yang, V. W., Ntambi, J. M., Geiman, D. E., Landschulz, W. H., Friedman, A. D., Nakabeppu, Y. Kelly, T. J. & Lane, M. D. (1989) Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes, Genes & Dev. 3, 1323-1335.
    • (1989) Genes & Dev. , vol.3 , pp. 1323-1335
    • Christy, R.J.1    Yang, V.W.2    Ntambi, J.M.3    Geiman, D.E.4    Landschulz, W.H.5    Friedman, A.D.6    Nakabeppu, Y.7    Kelly, T.J.8    Lane, M.D.9
  • 33
    • 0023649835 scopus 로고
    • CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements
    • Luckow, B. & Schütz, G. (1987) CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements, Nucleic Acids Res. 15, 5490.
    • (1987) Nucleic Acids Res. , vol.15 , pp. 5490
    • Luckow, B.1    Schütz, G.2
  • 34
  • 35
    • 0023906490 scopus 로고
    • Characterization of response elements tor androgens, glucocorticoids and progestins in mouse mammary tumour virus
    • Ham, J., Thomson, A., Needham, M., Webb, P. & Parker, M. (1988) Characterization of response elements tor androgens, glucocorticoids and progestins in mouse mammary tumour virus, Nucleic Acids Res. 16, 5263-5276.
    • (1988) Nucleic Acids Res. , vol.16 , pp. 5263-5276
    • Ham, J.1    Thomson, A.2    Needham, M.3    Webb, P.4    Parker, M.5
  • 36
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
    • Dignam, J. P., Lebowitz, R. M. & Roeder, R. G. (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei, Nucleic Acids Res. 11, 1475-1489.
    • (1983) Nucleic Acids Res. , vol.11 , pp. 1475-1489
    • Dignam, J.P.1    Lebowitz, R.M.2    Roeder, R.G.3
  • 37
    • 0028267164 scopus 로고
    • Transcriptional control of the stearoyl-coA desaturase-1 gene by polyunsaturated fatty acids
    • Landschulz, K. T., Jump, U. B., MacDougald, U. A. & Lane, M. D. (1994) Transcriptional control of the stearoyl-coA desaturase-1 gene by polyunsaturated fatty acids, Biochem. Biophys. Res. Commun. 200, 763-768.
    • (1994) Biochem. Biophys. Res. Commun. , vol.200 , pp. 763-768
    • Landschulz, K.T.1    Jump, U.B.2    MacDougald, U.A.3    Lane, M.D.4
  • 38
    • 0023663884 scopus 로고
    • Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain
    • Kadonaga, J. T., Carner, K. R., Masiarz, F. R. & Tjian, R. (1987) Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain, Cell 51, 1079-1090.
    • (1987) Cell , vol.51 , pp. 1079-1090
    • Kadonaga, J.T.1    Carner, K.R.2    Masiarz, F.R.3    Tjian, R.4
  • 39
    • 0031013332 scopus 로고    scopus 로고
    • The glucocorticoid-responsive gene cascade. Activation of the rat arginase gene through induction of C/EBPb
    • Gotoh, T., Chowdhury, S., Takiguchi, M. & Mori, M. (1997) The glucocorticoid-responsive gene cascade. Activation of the rat arginase gene through induction of C/EBPb, J. Biol. Chem. 272, 3694-3698.
    • (1997) J. Biol. Chem. , vol.272 , pp. 3694-3698
    • Gotoh, T.1    Chowdhury, S.2    Takiguchi, M.3    Mori, M.4
  • 40
    • 0029851231 scopus 로고    scopus 로고
    • Functional interactions between Stat5 and the glucocorticoid receptor
    • Stöcklin, E., Wissler, M., Gouilleux, F. & Groner, B. (1996) Functional interactions between Stat5 and the glucocorticoid receptor, Nature 383, 726-728.
    • (1996) Nature , vol.383 , pp. 726-728
    • Stöcklin, E.1    Wissler, M.2    Gouilleux, F.3    Groner, B.4
  • 41
    • 0028878375 scopus 로고
    • Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins
    • Yeh, W. C., Cao, Z., Classon, M. & McKnight, S. (1995) Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins, Genes & Dev. 9, 168-181.
    • (1995) Genes & Dev. , vol.9 , pp. 168-181
    • Yeh, W.C.1    Cao, Z.2    Classon, M.3    McKnight, S.4
  • 42
    • 0026050219 scopus 로고
    • Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells
    • Cao, Z., Umek, R. M. & McKnight, S. L. (1991) Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells, Genes & Dev. 5, 1538-1552.
    • (1991) Genes & Dev. , vol.5 , pp. 1538-1552
    • Cao, Z.1    Umek, R.M.2    McKnight, S.L.3
  • 43
    • 0028263634 scopus 로고
    • Glucocorticoids reciprocally regulate expression of the CCAAT/Enhancer-binding protein α and δ genes in 3T3-L1 adipocytes and white adipose tissue
    • MacDougald, O. A., Cornelius, P., Lin, F. T., Chen, S. S. & Lane, M. D. (1994) Glucocorticoids reciprocally regulate expression of the CCAAT/Enhancer-binding protein α and δ genes in 3T3-L1 adipocytes and white adipose tissue, J. Biol. Chem. 269, 19 041-19 047.
    • (1994) J. Biol. Chem. , vol.269 , pp. 19041-19047
    • MacDougald, O.A.1    Cornelius, P.2    Lin, F.T.3    Chen, S.S.4    Lane, M.D.5
  • 44
    • 0030855190 scopus 로고    scopus 로고
    • Leptin inhibition of hypothalamic-pituitary-adrenal axis in response to stress
    • Heiman, M. L., Ahima, R. S., Craft, L. S., Schoner, B., Stephens, T. W. & Flier, J. S. (1997) Leptin inhibition of hypothalamic-pituitary-adrenal axis in response to stress, Endocrinology 138, 3859-3863.
    • (1997) Endocrinology , vol.138 , pp. 3859-3863
    • Heiman, M.L.1    Ahima, R.S.2    Craft, L.S.3    Schoner, B.4    Stephens, T.W.5    Flier, J.S.6
  • 48
    • 0015748455 scopus 로고
    • The effect of adrenalectomy on the development of the obese-hyperglycemic syndrome in ob/ob mice
    • Solomon, J. & Mayer, J. (1973) The effect of adrenalectomy on the development of the obese-hyperglycemic syndrome in ob/ob mice. Endocrinology 93, 510-513.
    • (1973) Endocrinology , vol.93 , pp. 510-513
    • Solomon, J.1    Mayer, J.2
  • 50
    • 0018248550 scopus 로고
    • Effects of adrenalectomy on thyroid function and insulin levels in obese (ob/ob) mice
    • Yukimura, Y. & Bray, G. A. (1978) Effects of adrenalectomy on thyroid function and insulin levels in obese (ob/ob) mice. Proc. Soc. Exp. Biol. Med. 159, 364-367.
    • (1978) Proc. Soc. Exp. Biol. Med. , vol.159 , pp. 364-367
    • Yukimura, Y.1    Bray, G.A.2
  • 51
    • 0021291131 scopus 로고
    • Adrenalectomy and food restriction in the genetically obese (ob/ob) mouse
    • Saito, M. & Bray, G. A. (1984) Adrenalectomy and food restriction in the genetically obese (ob/ob) mouse. Am. J. Physiol. 246, R20-R25.
    • (1984) Am. J. Physiol. , vol.246
    • Saito, M.1    Bray, G.A.2
  • 53
    • 0030852568 scopus 로고    scopus 로고
    • Plasma leptin levels do not change in patients with Cushing's disease shorthly after correction of hypercortisolism
    • Cizza, G., Lotsikas, A. J., Licinio, J., Gold, P. W. & Chrousos, G. P. (1997) Plasma leptin levels do not change in patients with Cushing's disease shorthly after correction of hypercortisolism, J. Clin. Endocrinol. Metab. 82, 2747-2750.
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 2747-2750
    • Cizza, G.1    Lotsikas, A.J.2    Licinio, J.3    Gold, P.W.4    Chrousos, G.P.5
  • 55
    • 0021522787 scopus 로고
    • Dexamethasone insulin resistance enhances β-cell responsiveness to glucose in normal men
    • Beard, J. C., Halter, J. B., Best, J. D., Pfeiffer, M. A. & Porte, D. J. (1984) Dexamethasone insulin resistance enhances β-cell responsiveness to glucose in normal men. Am. J. Physiol. 247, E592-E597.
    • (1984) Am. J. Physiol. , vol.247
    • Beard, J.C.1    Halter, J.B.2    Best, J.D.3    Pfeiffer, M.A.4    Porte, D.J.5
  • 56
    • 0023195072 scopus 로고
    • Induction of mRNA for phosphoenolpyruvate carboxykinase (GTP) by dexamethasone in cultured rat hepatocytes requires ongoing protein synthesis
    • Nebes, V. L. & Morris, S. M. (1987) Induction of mRNA for phosphoenolpyruvate carboxykinase (GTP) by dexamethasone in cultured rat hepatocytes requires ongoing protein synthesis, Biochem. J. 246, 237-240.
    • (1987) Biochem. J. , vol.246 , pp. 237-240
    • Nebes, V.L.1    Morris, S.M.2
  • 57
    • 0029978521 scopus 로고    scopus 로고
    • Active repression mechanism of eukaryotic transcription repressors
    • Hanna-Rose, W. & Hansen, U. (1996) Active repression mechanism of eukaryotic transcription repressors. Trends Genet. 12, 229-234.
    • (1996) Trends Genet. , vol.12 , pp. 229-234
    • Hanna-Rose, W.1    Hansen, U.2


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