Endocrine Effects of Food Intake: Insulin, Ghrelin, and Leptin Responses to a Single Bolus of Essential Amino Acids in Humans

Annals of Nutrition and Metabolism

Volumn 47, Issue 6, 2003, Pages 312-318

  Knerr, I ^a,b   Groschl M ^a   Rascher, W ^a   Rauh, M ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Amino acids; Eptin; Ghrelin; Insulin

Indexed keywords

ALBUMIN; AMINO ACID; ESSENTIAL AMINO ACID; GHRELIN; GLUCOSE; HORMONE; INSULIN; LEPTIN; METHIONINE; UREA;

ADULT; ALBUMIN BLOOD LEVEL; AMINO ACID BLOOD LEVEL; AMINOACIDEMIA; ARTICLE; BODY MASS; CONTROLLED STUDY; DIET RESTRICTION; ENDOCRINE FUNCTION; EXPERIMENT; FEMALE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HEMOCONCENTRATION; HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; HYPERINSULINEMIA; INSULIN RELEASE; MALE; MEASUREMENT; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; TIME; UREA BLOOD LEVEL;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ALBUMINS; AMINO ACIDS, ESSENTIAL; AREA UNDER CURVE; BLOOD GLUCOSE; EATING; FASTING; FEMALE; HUMANS; INSULIN; LEPTIN; MALE; PEPTIDE HORMONES; UREA;

EID: 1342269802     PISSN: 02506807     EISSN: None     Source Type: Journal    
DOI: 10.1159/000072405     Document Type: Article

References (31)

1. Friedman JM, Halaas JL: Leptin and the regulation of body weight in mammals. Nature 1998;5:763-770.
2. Dötsch J, Nüsken K-D, Knerr I, Kirschbaum M, Repp R, Rascher W: Leptin and neuropeptide Y gene expression in human placenta: Ontogeny and evidence for similarities to hypothalamic regulation. J Clin Endocrinol Metab 1999;84:2755-2758.
3. Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, Moizo L, Lehy T, Guerre-Millo M, Le Marchand-Brustel Y, Lewin MJ: The stomach is a source of leptin. Nature 1998;394:790-793.
4. Gröschl M, Rauh M, Wagner R, Neuhuber W, Metzler M, Tamgüney G, Zenk J, Schoof E, Dörr HG, Blum WF, Rascher W Dötsch J: Identification of leptin in human saliva. J Clin Endocrinol Metab 2001;86:5234-5239.
5. Schwartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, Lasser G, Prunkard DE, Porte D Jr, Woods SC, Seeley RJ, and Weigle DS: Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 1996;45:531-535.
6. Herpertz S, Albers N, Wagner R, Pelz B, Kopp W, Mann K, Blum WF, Senf W Hebebrand J: Longitudinal changes of circadian leptin insulin and cortisol plasma levels and their correlation during refeeding in patients with anorexia nervosa. Eur J Endocrinol 2000;142:373-379.
7. Lawrence CB, Snape A,, Baudoin F, and Luckman SM: Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers. Endocrinology 2002;143:155-162.
8. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR: Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 2001;86:5992.
9. Toshinai K, Mondal MS, Nakazato M, Date Y, Murakami N, Kojima M, Kangawa K, Matsukura S: Upregulation of ghrelin expression in the stomach upon fasting insulin-induced hypoglycemia and leptin administration. Biochem Biophys Res Commun 2001;281:1220-1225.
10. Ahren B, Larsson H: Leptin-a regulator of islet function? Its plasma levels correlate with glucagon and insulin secretion in healthy women. Metabolism 1997;46:1477-1481.
11. Drewes C, Nauck MA, Horn R, Holst J, Schmiegel W, Brabant G: A liquid mixed meal or exogenous glucagon-like peptide 1 (GLP-1) do not alter plasma leptin concentrations in healthy volunteers. Acta Diabetol 1997;34:230-234.
12. Liao K, Lane, MD: Expression of a novel insulin-activated amino acid transporter gene during differentiation of 3T3-L1 preadipocytes into adipocytes. Biochem Biophys Res Commun 1995;208:1008-1015.
13. Brusilow SW, Maestri NE: Urea cycle disorders: Diagnosis, pathophysiology and therapy. Adv Pediatr 1996;43:127-170.
14. Gröschl M, Wagner R, Dörr HG, Blum W, Rascher W and Dötsch J: Variability of leptin values measured from different sample matrices. Horm Res 2000;54:26-31.
15. Gröschl M, Wagner R, Dötsch J, Rascher W, Rauh M: Pre-analytical influences on the measurement of ghrelin. Clin Chem 2002;48:1114-1116.
16. Patti ME, Brambilla E, Luzi L, Landaker EJ, Kahn CR: Bidirectional modulation of insulin action by amino acids. J Clin Invest 1998;101:1519-1529.
17. Rossetti L, Rothman DL, DeFronzo RA, Shulman GI: Effect of dietary protein on in vivo insulin action and liver glycogen repletion. Am J Physiol 1989;257:E212-219.
18. Mönch E, Herrmann ME, Brösicke H, Schöffer A, Keller M: Utilisation of amino acid mixtures in adolescents with phenylketonuria. Eur J Pediatr 1996;155 (suppl 1):S115-S120.
19. Herrmann ME, Brösicke H, Keller M, Mönch E, Helge H: Dependence of the utilisation of a phenylalanine-free amino acid mixture on different amounts of single dose ingested. Eur J Pediatr 1994;153:501-503.
20. Stegink LD, Filer LJ, Brummer MC, Baker GL, Krause WL, Bell EF, Ziegler EE: Plasma amino acid concentrations and amino acid ratios in normal adults and adults heterozygous for phenylketonuria ingesting a hamburger and milk shake meal. Am J Clin Nutr 1991;53:670-675.
21. Darmaun D: Role of nutrients in the regulation of in vivo protein metabolism in humans. Acta Paediatr Suppl 1999;433:92-94.
22. Ferrannini E, Bevilacqua S, Lanzone L, Bonadonna R, Brandi L, Oleggini M, Boni C, Buzzigoli G, Ciociaro D, Luzi L, DeFronzo RA: Metabolic interactions of amino acids and glucose in healthy humans. Diabetes Nutr Metab 1988;3:175-186.
23. Van Loon LJC, Kruijshoop M, Verhagen H, Saris WHM, Wagenmakers AJM: Ingestion of protein hydrolysate and amino acid-carbohydrate mixtures increases postexercise plasma insulin responses in men. J Nutr 2000;130:2508-2513.
24. Van Loon LJC, Saris WHM, Verhagen H, Wagenmakers AJM: Plasma insulin responses after ingestion of different amino acid or protein mixtures with carbohydrate. Am J Clin Nutr 2000;72:96-105.
25. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S: A role for ghrelin in the central regulation of feeding. Nature 2001;409:194-198.
26. Schwartz MW, Woods SC, Porte D, Seeley RJ, Baskin DG: Central nervous system control of food intake. Nature 2000;404:661-671.
27. Date Y, Murakami N, Kojima M, Kuroiwa T, Matsukura S, Kangawa K, Nakazato M: Central effects of a novel acylated peptide, ghrelin, on growth hormone release in rats. Biochem Biophys Res Commun 2000;275:477-480.
28. Horvath TL, Diano S, Sotonyi P, Heiman M, Tschöp M: Minireview: Ghrelin and the regulation of energy balance - a hypothalamic perspective. Endocrinology 2001;142:4163-4169.
29. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS: A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 2001;50:1714-1719.
30. Ballinger AB, Clark ML: L-phenylalanine releases cholecystokinin (CCK) and is associated with reduced food intake in humans: Evidence for a physiological role of CCK in control of eating. Metabolism 1994;43:735-738.
31. Hall WL, Millward DJ, Long SJ, Morgan LM: Casein and whey exert different effects on plasma amino acid profiles, gastrointestinal hormone secretion and appetite. Br J Nutr 2003;89:239-248.