SIRT1: Tumor promoter or tumor suppressor?

Medical Hypotheses

Volumn 67, Issue 2, 2006, Pages 341-344

  Lim, Chang Su ^a  

^a Fralin Life Science Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN P300; PROTEIN P53; SILENT INFORMATION REGULATOR PROTEIN; SILENT INFORMATION REGULATOR PROTEIN 1; TRANSCRIPTION FACTOR E2A; TRANSCRIPTION FACTOR FKHR; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; DNA DAMAGE; EMBRYO DEVELOPMENT; HYPOTHESIS; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; SENESCENCE; TUMOR GROWTH;

AGING; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HISTONE DEACETYLASES; HUMANS; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUINS; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

MAMMALIA;

EID: 33744774692     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2006.01.050     Document Type: Article

References (31)

1. Guarente L. Sir2 links chromatin silencing, metabolism, and aging. Genes Dev 14 9 (2000) 1021-1026
2. Blander G., and Guarente L. The Sir2 family of protein deacetylases. Annu Rev Biochem 73 (2004) 417-435
3. Vaziri H., Dessain S.K., Ng Eaton E., et al. hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107 2 (2001) 149-159
4. Anekonda T.S., and Reddy P.H. Neuronal protection by sirtuins in Alzheimer's disease. J Neurochem 96 2 (2006) 305-313
5. Brunet A., Sweeney L.B., Sturgill J.F., et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303 5666 (2004) 2011-2015
6. Rodgers J.T., Lerin C., Haas W., Gygi S.P., Spiegelman B.M., and Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434 7029 (2005) 113-118
7. Picard F., Kurtev M., Chung N., et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429 6993 (2004) 771-776
8. Bordone L., Motta M.C., Picard F., et al. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic & #946; cells. PLoS Biol 4 2 (2006)
9. Langley E., Pearson M., Faretta M., et al. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. Embo J 21 10 (2002) 2383-2396
10. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37 (1965) 614-636
11. Zglinicki T.v., Saretzki G., Ladhoff J., Fagagna F.d.A.d., and Jackson S.P. Human cell senescence as a DNA damage response. Mech Ageing Dev 126 1 (2005) 111-117
12. Chen Q., and Ames B.N. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc Natl Acad Sci USA 91 10 (1994) 4130-4134
13. Duan J., Duan J., Zhang Z., and Tong T. Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening. Int J Biochem Cell Biol 37 7 (2005) 1407-1420
14. Robles S.J., and Adami G.R. Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts. Oncogene 16 9 (1998) 1113-1123
15. Serrano M., Lin A.W., McCurrach M.E., Beach D., and Lowe S.W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88 5 (1997) 593-602
16. Shay J.W., and Wright W.E. Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis 26 5 (2005) 867-874
17. Pompei F., and Wilson R. A quantitative model of cellular senescence influence on cancer and longevity. Toxicol Ind Health 18 8 (2002) 365-376
18. Barlow A.L., van Drunen C.M., Johnson C.A., Tweedie S., Bird A., and Turner B.M. dSIR2 and dHDAC6: two novel, inhibitor-resistant deacetylases in Drosophila melanogaster. Exp Cell Res 265 1 (2001) 90-103
19. Ota H., Tokunaga E., Chang K., et al. Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene 25 2 (2006) 176-185
20. Daitoku H., Hatta M., Matsuzaki H., et al. Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci USA 101 27 (2004) 10042-10047
21. Motta M.C., Divecha N., Lemieux M., et al. Mammalian SIRT1 represses forkhead transcription factors. Cell 116 4 (2004) 551-563
22. van der Horst A., Tertoolen L.G., de Vries-Smits L.M., Frye R.A., Medema R.H., and Burgering B.M. FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J Biol Chem 279 28 (2004) 28873-28879
23. Bouras T., Fu M., Sauve A.A., et al. SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem 280 11 (2005) 10264-10276
24. Balaban R.S., Nemoto S., and Finkel T. Mitochondria, oxidants, and aging. Cell 120 4 (2005) 483-495
25. Takata T., and Ishikawa F. Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. Biochem Biophys Res Commun 301 1 (2003) 250-257
26. McBurney M.W., Yang X., Jardine K., Bieman M., Th'ng J., and Lemieux M. The absence of SIR2alpha protein has no effect on global gene silencing in mouse embryonic stem cells. Mol Cancer Res 1 5 (2003) 402-409
27. Leibiger I.B., and Berggren P.O. Sirt1: a metabolic master switch that modulates lifespan. Nat Med 12 1 (2006) 34-36
28. Chua K.F., Mostoslavsky R., Lombard D.B., et al. Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab 2 1 (2005) 67-76
29. Hofseth L.J., Hussain S.P., and Harris C.C. p53: 25 years after its discovery. Trends Pharmacol Sci 25 4 (2004) 177-181
30. Michishita E., Park J.Y., Burneskis J.M., Barrett J.C., and Horikawa I. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell 16 10 (2005) 4623-4635
31. Solomon J.M., Pasupuleti R., Xu L., et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol 26 1 (2006) 28-38