Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy

Nature Medicine

Volumn 13, Issue 11, 2007, Pages 1382-1387

  Day, Sam E ^a,b   Kettunen, Mikko I ^a,b   Gallagher, Ferdia A ^a,b,c   Hu, De En ^a,b   Lerche, Mathilde ^d   Wolber, Jan ^e   Golman, Klaes ^d   Ardenkjaer Larsen, Jan Henrik ^e   Brindle, Kevin M ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d Imagnia AB   (Sweden)

^e GE HEALTHCARE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOXYL GROUP; LACTATE DEHYDROGENASE; PYRUVATE CARBON 13; PYRUVIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER CHEMOTHERAPY; CARBON NUCLEAR MAGNETIC RESONANCE; CARCINOGENESIS; CELL DEATH; HYPERPOLARIZATION; LYMPHOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPECTROSCOPY;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARBON ISOTOPES; CELL DEATH; CELL LINE, TUMOR; ETOPOSIDE; LACTATE DEHYDROGENASES; LACTIC ACID; LYMPHOMA; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MICE; NEOPLASM TRANSPLANTATION; PYRUVIC ACID;

MUS;

EID: 35948970970     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1650     Document Type: Article

References (26)

1. Neves, A.A. & Brindle, K.M. Assessing responses to cancer therapy using molecular imaging. Biochim. Biophys. Acta 1766, 242-261 (2006).
2. Czernin, J., Weber, W.A. & Herschman, H.R. Molecular imaging in the development of cancer therapeutics. Annu. Rev. Med. 57, 99-118 (2006).
3. Weber, W.A. Positron emission tomography as an imaging biomarker. J. Clin. Oncol. 24, 3282-3292 (2006).
4. Stroobants, S. et al. (18)FDG-Positron emission tomography for the early prediction of response in advanced soft tissue sarcoma treated with imatinib mesylate (Glivec). Eur. J. Cancer 39, 2012-2020 (2003).
5. Kettunen, M.I. & Brindle, K.M. Apoptosis detection using magnetic resonance imaging and spectroscopy. Prog. Nucl. Magn. Reson. Spectrosc. 47, 175-185 (2005).
6. Ross, B.D. et al. Evaluation of cancer therapy using diffusion magnetic resonance imaging. Mol. Cancer Ther. 2, 581-587 (2003).
7. Moffat, B.A. et al. Functional diffusion map: A noninvasive MRI biomarker for early stratification of clinical brain tumor response. Proc. Natl. Acad. Sci. USA 102, 5524-5529 (2005).
8. 13C nuclear magnetic resonance. Science 205, 160-166 (1979).
9. Ardenkjaer-Larsen, J.H. et al. Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR. Proc. Natl. Acad. Sci. USA 100, 10158-10163 (2003).
10. Golman, K., Ardenkjær-Larsen, J.H., Petersson, J.S., Månsson, S. & Leunbach, I. Molecular imaging with endogenous substances. Proc. Natl. Acad. Sci. USA 100, 10435-10439 (2003).
11. Golman, K., in 't Zandt, R. & Thaning, M. Real-time metabolic imaging. Proc. Natl. Acad. Sci. USA 103, 11270-11275 (2006).
12. 13C. Acad. Radiol. 13, 932-942 (2006).
13. Golman, K., Zandt, R.I., Lerche, M., Pehrson, R. & Ardenkjaer-Larsen, J.H. Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis. Cancer Res. 66, 10855-10860 (2006).
14. Brindle, K.M. NMR methods for measuring enzyme kinetics in vivo. Prog. Nucl. Magn. Reson. Spectrosc. 20, 257-293 (1988).
15. 1H-NMR study of the activity expressed by lactate dehydrogenase in the human erythrocyte. Eur. J. Biochem. 158, 299-305 (1986).
16. 1H MRS-visible lipids accumulate during apoptosis of lymphoma cells in vitro and in vivo. Magn. Reson. Med. 54, 43-50 (2005).
17. Poot, M. & Pierce, R.H. Detection of changes in mitochondrial function during apoptosis by simultaneous staining with multiple fluorescent dyes and correlated multiparameter flow cytometry. Cytometry 35, 311-317 (1999).
18. Sims, J.L., Berger, S.J. & Berger, N.A. Poly(ADP-ribose) polymerase inhibitors preserve nicotinamide adenine dinucleotide and adenosine 5′-triphosphate pools in DNA-damaged cells: mechanism of stimulation of unscheduled DNA synthesis. Biochemistry 22, 5188-5194 (1983).
19. 31P MRS. Magn. Reson. Med. 40, 411-420 (1998).
20. Filipovic, D.M., Meng, X. & Reeves, W.B. Inhibition of PARP prevents oxidant-induced necrosis but not apoptosis in LLC-PK1 cells. Am. J. Physiol. 277, F428-F436 (1999).
21. 1H nuclear magnetic resonance spectroscopy: Effect of 5-fluorouracil on lactate levels in radiation-induced fibrosarcoma I tumours. Cancer Res. 58, 1063-1067 (1998).
22. Poptani, H. et al. Detecting early response to cyclophosphamide treatment of RIF-1 tumors using selective multiple quantum spectroscopy (SelMQC) and dynamic contrast enhanced imaging. NMR Biomed. 16, 102-111 (2003).
23. 1H MRS detects polyunsaturated fatty acid accumulation during gene therapy of glioma: Implications for the in vivo detection of apoptosis. Nat. Med. 5, 1323-1327 (1999).
24. Anthony, M.L., Zhao, M. & Brindle, K.M. Inhibition of phosphatidylcholine biosynthesis following induction of apoptosis in HL-60 cells. J. Biol. Chem. 274, 19686-19692 (1999).
25. Zhao, M., Beauregard, D.A., Loizou, L., Davletov, B. & Brindle, K.M. Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent. Nat. Med. 7, 1241-1244 (2001).
26. Vassault, A. Lactate dehydrogenase. in Methods of Enzymatic Analysis Vol. 3 (ed. Bergmeyer, H.U.) 118-126 (Verlag Chemie, Deerfield Beach, Florida, 1983).