Leptin is a risk marker for first-ever hemorrhagic stroke in a population-based cohort

Stroke

Volumn 30, Issue 2, 1999, Pages 328-337

  Söderberg, Stefan ^a,c   Ahrén, Bo ^b   Stegmayr, Birgitta ^a   Johnson, Owe ^a   Wiklund, Per Gunnar ^a   Weinehall, Lars ^a   Hallmans, Göran ^a   Olsson, Tommy ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c UMEÅ UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Leptin; Risk factors; Stroke, hemorrhagic; Stroke, ischemic

Indexed keywords

GLUCOSE; INSULIN; LEPTIN;

ADULT; AGED; ARTICLE; BODY MASS; BRAIN HEMORRHAGE; CARDIOVASCULAR DISEASE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE MARKER; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTENSION; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL; RISK FACTOR;

EID: 0344959452     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.30.2.328     Document Type: Article

References (47)

1. Feinberg WM. Primary and secondary stroke prevention. Curr Opin Neurol. 1996;9:46-52.
2. Wolf PA, Kannel WB, D'Agostino RB. Epidemiology of stroke. In: Ginsberg MD, Bogousslavsky J, eds. Cerebrovascular Disease: Pathophysiology, Diagnosis, and Management. Vol 2. Malden, Mass: Blackwell Scientific; 1998:834-849.
3. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the Systolic Hypertension in the Elderly Program (SHEP): SHEP Cooperative Research Group. JAMA. 1991;265:3255-3264.
4. MacMahon S, Peto R, Cutler J, Collins R, Sorlie P, Neaton J, Abbott R, Godwin J, Dyer A, Stamler J. Blood pressure, stroke, and coronary heart disease, part 1: prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet. 1990;335:765-774.
5. Reaven GM. Role of insulin resistance in human disease. Diabetes. 1988;37:1595-1607.
6. Haffner SM. Epidemiology of hypertension and insulin resistance syndrome. J Hypertens Suppl. 1997;15:S25-S30.
7. Reaven GM, Lithell H, Landsberg L. Hypertension and associated metabolic abnormalities: the role of insulin resistance and the sympathoadrenal system. N Engl J Med. 1996;334:374-381.
8. Shinozaki K, Naritomi H, Shimizu T, Suzuki M, Ikebuchi M, Sawada T, Harano Y. Role of insulin resistance associated with compensatory hyperinsulinemia in ischemic stroke. Stroke. 1996;27:37-43.
9. Girard J. Is leptin the link between obesity and insulin resistance? Diabetes Metab. 1997;3:16-24.
10. Haynes WG, Sivitz WI, Morgan DA, Walsh SA, Mark AL. Sympathetic and cardiorenal actions of leptin. Hypertension. 1997;30:619-623.
11. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 1995;269:546-549.
12. Caro JF, Sinha MK, Kolaczynski JW, Zhang PL, Considine RV. Leptin: the tale of an obesity gene. Diabetes. 1996;45:1455-1462.
13. Flier SF. What's in a name? In search of leptin's physiological role. J Clin Endocrinol Metab. 1998;83:1407-1413.
14. WHO MONICA Project Principal Investigators (prepared by Tunstall-Pedoe H). The World Health Organization MONICA Project (Monitoring Trends and Determinants in Cardiovascular Disease): a major international collaboration. J Clin Epidemiol. 1988;41:105-114.
15. Brännström I. Community Participation and Social Patterning in Cardiovascular Disease Intervention. Umeå, Sweden: University of Umeå; 1993. Dissertation.
16. WHO MONICA Project (prepared by Tunstall-Pedoe H, Kuulasmaa K, Amouyel P, Arveiler D, Rajakangas AM, Pajak A). Myocardial infarction and coronary deaths in the World Health Organization MONICA Project: registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents. Circulation. 1994;90: 583-612.
17. Stegmayr B, Asplund K. Measuring stroke in the population: quality of routine statistics in comparison with a population-based stroke registry. Neuroepidemiology. 1992;11:204-213.
18. Weinehall L, Johnson O, Jansson JH, Boman K, Huhtasaari F, Hallmans G, Dahlen GH, Wall S. Perceived health modifies the effect of biomedical risk factors in the prediction of acute myocardial infarction: an incident case-control study from northern Sweden. J Intern Med. 1998;243: 99-107.
19. Bray GA. An approach to the classification and evaluation of obesity. In: Björntorp P, Brodoff BN, eds. Obesity. Philadelphia, Pa: JB Lippincott Co; 1992.
20. Diabetes mellitus. Report of a WHO Study Group. World Health Organ Tech Rep Ser. 1985;727:1-113.
21. Weinehall L, Hallgren C-G, Westman G, Janlert U, Wall S. Reduction of selection bias in primary prevention of cardiovascular disease through involvement of primary health care. Scand J Prim Health Care. In press.
22. Stegmayr B. Stroke in the Community: Studies on Risk Factors, Incidence, Case Fatality, Severity and Secular Trends in the Northern Sweden MONICA Project, With Multinational Comparisons. Umeå, Sweden: University of Umeå; 1996. Dissertation.
23. Huhtasaari F, Asplund K, Stegmayr B, Lundberg V, Wester PO. Trends in cardiovascular risk factors in the Northern Sweden MONICA Study: who are the winners? Cardiovasc Risk Factors. 1993;3:215-221.
24. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996;334:292-295.
25. Haffner SM, Miettinen H, Mykkanen L, Karhapaa P, Rainwater DL, Laakso M. Leptin concentrations and insulin sensitivity in normoglycemic men. Int J Obes Relat Metab Disord. 1997;21:393-399.
26. Söderberg S, Ahrén B, Jansson J-H, Johnson O, Hallmans G, Asplund K, Olsson T. Leptin is associated with increased risk of myocardial infarction. Eur Heart J. 1998:18(suppl):450. Abstract.
27. Schwartz MW, Seeley RJ. Seminars in medicine of the Beth Israel Deaconess Medical Center: neuroendocrine responses to starvation and weight loss. N Engl J Med. 1997;336:1802-1811.
28. Bray GA, York DA. Leptin and clinical medicine: a new piece in the puzzle of obesity. J Clin Endocrinol Metab. 1997;82:2771-2776.
29. de Courten M, Zimmet P, Hodge A, Collins V, Nicolson M, Staten M, Dowse G, Alberti KG. Hyperleptinaemia: the missing link in the metabolic syndrome? Diabet Med. 1997;14:200-208.
30. Haynes WG, Morgan DA, Walsh SA, Mark AL, Sivitz WI. Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest. 1997;100:270-278.
31. Dunbar JC, Hu Y, Lu H. Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats. Diabetes. 1997;46:2040-2043.
32. Shek EW, Brands MW, Hall JE. Chronic leptin infusion increases arterial pressure. Hypertension. 1998;31:409-414.
33. Glaum SR, Hara M, Bindokas VP, Lee CC, Polonsky KS, Bell GI, Miller RJ. Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus. Mol Pharmacol. 1996;50:230-235.
34. Howard G, O'Leary DH, Zaccaro D, Haffner S, Rewers M, Hamman R, Selby JV, Saad MF, Savage P, Bergman R. Insulin sensitivity and atherosclerosis: the Insulin Resistance Atherosclerosis Study (IRAS) Investigators. Circulation. 1996;93:1809-1817.
35. Saad MF, Khan A, Sharma A, Michael R, Riad-Gabriel MG, Boyadjian R, Jinagouda SD, Steil GM, Kamdar V. Physiological insulinemia acutely modulates plasma leptin. Diabetes. 1988;47:544-549.
36. Kolaczynski JW, Nyce MR, Considine RV, Boden G, Nolan JJ, Henry R, Mudaliar SR, Olefsky J, Caro JF. Acute and chronic effects of insulin on leptin production in humans: studies in vivo and in vitro. Diabetes. 1996;45:699-701.
37. Grassi G, Seravalla G, Colombo M, Bolla G, Cattaneo BM, Cavagnini F, Mancia G. Body weight reduction, sympathetic nerve traffic, and arterial baroreflex in obese normotensive humans. Circulation. 1998;97: 2037-2042.
38. Sharrett AR, Patsch W, Sorlie PD, Heiss G, Bond MG, Davis CE. Associations of lipoprotein cholesterols, apolipoproteins A-I and B, and triglycerides with carotid atherosclerosis and coronary heart disease. The Atherosclerosis Risk in Communities (ARIC) Study. Arterioscler Thromb. 1994;14:1098-1104.
39. Heiss G, Sharrett AR, Barnes R, Chambless LE, Szklo M, Alzola C. Carotid atherosclerosis measured by B-mode ultrasound in populations: associations with cardiovascular risk factors in the ARIC study. Am J Epidemiol. 1991;134:250-256.
40. Söderberg S, Ahrén B, Eliasson M, Johnson O, Olsson T. Plasma leptin levels are associated with abnormal fibrinolysis in men and postmenopausal women. J Intern Med. In press.
41. Haffner SM, Gingerich RL, Miettinen H, Stern MP. Leptin concentrations in relation to overall adiposity and regional body fat distribution in Mexican Americans. Int J Obes Relat Metab Disord. 1996;20:904-908.
42. Ronnemaa T, Karonen SL, Rissanen A, Koskenvuo M, Koivisto VA. Relation between plasma leptin levels and measures of body fat in identical twins discordant for obesity. Ann Intern Med. 1997;126:26-31.
43. Lapidus L, Bengtsson C, Larsson B, Pennert K, Rybo E, Sjöstrom L. Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden. Br Med J. 1984;289:1257-1261.
44. Larsson B, Svärdsudd K, Welin L, Wilhelmsen L, Björntorp P, Tibblin G. Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913. Br Med J (Clin Res Ed). 1984;288:1401-1404.
45. Sacco RL, Benjamin EJ, Broderick JP, Dyken M, Easton JD, Feinberg WM, Goldstein LB, Gorelick PB, Howard G, Kittner SJ, Manolio TA, Whisnant JP, Wolf PA. American Heart Association Prevention Conference, IV: Prevention and rehabilitation of stroke: risk factors. Stroke. 1997;28:1507-1517.
46. Juhan-Vague I, Alessi MC. Fibrinolysis and risk of coronary artery disease. Fibrinolysis. 1996;10:127-136.
47. Sinha MK, Ohannesian JP, Heiman ML, Kriauciunas A, Stephens TW, Magosin S, Marco C, Caro JF. Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects. J Clin Invest. 1996;97:1344-1347.