Increased OB gene expression leads to elevated plasma leptin concentrations in patients with chronic primary hyperinsulinemia

Diabetes

Volumn 47, Issue 10, 1998, Pages 1625-1629

  D'Adamo, Monica ^d   Buongiorno, Angela ^b   Maroccia, Ettore ^b   Leonetti, Frida ^a   Barbetti, Fabrizio ^e   Giaccari, Andrea ^c   Zorretta, Domenico ^b   Tamburrano, Guido ^a   Sbraccia, Paolo ^a,b,f  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c CATHOLIC UNIVERSITY   (Italy)

^d UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^e SAN RAFFAELE HOSPITAL   (Italy)

^f POLICLINICO UMBERTO I   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; LEPTIN; MESSENGER RNA;

ADIPOSE TISSUE; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; HUMAN; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; OBESITY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADIPOSE TISSUE; ADULT; BLOOD GLUCOSE; FASTING; FEMALE; GENE EXPRESSION; HUMANS; HYPERINSULINISM; INSULIN; INSULINOMA; LEPTIN; MALE; MIDDLE AGED; OBESITY; PANCREATIC NEOPLASMS; POLYMERASE CHAIN REACTION; PROTEINS; RNA, MESSENGER; RNA-DIRECTED DNA POLYMERASE;

EID: 0031665979     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.47.10.1625     Document Type: Article

References (38)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432, 1995
2. Masuzaki H, Ogawa Y, Isse N, Satoh N, Okazaki T, Shigemoto M, Mori K, Tamura N, Hosoda K, Yoshimasa Y, Jingami H, Kawada T, Nakao K: Human obese gene expression: adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 44:855-858, 1995
3. Tartaglia LA: The leptin receptor. J Biol Chem 272:6093-6096, 1997
4. Caro JF, Sinha MK, Kolacynski JW, Zhang PL, Considine RV: Leptin: the tale of an obesity gene. Diabetes 45:1455-1462, 1996
5. Flier JS: Leptin expression and action: new experimental paradigms. Proc Natl Acad Sci U S A 94:4242-4245, 1997
6. Tritos NA, Mantzoros CS: Leptin: its role in obesity and beyond. Diabetologia 40:1371-1379, 1997
7. Bray GA, York DA: Leptin and clinical medicine: a new piece in the puzzle of obesity. J Clin Endocrinol Metab 82:2771-2776, 1997
8. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM: Leptin levels in human and rodent: measurement of plasma leptin and ob mRNA in obese and weight- reduced subjects. Nat Med 1:1155-1161, 1995
9. Considine RV, Sinha MK, Heiman ML, Kriaciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF: Serum immunoreactive-leptin concentrations in normal weight and obese humans. N Engl J Med 334:292-295, 1996
10. Dagogo-Jack S, Fanelli C, Paramore D, Brothers J, Landt M: Plasma leptin and insulin relationships in obese and nonobese humans. Diabetes 45:695-698, 1996
11. Frederich BC, Lollmann B, Herman A, Napolitano-Rosen A, Kahn BB, Lowell BB, Flier JS: Expression of ob mRNA and its encoded protein in rodents: impact on nutrition and obesity. J Clin Invest 96:1658-1663, 1995
12. Cusin I, Sainsburry A, Doyle P, Rohner-Jeanrenaud F, Jeanrenaud B: The ob gene and insulin: a relationship leading to clues to the understanding of obesity. Diabetes 44:1467-1470, 1995
13. Leroy P, Dessolin S, Villageois P, Moon BC, Friedman JM, Ailhaud G, Dani C: Expression of ob gene in adipose cell: regulation by insulin. J Biol Chem 271:2365-2368, 1996
14. Saladin R, De Vos P, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwerx J: Transient increase in obese gene expression after food intake or insulin administration. Nature 377:527-529, 1995
15. Trayburn P, Thomas MEA, Duncan JS, Rayner DV: Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (ob/ob) mice. FEBS Lett 368:488-490, 1995
16. Kolaczynski JW, Nyce MR, Considine RV, Boden G, Nolan JJ, Henry R, Mudaliar SR, Olefsky J, Caro JF: Acute and chronic effects of insulin on leptin production in humans: studies in vivo and in vitro. Diabetes 45:699-701, 1996
17. Wabitsh M, Jensen PB, Blum WF, Christoffersen CT, Englaro P, Heinze E, Rasher W, Teller W, Tornqvist H, Hauner H: Insulin and cortisol promote leptin production in cultured human fat cells. Diabetes 45:1435-1438, 1996
18. Malmström R, Taskinen M-R, Karonen S-L, Yki-Järvinen H: Insulin increases plasma leptin in normal subjects and patients with NIDDM. Diabetologia 39:993-996, 1996
19. Vidal H, Aubouef D, DeVos P, Staels B, Riou JP, Auwerx J, Laville M: The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue. J Clin Invest 98:251-255, 1996
20. Pratley RE, Nicolson M, Bogardus C, Ravussin E: Effects of acute hyperinsulinemia on plasma leptin concentrations in insulin-sensitive and insulin-resistant Pima Indians. J Clin Endocrinol Metab 81:4418-4421, 1996
21. Ryan AS, Elahi D: The effects of acute hyperglycemia and hyperinsulinemia on plasma leptin levels: its relationships with body fat, visceral adiposity, and age in women. J Clin Endocrinol Metab 81:4433-4438, 1996
22. Utriainen T, Malmström R, Mäkimattila S, Yki Järvinen H: Supraphysiological hyperinsulinemia increases plasma leptin concentrations after 4 h in normal subjects. Diabetes 45:1364-1366, 1996
23. Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Earley AR, Barnett AH, Prins JB, O'Rahilly S: Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387:903-908, 1997
24. Segal KR, Landt M, Klein S: Relationship between insulin sensitivity and plasma leptin concentrations in lean and obese men. Diabetes 45:988-991, 1996
25. Auboeuf D, Vidal H: The use of the reverse transcription-competitive polymerase chain reaction to investigate the in vivo regulation of gene expression in small tissue samples. Anal Biochem 245:141-148, 1997
26. De Vos P, Saladin R, Auwerx J, Staels B: Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J Biol Chem 270:15958-15961, 1995
27. Larsson H, Ahren B: Short-term dexamethasone treatment increases plasma leptin independently of changes in insulin sensitivity in healthy women. J Clin Endocrinol Metab 81:4428-4432, 1996
28. Masuzaki H, Ogawa Y, Hosoda K, Miyawaki T, Hanaoka I, Hiroaka J, Yasuno A, Nishimura H, Yoshimasa Y, Nishi S, Nakao KJ: Glucocorticoid regulation of leptin synthesis and secretion in humans: elevated plasma leptin levels in Cushing's syndrome. Clin Endocrinol Metab 82:2542-2547, 1997
29. Dagogo-Jack S, Selke G, Melson AK, Newcomer JW: Robust leptin secretory responses to dexamethasone in obese subjects. J Clin Endocrinol Metab 82:3230-3233, 1997
30. Papaspyrou-Rao S, Shneider SH, Petersen RN, Fried SK: Dexamethasone increases leptin expression in humans in vivo. J Clin Endocrinol Metab 82:1635-1637, 1997
31. Kolaczynski JW, Goldstein BJ, Considine RV: Dexamethasone, OB gene, and leptin in humans: effect of exogenous hyperinsulinemia. J Clin Endocrinol Metab 82:3895-3897, 1998
32. Mitrakou A, Fanelli C, Veneman T, Perriello G, Calderone S, Platanisiotis D, Rambotti A, Raptis S, Brunetti P, Cryer P, Gerich J, Bolli G: Reversibility of unawareness of hypoglycemia in patients with insulinomas. N Engl J Med 329:834-839, 1993
33. Zimmet P, Hodge A, Nicolson M, Staten M, de Courten M, Moore J, Morawiecki A, Lubina J, Collier G, Alberti G, Dowse G: Serum leptin concentration, obesity, and insulin resistance in Western Samoans: cross sectional study. BMJ 313:965-969, 1996
34. Larsson H, Elmståhl S, Ahrén B: Plasma leptin levels correlate to islet function independently of body fat in women. Diabetes 45:1580-1584, 1996
35. Couillard C, Mauriege P, Prud'homme D, Nadeau A, Tremblay A, Bouchard C, Despres J-P: Plasma leptin concentrations: gender differences and associations with metabolic risk factors for cardiovascular disease. Diabetologia 40:1178-1184, 1997
36. Popovic V, Micic D, Danjanovic S, Zone S, Djurovic M, Ohradovic S, Petakov M, Dieguez C, Casanueva FF: Serum leptin and insulin concentrations in patients with insulinoma before and after surgery. Eur J Endocrinol 138:86-88, 1998
37. Schoeller DA, Cella LK, Sinha M, Caro J: Entrainment of the diurnal variation in plasma leptin levels (Abstract). Obes Res 4 (Snppl. 1):38S, 1996
38. Kim JB, Sarraf P, Wright M, Yao KM, Mueller E, Solanes G, Lowell BB, Spiegelman BM: Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. J Clin Invest 101:1-9, 1998