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Volumn 88, Issue 3, 2006, Pages 249-256

The role of leptin in leptin resistance and obesity

Author keywords

Age related obesity; Gene therapy; Leptin resistance; Leptin signaling; Melanocortins

Indexed keywords

ADENOVIRUS VECTOR; ALPHA INTERMEDIN DERIVATIVE; ANTIBIOTIC AGENT; DOXYCYCLINE; LEPTIN; LEPTIN RECEPTOR; MELANOCORTIN; PROOPIOMELANOCORTIN;

EID: 33745197808     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physbeh.2006.05.038     Document Type: Article
Times cited : (224)

References (44)
  • 1
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., and Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 372 6505 (1994) 425-432
    • (1994) Nature , vol.372 , Issue.6505 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 2
    • 0032177037 scopus 로고    scopus 로고
    • Unraveling the central nervous system pathways underlying responses to leptin
    • Elmquist J.K., Maratos-Flier E., Saper C.B., and Flier J.S. Unraveling the central nervous system pathways underlying responses to leptin. Nat Neurosci 1 6 (1998) 445-450
    • (1998) Nat Neurosci , vol.1 , Issue.6 , pp. 445-450
    • Elmquist, J.K.1    Maratos-Flier, E.2    Saper, C.B.3    Flier, J.S.4
  • 4
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman J.M., and Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 395 6704 (1998) 763-770
    • (1998) Nature , vol.395 , Issue.6704 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 6
    • 0029962467 scopus 로고    scopus 로고
    • Correction of obesity and diabetes in genetically obese mice by leptin gene therapy
    • Muzzin P., Eisensmith R.C., Copeland K.C., and Woo S.L. Correction of obesity and diabetes in genetically obese mice by leptin gene therapy. Proc Natl Acad Sci U S A 93 25 (1996) 14804-14808
    • (1996) Proc Natl Acad Sci U S A , vol.93 , Issue.25 , pp. 14804-14808
    • Muzzin, P.1    Eisensmith, R.C.2    Copeland, K.C.3    Woo, S.L.4
  • 7
    • 13344280346 scopus 로고    scopus 로고
    • Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice
    • Schwartz M.W., Baskin D.G., Bukowski T.R., Kuijper J.L., Foster D., Lasser G., et al. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45 4 (1996) 531-535
    • (1996) Diabetes , vol.45 , Issue.4 , pp. 531-535
    • Schwartz, M.W.1    Baskin, D.G.2    Bukowski, T.R.3    Kuijper, J.L.4    Foster, D.5    Lasser, G.6
  • 8
    • 0030669288 scopus 로고    scopus 로고
    • Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity
    • Widdowson P.S., Upton R., Buckingham R., Arch J., and Williams G. Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity. Diabetes 46 11 (1997) 1782-1785
    • (1997) Diabetes , vol.46 , Issue.11 , pp. 1782-1785
    • Widdowson, P.S.1    Upton, R.2    Buckingham, R.3    Arch, J.4    Williams, G.5
  • 9
    • 0030856122 scopus 로고    scopus 로고
    • Leptin gene expression increases with age independent of increasing adiposity in rats
    • Li H., Matheny M., Nicolson M., Tumer N., and Scarpace P.J. Leptin gene expression increases with age independent of increasing adiposity in rats. Diabetes 46 12 (1997) 2035-2039
    • (1997) Diabetes , vol.46 , Issue.12 , pp. 2035-2039
    • Li, H.1    Matheny, M.2    Nicolson, M.3    Tumer, N.4    Scarpace, P.J.5
  • 10
    • 0036786420 scopus 로고    scopus 로고
    • Reduced central leptin sensitivity in rats with diet-induced obesity
    • Levin B.E., and Dunn-Meynell A.A. Reduced central leptin sensitivity in rats with diet-induced obesity. Am J Physiol Regul Integr Comp Physiol 283 4 (2002) R941-R948
    • (2002) Am J Physiol Regul Integr Comp Physiol , vol.283 , Issue.4
    • Levin, B.E.1    Dunn-Meynell, A.A.2
  • 11
    • 0032747280 scopus 로고    scopus 로고
    • Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial
    • Heymsfield S.B., Greenberg A.S., Fujioka K., Dixon R.M., Kushner R., Hunt T., et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 282 16 (1999) 1568-1575
    • (1999) JAMA , vol.282 , Issue.16 , pp. 1568-1575
    • Heymsfield, S.B.1    Greenberg, A.S.2    Fujioka, K.3    Dixon, R.M.4    Kushner, R.5    Hunt, T.6
  • 13
    • 0035800015 scopus 로고    scopus 로고
    • Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats
    • Scarpace P.J., Matheny M., and Tumer N. Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats. Neuroscience 104 4 (2001) 1111-1117
    • (2001) Neuroscience , vol.104 , Issue.4 , pp. 1111-1117
    • Scarpace, P.J.1    Matheny, M.2    Tumer, N.3
  • 14
    • 0034085453 scopus 로고    scopus 로고
    • Impaired leptin signal transduction with age-related obesity
    • Scarpace P.J., Matheny M., and Shek E.W. Impaired leptin signal transduction with age-related obesity. Neuropharmacology 39 10 (2000) 1872-1879
    • (2000) Neuropharmacology , vol.39 , Issue.10 , pp. 1872-1879
    • Scarpace, P.J.1    Matheny, M.2    Shek, E.W.3
  • 15
    • 0034006768 scopus 로고    scopus 로고
    • Impaired leptin responsiveness in aged rats
    • Scarpace P.J., Matheny M., Moore R.L., and Tumer N. Impaired leptin responsiveness in aged rats. Diabetes 49 3 (2000) 431-435
    • (2000) Diabetes , vol.49 , Issue.3 , pp. 431-435
    • Scarpace, P.J.1    Matheny, M.2    Moore, R.L.3    Tumer, N.4
  • 16
    • 0033931981 scopus 로고    scopus 로고
    • Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
    • El-Haschimi K., Pierroz D.D., Hileman S.M., Bjorbaek C., and Flier J.S. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest 105 12 (2000) 1827-1832
    • (2000) J Clin Invest , vol.105 , Issue.12 , pp. 1827-1832
    • El-Haschimi, K.1    Pierroz, D.D.2    Hileman, S.M.3    Bjorbaek, C.4    Flier, J.S.5
  • 17
    • 0035957791 scopus 로고    scopus 로고
    • Enhanced leptin transport across the blood-brain barrier by alpha 1-adrenergic agents
    • Banks W.A. Enhanced leptin transport across the blood-brain barrier by alpha 1-adrenergic agents. Brain Res 899 1-2 (2001) 209-217
    • (2001) Brain Res , vol.899 , Issue.1-2 , pp. 209-217
    • Banks, W.A.1
  • 18
    • 3042516972 scopus 로고    scopus 로고
    • Effects of lipopolysaccharide on leptin transport across the blood-brain barrier
    • Nonaka N., Hileman S.M., Shioda S., Vo T.Q., and Banks W.A. Effects of lipopolysaccharide on leptin transport across the blood-brain barrier. Brain Res 1016 1 (2004) 58-65
    • (2004) Brain Res , vol.1016 , Issue.1 , pp. 58-65
    • Nonaka, N.1    Hileman, S.M.2    Shioda, S.3    Vo, T.Q.4    Banks, W.A.5
  • 20
    • 0032763709 scopus 로고    scopus 로고
    • Impaired transport of leptin across the blood-brain barrier in obesity
    • Banks W.A., DiPalma C.R., and Farrell C.L. Impaired transport of leptin across the blood-brain barrier in obesity. Peptides 20 11 (1999) 1341-1345
    • (1999) Peptides , vol.20 , Issue.11 , pp. 1341-1345
    • Banks, W.A.1    DiPalma, C.R.2    Farrell, C.L.3
  • 21
    • 0034089526 scopus 로고    scopus 로고
    • Fasting, but not adrenalectomy, reduces transport of leptin into the brain
    • Kastin A.J., and Akerstrom V. Fasting, but not adrenalectomy, reduces transport of leptin into the brain. Peptides 21 5 (2000) 679-682
    • (2000) Peptides , vol.21 , Issue.5 , pp. 679-682
    • Kastin, A.J.1    Akerstrom, V.2
  • 22
    • 0030840464 scopus 로고    scopus 로고
    • STATs and gene regulation
    • Darnell Jr. J.E. STATs and gene regulation. Science 277 5332 (1997) 1630-1635
    • (1997) Science , vol.277 , Issue.5332 , pp. 1630-1635
    • Darnell Jr., J.E.1
  • 23
    • 0037456304 scopus 로고    scopus 로고
    • STAT3 signalling is required for leptin regulation of energy balance but not reproduction
    • Bates S.H., Stearns W.H., Dundon T.A., Schubert M., Tso A.W., Wang Y., et al. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421 6925 (2003) 856-859
    • (2003) Nature , vol.421 , Issue.6925 , pp. 856-859
    • Bates, S.H.1    Stearns, W.H.2    Dundon, T.A.3    Schubert, M.4    Tso, A.W.5    Wang, Y.6
  • 24
    • 0142063578 scopus 로고    scopus 로고
    • Central leptin gene therapy fails to overcome leptin resistance associated with diet-induced obesity
    • Wilsey J., Zolotukhin S., Prima V., and Scarpace P.J. Central leptin gene therapy fails to overcome leptin resistance associated with diet-induced obesity. Am J Physiol Regul Integr Comp Physiol 285 5 (2003) R1011-R1020
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.285 , Issue.5
    • Wilsey, J.1    Zolotukhin, S.2    Prima, V.3    Scarpace, P.J.4
  • 25
    • 2942556882 scopus 로고    scopus 로고
    • Caloric restriction reverses the deficits in leptin receptor protein and leptin signaling capacity associated with diet-induced obesity: role of leptin in the regulation of hypothalamic long-form leptin receptor expression
    • Wilsey J., and Scarpace P.J. Caloric restriction reverses the deficits in leptin receptor protein and leptin signaling capacity associated with diet-induced obesity: role of leptin in the regulation of hypothalamic long-form leptin receptor expression. J Endocrinol 181 2 (2004) 297-306
    • (2004) J Endocrinol , vol.181 , Issue.2 , pp. 297-306
    • Wilsey, J.1    Scarpace, P.J.2
  • 26
    • 0036831235 scopus 로고    scopus 로고
    • Hypothalamic delivery of doxycycline-inducible leptin gene allows for reversible transgene expression and physiological responses
    • Wilsey J., Zolotukhin S., Prima V., Shek E.W., Matheny M.K., Scarpace P.J., et al. Hypothalamic delivery of doxycycline-inducible leptin gene allows for reversible transgene expression and physiological responses. Gene Ther 9 22 (2002) 1492-1499
    • (2002) Gene Ther , vol.9 , Issue.22 , pp. 1492-1499
    • Wilsey, J.1    Zolotukhin, S.2    Prima, V.3    Shek, E.W.4    Matheny, M.K.5    Scarpace, P.J.6
  • 27
    • 4644359357 scopus 로고    scopus 로고
    • Aged-obese rats exhibit robust responses to a melanocortin agonist and antagonist despite leptin resistance
    • Zhang Y., Matheny M., Tumer N., and Scarpace P.J. Aged-obese rats exhibit robust responses to a melanocortin agonist and antagonist despite leptin resistance. Neurobiol Aging 25 10 (2004) 1349-1360
    • (2004) Neurobiol Aging , vol.25 , Issue.10 , pp. 1349-1360
    • Zhang, Y.1    Matheny, M.2    Tumer, N.3    Scarpace, P.J.4
  • 28
    • 0036226005 scopus 로고    scopus 로고
    • Central leptin gene delivery evokes persistent leptin signal transduction in young and aged-obese rats but physiological responses become attenuated over time in aged-obese rats
    • Scarpace P.J., Matheny M., Zhang Y., Tumer N., Frase C.D., Shek E.W., et al. Central leptin gene delivery evokes persistent leptin signal transduction in young and aged-obese rats but physiological responses become attenuated over time in aged-obese rats. Neuropharmacology 42 4 (2002) 548-561
    • (2002) Neuropharmacology , vol.42 , Issue.4 , pp. 548-561
    • Scarpace, P.J.1    Matheny, M.2    Zhang, Y.3    Tumer, N.4    Frase, C.D.5    Shek, E.W.6
  • 29
    • 0036323306 scopus 로고    scopus 로고
    • Leptin-induced leptin resistance reveals separate roles for the anorexic and thermogenic responses in weight maintenance
    • Scarpace P.J., Matheny M., Zhang Y., Shek E.W., Prima V., Zolotukhin S., et al. Leptin-induced leptin resistance reveals separate roles for the anorexic and thermogenic responses in weight maintenance. Endocrinology 143 8 (2002) 3026-3035
    • (2002) Endocrinology , vol.143 , Issue.8 , pp. 3026-3035
    • Scarpace, P.J.1    Matheny, M.2    Zhang, Y.3    Shek, E.W.4    Prima, V.5    Zolotukhin, S.6
  • 30
    • 0038168650 scopus 로고    scopus 로고
    • Leptin-induced leptin resistant rats exhibit enhanced responses to the melanocortin agonist MT II
    • Scarpace P.J., Matheny M., Zolotukhin S., Tumer N., and Zhang Y. Leptin-induced leptin resistant rats exhibit enhanced responses to the melanocortin agonist MT II. Neuropharmacology 45 2 (2003) 211-219
    • (2003) Neuropharmacology , vol.45 , Issue.2 , pp. 211-219
    • Scarpace, P.J.1    Matheny, M.2    Zolotukhin, S.3    Tumer, N.4    Zhang, Y.5
  • 31
    • 21344466081 scopus 로고    scopus 로고
    • Leptin resistance exacerbates diet-induced obesity and is associated with diminished maximal leptin signalling capacity in rats
    • Scarpace P.J., Matheny M., Tumer N., Cheng K.Y., and Zhang Y. Leptin resistance exacerbates diet-induced obesity and is associated with diminished maximal leptin signalling capacity in rats. Diabetologia 48 6 (2005) 1075-1083
    • (2005) Diabetologia , vol.48 , Issue.6 , pp. 1075-1083
    • Scarpace, P.J.1    Matheny, M.2    Tumer, N.3    Cheng, K.Y.4    Zhang, Y.5
  • 32
    • 4043154233 scopus 로고    scopus 로고
    • Unabated anorexic and enhanced thermogenic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression
    • Li G., Zhang Y., Wilsey J.T., and Scarpace P.J. Unabated anorexic and enhanced thermogenic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression. J Endocrinol 182 1 (2004) 123-132
    • (2004) J Endocrinol , vol.182 , Issue.1 , pp. 123-132
    • Li, G.1    Zhang, Y.2    Wilsey, J.T.3    Scarpace, P.J.4
  • 33
    • 0030928715 scopus 로고    scopus 로고
    • Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus
    • Cheung C.C., Clifton D.K., and Steiner R.A. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 138 10 (1997) 4489-4492
    • (1997) Endocrinology , vol.138 , Issue.10 , pp. 4489-4492
    • Cheung, C.C.1    Clifton, D.K.2    Steiner, R.A.3
  • 34
    • 0032900284 scopus 로고    scopus 로고
    • Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides
    • Marsh D.J., Hollopeter G., Huszar D., Laufer R., Yagaloff K.A., Fisher S.L., et al. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet 21 1 (1999) 119-122
    • (1999) Nat Genet , vol.21 , Issue.1 , pp. 119-122
    • Marsh, D.J.1    Hollopeter, G.2    Huszar, D.3    Laufer, R.4    Yagaloff, K.A.5    Fisher, S.L.6
  • 36
    • 0030775971 scopus 로고    scopus 로고
    • Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
    • Schwartz M.W., Seeley R.J., Woods S.C., Weigle D.S., Campfield L.A., Burn P., et al. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46 12 (1997) 2119-2123
    • (1997) Diabetes , vol.46 , Issue.12 , pp. 2119-2123
    • Schwartz, M.W.1    Seeley, R.J.2    Woods, S.C.3    Weigle, D.S.4    Campfield, L.A.5    Burn, P.6
  • 37
    • 0035081809 scopus 로고    scopus 로고
    • Melanocortin receptors: their functions and regulation by physiological agonists and antagonists
    • Abdel-Malek Z.A. Melanocortin receptors: their functions and regulation by physiological agonists and antagonists. Cell Mol Life Sci 58 3 (2001) 434-441
    • (2001) Cell Mol Life Sci , vol.58 , Issue.3 , pp. 434-441
    • Abdel-Malek, Z.A.1
  • 38
    • 0033938492 scopus 로고    scopus 로고
    • CNS melanocortin system involvement in the regulation of food intake
    • Benoit S., Schwartz M., Baskin D., Woods S.C., and Seeley R.J. CNS melanocortin system involvement in the regulation of food intake. Horm Behav 37 4 (2000) 299-305
    • (2000) Horm Behav , vol.37 , Issue.4 , pp. 299-305
    • Benoit, S.1    Schwartz, M.2    Baskin, D.3    Woods, S.C.4    Seeley, R.J.5
  • 39
    • 0035936764 scopus 로고    scopus 로고
    • Obesity and the regulation of energy balance
    • Spiegelman B.M., and Flier J.S. Obesity and the regulation of energy balance. Cell 104 4 (2001) 531-543
    • (2001) Cell , vol.104 , Issue.4 , pp. 531-543
    • Spiegelman, B.M.1    Flier, J.S.2
  • 40
    • 27744596351 scopus 로고    scopus 로고
    • Hypothalamic pro-opiomelanocortin gene delivery ameliorates obesity and glucose intolerance in aged rats
    • Li G., Zhang Y., Wilsey J.T., and Scarpace P.J. Hypothalamic pro-opiomelanocortin gene delivery ameliorates obesity and glucose intolerance in aged rats. Diabetologia 48 11 (2005) 2376-2385
    • (2005) Diabetologia , vol.48 , Issue.11 , pp. 2376-2385
    • Li, G.1    Zhang, Y.2    Wilsey, J.T.3    Scarpace, P.J.4
  • 41
    • 0042767613 scopus 로고    scopus 로고
    • Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats
    • Li G., Mobbs C.V., and Scarpace P.J. Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats. Diabetes 52 8 (2003) 1951-1957
    • (2003) Diabetes , vol.52 , Issue.8 , pp. 1951-1957
    • Li, G.1    Mobbs, C.V.2    Scarpace, P.J.3
  • 42
    • 9244219587 scopus 로고    scopus 로고
    • Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
    • Munzberg H., Flier J.S., and Bjorbaek C. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 145 11 (2004) 4880-4889
    • (2004) Endocrinology , vol.145 , Issue.11 , pp. 4880-4889
    • Munzberg, H.1    Flier, J.S.2    Bjorbaek, C.3
  • 43
    • 0036066483 scopus 로고    scopus 로고
    • The concept of selective leptin resistance: evidence from agouti yellow obese mice
    • Correia M.L., Haynes W.G., Rahmouni K., Morgan D.A., Sivitz W.I., and Mark A.L. The concept of selective leptin resistance: evidence from agouti yellow obese mice. Diabetes 51 2 (2002) 439-442
    • (2002) Diabetes , vol.51 , Issue.2 , pp. 439-442
    • Correia, M.L.1    Haynes, W.G.2    Rahmouni, K.3    Morgan, D.A.4    Sivitz, W.I.5    Mark, A.L.6
  • 44
    • 0036628739 scopus 로고    scopus 로고
    • Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications
    • Mark A.L., Correia M.L., Rahmouni K., and Haynes W.G. Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications. J Hypertens 20 7 (2002) 1245-1250
    • (2002) J Hypertens , vol.20 , Issue.7 , pp. 1245-1250
    • Mark, A.L.1    Correia, M.L.2    Rahmouni, K.3    Haynes, W.G.4


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