Targeting the plasmepsin 4 orthologs of Plasmodium sp. with "double drug" inhibitors

Protein and Peptide Letters

Volumn 15, Issue 9, 2008, Pages 868-873

  Janka, Linda ^a   Clemente, Jose ^a   Vaiana, N ^b   Sparatore, A ^b   Romeo, Sergio ^b   Dunn, Ben M ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

A combination of two molecular entities in one compound that kill a pathogen by two mechanisms; A word derived from plasmodium pepsin; Double drug; Plasmepsin; Proteolytic enzyme from the plasmodium species; Statine

Indexed keywords

AMINO ACID; ANTIMALARIAL AGENT; ASPARTIC PROTEINASE; ENZYME PRECURSOR; PLASMEPSIN; PRIMAQUINE; PROTEINASE INHIBITOR; PROTOZOAL PROTEIN; STATINE;

AFFINITY CHROMATOGRAPHY; ANIMAL; ARTICLE; CELL INCLUSION; CELL VACUOLE; CHEMICAL STRUCTURE; DRUG ANTAGONISM; ENZYMOLOGY; GEL CHROMATOGRAPHY; GENE EXPRESSION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; PLASMODIUM; PROTEIN RENATURATION;

AMINO ACIDS; ANIMALS; ANTIMALARIALS; ASPARTIC ENDOPEPTIDASES; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, GEL; ENZYME PRECURSORS; GENE EXPRESSION; INCLUSION BODIES; MODELS, MOLECULAR; PLASMODIUM; PRIMAQUINE; PROTEASE INHIBITORS; PROTEIN RENATURATION; PROTOZOAN PROTEINS; VACUOLES;

PLASMODIUM FALCIPARUM; PLASMODIUM SP.;

EID: 52749095342     PISSN: 09298665     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986608785849218     Document Type: Article

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