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Volumn 86, Issue 6, 2003, Pages 2173-2191

Development of a new class of inhibitors for the malarial aspartic protease plasmepsin II based on a central 7-azabicyclo[2.2.1]heptane scaffold

(8) Carcache, David A a Hörtner, Simone R a Seiler, Paul a Diederich, François a Dorn, Arnulf b Märki, Hans Peter b Binkert, Christoph c Bur, Daniel c

a ETH ZURICH (Switzerland)

b F HOFFMANN LA ROCHE LTD (Switzerland)

c ACTELION PHARMACEUTICALS LTD (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; HYDROGEN BONDS; HYDROPHOBICITY; MALARIA CONTROL; MOLECULAR STRUCTURE; SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL);

CATABOLISM;

ENZYMES;

ANTIMALARIAL AGENT; ASPARTIC PROTEINASE INHIBITOR; NORBORNANE DERIVATIVE; PIPERIDINE DERIVATIVE; PLASMEPSIN II; RENIN;

ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; PLASMODIUM; PRIORITY JOURNAL; PROTON TRANSPORT; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION;

EID: 0043027664 PISSN: 0018019X EISSN: None Source Type: Journal
DOI: 10.1002/hlca.200390176 Document Type: Article

Times cited : (23)

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