High antiplasmodial activity of novel plasmepsins I and II inhibitors

Journal of Medicinal Chemistry

Volumn 49, Issue 25, 2006, Pages 7440-7449

  Dell'Agli, Mario ^a   Parapini, Silvia ^a   Galli, Germana ^a   Vaiana, Nadia ^a   Taramelli, Donatella ^a   Sparatore, Anna ^a   Liu, Peng ^b   Dunn, Ben M ^b   Bosisio, Enrica ^a   Romeo, Sergio ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIHYDROXYETHYLENE; 2 [[4 [4 [[1 [1 (BUTYLAMINO) 3 HYDROXY 6 METHYL 1 OXOHEPTAN 4 YLAMINO] 3 METHYL 1 OXOPENTAN 2 YL]CARBAMOYL]PHENOXY]BENZAMIDO]PROPANAMIDO] 6 (TERT BUTOXYCARBONYL)HEXANOIC ACID PROPYL ESTER; 2 [[4 [4 [[1 [1 (BUTYLAMINO) 3 HYDROXY 6 METHYL 1 OXOHEPTAN 4 YLAMINO] 3 METHYL 1 OXOPENTAN 2 YL]CARBAMOYL]PHENOXY]BENZAMIDO]PROPANAMIDO] 6 AMINOHEXANOIC ACID PROPYL ESTER; 4 [2 [4 [4 [[1 [1 [4 (6 METHOXYQUINOLIN 8 YLAMINO)PENTYLAMINO] 1 OXOPROPAN 2 YLAMINO] 4 METHYL 1 OXOPENTAN 2 YL]CARBAMOYL]PHENOXY]BENZAMIDO] 3 METHYLPENTANAMIDO] 3 HYDROXY 6 METHYLHEPTANOIC ACID BUTYLAMIDE; 4 [2 [4 [4 [[1 [4 (6 METHOXYQUINOLIN 8 YLAMINO)PENTYLAMINO] 4 METHYL 1 OXOPENTAN 2 YL]CARBAMOYL]PHENOXY]BENZAMIDO] 3 METHYLPENTANAMIDO] 3 HYDROXY 6 METHYLHEPTANOIC ACID BUTYLAMIDE; CHLOROQUINE; NORSTATINE; PLASMEPSIN 1 INHIBITOR; PLASMEPSIN II INHIBITOR; PLASMEPSIN INHIBITOR; PRIMAQUINE; PS 777621; STATINE DERIVATIVE;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG SELECTIVITY; FIBROBLAST; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIPOPHILICITY; NONHUMAN; PLASMODIUM FALCIPARUM;

AMINOQUINOLINES; ANIMALS; ANTIMALARIALS; ASPARTIC ENDOPEPTIDASES; CATHEPSIN D; CELLS, CULTURED; DIPEPTIDES; DRUG RESISTANCE; FIBROBLASTS; HUMANS; LEUCINE; MODELS, MOLECULAR; PLASMODIUM FALCIPARUM; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33845497127     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm061033d     Document Type: Article

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