Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs

Journal of Medicinal Chemistry

Volumn 47, Issue 13, 2004, Pages 3353-3366

  Johansson, Per Ola ^a   Chen, Yantao ^a   Belfrage, Anna Karin ^a   Blackman, Michael J ^b   Kvarnström, Ingemar ^a   Jansson, Katarina ^c   Vrang, Lotta ^c   Hamelink, Elizabeth ^c   Hallberg, Anders ^d   Rosenquist, Åsa ^a,c   Samuelsson, Bertil ^c,e  

^a LINKÖPING UNIVERSITY   (Sweden)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^c MEDIVIR AB   (Sweden)

^d UPPSALA UNIVERSITY   (Sweden)

^e STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ASPARTIC PROTEINASE; CATHEPSIN D; N [1 (4 BROMOBENZYLOXYMETHYL) 2 HYDROXY 3 [2 (3 METHOXYPHENYL)ETHYLCARBAMOYL]PROPYL] 2,4,6 TRIFLUOROBENZAMIDE; N [1 (4 BROMOBENZYLOXYMETHYL) 3 CYCLOHEXYLCARBAMOYL 2 HYDROXYPROPYL] 2,4,6 TRIFLUOROBENZAMIDE; PLASMEPSIN I; PLASMEPSIN II; PYRIDINE 2 CARBOXYLIC ACID [1 (4 BROMOBENZYLOXYMETHYL) 3 ( 1 CARBAMOYL 3 METHYLBUTYLCARBAMOYL)ETHYLCARBAMOYL 2 HYDROXYPROPYLCARBAMOYL 2 METHYLPROPYL]AMIDE; STATINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; ERYTHROCYTE; HUMAN; HUMAN CELL; NONHUMAN; PLASMODIUM FALCIPARUM; SOLID;

ACRYLONITRILE; ANIMALS; ANTIMALARIALS; ASPARTIC ENDOPEPTIDASES; CATHEPSIN D; COMBINATORIAL CHEMISTRY TECHNIQUES; DIPEPTIDES; HUMANS; MODELS, MOLECULAR; MOLECULAR MIMICRY; PLASMODIUM FALCIPARUM; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 2942610564     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm031106i     Document Type: Article

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