C2-symmetric inhibitors of Plasmodium falciparum plasmepsin II: Synthesis and theoretical predictions

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 17, 2003, Pages 3723-3733

  Ersmark, Karolina ^a   Feierberg, Isabella ^a   Bjelic, Sinisa ^a   Hultén, Johan ^a   Samuelsson, Bertil ^b   Åqvist, Johan ^a   Hallberg, Anders ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b MEDIVIR AB   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; N1,N6 BIS(2 HYDROXY 1 INDANYL) 2,5 DI(ALLYOXY) 3,4 DIHYDROXYHEXANE 1,6 DIAMIDE; N1,N6 BIS[2 METHYL 1 (METHYLCARBAMOYL)PROPYL] 2,5 DI(ALLYOXY) 3,4 DIHYDROXYHEXANE 1,6 DIAMIDE; N1,N6 BIS[2 METHYL 1 (METHYLCARBAMOYL)PROPYL] 2,5 DI(BENZYLOXY) 3,4 DIHYDROXYHEXANE 1,6 DIAMIDE; PLASMEPSIN II; PLASMEPSIN II INHIBITOR; UNCLASSIFIED DRUG; AMINOINDANOL; ANTIMALARIAL AGENT; ASPARTIC PROTEINASE; INDAN DERIVATIVE; MANNITOL; PROTEINASE INHIBITOR;

ARTICLE; BINDING AFFINITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENTHALPY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; METHODOLOGY; PLASMODIUM FALCIPARUM; PREDICTION; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; ANIMAL; BINDING SITE; CHEMICAL MODEL; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; METABOLISM; SYNTHESIS; THERMODYNAMICS;

PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; ASPARTIC ENDOPEPTIDASES; BINDING SITES; INDANS; MANNITOL; MODELS, CHEMICAL; PLASMODIUM FALCIPARUM; PROTEASE INHIBITORS; STEREOISOMERISM; THERMODYNAMICS;

EID: 0041620630     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00339-0     Document Type: Article

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