Active site contribution to specificity of the aspartic proteases plasmepsins I and II

Journal of Biological Chemistry

Volumn 277, Issue 43, 2002, Pages 41009-41013

  Siripurkpong, Pilaiwan ^a,b   Yuvaniyama, Jirundon ^a,b   Wilairat, Prapon ^a,b   Goldberg, Daniel E ^a,b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CRYSTAL STRUCTURE; DRUG PRODUCTS; MALARIA CONTROL;

KINETIC PARAMETERS;

ENZYMES;

ASPARTIC PROTEINASE; PLASMEPSIN I; PLASMEPSIN II;

AMINO TERMINAL SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME SPECIFICITY; ENZYME STRUCTURE; KINETICS; MOLECULAR RECOGNITION; NONHUMAN; PLASMODIUM; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS;

ASPARTIC ENDOPEPTIDASES; BASE SEQUENCE; BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA PRIMERS; HEMOGLOBINS; HYDROLYSIS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

PROTOZOA;

EID: 0037175033     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M204852200     Document Type: Article

References (24)

1. Trigg, P. I., and Kondrachine, A. V. (1998) Bull. W.H.O. 76, 11-16
2. Banerjee, R., Liu, J., Beatty, W., Pelosof, L., Klemba, M., and Goldberg, D. E. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 990-995
3. Goldberg, D. E., Slater, A. F., Beavis, R., Chait, B., Cerami, A., and Henderson, G. B. (1991) J. Exp. Med. 173, 961-969
4. Goldberg, D. E. (1992) Infect. Agents Dis. 1, 207-211
5. Francis, S. E., Gluzman, I. Y., Oksman, A., Banerjee, D., and Goldberg, D. E. (1996) Mol Biochem. Parasitol. 83, 189-200
6. Gluzman, I. Y., Francis, S. E., Oksman, A., Smith, C. E., Duffin, K. L., and Goldberg, D. E. (1994) J. Clin. Invest. 93, 1602-1608
7. Eggleson, K. K., Duffin, K. L., and Goldberg, D. E. (1999) J. Biol. Chem. 274, 32411-32417
8. Dame, J. B., Reddy, G. R., Yowell, C. A., Dunn, B. M., Kay, J., and Berry, C. (1994) Mol. Biochem. Parasitol. 64, 177-190
9. Kolakovich, K. A., Gluzman, I. Y., Duffin, K. L., and Goldberg, D. E. (1997) Mol. Biochem. Parasitol. 87, 123-135
10. Gavigan, C. S., Dalton, J. P., and Bell, A. (2001) Mol. Biochem. Parasitol. 117, 37-48
11. Coombs, G. H., Goldberg, D. E., K]emba, M., Berry, C., Kay, J., and Mottram, J. C. (2001) Trends Parasitol. 17, 532-537
12. Francis, S. E., Gluzman, I. Y., Oksman, A., Knickerbocker, A., Mueller, R., Bryant, M. L., Sherman, D. R., Russell, D. G., and Goldberg, D. E. (1994) EMBO J. 13, 306-317
13. Moon, R. P., Tyas, L., Certa, U., Rupp, K., Bur, D., Jacquet, C., Matile, H., Loetscher, H., Grueninger-Leitch, F., Kay, J., Dunn, B. M., Berry, C., and Ridley, R. G. (1997) Eur. J. Biochem. 244, 552-560
14. Haque, T. S., Skillman, A. G., Lee, C. E., Habashita, H., Gluzman, I. Y., Ewing, T. J., Goldberg, D. E., Kuntz, I. D., and Ellman, J. A. (1999) J. Med. Chem. 42, 1428-1440
15. Silva, A. M., Lee, A. Y., Gulnik, S. V., Maier, P., Collins, J., Bhat, T. N., Collins, P. J., Cachau, R. E., Luker, K. E., Gluzman, I. Y., Francis, S. E., Oksman, A., Goldberg, D. E., and Erickson, J. W. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 10034-10039
16. Bernstein, N. K., Cherney, M. M., Loetscher, H., Ridley, R. G., and James, M. N. (1999) Nat. Struct. Biol. 6, 32-37
17. Luker, K. E., Francis, S. E., Gluzman, I. Y., and Goldberg, D. E. (1996) Mol. Biochem. Parasitol. 79, 71-78
18. Williams, J. W., and Morrison, J. F. (1979) Methods Enzymol. 63, 437-467
19. Knight, C. G. (1995) Methods Enzymol. 248, 85-101
20. Copeland, R. A. (2000) Enzymes: A Practical Introduction to Structure, Mechanism, and Data Analysis, 2nd, Ed., Wiley-VCH, Inc., New York, NY
21. Turk, B. E., Huang, L. L., Piro, E. T., and Cantley, L. C., (2001)Nat. Biotechnol. 19, 661-667
22. Khan, A. R., Khazanovich-Bernstein, N., Bergmann, E. M., and James, M. N. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 10968-10975
23. Poorman, R. A., Tomasselli, A. G., Heinrikson, R. L., and Kezdy, F. J. (1991) J. Biol. Chem. 266, 14554-14561
24. Koradi, R., Billeter, M., and Wuthrich, K. (1996) J. Mol. Graph. 14, 51-55, 29-32