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ChemMedChem

Volumn 3, Issue 2, 2008, Pages 237-240

Exploring the flap pocket of the antimalarial target plasmepsin II: The "55% rule" applied to enzymes

(5) Zürcher, Martina a Gottschalk, Thomas a Meyer, Solange b Bur, Daniel b Diederich, François a

a ETH ZURICH (Switzerland)

b ACTELION PHARMACEUTICALS LTD (Switzerland)

Author keywords

Aspartic proteases; Drug design; Inhibitors; Malaria; Molecular recognition

Indexed keywords

ANTIMALARIAL AGENT; ASPARTIC PROTEINASE; PLASMEPSIN II; PROTEINASE INHIBITOR;

ALGORITHM; ANIMAL; ARTICLE; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; ENZYMOLOGY; GROWTH, DEVELOPMENT AND AGING; IC 50; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

ALGORITHMS; ANIMALS; ANTIMALARIALS; ASPARTIC ENDOPEPTIDASES; BINDING SITES; DRUG DESIGN; INHIBITORY CONCENTRATION 50; PLASMODIUM FALCIPARUM; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 45249123710 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.200700236 Document Type: Article

Times cited : (44)

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