Structure and mechanism of drug efflux machinery in Gram negative bacteria

Current Drug Targets

Volumn 9, Issue 9, 2008, Pages 719-728

  Pietras, Zbigniew ^a   Bavro, Vassiliy N ^a   Furnham, Nicholas ^b   Pellegrini Calace, Marialuisa ^b   Milner White, E James ^c   Luisi, Ben F ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b EUROPEAN BIOINFORMATICS INSTITUTE   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

AcrB; Antibiotic resistance; Drug efflux pumps; Membrane fusion proteins; RND transporters; TolC

Indexed keywords

BACTERIAL PROTEIN; CARRIER PROTEIN; INNER MEMBRANE PROTEIN; MEMBRANE FUSION PROTEIN; OUTER MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

BACTERIAL METABOLISM; BACTERIAL OUTER MEMBRANE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CYTOPLASM; DRUG TRANSPORT; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; MEMBRANE STRUCTURE; MEMBRANE TRANSPORT; MOLECULAR DOCKING; MOLECULAR INTERACTION; NONHUMAN; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN FUNCTION; PROTON MOTIVE FORCE; REVIEW;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BIOLOGICAL TRANSPORT; DRUG RESISTANCE, BACTERIAL; ELECTROCHEMISTRY; GRAM-NEGATIVE BACTERIA; MEMBRANE POTENTIALS; MEMBRANE PROTEINS; MODELS, MOLECULAR; PROTEIN CONFORMATION;

EID: 52449124145     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945008785747743     Document Type: Review

References (62)

1. Poole, K. (2001) Curr. Opin. Microbiol., 4(5), 500-508.
2. Sulavik, M. C.; Houseweart, C.; Cramer, C.; Jiwani, N.; Murgolo, N.; Greene, J.; DiDomenico, B.; Shaw, K. J.; Miller, G. H.; Hare, R.; Shimer, G. (2001) Antimicrob. Agents Chemother., 45(4), 1126-1136.
3. Borges-Walmsley, M. I.; McKeegan, K. S.; Walmsley, A. R. (2003) Biochem. J., 376(Pt 2), 313-338.
4. Delepelaire, P. (2004) Biochim. Biophys. Acta, 1694(1-3), 149-161.
5. Thanassi, D. G.; Hultgren, S. J. (2000) Curr. Opin. Cell Biol., 12(4), 420-430.
6. Dawson, R. J.; Locher, K. P. (2006) Nature, 443(7108), 180-185.
7. Nikaido, H.; Zgurskaya, H. I. (2001) J. Mol. Microbiol. Biotechnol., 3(2), 215-218.
8. Kobayashi, N.; Nishino, K.; Yamaguchi, A. (2001) J. Bacteriol., 183(19), 5639-5644.
9. Tikhonova, E. B.; Devroy, V. K.; Lau, S. Y.; Zgurskaya, H. I. (2007) Mol. Microbiol., 63(3), 895-910.
10. Akama, H.; Kanemaki, M.; Yoshimura, M.; Tsukihara, T.; Kashiwagi, T.; Yoneyama, H.; Narita, S.; Nakagawa, A.; Nakae, T. (2004) J. Biol. Chem., 279(51), 52816-52819.
11. Federici, L.; Du, D.; Walas, F.; Matsumura, H.; Fernandez-Recio, J.; McKeegan, K. S.; Borges-Walmsley, M. I.; Luisi, B. F.; Walmsley, A. R. (2005) J. Biol. Chem., 280(15), 15307-15314.
12. Koronakis, V.; Sharff, A.; Koronakis, E.; Luisi, B.; Hughes, C. (2000) Nature, 405(6789), 914-919.
13. Murakami, S.; Nakashima, R.; Yamashita, E.; Yamaguchi, A. (2002) Nature, 419(6907), 587-593.
14. Akama, H.; Matsuura, T.; Kashiwagi, S.; Yoneyama, H.; Narita, S.; Tsukihara, T.; Nakagawa, A.; Nakae, T. (2004) J. Biol. Chem., 279(25), 25939-25942.
15. Higgins, M. K.; Bokma, E.; Koronakis, E.; Hughes, C.; Koronakis, V. (2004) Proc. Natl. Acad. Sci. USA, 101(27), 9994-9999.
16. Mikolosko, J.; Bobyk, K.; Zgurskaya, H. I.; Ghosh, P. (2006) Structure, 14(3), 577-587.
17. Fernandez-Recio, J.; Walas, F.; Federici, L.; Venkatesh Pratap, J.; Bavro, V. N.; Miguel, R. N.; Mizuguchi, K.; Luisi, B. (2004) FEBS Lett., 578(1-2), 5-9.
18. Lobedanz, S.; Bokma, E.; Symmons, M. F.; Koronakis, E.; Hughes, C.; Koronakis, V. (2007) Proc. Natl. Acad. Sci. USA, 104(11), 4612-4617.
19. Bavro, V. N.; Pietras, Z.; Furnham, N.; Perez-Cano, L.; Fernandez-Recio, J.; Pei, X. Y.; Misra, R.; Luisi, B. (2008) Mol. Cell, 30(1), 114-121.
20. Fralick, J. A. (1996) J. Bacteriol., 178(19), 5803-5805.
21. Wandersman, C.; Delepelaire, P. (1990) Proc. Natl. Acad. Sci. USA, 87(12), 4776-4780.
22. Andersen, C.; Koronakis, E.; Hughes, C.; Koronakis, V. (2002) Mol. Microbiol., 44(5), 1131-1139.
23. Augustus, A. M.; Celaya, T.; Husain, F.; Humbard, M.; Misra, R. (2004) J. Bacteriol., 186(6), 1851-1860.
24. Watson, J. D.; Milner-White, E. J. (2002) J. Mol. Biol., 315(2), 171-182.
25. Calladine, C. R.; Sharff, A.; Luisi, B. (2001) J. Mol. Biol., 305(3), 603-618.
26. Sharff, A.; Fanutti, C.; Shi, J.; Calladine, C.; Luisi, B. (2001) Eur. J. Biochem., 268(19), 5011-5026.
27. Eswaran, J.; Hughes, C.; Koronakis, V. (2003) J. Mol. Biol., 327(2), 309-315.
28. Dastidar, V.; Mao, W.; Lomovskaya, O.; Zgurskaya, H. I. (2007) J. Bacteriol., 189(15), 5550-5558.
29. Das, D.; Xu, Q. S.; Lee, J. Y.; Ankoudinova, I.; Huang, C.; Lou, Y.; DeGiovanni, A.; Kim, R.; Kim, S. H. (2007) J. Struct. Biol., 158(3), 494-502.
30. Murakami, S.; Nakashima, R.; Yamashita, E.; Matsumoto, T.; Yamaguchi, A. (2006) Nature, 443(7108), 173-179.
31. Seeger, M. A.; Schiefner, A.; Eicher, T.; Verrey, F.; Diederichs, K.; Pos, K. M. (2006) Science, 313(5791), 1295-1298.
32. Seeger, M. A.; von Ballmoos, C.; Eicher, T.; Brandstatter, L.; Verrey, F.; Diederichs, K.; Pos, K. M. (2008) Nat. Struct. Mol. Biol., 15(2), 199-205.
33. Sennhauser, G.; Amstutz, P.; Briand, C.; Storchenegger, O.; Grutter, M. G. (2006) PLoS Biol., 5(1), e7.
34. Takatsuka, Y.; Nikaido, H. (2007) J. Bacteriol., 189(23), 8677-8684.
35. Tamura, N.; Murakami, S.; Oyama, Y.; Ishiguro, M.; Yamaguchi, A. (2005) Biochemistry, 44(33), 11115-11121.
36. Tornroth-Horsefield, S.; Gourdon, P.; Horsefield, R.; Brive, L.; Yamamoto, N.; Mori, H.; Snijder, A.; Neutze, R. (2007) Structure, 15(12), 1663-1673.
37. Johnson, J. M.; Church, G. M. (1999) J. Mol. Biol., 287(3), 695-715.
38. Husain, F.; Humbard, M.; Misra, R. (2004) J. Bacteriol., 186(24), 8533-8536.
39. Tikhonova, E. B.; Wang, Q.; Zgurskaya, H. I. (2002) J. Bacteriol., 184(23), 6499-6507.
40. Tikhonova, E. B.; Zgurskaya, H. I. (2004) J. Biol. Chem., 279(31), 32116-32124.
41. Touze, T.; Eswaran, J.; Bokma, E.; Koronakis, E.; Hughes, C.; Koronakis, V. (2004) Mol. Microbiol., 53(2), 697-706.
42. Borges-Walmsley, M. I.; Beauchamp, J.; Kelly, S. M.; Jumel, K.; Candlish, D.; Harding, S. E.; Price, N. C.; Walmsley, A. R. (2003) J. Biol. Chem., 278(15), 12903-12912.
43. Thanabalu, T.; Koronakis, E.; Hughes, C.; Koronakis, V. (1998) Embo J., 17(22), 6487-6496.
44. Zgurskaya, H. I.; Nikaido, H. (2000) J. Bacteriol., 182(15), 4264-4267.
45. Stegmeier, J. F.; Polleichtner, G.; Brandes, N.; Hotz, C.; Andersen, C. (2006) Biochemistry, 45(34), 10303-10312.
46. Vaccaro, L.; Koronakis, V.; Sansom, M. S. (2006) Biophys. J., 91(2), 558-564.
47. Fernandez-Recio, J.; Totrov, M.; Skorodumov, C.; Abagyan, R. (2005) Proteins, 58(1), 134-143.
48. Andersen, C.; Koronakis, E.; Bokma, E.; Eswaran, J.; Humphreys, D.; Hughes, C.; Koronakis, V. (2002) Proc. Natl. Acad. Sci. USA, 99(17), 11103-11108.
49. Higgins, M. K.; Eswaran, J.; Edwards, P.; Schertler, G. F.; Hughes, C.; Koronakis, V. (2004) J. Mol. Biol., 342(3), 697-702.
50. Gerken, H.; Misra, R. (2004) Mol. Microbiol., 54(3), 620-631.
51. Bokma, E.; Koronakis, E.; Lobedanz, S.; Hughes, C.; Koronakis, V. (2006) FEBS Lett., 580(22), 5339-5343.
52. Nehme, D.; Poole, K. (2007) J. Bacteriol., 189(17), 6118-6127.
53. Vediyappan, G.; Borisova, T.; Fralick, J. A. (2006) J. Bacteriol., 188(11), 3757-3762.
54. Eda, S.; Maseda, H.; Yoshihara, E.; Nakae, T. (2006) FEMS Microbiol. Lett., 254(1), 101-107.
55. Krishnamoorthy, G.; Tikhonova, E. B.; Zgurskaya, H. I. (2008) J. Bacteriol., 190(2), 691-698.
56. Ip, H.; Stratton, K.; Zgurskaya, H.; Liu, J. (2003) J. Biol. Chem., 278(50), 50474-50482.
57. Aires, J. R.; Nikaido, H. (2005) J. Bacteriol., 187(6), 1923-1929.
58. Bunikis, I.; Denker, K.; Ostberg, Y.; Andersen, C.; Benz, R.; Bergstrom, S. (2008) PLoS Pathog., 4(2), e1000009.
59. Kawabe, T.; Fujihira, E.; Yamaguchi, A. (2000) J. Biochem., 128(2), 195-200.
60. Meroueh, S. O.; Bencze, K. Z.; Hesek, D.; Lee, M.; Fisher, J. F.; Stemmler, T. L.; Mobashery, S. (2006) Proc. Natl. Acad. Sci. USA, 103(12), 4404-4409.
61. Piao, S.; Xu, Y.; Ha, N. C. (2008) Acta Crystallogr. Sect. F. Struct. Biol. Cryst. Commun., 64(Pt 5), 391-393.
62. Baker, N. A.; Sept, D.; Joseph, S.; Holst, M. J.; McCammon, J. A. (2001) Proc. Natl. Acad. Sci. USA, 98(18), 10037-10041.