The role of the TolC family in protein transport and multidrug efflux from stereochemical certainty to mechanistic hypothesis

European Journal of Biochemistry

Volumn 268, Issue 19, 2001, Pages 5011-5026

  Sharff, Andrew ^a,b   Fanutti, Cristina ^a   Shi, Jiye ^a   Calladine, Chris ^a   Luisi, Ben ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ASTEX PHARMACEUTICALS   (United Kingdom)

Author keywords

helical barrel; Antiporter; ATP binding cassette; Membrane protein; Multidrug efflux; Porin; Protein transport

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL PROTEIN; CARRIER PROTEINS AND BINDING PROTEINS; HEMOLYSIN; HYBRID PROTEIN; TOLC PROTEIN; TOXIN; UNCLASSIFIED DRUG;

BACTERIAL MEMBRANE; BACTERIAL VIRULENCE; COILED BODY; CRYSTAL STRUCTURE; ESCHERICHIA COLI; EXTRACELLULAR SPACE; GRAM NEGATIVE BACTERIUM; IMAGE ANALYSIS; MEMBRANE TRANSPORT; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; REVIEW; SEQUENCE HOMOLOGY; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

BACTERIAL OUTER MEMBRANE PROTEINS; BIOLOGICAL TRANSPORT; ESCHERICHIA COLI PROTEINS; MEMBRANE FUSION; MEMBRANE TRANSPORT PROTEINS; MODELS, MOLECULAR; PHARMACEUTICAL PREPARATIONS; PROTEIN CONFORMATION; PROTEIN TRANSPORT; STEREOISOMERISM;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0034792632     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0014-2956.2001.02442.x     Document Type: Review

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