Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 34, Issue 3, 2007, Pages 401-431

  Willmann, Stefan ^a   Höhn, Karsten ^a   Edginton, Andrea ^a   Sevestre, Michael ^a   Solodenko, Juri ^a   Weiss, Wolfgang ^a   Lippert, Jörg ^a   Schmitt, Walter ^a  

^a BAYER AG   (Germany)

Author keywords

Generic model; Interindividual variability; PBPK; Pharmacokinetics; Population modeling; Simulation

Indexed keywords

CIPROFLOXACIN; PACLITAXEL;

ALGORITHM; ANALYTICAL PARAMETERS; ANTHROPOMETRY; ARTICLE; BLOOD FLOW; BODY HEIGHT; BODY MASS; BODY WEIGHT; CORRELATION ANALYSIS; GENDER; ORGAN WEIGHT; POPULATION MODEL; PRIORITY JOURNAL; RACE; SENSITIVITY ANALYSIS; SIMULATION;

ADULT; AGE FACTORS; ALGORITHMS; BODY HEIGHT; BODY MASS INDEX; BODY WEIGHT; CIPROFLOXACIN; COMPUTER SIMULATION; CONTINENTAL POPULATION GROUPS; FEMALE; HUMANS; MALE; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; PACLITAXEL; PHARMACOKINETICS; POPULATION SURVEILLANCE; REFERENCE VALUES; REGIONAL BLOOD FLOW; REPRODUCIBILITY OF RESULTS; SEX FACTORS; USER-COMPUTER INTERFACE;

EID: 34249905607     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10928-007-9053-5     Document Type: Article

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