Effects of food on drug absorption

Annual Review of Nutrition

Volumn 16, Issue , 1996, Pages 383-416

  Welling, Peter G ^a  

^a PFIZER INC   (United States)

Author keywords

drug levels; interactions; meals

Indexed keywords

ALENDRONIC ACID; AMBENONIUM; ANTIBIOTIC AGENT; ANTICONVULSIVE AGENT; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; ANTIPARASITIC AGENT; ANTIPARKINSON AGENT; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CEPHALOSPORIN DERIVATIVE; CHOLINESTERASE INHIBITOR; CYCLOSPORIN; DIURETIC AGENT; ERYTHROMYCIN DERIVATIVE; HYPERTENSIVE AGENT; HYPOCHOLESTEROLEMIC AGENT; METHOTREXATE; MONOAMINE OXIDASE INHIBITOR; MORPHINE; PURINE NUCLEOSIDE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SALICYLIC ACID DERIVATIVE; SEROTONIN AGONIST; TACRINE; THEOPHYLLINE; UNINDEXED DRUG; VERAPAMIL; ZIDOVUDINE;

DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; FOOD DRUG INTERACTION; HUMAN; LIPID DIET; LOW FAT DIET; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REVIEW; STOMACH MOTILITY;

EID: 0029825085     PISSN: 01999885     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.nutr.16.1.383     Document Type: Review

References (222)

1. Albertioni F, Juliusson G, Liliemark J. 1993. On the bioavailability of 2-chloro-2′-deoxyadenosine (CdA): the influence of food and omeprazole. Eur. J. Clin. Pharmacol. 44:579-82
2. Arkinstall WW, Brar PS, Stewart JH. 1991. Repeated dosing of Uniphyl tablets under fed and fasting conditions: comparison of serum theophylline levels, pulmonary function and asthma symptoms. Ann. Allergy 67:583-87
3. Astarloa R, Mena MA, Sanchez V, De La Vega L, De Yébenes JG. 1992. Clinical and pharmacokientic effects of a diet rich in insoluble fiber on Parkinson disease. Clin. Neuropharmacol. 15:375-30
4. Axelson JE, Chan GLY, Kirsten EB, Mason WD, Lanman EC, Kerr CE. 1987. Enhancement of the bioavailability of propafenone by food. Br. J. Clin. Pharmacol. 23:735-41
5. Bailey DG, Spence JD, Munoz C, Arnold JMO. 1991. Interaction of citrus juices with felodipine and nifedipine. Lancet 337:268-69
6. Bannwarth B, Combes C, Vinçon G, Bouchet JL, Aparicio M, Bégaud B. 1992. Influence of low protein diet on the pharmacokinetics of carbamazepine in chronic renal failure. Fundam. Clin. Pharmacol. 6:222
7. Barbhaiya RH, Patel RB, Corrick-West HP, Joslin RS, Welling PG. 1982. Comparative bioavailability of hydrochlorothiazide from oral tablet dosage forms, determined by plasma and urinary excretion models. Biopharm. Drug Dispos. 3:329-36
8. Barbhaiya RH, Shukla UA, Gleason CR, Shyu WC, Pittman KA. 1990. Comparison of the effects of food on the pharmacokinetics of cefprozil and cefaclor. Antimicrob. Agents Chemother. 34: 1210-13
9. Barnwell SG, Laudanski T, Dwyer M, Story MJ, Guard P, et al. 1993. Reduced bioavailability of atenolol in man: the role of bile acids. Int. J. Pharm. 89:245-50
10. Barone JA, Koh JG, Bierman RH, Colaizzi JL, Swanson KA, et al. 1993. Food interactions and steady state pharmacokinetics of itraconazole capsules in healthy male volunteers. Antimicrob. Agents Chemother. 37:778-84
11. Bass J, Shepard KV, Lee JW, Hulse J. 1992. An evaluation of the effect of food on the oral bioavailability of sustained-release morphine sulfate tablets (Oramorph SR) after multiple doses. J. Clin. Pharmacol. 32:1003-7
12. Beckermann B, Beneke M, Böttcher M, Dietrich H, Horstmann R, Seitz I. 1993. Influence of formulation, food or antacids on the pharmacokinetics of BAY X 1005 in human volunteers. Arch. Pharmacol. 347(Suppl.):R27
13. Beerman B, Groschinsky-Grind M. 1978. Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline. Eur. J. Clin. Pharmacol. 13:385-37
14. Belch JJF, McLaren M, Lau CS, MacKay IR, Bancroft A, et al. 1993. Cicaprost, an orally active prostacyclin analogue: its effects on platelet aggregation and skin blood flow in normal volunteers. Br. J. Clin. Pharmacol. 35: 643-47
15. Bergmann JH, Simonneau G, Chassany O, Caulin C. 1992. Effet de la prise d'un repas et d'un anti acide sur la cinetique de l'acetorphan. Therapie 47: 229
16. Bieck PR, Antonin K-H, Schmidt E. 1993. Clinical pharmacology of reversible nonoamine oxidase-A inhibitors. Clin. Neuropharmacol. 16(Suppl. 2): S34-41
17. Blouin RA, Stoeckel K. 1993. Cefetamet pivoxil clinical pharmacokinetics. Drug Dispos. 25:172-88
18. Brookes LG, Sambol NC, Lin ET, Gee W, Benet LZ. 1991. Effect of dosage form, dose and food on the pharmacokinetics of metformin. Pharm. Res. 8 (Suppl.):S320
19. Chao ST, Prather D, Pinson D, Coen P, Pruitt B, et al. 1991. Effect of food on bioavailability of pseudoephedrine and brompheniramine administered from a gastrointestinal therapeutic system. J. Pharm. Sci. 80:432-35
20. Charman WN, Rogge MC, Boddy AW, Berger BM. 1993. Effect of food and a monoglyceride emulsion formulation on danazol bioavailability. J. Clin. Pharmacol. 33:381-86
21. Chaufour S, Funck-Brentano C, Jaillon P. 1992. Pharmacokinetics of trimetazidine SR in healthy volunteers: influence of food on oral drug disposition. Fundam. Clin. Pharmacol. 6:225
22. Choi RL, Sun JX, Kochak GM. 1993. The effect of food on the relative bioavailability of fadrazole hydrochloride. Biopharm. Drug Dispos. 14:779-84
23. Chu S-Y, Park Y, Locke C, Wilson DS, Cavanaugh JC. 1992. Drug-food intereaction potential of clarithromycin, a new macrolide antimicrobial. J. Clin. Pharmacol. 32:32-36
24. Cole AFD, Baxter JG, Jackson BJ, Hew-Wing P, Güntert TW, Lalka D. 1992. Pharmacokinetic and metabolic aspects of the moclobemide-food interaction. Psycopharmacology 106:S37-39
25. Cole SK, Story MJ, Laudanski T, Dwyer M, Attwood D, et al. 1992. Targeting drugs to the enterohepatic circulation: a potential drug delivery system designed to enhance the bioavailability of indomethacin. Int. J. Pharm. 80:63-73
26. Confalonieri S, Cosmi G, Guiso G, Gherardi S, Guido M, Caccia S. 1992. The pharmacokinetics of a potential memory-enhancing compound, CL 275838, in fasted and fed volunteers. Drug Invest. 4:322-28
27. Conway EL, McNeil JJ, Hurley J, Jackman GP, Krum H, et al. 1993. The effects of food on the oral bioavailability of doxazosin in hypertensive subjects. Drug Invest. 6:90-95
28. Cook CS, Hauswald CL, Grahn AY, Kowalski K, Karim A, et al. 1990. Suitability of the dog as an animal model for evaluating theophylline absorption and food effects from different formulations. Int. J. Pharm. 60:125-32
29. Cook HJ, Mundo CR, Fonseca L, Gasque L, Moreno-Esparza R. 1993. Influence of the diet on bioavailability of tetracycline. Biopharm. Drug Dispos. 14:549-53
30. Degen PH, Cardot JM, Czendlik C, Dieterle W. 1993. Influence of food on the disposition of the monoamine oxidase-A inhibitor brofaromine in healthy volunteers. Biopharm. Drug Dispos. 14: 209-15
31. Degen PH, Flesch G, Cardot J-M, Czendlik C, Dieterle W. 1994. The influence of food on the disposition of the antiepileptic oxcarbazone and its major metabolites in healthy volunteers. Biopharm. Drug Dispos. 15:519-26
32. De Mey C, Meineke I. 1992. Prandial and diurnal effects on the absorption of orally administered enteric coated 5-aminosalicylic acid (5-ASA). Br. J. Clin. Pharmacol. 33:179-82
33. Desante KA, Zeckel ML. 1992. Pharmacokinetic profile of loracarbef. Am. J. Med. 92:16S-19S
34. Desmond PV, Harman PJ, Gannoulis N, Kamm M, Mashford ML. 1990. The effect of an antacid and food on the absorption of cimetidine and ranitidine. J. Pharm. Pharmacol. 42:352-54
35. Devane JG, Kelly JG. 1991. Effect of food on the bioavailability of a multiparticulate sustained-release verapamil formulation. Adv. Ther. 8:48-53
36. Devane JG, Kelly JG, Geoghegan B. 1990. Pharmacokinetic and in vitro characteristics of sustained release verapamil products. Drug Dev. Ind. Pharm. 16:1233-48
37. deVries TM, Voigtman RE, Posvar EL, Nesbitt RU, Forgue ST. 1991. Pharmacokinetic characterization of a procainamide tablet suitable for twice daily dosing. Pharm. Res. 8(Suppl.):S315
38. Doose DR, Gisclon LG, Stellar SM, Riffits JM, Hills JF. 1992. The effect of food on the bioavailability of topiramate from 100- and 400-mg tablets in healthy male subjects. Epilepsia 33 (Suppl. 3): 105
39. Doose DR, Minn FL, Stellar S, Nayak RK. 1992. Effects of meals and meal composition on the bioavailability of fenretidine. J. Clin. Pharmacol. 32: 1089-95
40. Dressman JB, Berardi RR, Elta GH, Gray TM, Montgomery PA, et al. 1992. Absorption of flurbiprofen in the fed and fasted states. Pharm. Res. 9:901-7
41. Drew RH, Gallis HA. 1992. Azithromycin-spectrum of activity, pharmacokinetics, and clinical applications. Pharmacotherapy 12:161-73
42. Ducharme MP, Edwards DJ, McNamara PJ, Stoeckel K. 1993. Bioavailability of syrup and tablet formulations of cefetamet pivoxil. Antimicrob. Agents Chemother. 37:2706-9
43. Dudley MN, Marchbanks CR, Flor SC, Beals B. 1991. The effect of food or milk on the absorption kinetics of ofloxacin. Eur. J. Clin. Pharmacol. 41:569-71
44. Dupuis LL, Koren G, Silverman ED, Laxer RM. 1992. Influence of food on the bioavailability of oral methotrexate (MTX). Arthritis Rheum. 35(Suppl.): S57
45. Du Souich P, Lery N, Lery L, Varin F, Boucher S, et al. 1990. Influence of food on the bioavailability of diltiazem and two of its metabolites following the administration of conventional tablets and slow-release capsules. Biopharm. Drug Dispos. 11:137-47
46. Edgar B, Bailey D, Bergstrand R, Johnsson G, Regårdh CG. 1992. Acute effects of drinking grapefruit juice on the pharmacokinetics and dynamics of felodopine and its potential clinical relevance. Eur. J. Clin. Pharmacol. 42:313-17
47. Ehrsson H, Wallin I, Ros AM, Eksborg S, Berg M. 1994. Food-induced increase in bioavailability of 5-methoxypsoralen. Eur. J. Clin. Pharmacol. 46:375-77
48. Eller MG, Della-Coletta AA. 1990. Absence of effect of food on alprazolam absorption from sustained release tablets. Biopharm. Drug Dispos. 11:31-37
49. Eller MG, Walker BJ, Yuh L, Antony KK, McNutt BE, Okerholm RA. 1992. Absence of food effects on the pharmacokinetics of terfenadine. Biopharm. Drug Dispos. 13:171-77
50. Ewe K, Press AG, Dederer W. 1989. Gastrointestinal transit of undigestible solids measured by metal detector EAS II. Eur. J. Clin. Invest. 19:291-97
51. Faulkner JK, Hayden ML, Chasseaud LF, Taylor T. 1989. Absorption of amlodipine unaffected by food. Arzneim. Forsch. 39:799-801
52. Fiese EF, Steffen SH. 1990. Comparison of the acid stability of azithromycin and erythromycin A. J. Antimicrob. Chemother. 25(Suppl. A):39-47
53. Fowles SE, Fairless AJ, Pierce DM, Prince WT. 1990. A further study of the effect of food on the bioavailability and pharmacokinetics of penciclovir after oral administration of famciclovir. Br. J. Clin. Pharmacol. 29:657-58
54. Fowles SE, Pierce DM, Prince WT, Thow JC. 1990. Effect of food on the bioavailability and pharmacokinetics of penciclovir, a novel antiherpes agent, following oral administration of the prodrug, famciclovir. Br. J. Clin. Pharmacol. 29:620-21
55. Frishman WH. 1993. A new extended-release formulation of diltiazem HCl for the treatment of mild-to-moderate hypertension. J. Clin. Pharmacol. 33:612-22
56. Frost RW, Carlson JD, Dietz AJK, Heyd A, Lettieri JT. 1989. Ciprofloxacin pharmacokinetics after a standard or high-fat/high-calcium breakfast. J. Clin. Pharmacol. 29:953-55
57. Frydman A. 1992. Pharmacokinetic profile of nicorandil in humans: an overview. J. Cardiovasc. Pharmacol. 20 (Suppl. 3):S34-44
58. Fujimaki Y, Sudo K, Hakusui H, Tachizawa H, Murasaki M. 1992. Single- and multiple-dose pharmacokinetics of nefiracetam a new nootropic agent, in healthy volunteers. J. Pharm. Pharmacol. 44:750-54
59. Gan V, Chu S-Y, Kusmiesz HT, Craft JC. 1992. Pharmacokinetics of a clarithromycin suspension in infants and children. Antimicrob. Agents Chemother. 36:2478-80
60. Gertz BJ, Holland SD, Kline WF, Matuszewski BK, Porras AG. 1993. Clinical pharmacology of alendronate sodium. Osteoporosis Int. 3(Suppl. 3): S13-16
61. Gillespie NG, Mena I, Cotzias GC, Bell MA. 1973. Diets affecting treatment of parkinsonism with levodopa. J. Am. Diet. Assoc. 62:525-28
62. Granneman GR, Mukherjee D. 1992. The effect of food on the bioavailability of temafloxacin. A review of 3 studies. Clin. Pharmacokinet. 22(Suppl. 1):48-56
63. Greb WH, Brett MA, Buscher G, Dierdorf H-D, von Schrader HW, et al. 1989. Absorption of paroxetine under various dietary conditions and following antacid intake. Acta Psychiatr. Scand. 80(Suppl. 350):99-101
64. Gupta SK, Benet LZ. 1990. High-fat meals increase the clearance of cyclcsporine. Pharm. Res. 7:46-48
65. Gupta SK, Manfro RC, Tomlanovich SJ, Gambertoglio JG, Garovoy MR, Benet LZ. 1990. Effect of food on the pharmacokinetics of cyclosporine in healthy subjects following oral and intravenous administration. J. Clin. Pharmacol. 30:643-53
66. Haegele KD, Hinze Ch, Jode-Ohlenbusch A-M, Creamer G, Borlack J. 1991. Effects of a standardized meal on the pharmacokinetics of the new cardiotonic agent piroximone. Arzneim. Forsch. 41:1225-29
67. Hamaguchi T, Shinkuma D, Irie T, Yamanaka Y, Monta Y, et al. 1993. Effect of a high-fat meal on the bioavailability of phenytoin in a commerical powder with a large particle size. Int. J. Clin. Pharmacol. 31:326-30
68. Hanyok JJ. 1993. Clinical pharmacokinetics of sotalol. Am. J. Cardiol. 12: 19A-26A
69. Harrison LI, Mitra AK, Kehe CR, Klinger NM, Wick KA, et al. 1993. Kinetics of absorption of a new once-a-day formulation of theophylline in the presence and absence of food. J. Pharm. Sci. 82:644-48
70. Harrison LI, Riedel DJ, Armstrong KE, Goldlust MB, Ekholm BP. 1992. Effect of food on salsalate absorption. Ther. Drug Monit. 14:87-91
71. Hilleman DE, Mohiuddin SM, Destache CJ, Stoysich AM, Nipper HC, Maleskar MA. 1992. Impact of food on the bioavailability of encainide. J. Clin. Pharmacol. 32:833-37
72. Hoke JF, Chi EM, Anthony KK, Kulmala HK, Sussman NM, Okerholm RA. 1991. Effect of food on the bioavailability of vigabatrin tablets. Epilepsia 32(Suppl. 3):6-7
73. Holmes B, Brogden RN, Richards DM. 1985. Norfloxacin: a review of its antimicrobial activity, pharmacokinetic properties and therapeutic use. Drugs 30:482-513
74. Honcharik N, Yatscoff RW, Jeffery JR, Rush DN. 1991. The effect of meal composition on cyclosporine absorption. Transplantation 52:1087-89
75. Honma A, Ikeda K, Udo N, Sdamori M, Hasegawa K, et al. 1986. Aniracetam: clinical phase I study of aniracetam. J. Clin. Ther. Med. 2:929-52
76. Hoon TJ, McCollam PL, Beckman KJ, Hariman RJ, Bauman JL. 1992. Impact of food on the pharmacokinetics and electrocardiographic effects of sustained release verapamil in normal subjects. Am. J. Cardiol. 70:1072-76
77. Hooper WD, Dickinson RG, Eadie MJ. 1990. Effect of food on absorption of lomefloxacin. Antimicrob. Agents Chemother. 34:1797-99
78. Hopkins A. 1966. The pattern of gastric emptying: a new review of old results. J. Physiol. 182:144-49
79. Hughes WT, Kennedy W, Shenep JL, Flynn PM, Hetherington SV, et al. 1991. Safety and pharmacokinetics of 566C80, a hydroxynaphthoquinone with antipneumocystis carinii activity: a phase 1 study in human immunodefficiency virus (HIV)-infected man. J. Infect. Dis. 163:843-48
80. Hunt TL, Kaiko RF. 1991. Comparison of the pharmacokinetic profiles of two oral controlled-release morphine formulations in healthy young adults. Clin. Ther. 13:482-88
81. Hussey EK, Donn KH, Powell JR, Lahey AP, Pakes GE. 1991. Albuterol extended-release products: effect of food on the pharmacokinetics of single oral doses of Volmax® and Proventil® repetabs in healthy male volunteers. J. Clin. Pharmacol. 31:561-64
82. Ingwersen SH, Mant TGK, Larson JJ. 1993. Food intake increases the relative oral bioavailability of vanoxerine. Br. J. Clin. Pharmacol. 35:308-10
83. Iseki K, Satoh Y, Sugawara M, Miyazaki K. 1994. Effect of Enterued® administration on the intestinal absorption of orally active cefem antibiotics. J. Pharm. Soc. Jpn. 114:233-40
84. Jallad NS, Callejas HJ, Woo-Ming RB, Weidler DJ. 1991. The pharmacokinetics of astemizole plus pseudoephedrine when taken with a standardized meal. J. Clin. Pharmacol. 31:863
85. Järvinen A, Nykänen S, Mattila J, Haataja H. 1992. Effect of food on absorption and hydrolysis of erythromycin acistrate. Arzneim. Forsch. 42:73-76
86. Johnson BF, O'Grady J, Sabey GA, Bye C. 1978. Effect of a standard breakfast on digoxin absorption in normal subjects. Clin. Pharmacol. Ther. 23:315-19
87. Kaiko R, Grandy R, Thomas G, Goldenheim P. 1990. A single-dose study of the effect of food ingestion and timing of dose administration on the pharmacokinetic profile of 30 mg sustained-release morphine sulfate tablets. Curr. Ther. Res. 47:869-78
88. Kann J, Levitt MJ, Horodniak JW, Pav JW. 1989. Food effects on the nighttime pharmacokinetics of Theo-Dur tablets. Ann. Allergy 63:282-86
89. Keown PA, Stiller CR, Laupacis AL, Howson W, Coles R, et al. 1982. The effects and side effects of cyclosporine: relationships to drug pharmacokinetics. Transpl. Proc. 14:659-61
90. Kivistö KT, Ojala-Karlsson P, Neuvonen PJ. 1992. Inhibition of norfloxacin absorption by dairy products. Antimicrob. Agents Chemother. 36:489-91
91. Klamerus KJ, Troy SM, Ben-Maimon CS, Chiang ST. 1993. Effect of age, gender, and food on zalospirone disposition. Clin. Pharmacol. Ther. 53:193
92. Kleinbloesem CH, Ouwerkerk M, Brödenfeldt R. 1993. Food effect with extended release formulations: nifedipine. Clin. Pharmacol. Ther. 53:207
93. Knupp CA, Milbrath R, Barbhaiya RH. 1993. Effect of time of food administration on the bioavailability of didanosine from a chewable tablet formulation. J. Clin. Pharmacol. 33:568-73
94. Kopitar Z, Vrhovac B, Povic L, Plavic F, Francetic I, Urbancic J. 1991. The effect of food and metoclopramide on the pharmacokinetics and side effects of bromocriptine. Eur. J. Drug Metab. Pharmacokinet. 16:177-81
95. Korth-Bradey JM, Fruncillo RJ, Klamerus K-J, Chiang ST, Conrad KA. 1992. The influence of high and low fat meals on single dose pharmacokinetics of zalospirone. Pharm. Res. 9(Suppl.): S326
96. Kosoglou T, Kazierad D, Schentag JJ, Patrick JE, Heimark L, et al. 1993. Effect of food and gastric emptying rate (GER) on the bioavailability (BA) of 5-ISMN. Clin. Pharm. Ther. 53:206
97. Kozloski GD, de Vito JM, Johnson JB, Holmes GB, Adams MA, Hunt TL. 1992. Bioequivalence of verapamil hydrochloride extended-release pellet-filled capsules when opened and sprinkled on food and when swalled intact. Clin. Pharm. 11:539-42
98. Kozloski GD, De Vito JM, Kisicki JC, Johnson JB. 1992. The effect of food on the absorption of methotrexate sodium tablets in healthy volunteers. Arthritis Rheum. 35:761-64
99. Lasswell AB, Loreck ES. 1992. Development of a program in accord with JACAHO standards for counseling on potential drug-food interactions. J. Am. Diet. Assoc. 92:1124-25
100. Lecaillon JB, Dubois JP, Soula G, Pichard E, Poltera AA, Ginger CD. 1990. The influence of food on the pharmacokinetics of CGP 6140 (amocarzine) after oral administration of a 1200 mg single dose to patients with onchocerciasis. Br. J. Clin. Pharmacol. 30:629-33
101. Lecaillon JB, Poltera AA, Zea-Flores G, De Ramirez I, Nowell De Arevalo A. 1991. Influence of food related to dose on the pharmacokinetics of amocarzine and of its N-oxide metabolite CGP 13 231, after oral administration to 20 onchocerciasis male patients from Guatemala. Trop. Med. Parasitol. 42: 286-90
102. Levine MAH, Walker SE, Paton TW. 1992. The effect of food or sucralfate on the bioavailability of S(+) and R(-) enantiomers of ibuprofen. J. Clin. Pharmacol. 32:1110-14
103. Liao S, Hills J, Stubbs RJ, Nayak RK. 1992. The effect of food on the bioavailability of tramadol. Pharm. Res. 9 (Suppl.):S308
104. Lindholm A, Henricsson S, Dahlqvist R. 1990. The effect of food and bile acid administration on the relative bioavailability of cyclosporin. Br. J. Clin. Pharmacol. 29:541-48
105. Lode H, Stahlmann R, Koeppe P. 1979. Comparative pharmacokinetics of cephalexin, cefaclor, cefadroxil, and CGP 9000. Antimicrob. Agents Chemother. 16:1-6
106. Lohmann A, Dingler E, Sommer W, Schaffler K, Wober W, Schmidt W. 1992. Bioavailability of vinpocetine and interference of the time of application with food intake. Arzneim. Forsch. 42: 914-17
107. Lotterer E, Ruhnke M, Trautmann M, Beyer R, Bauer FE. 1991. Decreased and variable systemic availability of zidovudine in patients with AIDS if administered with a meal. Eur. J. Clin. Pharmacol. 40:305-8
108. Lubowski TJ, Nightingale CH, Sweeney K, Quintiliani R. 1992. The relative bioavailability of temafloxacin administered through a nasogastric tube with and without enterai feeding. Clin. Pharmacokinet. 22(Suppl. 1):43-47
109. Lucas S, Rowinsky E, Wargin W, Hohneker J, Hsieh A, Donebower R. 1993. Results of a study of the effect of food on the bioavailability and pharmacokinetics of Navelbine® liquid-filled soft gelatin capsules. Proc. Am. Soc. Clin. Pharmacol. 12:160
110. MacGowan AP, Greig MA, Andrews JM, Reeves DS, Wise R. 1989. Pharmacokinetics and tolerance of a new film-coated tablet of sodium fusidate administered as a single oral dose to healthy volunteers. J. Antimicrob. Chemother. 23:409-15
111. MacKay J, Mackie AE, Palmer JL, Moult A, Baber NS. 1992. Investigation into the mechanism for the improved oral systemic bioavailability of cefuroxime from cefuroxime axetil when taken after food Br. J. Clin. Pharmacol. 33:326P-27P
112. McLachlan AJ, Cutler DJ. 1991. Bioavailability of hydroxychloroquine in rheumatoid arthritis patients using deconvolution techniques. Aust. J. Hosp. Pharm. 21:333
113. McLean AJ, McNamara PJ, DuSouich P, Gibaldi M, Lalka D. 1978. Food, splanchnic blood flow and bioavailability of drugs subject to first-pass metabolism. Clin. Pharmacol. Ther. 24:5-10
114. McNeil JJ, Drummer OH, Raymond K, Conway EL, Louis WJ. 1991. The influence of food on the oral bioavailability of terazosin. Eur. J. Gastroenterol. Hepatol. 3:405-12
115. Margalith D, Duroux P, Bauerfeind P, Emde C, Koelz H-R, et al. 1991. Famotidine should be taken with supper. The effect of drug-meal interactions on gastric acidity and plasma famtotidine levels. Eur. J. Gastroenterol. Hepatol. 3: 405-12
116. Mattila MJ, Neuvonen PJ, Gothoni G, Hackman R. 1972. Interference of iron preparations and milk with the absorption of tetracyclines. In Toxicological Problems of Drug Combinations, ed. SB Baker, GA Neuhaus, pp. 128-33. Amsterdam: Excerpta Medica
117. Melander A, McLean A. 1983. Influence of food intake on presystemic clearance of drugs. Clin. Pharmacokinet. 8:286-96
118. Melander A, Stenberg P, Liedholm H, Scherston B, Wahlin-Boll E. 1979. Food-induced reduction in bioavailability of atenolol. Eur. J. Clin. Pharmacol. 16:327-30
119. Mengel H, Gustavson LE, Soerensen HJ, McKelvy JF, Pierce MW, Houston A. 1991. Effect of food on the bioavailability of tiagabine HCI. Epilepsia 32 (Suppl. 3):6
120. Mihara M, Ohnishi A, Tomono Y, Hasegawa J, Shimamura Y, et al. 1993. Pharmacokinetics of E2020 a new compound for Alzheimer's disease in healthy male volunteers. Int. J. Clin. Pharmacol. 31:223-29
121. Monk JP, Campoli-Richards DM. 1987. Ofloxacin: a review of its antibacterial activity pharmacokinetic properties and therapeutic use. Drugs 33:346-91
122. Motohiro T, Handa S, Yamada S, Oki S, Tsumura N, et al. 1992. Pharmacokinetics and clinical effects of cefdinir 10% fine granules in pediatrics. Jpn. J. Antibiot. 45:74-86
123. Muralidharan G, Yacobi A, Blotner S, Bryzinski B, Carver A, et al. 1992. Pharmacokinetics of bisoprolol (B) and hydrochlorothiazide (HCTZ) after administration of a combination tablet of B/HCTZ (10/6.25 mg) in fasted and nonfasted healthy volunteers. Pharm. Res. 9(Suppl.):S321
124. Nakamura H, Iwai N. 1992. Pharmacokinetic studies on oral antibiotics in pediatrics. V. A pharmacokinetic study on cefdinir in pediatrics. Jpn. J. Antibiol. 45:12-27
125. Nakamura H, Iwai N. 1992. Pharmacokinetic study on oral antibiotics in pediatrics. IIIA. Pharmacokinetic study on cefprozil in pediatrics. Jpn. J. Antibiol. 45:1489-504
126. Nakashima M, Uematsu T, Oguma T, Yoshida T, Kimura Y, Konishi M. 1993. Phase I study of S-1108, a new ester-type oral cephem antibiotic. Chemotherapy 41(Suppl. 1):109-25
127. Narang PK, Lewis RC, Bianchine JR. 1992. Rifabutin absorption in humans: relative bioavailability and food effect. Clin. Pharm. Ther. 52:335-41
128. Nazareno LA, Holazo AA, Limjuco R, Massarella JW, Koss-Twardy S, Min B. 1992. The effect of food on absorption of dideoxycytidine (ddC) in HIV-positive patients. Pharm. Res. 9:S321
129. Neuvonen PJ, Kivistö KT. 1989. The clinical significance of food-drug interactions: a review. Med. J. Aust. 150:36-40
130. Neuvonen PJ, Kivistö KT. 1992. Milk and yoghurt do not impair the absorption of ofloxacin. Br. J. Clin. Pharmacol. 33:346-48
131. Neuvonen PJ, Kivistö KT, Lehto P. 1991. Interference of dairy products with the absorption of ciprofloxacin. Clin. Pharmacol. Ther. 50:498-502
132. Nichols AI, Everitt D, Portelli S, Moore N, Law D, et al. 1992. The effect of food on the single dose pharmacokinetics of the leukotriene receptor antagonist SK&F 106203. Pharm. Res. 9(Suppl.): S309
133. Nilsen OG, Dale O. 1992. Single dose pharmacokinetics of trazodone in healthy subjects. Pharmacol. Toxicol. 71:150-53
134. Oguey D, Kölliker F, Gerber NJ, Reichen J. 1992. Effect of food on the bioavailability of low-dose methotrexate in patients with rheumatoid arthritis. Arthritis Rheum. 35:611-14
135. Oguma T, Yamada H, Sawaki M, Narita N. 1991. Pharmacokinetic analysis of the effects of different foods on absorption of cefaclor. Antimicrob. Agents Chemother. 35:1729-35
136. Ohdo S, Nakano S, Ogawa N. 1992. Circadian changes of valproate kinetics depending on meal condition in humans. J. Clin. Pharmacol. 32:822-26
137. Ohtsubo K, Fujii N, Higuch S, Aoyama T, Goto I, Tatsuhara T. 1992. Influence of food on serum ambenonium concentration in patients with my asthenia gravis. Eur. J. Clin. Pharmacol. 42:371-74
138. Olanoff LS, Walle T, Cowart TD, Walle KU, Oexmann MJ, Conradi EC. 1986. Food Effects on propranolol systemic and oral clearance: support for a blood flow hypothesis. Clin. Pharmacol. Ther. 40:408-14
139. Palazzini E, Cristoformi M, Babbini M. 1992. Bioavailability of a new controlled-release oral naproxen formulation with and without food. Int. J. Clin. Pharm. Res. 12:179-84
140. Pan HY, Devault AR, Brescia D, Willard DA, McGovern ME, et al. 1993. Effect of food on pravastatin pharmacokinetics and pharmacodynamics. Int. J. Clin. Pharmacol. 31:291-94
141. Peck RW, Weatherley BC, Posner J. 1993. The pharmacokinetics of 882C, a thymidine analogue with potent anti-VZV activity in healthy volunteers. Antivir. Res. 20(Suppl. 1):132
142. Pfeifer S. 1993. Einfluss von Nahrung auf die Pharmakokinetik von Arzneistoffen. Pharmazie 48:3-16
143. Pfeiffer A, Vidon N, Bovet M, Rongier M, Bernier JJ. 1990. Intestinal absorption of amiodarone in man. J. Clin. Pharmacol. 30:615-20
144. Phelan MJI, Orme M, Williams E, Thompson RN. 1991. Food has no effect on the pharmacokinetics of methotrexate in patients with rheumatoid arthritis. Arthritis Rheum. 34 (Suppl.): S91
145. Pieniaszek HJ, Rakestraw DC, Schary WL, William RL. 1991. Influence of food on the oral absorption and bioavailability of moricizine. J. Clin. Pharmacol. 31:792-95
146. Plezia PM, Thornley SM, Kramer TH, Armstrong EP. 1990. The influence of enteral feedings on sustained-release theophylline absorption. Pharmacotherapy 10:356-61
147. Prescott LF, Yoovathaworn K, Makarananda K, Saivises R, Sriwatanakul K. 1993. Impaired absorption of paracatamol in vegetarians. Br. J. Clin. Pharmacol. 36:237-40
148. Ptachcinski RJ, Venkataramanan R, Rosenthal JT, Burckart GJ, Taylor RJ, Hakala TR. 1985. The effect of food on cyclosporine absorption. Transplantation 40:174-76
149. Rapin J-R. 1992. Effect of food on calcium antagonists pharmacokinetics. Pharm. Weekbl. 14(Suppl. E):5
150. Roberts RJ, Leff RD. 1989. Influence of absorbable and nonabsorbable lipids and lipidlike substances on drug bioavailaiblity. Clin. Pharmacol. 45: 299-304
151. Robertson DRC, Higginson I, MacKlin BS, Renwick AG, Waller DG, George CF. 1991. The influence of protein containing meals on the pharmacokinetics of levedopa in healthy volunteers. Br. J. Clin. Pharmacol. 31:413-17
152. Rolan PE, Mercer AJ, Weatherley BC, Holdich T, Meire H, et al. 1994. Examination of some factors responsible for food-induced increase in absorption of atovaquone. Br. J. Clin. Pharmacol. 37:13-20
153. Rolan PE, Mercer AJ, Weatherley BC, Holdich T, Ridout G, et al. 1992. Investigation of the factors responsible for a food-induced increase in absorption of a novel antiprotozoal drug 566C80. Br. J. Clin. Pharmacol. 33:226P-27P
154. Roller S, Lode H, Stelzer I, Deppermann KM, Boeckh M, Koeppe P. 1992. Pharmacokinetics of loracarbef and interaction with acetylcysteine. Eur. J. Clin. Microbiol. Infect. Dis. 11:851-55
155. Roncari G. 1993. Human pharmacokinetics of aniracetam. Drug Inv. 5(Suppl. 1):68-72
156. Roos RAC, Tijssen MAJ, Van der Velde EA, Breimer DD. 1993. The influence of a standard meal on Sinemet CR absorption in patients with Parkinson's disease. Clin. Neurol. Surg. 95:215-19
157. Rosenborg J, Nyberg L, Delén A-M. 1991. Dietary habits do not influence the dosage of Bambec® tablets. Eur. Resp. J. 4(Suppl. 14):434S
158. Ruhnke M, Bauer FE, Seifert M, Trautmann M, Hille H, Koeppe P. 1993. Effects of standard breakfast on pharmacokinetics of oral zidovudine in patients with AIDS. Antimcrob. Agents Chemother. 34:2153-58
159. Russell GAB, Martin RP. 1989. Flecainide toxicity. Arch. Dis. Child. 64: 860-62
160. Sahai J, Gallicano K, Garber G, McGilvery I, Hawley-Foss N, et al. 1992. The effect of a protein meal on zidovudine pharmacokinetics in HIV-infected patients. Br. J. Clin. Pharmacol. 33:657-60
161. Saito A. 1993. Effects of food, ceruletide and ranitidine on the pharmacokinetics of the oral cephalosporin S-1108 in humans. Chemotherapy 39: 374-85
162. Sakashita M, Yamaguchi T, Miyazaki H, Sekine Y, Nomiyama T, et al. 1993. Pharmacokinetics of the gastrokinetic agent mosapride citrate after single and multiple oral administrations in healthy subjects. Arzneim. Forsch. 43:867-72
163. Sakashita M, Yokogawa M, Yamaguchi T, Sekine Y. 1991. Pharmacokinetics of sparfloxacin in man. Yakubutsu Dotai 6:43-51
164. Sanchez N, Sheiner LB, Halkin H, Melmon KL. 1973. Pharmacokinetics of digoxin: interpreting bioavailability. Br. Med. J. 20:132-34
165. Sandberg A, Abrahamsson B, Regårdh C-G, Wieselgren I, Bergstrand R. 1990. Pharmacokinetic and biopharmaceutic aspects of once daily treatment with metoprolol CR/ZOK: a review article. J. Clin. Pharmacol. 30:S2-16
166. Sandberg A, Ragnarsson G, Johnson UE, Sjögren J. 1988. Design of a new multiple-unit controlled-release formulation of metoprolol - Metoprolol CR. Eur. J. Clin. Pharmacol. 33(Suppl.):S3-7
167. Schaefer HG, Beermann D, Horstmann R, Wargenau M, Heibel BA, Kuhlmann J. 1993. Effect of food on the pharmacokinetics of the active metabolite of the prodrug repirinast. J. Pharm. Sci. 82:107-9
168. Segre G, Cerretani D, Moltoni L, Urso R. 1992. Pharmacokinetics of rufloxacin in healthy volunteers. Eur. J. Clin. Pharmacol. 42:101-5
169. Semple HA, Koo W, Tam YK, Ngo L-Y, Coutts RT. 1991. Interactions between hydralazine and oral nutrients in humans. Ther. Drug Monit. 13:304-8
170. Shah J, Fratis A, Ellis D, Murakami S, Teitelbaum P. 1990. Effect of food and antacid on absorption of orally administered ticlopidine hydrochloride. J. Clin. Pharmacol. 30:733-36
171. Shelton MJ, Morse GD, Portmore A, Blum R, Saddler B, Reichman RC. 1993. Prolonged, but not diminished zidovudine (ZDV) absorption by food. Clin. Pharm. Ther. 53:207
172. Shinkuma D, Hamaguchi T, Kobayashi M, Yamanaka Y, Mizuno N. 1990. Effects of food intake and meal size on the bioavailability of sulpiride in two dosage forms. Int. J. Clin. Pharmacol. 28:440-42
173. Shukla VA, Pittman KA, Barbhaiya RH. 1992. Pharmacokinetics interactions of cefprozil with food, propantheline, metoclopramide, and probenecid in healthy volunteers. Clin. Pharmacol. 2:725-31
174. Shyu WC, Knupp CA, Pittman KA, Dunkle L, Barbhaiya RH. 1991. Food-induced reduction in bioavailability of didanosine. Clin. Pharmacol. Ther. 50: 503-7
175. Simon JA, Robinson DE, Andrews MC, Hildebrand JR III, Rocci ML, et al. 1993. The absorption of micronized progesterone: the effect of food, dose proportionality, and comparison with intramuscular progesterone. Fertil. Steril. 60:26-33
176. Smith HT, Jokubaitis LA, Troendle AJ, Hwang DS, Robinson WT. 1993. Pharmacokinetics of fluvastatin and specific drug interactions. Am. J. Hyperten. 6: 375S-82S
177. Sörgel F, Kinzig M. 1993. Pharmacokinetics of gyrase inhibitors. Part 1 : basic chemistry and gastrointestinal disposition. Am. J. Med. 94:44S-55S
178. Sun JX, Cipriano A, Chan K, Klibaner M, John VA. 1994. Effect of food on the relative bioavailability of a hypolipidemic agent (CGP 43371 ) in healthy subjects. J. Pharm. Sci. 83:264-66
179. Svensson CK, Edwards DJ, Mauriello PM, Barde SH, Foster AC, et al. 1983. Effect of food on hepatic blood flow: implication in the food effect phenomenon. Clin. Pharmacol. Ther. 34:316-23
180. Tam YK, Kneer J, Dubach UC, Stoeckel K. 1990. Effects of timing of food and fluid volume on cefetamet pivoxil absorption in healthy normal volunteers. Antimicrob. Agents Chemother. 34: 1556-59
181. Tanimura M, Kataoka S, Fujita Y. 1991. Basic and clinical studies of sparfloxacinin urinary tract infections. Chemotherapy 39(Suppl. 4):523-30
182. Tay LK, Sciacca MA, Sostrin MB, Farmen RH, Pittman KA. 1993. Effect of food on the bioavailability of gepirone in humans. J. Clin. Pharmacol. 33:631-35
183. Taylor DM, Massey CA, Willson WG, Dhillon SA. 1993. Lowered phenytoin serum concentrations during therapy with liquid food concentrates. Ann. Pharmacother. 27:369
184. Terhaag B, Gramatte T, Hrdlicka P, Richter K, Feller K. 1991. The influence of food on the absorption of diclofenac as a pure substance. Int. J. Clin. Pharmacol. 29:418-21
185. Terhaag B, Hrdlicka P, Gramatte T, Richter K, Feller K. 1990. Zum
186. Thakker KM, Mangat S, Wagner W, Castellana J, Kochak GM. 1992. Effect of food and relative bioavailability following single doses of diclofenac 150 mg hydrogel bead (HGB) capsules in healthy humans. Biopharm. Drug Dispos. 13:327-35
187. Thebault JJ, Montay G, Ebmeier M, Douin MJ, Millerioux L, et al. 1990. Effect of food on the bioavailability of the new quinolone sparfloxacin. Proc 30th Interscience Conference on Antimicrob. Agents Chemother., Atlanta, Oct. 21-24, pp. 294
188. Theodor RA, Weimann H-J, Weber W, Müller M, Michaelis K. 1992. Influence of food on the oral bioavailability of moxonidine. Eur. J. Drug Metab. Pharmacokinet. 17:61-66
189. Tsutsumi K, Nakashima H, Kotegawa T, Nakano S. 1992. Influence of food on the absorption of beta-methyldigoxin. J. Clin. Pharmacol. 32:157-62
190. Ueda Y, Matsumoto F, Imai T, Sakurai I, Takahashi T, Morita M. 1993. Effect of probenecid and a meal load on the pharmacokinetics of zidovudine. Chemotherapy Tokyo 41:499-503
191. Unadkat JD, Collier AC, Crosby SS, Cummings D, Opheim KE, Corey L. 1990. Pharmacokinetics of oral zidovudine (azidothymidine) in patients with AIDS when administered with and without a high-fat meal. AIDS 4:229-32
192. Vance-Bryan K, Guay DRP, Rotschafer JC. 1990. Clinical pharmacokinetics of ciprofloxacin. Clin. Pharmacokinet. 19: 434-61
193. Van Harten J, Van Bemmel P, Dobrinska MR, Ferguson RK, Raghoebar M. 1991. Bioavailability of fluvoxamine given with and without food. Biopharm. Drug Dispos. 12:571-76
194. Van Peer A, Woestenborghs R, Heykants J, Gasparini R, Gauwenbergh G. 1989. The effects of food and dose on the oral systemic availability of itraconazole in healthy subjects. Eur. J. Clin. Pharmacol. 36:423-26
195. Walter-Sack IE, De Vries JX, Nickel B, Stenzhorn G, Weber E. 1989. The influence of different formula diets and different pharmaceutical formulations on the systemic availability of paracetamol, gallbladder size, and plasma glucose. Int. J. Clin. Pharmacol. 27:544-50
196. Warneke G, Setnikar I. 1993. Effects of a meal on the pharmacokinetics of fluoride from oral monofluorophosphate. Arzneim. Forsch. 43:590-95
197. Weber C, Roos B, Birnboeck H, Van Brummelen P. 1993. Effect of food on the oral bioavailability of the renin inhibitor remikirin (RO 42-5892). Br. J. Clin. Pharmacol. 36:177P-78P
198. Weimann H-J, Rudolph M. 1992. Clinical pharmacokientics of moxonidine. J. Cardiovasc. Pharmacol. 20(Suppl. 4): S37-S41
199. Welling PG. 1977. Influence of food and diet on gastrointestinal drug absorption: a review. J. Pharmacokinet. Biopharmacol. 5:291-334
200. Welling PG. 1989. Effects of food on drug absorption. Pharmacol. Ther. 43: 425-41
201. Welling PG. 1993. Necessity of food studies: implications of food effects. In Bio-International: Bioavailability, Bioequivalence and Pharmacokinetics, ed. KK Midha, HH Blume, pp. 211-21. Stuttgart: Medpharm Sci.
202. Welling PG, Elliott RL, Pitterle ME, Corrick-West HP, Lyons LL. 1979. Plasma levels following single and repeated doses of erythromycin estolate and erythromycin stearate. J. Pharm. Sci. 68:150-55
203. Welling PG, Tse FLS. 1982. The influence of food on the absorption of antimicrobial agents. J. Antimicrob. Chemother. 9:7-27
204. Wells TG, Sinaiko AR. 1991. Antihypertensive effect and pharmacokinetics of nitrendipine in children. J. Pediatr. 118:638-43
205. Welty DF, Siedlick PH, Posvar EL, Selen A, Sedman AJ. 1994. The temporal effect of food on tacrine bioavailability. J. Clin. Pharmacol. 34: 985-88
206. Wessels JC, Koeleman HA, Boneschans B, Steyn HS. 1992. The influence of different types of breakfast on the absorption of paracetamol among members of an ethnic group. Int. J. Clin. Pharmacol. 30:208-13
207. Wilding IR, Davis SS, Sparrow RA, Bloor JR, Hayes G, Ward GT. 1992. The effect of food on the in vivo behavior of a novel sustained release formulation of tiaprofenic acid. Int. J. Pharm. 83:155-61
208. Wilding IR, Hardy JC, Maccari M, Ravelli V, Davis SS. 1991. Scintigraphic and pharmacokinetic assessment of a multiparticulate sustained release formulation of diltiazem. Int. J. Pharm. 76:133-43
209. Wilding IR, Hardy JG, Davis SS, Melia CD, Evans DF, et al. 1991. Characterization of the in vivo behavior of a controlled-release formulation of levodopa (Sinemet CR). Clin. Neuropharmacol. 14:305-21
210. Williams DB, O'Reilly WJ, Boehm G, Story MJ. 1990. Absorption of doxycycline from a controlled release pellet formulation: the influence of food on bioavailability. Biopharm. Drug Dispos. 11:93-105
211. Williams L, Davis JA, Lowenthal DT. 1993. The influence of food on the absorption and metabolism of drugs. Clin. Nutr. 77:815-29
212. Williams PE, Harding SM. 1984. The absolute bioavailability of oral cefuroxme axetil in male and female volunteers after fasting and after food. J. Antimicrob. Chemother. 13:191-96
213. Willis JV, Kendall MJ, Jack DB. 1981. The influence of food on the absorption of diclofenac after single and multiple oral doses. Eur. J. Clin. Pharmacol. 19:33-37
214. Wilson CG, Washington N, Greaves JL, Washington C, Wilding IR, et al. 1991. Predictive modelling of the behavior of a controlled release buflomedil HCl formulation using scintographic and pharmacokinetic data. Int. J. Pharm. 72: 79-86
215. Wix AR, Doering PL, Hatton RC. 1992. Drug-food interaction counseling programs at teaching hospitals. Am. J. Hosp. Pharm. 49:855-60
216. Wright CE. 1992. The influence of meal timing on the kinetics (PK) and dynamics (PD) of alprazolam sustained release tablets (ASR). Pharm. Res. 9(Suppl.): S285
217. Yamaguchi T, Ikeda C, Sekine Y. 1986. Intestinal absorption of a β-adrenergic blocking agent Nadolol. II: Mechanism of the inhibitory effect on the intestinal absorption of Nadolol by sodium cholate in rats. Chem. Pharm. Bull. 34:3836-43
218. 4 receptor antagonist. Br. J. Clin. Pharmacol. 34:169P-170P
219. Yong C-L, Yu D, Eden L, Eichmeyer L, Giessing D. 1991. Effect of food on the pharmacokinetics of oxybutinin in normal subjects. Pharm. Res. 8(Suppl.): S320
220. Yu DK, Morrill B, Bhargava VO, Giesing DH, Weir SJ. 1992. Effect of food coadministration on Cardizem CDÔ capsule bioavailability. Pharm. Res. 9 (Suppl.):S323
221. Yuen KH, Deshmukh AA, Newton JM, Short M, Melchor R. 1993. Gastrointestinal transit and absorption of theophylline from a multiparticulate controlled release formulation. Int. J. Pharm. 97: 61-77
222. Zimmermann T, Yeates RA, Laufen H, Pfaff O, Wildfeuer A. 1994. Influence of concomitant food intake on the oral absorption of two triazole antifungal agents, itraconazole and fluconazole. Eur. J. Clin. Pharmacol. 46:147-50