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Volumn 139, Issue 1, 2008, Pages 117-126

Glutamate receptor ligands attenuate allodynia and hyperalgesia and potentiate morphine effects in a mouse model of neuropathic pain

Author keywords

AMN082; LY379268; Morphine; MPEP; Neuropathic pain

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; AMN 082; GLUTAMATE RECEPTOR; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR 7; MORPHINE; UNCLASSIFIED DRUG;

EID: 51549111390     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2008.03.017     Document Type: Article
Times cited : (107)

References (68)
  • 1
    • 0027413423 scopus 로고
    • Glutamate immunocytochemistry in the dorsal horn after injury or stimulation of the sciatic nerve of rats
    • al-Ghoul W.M., Volsi G.L., Weinberg R.J., and Rustioni A. Glutamate immunocytochemistry in the dorsal horn after injury or stimulation of the sciatic nerve of rats. Brain Res Bull 30 (1993) 453-459
    • (1993) Brain Res Bull , vol.30 , pp. 453-459
    • al-Ghoul, W.M.1    Volsi, G.L.2    Weinberg, R.J.3    Rustioni, A.4
  • 2
    • 0036882079 scopus 로고    scopus 로고
    • [3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4 yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization
    • Anderson J.J., Rao S.P., Rowe B., Giracello D.R., Holtz G., Chapman D.F., et al. [3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4 yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization. J Pharmacol Exp Ther 303 (2002) 1044-1051
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 1044-1051
    • Anderson, J.J.1    Rao, S.P.2    Rowe, B.3    Giracello, D.R.4    Holtz, G.5    Chapman, D.F.6
  • 3
    • 0035124349 scopus 로고    scopus 로고
    • Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges
    • Attucci S., Carlà V., Mannaioni G., and Moroni F. Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges. Br J Pharmacol 132 (2001) 799-806
    • (2001) Br J Pharmacol , vol.132 , pp. 799-806
    • Attucci, S.1    Carlà, V.2    Mannaioni, G.3    Moroni, F.4
  • 4
    • 0028787326 scopus 로고
    • Blockade of both epileptogenesis and glutamate release by (1S,3S)-ACPD, a presynaptic glutamate receptor agonist
    • Attwell P.J., Kaura S., Sigala G., Bradford H.F., Croucher M.J., Jane D.E., et al. Blockade of both epileptogenesis and glutamate release by (1S,3S)-ACPD, a presynaptic glutamate receptor agonist. Brain Res 698 (1995) 155-162
    • (1995) Brain Res , vol.698 , pp. 155-162
    • Attwell, P.J.1    Kaura, S.2    Sigala, G.3    Bradford, H.F.4    Croucher, M.J.5    Jane, D.E.6
  • 5
    • 0034332480 scopus 로고    scopus 로고
    • Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus
    • Awad H., Hubert G.W., Smith Y., Levey A.I., and Conn P.J. Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus. J Neurosci 20 (2000) 7871-7879
    • (2000) J Neurosci , vol.20 , pp. 7871-7879
    • Awad, H.1    Hubert, G.W.2    Smith, Y.3    Levey, A.I.4    Conn, P.J.5
  • 6
    • 0030852182 scopus 로고    scopus 로고
    • In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group II metabotropic glutamate receptor agonist LY354740 in rats
    • Battaglia G., Monn J.A., and Schoepp D.D. In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group II metabotropic glutamate receptor agonist LY354740 in rats. Neurosci Lett 229 (1997) 161-164
    • (1997) Neurosci Lett , vol.229 , pp. 161-164
    • Battaglia, G.1    Monn, J.A.2    Schoepp, D.D.3
  • 7
    • 0037112011 scopus 로고    scopus 로고
    • Two distinct signaling pathways upregulate NMDA receptor responses via two distinct metabotropic glutamate receptor subtypes
    • Benquet P., Gee C.E., and Gerber U.J. Two distinct signaling pathways upregulate NMDA receptor responses via two distinct metabotropic glutamate receptor subtypes. Neurosci 22 (2002) 9679-9686
    • (2002) Neurosci , vol.22 , pp. 9679-9686
    • Benquet, P.1    Gee, C.E.2    Gerber, U.J.3
  • 8
    • 0023895875 scopus 로고
    • A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
    • Bennett G.J., and Xie Y.K. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33 (1988) 87-107
    • (1988) Pain , vol.33 , pp. 87-107
    • Bennett, G.J.1    Xie, Y.K.2
  • 9
    • 0024847290 scopus 로고
    • What is synergy?
    • Berenbaum M.C. What is synergy?. Pharmacol Rev 41 (1989) 93-141
    • (1989) Pharmacol Rev , vol.41 , pp. 93-141
    • Berenbaum, M.C.1
  • 10
    • 0033545233 scopus 로고    scopus 로고
    • Distribution and developmental changes in metabotropic glutamate receptor messenger RNA expression in the rat lumbar spinal cord
    • Berthele A., Boxall S.J., Urban A., Anneser J.M., Zieglgansberger W., Urban L., et al. Distribution and developmental changes in metabotropic glutamate receptor messenger RNA expression in the rat lumbar spinal cord. Brain Res Dev Brain Res 112 (1999) 39-53
    • (1999) Brain Res Dev Brain Res , vol.112 , pp. 39-53
    • Berthele, A.1    Boxall, S.J.2    Urban, A.3    Anneser, J.M.4    Zieglgansberger, W.5    Urban, L.6
  • 11
    • 0035094199 scopus 로고    scopus 로고
    • Peripheral group I metabotropic glutamate receptors modulate nociception in mice
    • Bhave G., Karim F., Carlton S.M., and Gereau IV R.W. Peripheral group I metabotropic glutamate receptors modulate nociception in mice. Nat Neurosci 4 (2001) 417-423
    • (2001) Nat Neurosci , vol.4 , pp. 417-423
    • Bhave, G.1    Karim, F.2    Carlton, S.M.3    Gereau IV, R.W.4
  • 12
    • 0033842964 scopus 로고    scopus 로고
    • Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanism of action in vivo
    • Bond A., Jones N.M., Hicks C.A., Whiffin G.M., Ward M.A., O'Neill M.F., et al. Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanism of action in vivo. J Pharmacol Exp Ther 294 (2000) 800-809
    • (2000) J Pharmacol Exp Ther , vol.294 , pp. 800-809
    • Bond, A.1    Jones, N.M.2    Hicks, C.A.3    Whiffin, G.M.4    Ward, M.A.5    O'Neill, M.F.6
  • 13
    • 0035934214 scopus 로고    scopus 로고
    • Localization of metabotropic glutamate receptors 2/3 on primary afferent axons in the rat
    • Carlton S.M., Hargett G.L., and Coggeshall R.E. Localization of metabotropic glutamate receptors 2/3 on primary afferent axons in the rat. Neuroscience 105 (2001) 957-969
    • (2001) Neuroscience , vol.105 , pp. 957-969
    • Carlton, S.M.1    Hargett, G.L.2    Coggeshall, R.E.3
  • 14
    • 33847331085 scopus 로고    scopus 로고
    • Colocalization of metabotropic glutamate receptors in rat dorsal root ganglion cells
    • Carlton S.M., and Hargett G.L. Colocalization of metabotropic glutamate receptors in rat dorsal root ganglion cells. J Comp Neurol 501 (2007) 780-789
    • (2007) J Comp Neurol , vol.501 , pp. 780-789
    • Carlton, S.M.1    Hargett, G.L.2
  • 16
    • 11844301325 scopus 로고    scopus 로고
    • Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats
    • Chen S.R., and Pan H.L. Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats. J Pharmacol Exp Ther 312 (2005) 120-126
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 120-126
    • Chen, S.R.1    Pan, H.L.2
  • 17
    • 0030995878 scopus 로고    scopus 로고
    • Pharmacology and functions of metabotropic glutamate receptors
    • Conn P.J., and Pin J.P. Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 37 (1997) 205-237
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 205-237
    • Conn, P.J.1    Pin, J.P.2
  • 18
    • 0030873754 scopus 로고    scopus 로고
    • Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: in vivo studies with (2S,1′S,2′S,3′R)-2-(2′-carboxy-3′-phenylcyclopropyl)glycine, a new potent and selective antagonist
    • Cozzi A., Attucci S., Peruginelli F., Marinozzi M., Luneia R., Pellicciari R., and Moroni F. Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: in vivo studies with (2S,1′S,2′S,3′R)-2-(2′-carboxy-3′-phenylcyclopropyl)glycine, a new potent and selective antagonist. Eur J Neurosci 9 (1997) 1350-1355
    • (1997) Eur J Neurosci , vol.9 , pp. 1350-1355
    • Cozzi, A.1    Attucci, S.2    Peruginelli, F.3    Marinozzi, M.4    Luneia, R.5    Pellicciari, R.6    Moroni, F.7
  • 19
    • 2342477651 scopus 로고    scopus 로고
    • Differential release of neurotransmitters from superficial and deep layers of the dorsal horn in response to acute noxious stimulation and inflammation of the rat paw
    • Dmitrieva N., Rodríguez-Malaver A.J., Pérez J., and Hernández L. Differential release of neurotransmitters from superficial and deep layers of the dorsal horn in response to acute noxious stimulation and inflammation of the rat paw. Eur J Pain 8 (2004) 245-252
    • (2004) Eur J Pain , vol.8 , pp. 245-252
    • Dmitrieva, N.1    Rodríguez-Malaver, A.J.2    Pérez, J.3    Hernández, L.4
  • 20
    • 0029997449 scopus 로고    scopus 로고
    • Immunohistochemical localization of mu-opioid receptors in the central nervous system of the rat
    • Ding Y.Q., Kaneko T., Nomura S., and Mizuno N. Immunohistochemical localization of mu-opioid receptors in the central nervous system of the rat. J Comp Neurol. 367 (1996) 375-402
    • (1996) J Comp Neurol. , vol.367 , pp. 375-402
    • Ding, Y.Q.1    Kaneko, T.2    Nomura, S.3    Mizuno, N.4
  • 21
    • 0344305540 scopus 로고    scopus 로고
    • Up-regulation of metabotropic glutamate receptor subtypes 3 and 5 in spinal cord in a clinical model of persistent inflammation and hyperalgesia
    • Dolan S., Kelly J.G., Monteiro A.M., and Nolan A.M. Up-regulation of metabotropic glutamate receptor subtypes 3 and 5 in spinal cord in a clinical model of persistent inflammation and hyperalgesia. Pain 106 (2003) 501-512
    • (2003) Pain , vol.106 , pp. 501-512
    • Dolan, S.1    Kelly, J.G.2    Monteiro, A.M.3    Nolan, A.M.4
  • 22
    • 0029834434 scopus 로고    scopus 로고
    • Comparison of nociceptive effects produced by intrathecal administration of mGluR agonists
    • Fisher K., and Coderre T.J. Comparison of nociceptive effects produced by intrathecal administration of mGluR agonists. Neuroreport 7 (1996) 2743-2747
    • (1996) Neuroreport , vol.7 , pp. 2743-2747
    • Fisher, K.1    Coderre, T.J.2
  • 23
    • 0030444724 scopus 로고    scopus 로고
    • The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception
    • Fisher K., and Coderre T.J. The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception. Pain 68 (1996) 255-263
    • (1996) Pain , vol.68 , pp. 255-263
    • Fisher, K.1    Coderre, T.J.2
  • 24
    • 0032498802 scopus 로고    scopus 로고
    • In vivo antinociceptive activity of anti-rat mGluR1 and mGluR5 antibodies in rats
    • Fundytus M.E., Fisher K., Dray A., Henry J.L., and Coderre T.J. In vivo antinociceptive activity of anti-rat mGluR1 and mGluR5 antibodies in rats. Neuroreport 9 (1998) 731-735
    • (1998) Neuroreport , vol.9 , pp. 731-735
    • Fundytus, M.E.1    Fisher, K.2    Dray, A.3    Henry, J.L.4    Coderre, T.J.5
  • 25
    • 0035150239 scopus 로고    scopus 로고
    • Knockdown of spinal metabotropic glutamate receptor 1 (mGluR(1)) alleviates pain and restores opioid efficacy after nerve injury in rats
    • Fundytus M.E., Yashpal K., Chabot J.G., Osborne M.G., Lefebvre C.D., Dray A., et al. Knockdown of spinal metabotropic glutamate receptor 1 (mGluR(1)) alleviates pain and restores opioid efficacy after nerve injury in rats. Br J Pharmacol 132 (2001) 354-367
    • (2001) Br J Pharmacol , vol.132 , pp. 354-367
    • Fundytus, M.E.1    Yashpal, K.2    Chabot, J.G.3    Osborne, M.G.4    Lefebvre, C.D.5    Dray, A.6
  • 26
    • 0032853255 scopus 로고    scopus 로고
    • 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist
    • Gasparini F., Lingenhöhl K., Stoehr N., Flor P.J., Heinrich M., Vranesic I., et al. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology 38 (1999) 1493-1503
    • (1999) Neuropharmacology , vol.38 , pp. 1493-1503
    • Gasparini, F.1    Lingenhöhl, K.2    Stoehr, N.3    Flor, P.J.4    Heinrich, M.5    Vranesic, I.6
  • 27
    • 0034648712 scopus 로고    scopus 로고
    • Group II and group III metabotropic glutamate receptor agonists depress synaptic transmission in the rat spinal cord dorsal horn
    • Gerber G., Zhong J., Youn D., and Randic M. Group II and group III metabotropic glutamate receptor agonists depress synaptic transmission in the rat spinal cord dorsal horn. Neuroscience 100 (2000) 393-406
    • (2000) Neuroscience , vol.100 , pp. 393-406
    • Gerber, G.1    Zhong, J.2    Youn, D.3    Randic, M.4
  • 28
    • 0028340911 scopus 로고
    • Inhibition of phosphoprotein phosphatases blocks metabotropic glutamate receptor effects in the rat nucleus tractus solitarii
    • Glaum S.R., and Miller R.J. Inhibition of phosphoprotein phosphatases blocks metabotropic glutamate receptor effects in the rat nucleus tractus solitarii. Mol Pharmacol 45 (1994) 1221-1226
    • (1994) Mol Pharmacol , vol.45 , pp. 1221-1226
    • Glaum, S.R.1    Miller, R.J.2
  • 29
    • 0036549258 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor 5 upregulation in A-fibers after spinal nerve injury: 2-methyl-6-(phenylethynyl)-pyridine (MPEP) reverses the induced cold hyperalgesia
    • Hudson L.J., Bevan S., McNair K., Gentry C., Fox A., Kuhn R., et al. Metabotropic glutamate receptor 5 upregulation in A-fibers after spinal nerve injury: 2-methyl-6-(phenylethynyl)-pyridine (MPEP) reverses the induced cold hyperalgesia. J Neurosci 22 (2002) 2660-2668
    • (2002) J Neurosci , vol.22 , pp. 2660-2668
    • Hudson, L.J.1    Bevan, S.2    McNair, K.3    Gentry, C.4    Fox, A.5    Kuhn, R.6
  • 30
    • 23644440111 scopus 로고    scopus 로고
    • Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing
    • Jones C.K., Eberle E.L., Peters S.C., Monn J.A., and Shannon H.E. Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing. Neuropharmacology 49 (2005) 206-218
    • (2005) Neuropharmacology , vol.49 , pp. 206-218
    • Jones, C.K.1    Eberle, E.L.2    Peters, S.C.3    Monn, J.A.4    Shannon, H.E.5
  • 31
    • 0037278221 scopus 로고    scopus 로고
    • Inhibitory effects of MPEP, an mGluR5 antagonist, and memantine, an N-methyl-D-aspartate receptor antagonist, on morphine antinociceptive tolerance in mice
    • Kozela E., Pilc A., and Popik P. Inhibitory effects of MPEP, an mGluR5 antagonist, and memantine, an N-methyl-D-aspartate receptor antagonist, on morphine antinociceptive tolerance in mice. Psychopharmacology (Berl) 165 (2003) 245-251
    • (2003) Psychopharmacology (Berl) , vol.165 , pp. 245-251
    • Kozela, E.1    Pilc, A.2    Popik, P.3
  • 32
    • 0031050960 scopus 로고    scopus 로고
    • Localization of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive, primary afferent fibers in the superficial layers of the spinal dorsal horn: an electron microscope study in the rat
    • Li H., Ohishi H., Kinoshita A., Shigemoto R., Nomura S., and Mizuno N. Localization of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive, primary afferent fibers in the superficial layers of the spinal dorsal horn: an electron microscope study in the rat. Neurosci Lett 223 (1997) 153-156
    • (1997) Neurosci Lett , vol.223 , pp. 153-156
    • Li, H.1    Ohishi, H.2    Kinoshita, A.3    Shigemoto, R.4    Nomura, S.5    Mizuno, N.6
  • 33
    • 0037178637 scopus 로고    scopus 로고
    • Activation of spinal group I metabotropic glutamate receptors in rats evokes local glutamate release and spontaneous nociceptive behaviors: effects of 2-methyl-6-(phenylethynyl)-pyridine pretreatment
    • Lorrain D.S., Correa L., Anderson J., and Varney M. Activation of spinal group I metabotropic glutamate receptors in rats evokes local glutamate release and spontaneous nociceptive behaviors: effects of 2-methyl-6-(phenylethynyl)-pyridine pretreatment. Neurosci Lett 327 (2002) 198-202
    • (2002) Neurosci Lett , vol.327 , pp. 198-202
    • Lorrain, D.S.1    Correa, L.2    Anderson, J.3    Varney, M.4
  • 34
    • 0029077507 scopus 로고
    • Experimental mononeuropathy reduces the antinociceptive effects of morphine: implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain
    • Mao J., Price D.D., and Mayer D.J. Experimental mononeuropathy reduces the antinociceptive effects of morphine: implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain. Pain 61 (1995) 353-364
    • (1995) Pain , vol.61 , pp. 353-364
    • Mao, J.1    Price, D.D.2    Mayer, D.J.3
  • 35
    • 0033529232 scopus 로고    scopus 로고
    • Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions
    • Mayer D.J., Mao J., Holt J., and Price D.D. Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions. Proc Natl Acad Sci U S A 96 (1999) 7731-7736
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 7731-7736
    • Mayer, D.J.1    Mao, J.2    Holt, J.3    Price, D.D.4
  • 36
    • 33847417406 scopus 로고    scopus 로고
    • Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain
    • Mika J., Osikowicz M., Makuch W., and Przewlocka B. Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain. Eur J Pharmacol. 560 (2007) 142-149
    • (2007) Eur J Pharmacol. , vol.560 , pp. 142-149
    • Mika, J.1    Osikowicz, M.2    Makuch, W.3    Przewlocka, B.4
  • 37
    • 0036144929 scopus 로고    scopus 로고
    • Role of group II and group III metabotropic glutamate receptors in spinal cord injury
    • Mills C.D., Johnson K.M., and Hulsebosch C.E. Role of group II and group III metabotropic glutamate receptors in spinal cord injury. Exp Neurol. 173 (2002) 153-167
    • (2002) Exp Neurol. , vol.173 , pp. 153-167
    • Mills, C.D.1    Johnson, K.M.2    Hulsebosch, C.E.3
  • 38
    • 29444435620 scopus 로고    scopus 로고
    • A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo
    • Mitsukawa K., Yamamoto R., Ofner S., Nozulak J., Pescott O., Lukic S., et al. A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proc Natl Acad Sci U S A 102 (2005) 18712-18717
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 18712-18717
    • Mitsukawa, K.1    Yamamoto, R.2    Ofner, S.3    Nozulak, J.4    Pescott, O.5    Lukic, S.6
  • 39
    • 8944234853 scopus 로고    scopus 로고
    • Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase
    • Monn J.A., Valli M.J., Johnson B.G., Salhoff C.R., Wright R.A., Howe T., et al. Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase. J Med Chem 39 (1996) 2990-3000
    • (1996) J Med Chem , vol.39 , pp. 2990-3000
    • Monn, J.A.1    Valli, M.J.2    Johnson, B.G.3    Salhoff, C.R.4    Wright, R.A.5    Howe, T.6
  • 40
    • 0029947776 scopus 로고    scopus 로고
    • Role of protein kinase C in desensitization of spinal delta-opioid-mediated antinociception in the mouse
    • Narita M., Mizoguchi H., Kampine J.P., and Tseng L.F. Role of protein kinase C in desensitization of spinal delta-opioid-mediated antinociception in the mouse. Br J Pharmacol 118 (1996) 1829-1835
    • (1996) Br J Pharmacol , vol.118 , pp. 1829-1835
    • Narita, M.1    Mizoguchi, H.2    Kampine, J.P.3    Tseng, L.F.4
  • 41
    • 24144487021 scopus 로고    scopus 로고
    • Involvement of spinal metabotropic glutamate receptor 5 in the development of tolerance to morphine-induced antinociception
    • Narita M., Suzuki M., Narita M., Niikura K., Nakamura A., Miyatake M., et al. Involvement of spinal metabotropic glutamate receptor 5 in the development of tolerance to morphine-induced antinociception. J Neurochem 94 (2005) 1297-1305
    • (2005) J Neurochem , vol.94 , pp. 1297-1305
    • Narita, M.1    Suzuki, M.2    Narita, M.3    Niikura, K.4    Nakamura, A.5    Miyatake, M.6
  • 42
    • 0029566973 scopus 로고
    • Presynaptic localization of a metabotropic glutamate receptor, mGluR7, in the primary afferent neurons: an immunohistochemical study in the rat
    • Ohishi H., Nomura S., Ding Y.Q., Shigemoto R., Wada E., Kinoshita A., et al. Presynaptic localization of a metabotropic glutamate receptor, mGluR7, in the primary afferent neurons: an immunohistochemical study in the rat. Neurosci Lett 202 (1995) 85-88
    • (1995) Neurosci Lett , vol.202 , pp. 85-88
    • Ohishi, H.1    Nomura, S.2    Ding, Y.Q.3    Shigemoto, R.4    Wada, E.5    Kinoshita, A.6
  • 43
    • 0028825040 scopus 로고
    • The loss of antinociceptive efficacy of spinal morphine in rats with nerve ligation injury is prevented by reducing spinal afferent drive
    • Ossipov M.H., Lopez Y., Nichols M.L., Bian D., and Porreca F. The loss of antinociceptive efficacy of spinal morphine in rats with nerve ligation injury is prevented by reducing spinal afferent drive. Neurosci Lett 199 (1995) 87-90
    • (1995) Neurosci Lett , vol.199 , pp. 87-90
    • Ossipov, M.H.1    Lopez, Y.2    Nichols, M.L.3    Bian, D.4    Porreca, F.5
  • 44
    • 33845871976 scopus 로고    scopus 로고
    • mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082
    • Pelkey K.A., Yuan X., Lavezzari G., Roche K.W., and McBain C.J. mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082. Neuropharmacology 52 (2007) 108-117
    • (2007) Neuropharmacology , vol.52 , pp. 108-117
    • Pelkey, K.A.1    Yuan, X.2    Lavezzari, G.3    Roche, K.W.4    McBain, C.J.5
  • 45
    • 0029874694 scopus 로고    scopus 로고
    • The metabotropic glutamate receptors, mGluR2 and mGluR3, show unique postsynaptic, presynaptic and glial localizations
    • Petralia R.S., Wang Y.X., Niedzielski A.S., and Wenthold R.J. The metabotropic glutamate receptors, mGluR2 and mGluR3, show unique postsynaptic, presynaptic and glial localizations. Neuroscience 71 (1996) 949-976
    • (1996) Neuroscience , vol.71 , pp. 949-976
    • Petralia, R.S.1    Wang, Y.X.2    Niedzielski, A.S.3    Wenthold, R.J.4
  • 46
    • 0029187946 scopus 로고
    • The metabotropic glutamate receptors: structure and functions
    • Pin J.P., and Duvoisin R. The metabotropic glutamate receptors: structure and functions. Neuropharmacology 34 (1995) 1-26
    • (1995) Neuropharmacology , vol.34 , pp. 1-26
    • Pin, J.P.1    Duvoisin, R.2
  • 47
    • 0035959976 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-d-aspartate responses in medium spiny striatal neurons
    • Pisani A., Gubellini P., Bonsi P., Conquet F., Picconi B., Centonze D., et al. Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-d-aspartate responses in medium spiny striatal neurons. Neuroscience 106 (2001) 579-587
    • (2001) Neuroscience , vol.106 , pp. 579-587
    • Pisani, A.1    Gubellini, P.2    Bonsi, P.3    Conquet, F.4    Picconi, B.5    Centonze, D.6
  • 48
    • 36249027065 scopus 로고    scopus 로고
    • Effects of inflammation on the ultrastructural localization of spinal cord dorsal horn group I metabotropic glutamate receptors
    • Pitcher M.H., Ribeiro-da-Silva A., and Coderre T.J. Effects of inflammation on the ultrastructural localization of spinal cord dorsal horn group I metabotropic glutamate receptors. J Comp Neurol 505 (2007) 412-423
    • (2007) J Comp Neurol , vol.505 , pp. 412-423
    • Pitcher, M.H.1    Ribeiro-da-Silva, A.2    Coderre, T.J.3
  • 49
    • 0033914156 scopus 로고    scopus 로고
    • Selective agonist of group II glutamate metabotropic receptors, LY354740, inhibits tolerance to analgesic effects of morphine in mice
    • Popik P., Kozela E., and Pilc A. Selective agonist of group II glutamate metabotropic receptors, LY354740, inhibits tolerance to analgesic effects of morphine in mice. Br J Pharmacol 130 (2000) 1425-1431
    • (2000) Br J Pharmacol , vol.130 , pp. 1425-1431
    • Popik, P.1    Kozela, E.2    Pilc, A.3
  • 50
    • 0032496689 scopus 로고    scopus 로고
    • Spinal opioid mu receptor expression in lumbar spinal cord of rats following nerve injury
    • Porreca F., Tang Q.B., Bian D., Riedl M., Elde R., and Lai J. Spinal opioid mu receptor expression in lumbar spinal cord of rats following nerve injury. Brain Res 795 (1998) 197-203
    • (1998) Brain Res , vol.795 , pp. 197-203
    • Porreca, F.1    Tang, Q.B.2    Bian, D.3    Riedl, M.4    Elde, R.5    Lai, J.6
  • 51
    • 0345391048 scopus 로고    scopus 로고
    • Spinal analgesic action of endomorphins in acute, inflammatory and neuropathic pain in rats
    • Przewlocka B., Mika J., Labuz D., Toth G., and Przewlocki R. Spinal analgesic action of endomorphins in acute, inflammatory and neuropathic pain in rats. Eur J Pharmacol. 367 (1999) 189-196
    • (1999) Eur J Pharmacol. , vol.367 , pp. 189-196
    • Przewlocka, B.1    Mika, J.2    Labuz, D.3    Toth, G.4    Przewlocki, R.5
  • 52
    • 33747036934 scopus 로고    scopus 로고
    • Analgesic effects of mGlu1 and mGlu5 receptor antagonists in the rat formalin test
    • Sevostianova N., and Danysz W. Analgesic effects of mGlu1 and mGlu5 receptor antagonists in the rat formalin test. Neuropharmacology 51 (2006) 623-630
    • (2006) Neuropharmacology , vol.51 , pp. 623-630
    • Sevostianova, N.1    Danysz, W.2
  • 53
    • 0035996526 scopus 로고    scopus 로고
    • Group II mGluR receptor agonists are effective in persistent and neuropathic pain models in rats
    • Simmons R.M., Webster A.A., Kalra A.B., and Iyengar S. Group II mGluR receptor agonists are effective in persistent and neuropathic pain models in rats. Pharmacol. Biochem. Behav. 73 (2002) 419-427
    • (2002) Pharmacol. Biochem. Behav. , vol.73 , pp. 419-427
    • Simmons, R.M.1    Webster, A.A.2    Kalra, A.B.3    Iyengar, S.4
  • 54
    • 0028057565 scopus 로고
    • Pre treatment with MK-801, a non-competitive NMDA antagonist, prevents development of mechanical hyperalgesia in a rat model of chronic neuropathy, but not in a model of chronic inflammation
    • Smith G.D., Wiseman J., Harrison S.M., Elliott P.J., and Brich P.J. Pre treatment with MK-801, a non-competitive NMDA antagonist, prevents development of mechanical hyperalgesia in a rat model of chronic neuropathy, but not in a model of chronic inflammation. Neurosci Lett 165 (1994) 79-83
    • (1994) Neurosci Lett , vol.165 , pp. 79-83
    • Smith, G.D.1    Wiseman, J.2    Harrison, S.M.3    Elliott, P.J.4    Brich, P.J.5
  • 55
    • 0032536413 scopus 로고    scopus 로고
    • Painful mononeuropathy in C57BL/Wld mice with delayed wallerian degeneration: differential effects of cytokine production and nerve regeneration on thermal and mechanical hypersensitivity
    • Sommer C., and Schäfers M. Painful mononeuropathy in C57BL/Wld mice with delayed wallerian degeneration: differential effects of cytokine production and nerve regeneration on thermal and mechanical hypersensitivity. Brain Res 784 (1998) 154-162
    • (1998) Brain Res , vol.784 , pp. 154-162
    • Sommer, C.1    Schäfers, M.2
  • 56
    • 0037448117 scopus 로고    scopus 로고
    • The mGluR5 selective antagonist 6-methyl-2-(phenylethynyl)-pyridine reduces the spinal neuron pain-related activity in mononeuropathic rats
    • Sotgiu M.L., Bellomi P., and Biella G.E. The mGluR5 selective antagonist 6-methyl-2-(phenylethynyl)-pyridine reduces the spinal neuron pain-related activity in mononeuropathic rats. Neurosci Lett 342 (2003) 85-88
    • (2003) Neurosci Lett , vol.342 , pp. 85-88
    • Sotgiu, M.L.1    Bellomi, P.2    Biella, G.E.3
  • 57
    • 0032562436 scopus 로고    scopus 로고
    • Inflammation alters the effects of mGlu receptor agonists on spinal nociceptive neurones
    • Stanfa L.C., and Dickenson A.H. Inflammation alters the effects of mGlu receptor agonists on spinal nociceptive neurones. Eur J Pharmacol 347 (1998) 165-172
    • (1998) Eur J Pharmacol , vol.347 , pp. 165-172
    • Stanfa, L.C.1    Dickenson, A.H.2
  • 58
    • 1542404590 scopus 로고    scopus 로고
    • Melanocortin 4 receptor is expressed in the dorsal root ganglions and down-regulated in neuropathic rats
    • Starowicz K., Bilecki W., Sieja A., Przewlocka B., and Przewlocki R. Melanocortin 4 receptor is expressed in the dorsal root ganglions and down-regulated in neuropathic rats. Neurosci Lett 358 (2004) 79-82
    • (2004) Neurosci Lett , vol.358 , pp. 79-82
    • Starowicz, K.1    Bilecki, W.2    Sieja, A.3    Przewlocka, B.4    Przewlocki, R.5
  • 61
    • 0001050064 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor involvement in models of acute and persistent pain: prospects for the development of novel analgesics
    • Varney M.A., and Gereau R.W. Metabotropic glutamate receptor involvement in models of acute and persistent pain: prospects for the development of novel analgesics. Curr Drug Targets CNS Neurol Disord. 1 (2002) 283-296
    • (2002) Curr Drug Targets CNS Neurol Disord. , vol.1 , pp. 283-296
    • Varney, M.A.1    Gereau, R.W.2
  • 62
    • 20944438126 scopus 로고    scopus 로고
    • The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles
    • Varty G.B., Grilli M., Forlani A., Fredduzzi S., Grzelak M.E., Guthrie D.H., et al. The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles. Psychopharmacology (Berl) 179 (2005) 207-217
    • (2005) Psychopharmacology (Berl) , vol.179 , pp. 207-217
    • Varty, G.B.1    Grilli, M.2    Forlani, A.3    Fredduzzi, S.4    Grzelak, M.E.5    Guthrie, D.H.6
  • 63
    • 0033763535 scopus 로고    scopus 로고
    • mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia
    • Walker K., Reeve A., Bowes M., Winter J., Wotherspoon G., Davis A., et al. mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia. Neuropharmacology 40 (2001) 10-19
    • (2001) Neuropharmacology , vol.40 , pp. 10-19
    • Walker, K.1    Reeve, A.2    Bowes, M.3    Winter, J.4    Wotherspoon, G.5    Davis, A.6
  • 64
    • 0033758569 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain
    • Walker K., Bowes M., Panesar M., Davis A., Gentry C., Kesingland A., et al. Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain. Neuropharmacology 40 (2001) 1-9
    • (2001) Neuropharmacology , vol.40 , pp. 1-9
    • Walker, K.1    Bowes, M.2    Panesar, M.3    Davis, A.4    Gentry, C.5    Kesingland, A.6
  • 65
    • 0031589694 scopus 로고    scopus 로고
    • Behavioural and electrophysiological evidence supporting a role for group I metabotropic glutamate receptors in the mediation of nociceptive inputs to the rat spinal cord
    • Young M.R., Fleetwood-Walker S.M., Dickinson T., Blackburn-Munro G., Sparrow H., Birch P.J., et al. Behavioural and electrophysiological evidence supporting a role for group I metabotropic glutamate receptors in the mediation of nociceptive inputs to the rat spinal cord. Brain Res 777 (1997) 161-169
    • (1997) Brain Res , vol.777 , pp. 161-169
    • Young, M.R.1    Fleetwood-Walker, S.M.2    Dickinson, T.3    Blackburn-Munro, G.4    Sparrow, H.5    Birch, P.J.6
  • 66
    • 0035860116 scopus 로고    scopus 로고
    • Metabotropic glutamate 1alpha receptors on peripheral primary afferent fibers: their role in nociception
    • Zhou S., Komak S., Du J., and Carlton S.M. Metabotropic glutamate 1alpha receptors on peripheral primary afferent fibers: their role in nociception. Brain Res 913 (2001) 18-26
    • (2001) Brain Res , vol.913 , pp. 18-26
    • Zhou, S.1    Komak, S.2    Du, J.3    Carlton, S.M.4
  • 67
    • 9944223305 scopus 로고    scopus 로고
    • Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities
    • Zhu C.Z., Wilson S.G., Mikusa J.P., Wismer C.T., Gauvin D.M., Lynch III J.J., et al. Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities. Eur J Pharmacol 506 (2004) 107-118
    • (2004) Eur J Pharmacol , vol.506 , pp. 107-118
    • Zhu, C.Z.1    Wilson, S.G.2    Mikusa, J.P.3    Wismer, C.T.4    Gauvin, D.M.5    Lynch III, J.J.6
  • 68
    • 0020525719 scopus 로고
    • Ethical guidelines for investigations of experimental pain in conscious animals
    • Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16 (1983) 109-110
    • (1983) Pain , vol.16 , pp. 109-110
    • Zimmermann, M.1


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