Behavioural and electrophysiological evidence supporting a role for group I metabotropic glutamate receptors in the mediation of nociceptive inputs to the rat spinal cord

Brain Research

Volumn 777, Issue 1-2, 1997, Pages 161-169

  Young, Marie R ^a   Fleetwood Walker, Susan M ^a   Dickinson, Tracey ^a   Blackburn Munro, Gordon ^a   Sparrow, Helen ^a   Birch, Phil J ^b,c   Bountra, Chas ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c GENERAL ELECTRIC COMPANY   (United States)

Author keywords

Analgesia; Metabotropic glutamate receptors; Nociception; Pain; Spinal cord

Indexed keywords

2 AMINO 3 PHOSPHONOPROPIONIC ACID; 4 CARBOXY 3 HYDROXYPHENYLGLYCINE; AZETIDINE DERIVATIVE; CYCLOTHIAZIDE; METABOTROPIC RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; MALE; MECHANICAL STIMULATION; NEUROMODULATION; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTIVE FIELD; THERMAL STIMULATION;

ALANINE; ANIMALS; ANTIHYPERTENSIVE AGENTS; BEHAVIOR, ANIMAL; BENZOTHIADIAZINES; CYCLOLEUCINE; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; GLYCINE; MALE; MUSTARD PLANT; NEUROPROTECTIVE AGENTS; NOCICEPTORS; PAIN; PHENYLACETATES; PLANT EXTRACTS; PLANT OILS; PLANTS, MEDICINAL; RATS; RATS, INBRED STRAINS; RECEPTORS, METABOTROPIC GLUTAMATE; RESORCINOLS; SPINAL CORD;

EID: 0031589694     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)01106-2     Document Type: Article

References (51)

1. [1] T. Abe, H. Sugihara, H. Nawa, R. Shigemoto, N. Mizuno, S. Nakanishi, Molecular characterisation of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/calcium signal transduction, J. Biol. Chem. 267 (1992) 13361-13368.
2. [2] A. Baskys, Metabotropic receptors and 'slow' excitatory actions of glutamate agonists in the hippocampus, Trends Pharmacol. 15 (1992) 92-96.
3. [3] Y. Ben-Ari, L. Aniksztejn, P. Bregestovski, Protein kinase C modulation of NMDA currents: an important link for long term potentiation induction, Trends Neurosci. 15 (1992) 333-339.
4. [4] E.F. Birse, S.A. Eaton, D.E. Jane, P.L.St.-J. Jones, R.H.P. Porter, P.C.-K. Pook, D.C. Sunter, P.M. Udvarhelyi, B. Wharton, P.J. Roberts, T.E. Salt, J.C. Watkins, Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system, Neuroscience 53 (1993) 481-488.
5. [5] D. Bleakman, K.I. Rusin, P.S. Chard, S.R. Glaum, R.J. Miller, Metabotropic glutamate receptors potentiate ionotropic glutamate responses in rat dorsal horn, Mol. Pharmacol. 42 (1992) 192-196.
6. [6] A. Bond, D. Lodge, Pharmacology of metabotropic glutamate receptor-mediated enhancement of responses to excitatory and inhibitory amino acids on rat spinal neurons in vivo, Neuropharmacology 34 (1995) 1015-1023.
7. 2+ uptake in brain neurons, Eur. J. Pharmacol. Mol. Pharmacol. 290 (1995) 105-115.
8. [8] R. Cerne, M. Randic, Modulation of AMPA and NMDA responses in rat spinal dorsal horn neurons by trans-ACPD, Neurosci. Lett. 144 (1992) 180-184.
9. 2+ channels in cultured cerebellar granule cells, J. Neurosci. 15 (1994) 135-143.
10. ++ block of NMDA receptor channels as a mechanism of modulation, Nature 356 (1992) 521-523.
11. [11] T.J. Coderre, R. Melzack, Contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury, J. Neurosci. 12 (1992) 3665-3670.
12. [12] T.J. Coderre, K. Yashpal, Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model, Eur. J. Neurosci. 6 (1994) 1328-1334.
13. [13] P.M. Dougherty, J. Palecek, V. Peleckova, L. Sorkin, W.D. Willis, The role of NMDA and non-NMDA excitatory amino acid receptors in the excitation of primate spinothalamic tract neurons by mechanical, chemical, thermal, and electrical stimuli, J. Neurosci. 12 (1992) 3025-3041.
14. [14] R.M. Duvoisin, C. Zhang, K. Ralmonell, A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb, J. Neurosci. 15 (1995) 3075-3083.
15. [15] S.A. Eaton, D.E. Jane, P.L.St.J. Jones, R.H.P. Porter, P.C.K. Pook, D.C. Sunter, P.M. Udvarheyli, P.J. Roberts, T.E. Salt, J.C. Watkins, Competitive antagonism at metabotropic glutmate receptors by (S)-4-carboxyphenylglycine (CPG) and RS-α-methyl-4-carboxyphenylglycine (MCPG), Eur. J. Pharmacol. Mol. Pharmacol. 244 (1993) 195-197.
16. [16] S.A. Eaton, E.F. Birse, B. Wharton, D.C. Sunter, P.M. Udvarheyli, J.C. Watkins, T.E. Salt, Mediation of thalamic sensory responses in vivo by ACPD-activated excitatory amino acid receptors, Eur. J. Neurosci. 5 (1993) 186-189.
17. [17] K. Fisher, T.J. Coderre, The contribution of metabotropic glutamate receptors to formalin-induced nociception, Pain 68 (1996) 255-263.
18. [18] K. Fisher, T.J. Coderre, Comparison of nociceptive effects produced by intrathecal administration of mGluR agonists, Neuroreport 7 (1996) 2743-2747.
19. [19] S.R. Glaum, D.C. Sunter, P.M. Udvarhelyi, J.C. Watkins, R. Miller, The actions of phenylglycine derived metabotropic glutamate receptor antagonists on multiple (1S,3R-ACPD responses in the rat nucleus of the tract solitarius, Neuropharmacology 32 (1993) 1419-1425.
20. [20] Y. Hayashi, N. Sekiyama, S. Nakanishi, D.E. Jane, D.C. Sunter, E.F. Birse, P.M. Udvarhelyi, J.C. Watkins, Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes, J. Neurosci. 14 (1994) 3370-3377.
21. [21] R.L. Hayes, J. Mao, D.D. Price, A. Germano, D. D'Avella, M. Fiori, D.L. Mayer, Pretreatment with gangliosides reduces abnormal nociceptive responses associated with a rodent mononeuropathy, Pain 48 (1992) 391-396.
22. [22] Y. Hayishi, Y. Tanabe, I. Aramori, M. Masu, K. Shimamoto, Y. Ohfune, S. Nakanishi, Agonist analysis of 2-(carboxypropyl)-glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells, Br. J. Pharmacol. 107 (1992) 539-543.
23. [23] J.L.K. Hylden, G.L. Wilcox, Intrathecal morphine in mice: a new technique, Eur. J. Pharmacol. 67 (1980) 313-316.
24. [24] A.J. Irving, J.G. Schofield, J.C. Watkins, D.C. Sunter, G.L. Collingridge, 1S,3R-ACPD stimulates and L-AP3 blocks calcium mobilization in rat cerebellar neurons, Eur. J. Pharmacol. 186 (1990) 363-365.
25. [25] D.M. Lovinger, K.L. Wong, K. Murakami, A. Routtenberg, Protein kinase C inhibitors eliminate hippocampal long-term potentiation, Brain Res. 436 (1987) 177-183.
26. [26] R.C. Malenka, J.A. Kauer, D.J. Perkel, M.D. Mank, P.T. Kelly, R.A. Nicoll, M.N. Waxham, An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation, Nature 340 (1989) 554-557.
27. [27] R. Malinow, R.V. Madison, R.W. Tsien, Persistent protein kinase activity underlying long-term potentiation, Nature 335 (1988) 821-824.
28. [28] D. Manahan-Vaughan, M. Reiser, J.-P. Pin, V. Wilsch, J. Bockaert, K.G. Reymann, G. Riedel, Physiological and pharmacological profile of trans-azetidine-2,4-dicarboxylic acid: metabotropic glutamate receptor agonism and effects on long-term potentiation, Neurosci. 72 (1996) 999-1008.
29. [29] O. Manzoni, F. Finiels-Marlier, I. Sassetti, J. Blockaert, C.I. Peuch, F.A.J. Sladeczek, The glutamate receptor of the Qp type activates protein kinase C and is regulated by protein kinase C, Neurosci. Lett. 109 (1990) 146-151.
30. [30] J. Mao, D.D. Price, R.L. Hayes, J. Lu, D.J. Mayer, Intrathecal MK801 and local anaesthesia reduce nociceptive behaviour in rats with experimental peripheral mononeuropathy, Brain Res. 576 (1992) 254-262.
31. 14C-2-deoxyglucose metabolic activity in rats with painful peripheral mononeuropathy, J. Neurophysiol. 70 (1993) 470-481.
32. [32] F.E. Munro, S.M. Fleetwood-Walker, R. Mitchell, Evidence for a role of protein kinase C in the sustained activation of dorsal horn neurons by cutaneous mustard oil application, Neurosci. Lett. 170 (1994) 199-202.
33. [33] Y. Nakajima, H. Iwakabe, C. Akazawa, H. Nawa, R. Shigemoto, N. Mizuno, S. Nakanishi, Molecular characterisation of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate, J. Biol. Chem. 268 (1993) 11868-11873.
34. [34] S. Nakanishi, Molecular diversity of glutamate receptors and implications for brain functions, Science 258 (1992) 597-609.
35. [35] V. Neugebauer, T. Lücke, H.-G. Schaible, Requirement of metabotropic glutamate receptors for the generation of inflammation-evoked hyperexcitability in rat spinal cord neurons, Eur. J. Neurosci. 6 (1994) 1179-1186.
36. [36] N. Okamoto, S. Hori, C. Akazawa, Y. Hayishi, R. Shigemoto, N. Mizuno, S. Nakanishi, Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction, J. Biol. Chem. 269 (1994) 1231-1236.
37. [37] J.-P. Pin, R. Duvoisin, Review: Neurotransmitter receptors I, The metabotropic glutamate receptors: structure and function, Neuropharmacology 34 (1995) 1-26.
38. [38] D.D. Schoepp, B.G. Johnson, E.C.R. Smith, L.A. McQuaid, Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by AP3, Mol. Pharmacol. 38 (1990) 222-228.
39. [39] D.D. Schoepp, J. Goldsworthy, B.G. Johnson, C.R. Salhoff, S.R. Baker, 3,5-dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus, J. Neurochem. 63 (1994) 769-772.
40. [40] N. Sekiyama, Y. Hayashi, S. Nakanishi, D.E. Jane, H.-W. Tse, E.F. Birse, J.C. Watkins, Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes, Br. J. Pharmacol. 117 (1996) 1493-1503.
41. [41] R.L. Sharp, N.G. Mayne, J.P. Burnett, Cyclothiazide differentially modulates human metabotropic glutamate receptors linked to phosphoinositide hydrolysis stimulation in oocytes, Eur. J. Pharmacol. Mol. Pharmacol. 269 (1994) R5-R7.
42. [42] K.J. Swartz, B.P. Bean, Inhibition of calcium channels in rat CA3 pyramidal neurons by a metabotropic glutamate receptor, J. Neurosci. 12 (1992) 4358-4371.
43. 2+ channels and synaptic transmission, Nature 361 (1993) 165-168.
44. [44] Y. Tanabe, M. Masu, T. Ishii, R. Shigemoto, S. Nakanishi, A family of glutamate receptors, Neuron 8 (1992) 169-179.
45. [45] W.G. Tingley, K.W. Roche, A.K. Thompson, R.L. Huganir, Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminus domain, Nature 364 (1993) 70-73.
46. [46] A. Valerio, P. Rizzonelli, M. Paterlini, B. Moretto, T. Knoepfel, R. Kuhn, M. Memo, P.F. Spano, mGluR5 immunolocalization in foetal and adult human spinal cord, Neuropharmacology 35 (1996) A33.
47. [47] Z. Vidnyánszky, J. Hámori, L. Négyessy, D. Rüegg, T. Knöpfel, R. Kuhn, T.J. Görcs, Cellular and subcellular localization of the mGluR5a metabotropic glutamate receptor in rat spinal cord, Neuroreport 6 (1994) 209-213.
48. [49] J.C. Watkins, G.L. Collingridge, Phenylglycine derivatives as antagonists of metabotropic glutamate receptors, Trends Pharmacol. 15 (1994) 333-342.
49. 3H-Phorbol 12,13-dibutyrate binding in spinal cord dorsal horn as well as persistent pain and hyperalgesia, which is reduced by inhibition of protein kinase C, J. Neurosci. 15 (1995) 3263-3272.
50. [51] M.R. Young, S.M. Fleetwood-Walker, R. Mitchell, F.E. Munro, Evidence for a role of metabotropic glutamate receptors in sustained nociceptive inputs to rat dorsal horn neurons, Neuropharmacology 33 (1994) 141-144.
51. [52] M.R. Young, S.M. Fleetwood-Walker, R. Mitchell, T. Dickinson, The involvement of metabotropic glutamate receptors and their intracellular signalling pathways in sustained nociceptive transmission in rat dorsal horn neurons, Neuropharmacology 34 (1995) 1033-1041.