Immunohistochemical localization of μ-opioid receptors in the central nervous system of the rat

Journal of Comparative Neurology

Volumn 367, Issue 3, 1996, Pages 375-402

  Ding, Yu Qiang ^a,b   Kaneko, Takeshi ^a   Nomura, Sakashi ^a   Mizuno, Noboru ^a  

^a KYOTO UNIVERSITY   (Japan)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

brain; immunohistochemistry; opioid; spinal cord

Indexed keywords

MU OPIATE RECEPTOR; POSTSYNAPTIC RECEPTOR; PRESYNAPTIC RECEPTOR;

ANIMAL TISSUE; ARTICLE; BRAIN REGION; IMMUNOHISTOCHEMISTRY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; RECEPTOR DENSITY;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY SPECIFICITY; BRAIN CHEMISTRY; CEREBRAL CORTEX; IMMUNOENZYME TECHNIQUES; LIMBIC SYSTEM; MALE; MEDULLA OBLONGATA; MESENCEPHALON; MOLECULAR SEQUENCE DATA; OLFACTORY BULB; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU; SPINAL CORD; THALAMUS;

EID: 0029997449     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9861(19960408)367:3<375::AID-CNE5>3.0.CO;2-2     Document Type: Article

References (88)

1. Aimone, L.D., and T L. Yaksh (1989) Opioid modulation of capsaicm-evoked release of substance P from the rat spinal cord in vivo. Peptides 10: 1127-1131.
2. Artymyshyn, R, T C. Eckenrode, and M. Murray (1987) Opiate binding sites in the interpeduncular nucleus of the rat. Normal distribution and effects of fasciculus retroflexus lesions. Neuroscience 23:159-172.
3. Arvidsson, U., M. Riedl, S Chakrabarti, J.-H. Lee, A.H. Nakano, R.J. Dado, H.H Loh, P.-Y. Law, M.W Wessendorf, and R. Elde (1995) Distribution and targeting of a μ-opioid receptor (MOR1) in brain and spinal cord. J. Neurosci. 15:3328-3341.
4. Atweh. S.F., and M.J. Kuhar (1977a) Autoradiographic localization of opiate receptors in rat brain. I. Spinal cord and lower medulla. Brain Res. 124:53-67.
5. Atweh. S.F., and M.J. Kuhar (1977b) Autoradiographic localization of opiate receptors in rat brain II. The brain stem. Brain Res 129:1-12.
6. Atweh, S.F., and M.J. Kuhar (1977c) Autoradiographic localization of opiate receptors in rat brain III. The telencephalon. Brain Res. 134:393-405.
7. Atweh. S.F., L.C. Murrin, and M.J. Kuhar (1978) Presynaptic localization of opiate receptors in the vagal and accessory optic systems: An autoradiographie study. Neuroscience 17:65-71
8. Bare. L A., E Mansson, and D. Yang (1994) Expression of two variants of the human μ opioid receptor mRNA in SK-N-SH cells and human brain FEBS Lett. 354:213-216.
9. Basbaum, A.I., and H.L. Fields (1978) Endogenous pain control mechanisms: review and hypothesis. Ann. Neurol. 4:451-462.
10. Basbaum, A I., and H.L. Fields (1984) Endogenous pain control systems brainstem spinal pathways and endorphin circuitry. Annu. Rev. Neurosci. 7:309-338.
11. Besse, D., M.C. Lombard, and J.M. Besson (1991) Autoradiographic distribution of μ, δ and κ opioid binding sites in the superficial dorsal horn, over the rostrocaudal axis of the rat spinal cord. Brain Res 548:287-291.
12. Besse, D., M.C. Lombard, and J.M. Besson (1992) Time-related decreases in μ. and δ opioid receptors in the superficial dorsal horn of the rat spinal cord following a large unilateral dorsal rhizotomy. Brain Res. 578:115-121.
13. Besse. D., M C. Lombard, J.M. Zajac, B.P. Roques, and J.M. Besson (1990) Pre- and postsynaptic distribution of μ, δ and κ opioid receptors in the superficial layers of the cervical dorsal horn of the rat spinal cord. Brain Res. 521:15-22.
14. Besson, J -M., and A. Chaouch (1987) Peripheral and spinal mechanisms of nociception. Physiol. Rev. 67:67-186.
15. Bidlack, J.M., and L.G Abood (1980) Solubilization of the opiate receptor. Life Sci. 27:331-340.
16. 1-opioid receptors in supraspinal opiate analgesia: a microinjection study. Brain Res. 447:25-34
17. Bunzow, J.R., G. Zhang. C. Bouvier, C. Saez, O.K. Ronnekleiv, MJ. Kelly, and D.K. Grandy (1995) Characterization and distnbution of a cloned rat μ-opioid receptor. J. Neurochem. 64:14-24.
18. Chen, Y, A. Mestek, J Liu, JA. Hurley, and L. Yu (1993) Molecular cloning and functional expression of a μ,-opioid receptor from rat brain. Mol. Pharmacol, 44:8-12.
19. Cho, T.M., J-I. Hasegawa, B.-L. Ge, and H.H. Loh (1986) Purification to apparent homogeneity of a μ-type opioid receptor from rat brain. Proc. Natl. Acad. Sci. USA. 83:4138-4142.
20. Crain, B.J., Chang. K.-J., and J.O. McNamara (1986) Quantitative autoradiographic analysis of mu and delta opioid binding sites in the rat hippocampal formation. J. Comp. Neurol. 246:170-180.
21. Delfs, J.M., H Kong, A. Mestek, Y. Chen, L. Yu, T. Reisine, and M.-F. Chesselet (1994) Expression of mu opioid receptor mRNA in rat brain: An in situ hybridization study at the single cell level. J. Comp Neurol. 345:46-68.
22. Ding, Y -Q., S Nomura, T. Kaneko, and N. Mizuno (1995a) Colocalization of μ-opioid receptor-like and substance P-like immunoreactivities in axon terminals wihtin the superficial layers of the medullary and spinal dorsal horns of the rat Neurosci. Lett. 198:45-48
23. Ding, Y.-Q., S Nomura, T. Kaneko, and N. Mizuno (1995b) Presynaptic localization of μ-opioid receptor-like immunoreactivity in retinal axon terminals within the terminal nuclei of the accessory optic tract: a light and electron microscope study in the rat. Neurosci. Lett. 199:139-142.
24. Duggan, A.W., and R.A. North (1984) Electrophysiology of opioids. Pharmacol. Rev. 35:219-281.
25. Fields, HL. A I. Basbaum (1978) Brainstem control of spinal paintransmission neurons. Annu. Rev. Physiol. 40:217-248.
26. Fukuda, K., S. Kato. K. Mori, M. Nishi, and H. Takeshima (1993) Primary structures and expression from cDNAs of rat opioid receptor δ- and μ,-subtypes. FEBS Lett. 327:311-314.
27. Gareon, J., J.L. Juarros, M.A. Castro, and P. Sanchez-Blazquez (1995) Antibodies to the cloned μ-opioid receptor detect various molecular weight forms in areas of mouse brain. Mol. Pharmacol. 47:738-744.
28. Gioamnni, T.L., A.D Howard. J.M. Hiller, and E.J. Simon (1985) Purification of an active opioid-binding protein from bovine striatum. J. Biol. Chem. 260:15117-15121.
29. Goldstein. A. (1987) Binding selectivity profiles for ligands of multiple receptor types; focus on opioid receptors. Trends Pharmacol. Sci. 8:456-459.
30. 1 opiate receptors in rat brain by using a computerized autoradiograpic subtraction technique. Proc. Natl. Acad. Sci. USA 82:6667-6671.
31. Goodman, R.R., S.H. Snyder, M.J. Kuhar, and W.S Young III (1980) Differentiation of delta and mu opiate receptor localizations by light microscopic autoradiography Proc. Natl. Acad. Sci. USA 77:6239-6423.
32. 125l]FK-33-824-labeled mu opioid receptors in the spinal cord of normal and deafferented rats. Neuroscience 43:197-209.
33. Hamel, E., and A. Beaudet (1987) Opioid receptors in rat neostriatum: radioautographic distribution at the electron microscopic level. Brain Res. 401:239-257.
34. Hassan. A H.S., O.F X Almeida, Ch. Gramsch and A. Herz (1989) Immunocytochemical demonstration of opioid receptors in selected rat brain areas and neuroblastoma X glioma hybrid (NG108-15) cells using a monoclonal anti-idiotypic antibody. Neuroscience 32:269-278.
35. Hassen, A.H., G. Feuerstein, and A.I. Faden (1983) Differential cardiovascular effects mediated by mu and kappa opiate receptors in hindbrain nuclei. Peptides 4:621-625
36. Hassen, A.H., G. Feuerstein, and A.I. Faden (1984) Selective cardiorespiratory effects mediated by mu opiate receptors in the nucleus ambiguus. Neuropharmacology 23:407-415.
37. Hassen, A.H., G. Feuerstein, A. Pfeiffer, and A.I. Faden (1982) δ versus μ receptors; cardiovascular and respiratory effects of opiate agonists microinjected into nucleus tractus solitarius of cats. Regul. Pept. 4:299-309.
38. Herkenham, M., and C B. Pert (1981) Mosaic distribution of opiate receptors, parafascicular projections and acetylcholinesterase in rat striatum. Nature 291:415-418.
39. Hiller, J.M , Y. Zhang, G. Bing, T.L. Gioannini, E.A. Stone, and E.J Simon (1994) Immunohistochemical localization of mu-opioid receptors in rat brain using antibodies generated against a peptide sequence present in a purified mu-opioid binding protein. Neuroscience 62:829-841.
40. Hirota, N., Y. Kuraishi, Y. Hino, Y. Sato, M. Satoh, and H. Takagi (1985) Met-enkephalin and morphine but not dynorphin inhibit noxious stimuliinduced release of substance P from rabbit dorsal horn in situ. Neuropharmacology 24:567-570.
41. Honda, C.N., and U. Arvidsson (1995) Immunohistochemical localization of delta- and mu-opioid receptors in primate spinal cord. NeuroReport 6:1025-1028.
42. Howard, A.D., S. de La Baume, T.L. Gioannini, J.M. Hiller, and E.J. Simon (1985) Covalent labeling of opioid receptors with radioiodinated human β-endorphin. J. Biol. Chem. 260:10833-10839.
43. Hsu, S.-H., L. Raine, and H. Fanger (1981) Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase technique: A comparison between ABC and unlabeled antibody (PAP) procedures. J. Histochem. Cytochem. 29:577-580.
44. Jin, W., N.M Lee, H.H. Loh, and S.A. Thayer (1994) Opioids mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells. J. Neurosci 14:1920-1929.
45. Kaneko. T., M Minami, M. Satoh, and N. Mizuno (1995) Immunocytochemical localisation of μ-opioid receptor in the rat caudate-putamen. Neuro-sci. Lett. 184:149-152.
46. La Motte, C., C.B. Pert, and S.H. Snyder (1976) Opiate receptor binding in primate spinal cord; distribution and changes after dorsal root section. Brain Res. 112:407-412.
47. Lawson, S N., and P J. Waddell (1991) Soma neurofilament immunoreactivity is related to cell size and fibre conduction velocity in rat primary sensory neurons. J. Physiol. (Lond) 435:41-63
48. Lewis, M.E., A. Pert, C B. Pert, and M. Herkeaham (1983) Opiate receptor localization in rat cerebral cortex. J Comp. Neurol. 216:339-358.
49. Lu, Y., and J.-S Han (1989) Cholecystokinin-octapeptide antagonizes morphine analgesia in periaqueduetal gray of the rat. Brain Res. 480:105-110.
50. Loughlin, S.E., P.M. Leslie, and J.H. Fallen (1994) Endogenous opioid systems. In G Paxinos (ed): The Rat Nervous System (2nd edn). San Diego: Academic Press, pp. 975-1001.
51. Maneckjee, R., R.S. Zukin, S. Archer, J. Michael, and P. Osei-Gyimah (1985) Purification and characterization of the μ opiate receptor from rat brain using affinity chromatography. Proc. Natl. Acad. Sci. USA. 82:594-598.
52. Maekawa, K., M. Minami, K. Yabuuchi, T. Toya, Y. Katao, Y. Hosoi, T. Onogi, and M. Satoh (1994) In situ hybridization study of μ-and κ-opioid receptor mRNAs in the rat spinal cord and dorsal root ganglia. Neurosci. Lett. 168;97-100.
53. Mansour, A., C.A. Fox, H. Akil, and S.J Watson (1995a) Opioid-receptor mRNA expression in the rat CNS. anatomical and functional implications. Trend Neruosci. 18:22-29.
54. Mansour, A., C.A. Fox, S Burke, H. Akil, and S.J. Watson (1995b) Immunohistochemical localization of the cloned μ-opîoid receptor in the rat CNS. J. Chem. Neuroanat. 8:283-305.
55. Mansour, A , C A. Fox, S Burke, F. Meng, R.C. Thompson, H. Akil, and S.J. Watson (1994a) Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: An in situ hybridization study. J. Comp. Neurol. 350:412-438.
56. Mansour, A., C.A. Fox, S. Burke, and S.J. Watson (1994b) Immunohistochemical localization of the mu opioid receptors. Reg. Pept. 54:179-180 (abstract).
57. Mansour, A., C-A. Fox, R.C. Thompson, H. Akil, S.J Watson (1994c) μ,-Opioid receptor mRNA expression in the rat CNS: comparison to μ,-receptor binding. Brain Res. 643:245-265.
58. Mansour, A., H. Khachaturian, M.E. Lewis, H. Akil, and S.J. Watson (1987) Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain J. Neurosci. 7:2445-2464
59. Mansour, A., H Khachaturian, M.E Lewis, H. Akil, and S.J. Watson (1988) Anatomy of CNS opioid receptors. Trends Neurosci. 11:308-314.
60. Mansour, A., M.E. Lewis, H. Khachaturian, H. Akil, and S.J. Watson (1986) Pharmacological and anatomical evidence of selective μ, δ, and κ opioid receptor binding in rat brain. Brain Res. 399:69-79.
61. Martin, W.R. (1984) Pharmacology of opioids. Pharmacol Rev. 35:283-323.
62. McLean, S., R.B. Rothman, and M Herkenham (1986) Autoradiographic localization of μ- and δ-opiate receptors in the forebrain of the rat. Brain Res 378:49-60.
63. McLean, S., R.B. Rothman, A E. Jacobson, K.C. Rice, and M Herkenham (1987) Distribution of opiate receptor subtypes and enkephalin and dynorphin immunoreactivity in the hippocampus of squirrel, guinea pig, rat, and hamster. J. Comp Neurol. 255:497-510.
64. 3H]dihydromorphine binding sites within the hippocampus of the rat. Eur. J. Pharmacol. 68:175-179.
65. Minami, M., K. Maekawa, K. Yabuuchi, and M. Satoh (1995) Double in situ hybridization on coexistence of μ-, δ- and κ-opioid receptor mRNAs with preprotachykimn A mRNA in the rat dorsal root ganglia. Mol. Brain Res. 30:203-210.
66. Minami, M., T. Onogi, T. Toya, Y. Katao, Y. Hosoi, K. Maekawa, S. Katsumata, K. Yabuuchi, and M. Satoh (1994) Molecular cloning and in situ hybridization histochemistry for rat μ,-opioid receptor. Neurosci. Res. 18:315-322.
67. Nestler, E.J. (1992) Molecular mechanisms of drug addiction J. Neurosci. 12:2439-2450.
68. Newman, E.L., and E.A. Barnard (1984) Identification of an opioid receptor subunit carrying the μ. binding site. Biochemistry 23:5385-5389.
69. Ninkovic, M., S.P. Hunt, and J.S. Kelly (1981) Effect of dorsal rhizotomy on the autoradiographic distribution of opiate and neurotensin receptors and neurotensin-like immunoreactivity within the rat spinal cord. Brain Res. 230:111-119.
70. Otsuka, M., and K. Yoshioka (1993) Neurotransmitter functions of mammalian tachykinins. Physiol. Rev. 73:229-308.
71. Pasternak, G.W. (1988) The Opiate Receptors. Clifton, New Jersey: Humana Press
72. Pasternak, G.W. (1993) Pharmacological mechanisms of opioid analgesics. Clin. Neuropharmacol. 16:1-18.
73. Pasternak, G.W., and P.L. Wood (1986) Multiple mμ opiate receptors Life Sci. 38:1889-1898.
74. Paxinos, G., and C Watson (1986) The Rat Brain in Stereotasic Coordinates (2nd edn), San Diego:Academic Press.
75. Pert, C.B., M.J. Kuhar, and S.H. Snyder (1976) Opiate receptor: Autoradiographic localization in rat brain. Proc. Natl. Acad. Sci. USA 73:3729-3733.
76. Quirion, R., W.D. Bowen, M. Herkenham, and C.B. Pert (1982) Visualization and solubilization of rat brain opiate receptors with a 'κ' ligand selectivity pattern. Cell. Mol. Neurobiol. 2:333-346.
77. 125l]FK33824. Peptides 8:1015-1021.
78. Sharif, N.A., and J.Hughes (1989) Discrete mapping of brain mu and delta opioid receptors using selective peptides: Quantitative autoradiography, species differences and comparison with kappa receptors. Peptides 10:499-522.
79. Tempel, A., and R.S. Zukin (1987) Neuroanatomical patterns of the μ, δ, and κ opioid receptors of rat brain as determined by quantitative in vitro autoradiography. Proc. Natl. Acad. Sci. USA 84:4308-4312.
80. Thompson, R.C., A. Mansour, H. Akil, and S. J Watson (1993) Cloning and pharmacological characterization of a rat μ. opioid receptor. Neuron 11:903-913.
81. Ueda, H., H. Harada, H. Misawa, M. Nozaki, and H. Takaki (1987) Purified opioid μ-receptor is of a different molecular size than δ-and κ-receptors. Neurosci Lett. 75:339-344.
82. Wang, J B, Y. Imai, C.M. Eppler, P. Gregor, C.E. Spivak, and G.R Uhl (1993) μ. opiate receptor. cDNA cloning and expression Proc. Natl Acad. Sci. USA 90:10230-10234.
83. 3H]opioid receptors in rat brain. Brain Res. 179:255-270.
84. Young III, W.S., J.K. Wamsley, M.A. Zarbin, and M.J. Kubar (1980) Opioid receptors undergo axonal flow. Science 210:76-78.
85. Zajac, J.-M , M.-C. Lombard, M. Peschanski, J.-M. Besson, and B.P. Roques (1989) Autoradiographic study of μ. and δ opioid binding sites and neutral endopeptidase-24:11 in rat after dorsal root rhizotomy. Brain Res 477:400-403.
86. Zastawny, R.L., S.R. George, T. Nguyen, R. Cheng, J. Tsatsos, R. BrionesUrbina, and B.F. O'Dowd (1994) Cloning, characterization, and distribution of a μ-opioid receptor in rat brain. J. Neurochem. 62:2099-2105
87. Zimprich, A , B Bacher, and V. Höllt (1994) Cloning and expression of an isoform of the mu-opioid receptor (rmuOR1B) Reg. Pept. 54:347-348 (abstract)
88. Zimpnch, A., T. Simon, and V, Höllt (1995) Cloning and expression of an isoform of the rat μopioid receptor (rMOR1B) which differs in agonist induced desensitization from rMOR1. FEES Lett. 359:142-146.