Role of group II and group III metabotropic glutamate receptors in spinal cord injury

Experimental Neurology

Volumn 173, Issue 1, 2002, Pages 153-167

  Mills, Charles D ^a   Johnson, Kathia M ^a   Hulsebosch, Claire E ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Central pain; Excitability; Metabotropic glutamate receptor; Spinal cord injury

Indexed keywords

2 AMINO 4 PHOSPHONOBUTYRIC ACID; 4 AMINOPYRIDINE DERIVATIVE; 4 AMINOPYRROLIDINE 2,4 DICARBOXYLATE; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR AGONIST; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; UNCLASSIFIED DRUG;

AMINO ACID BRAIN LEVEL; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; CONTUSION; EXPLORATORY BEHAVIOR; HYPERALGESIA; LOCOMOTION; MALE; MECHANICAL STRESS; NERVE CELL EXCITABILITY; NEUROMODULATION; NEUROTRANSMISSION; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; SPINAL CORD INJURY; THERMAL INJURY; TISSUE SPECIFICITY;

EID: 0036144929     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2001.7828     Document Type: Article

References (82)

1. Group II metabotropic glutamate receptor activation attenuates traumatic neuronal injury and improves neurological recovery after traumatic brain injury
2. Differential distribution of metabotropic glutamate receptors 1a, 1b, and 5 in the rat spinal cord
3. Agonists at metabotropic glutamate receptors presynaptically inhibit EPSCs in neonatal rat hippocampus
4. A sensitive and reliable locomotor rating scale for open field testing in rats
5. Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death
6. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
7. Intrathecal NMDA and non NMDA receptor antagonists reduce mechanical but not thermal allodynia in a rodent model of chronic central pain after spinal cord injury
8. Central dysesthesias syndrome in spinal cord injury patients
9. Enhanced expression of metabotropic glutamate receptor 3 messenger RNA in the rat spinal cord during ultraviolet irradiation induced peripheral inflammation
10. The neuroprotective activity of group-II metabotropic glutamate receptors requires new protein synthesis and involves a glial-neuronal signaling
11. Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death
12. The inhibitory mGluR agonist s-4-carboxy-3-hydroxy-phenylglycine selectively attenuates NMDA neurotoxicity and oxygen-glucose deprivation-induced neuronal death
13. Pain and depression in acute traumatic spinal cord injury: Origins of chronic problematic pain?
14. Chronic central pain after spinal cord injury
15. Clinical characteristics of central (dysesthetic) pain in spinal cord injury patients
16. Molecular determinants of metabotropic glutamate receptor signaling
17. Characterization of variables defining hindpaw withdrawal latency evoked by radiant thermal stimuli
18. Behavioural evidence supporting a different role for group I and II metabotropic glutamate receptors in spinal nociceptive transmission
19. Neuroprotective effects of group III mGluR in traumatic neuronal injury
20. Comparison of nociceptive effects produced by intrathecal administration of mGluR agonists
21. The contribution of metabotropic glutamate receptors to formalin-induced nociception
22. Presynaptic glutamate receptors depress excitatory monosynaptic transmission between hippocampal neurons
23. Group II and group III metabotropic glutamate receptor agonists depress synaptic transmission in the rat spinal cord dorsal horn
24. Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1
25. Alterations in AMPA receptor subunit expression after experimental spinal cord injury
26. Changes in NMDA receptor subunit expression in response to contusive spinal cord injury
27. A monitored contusion model of spinal cord injury in the rat
28. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis
29. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
30. The effects of arterial blood gas values on lesion volumes in a graded rat spinal cord contusion model
31. Rodent model of chronic central pain after spinal cord contusion injury
32. Metabotropic glutamate receptors in superficial laminae of the rat dorsal horn
33. 14C]2-deoxyglucose autoradiographic study
34. Antagonism of presynaptically mediated depressant responses and cyclic AMP-coupled metabotropic glutamate receptors
35. Changes in subcellular localization of metabotropic glutamate receptor subtypes during postnatal development of mouse thalamus
36. Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocmapus
37. Spinal cord injuries - Clinical, functional, and emotional status
38. Differential involvement of group II and group III mGluRs as autoreceptors at lateral and medial perforant path synapses
39. Protein kinase C and A3 adenosine receptor activation inhibit presynaptic metabotropic glutamate receptor (mGluR) function and uncouple mGluRs from GTP-binding proteins
40. Activation of PKC disrupts presynaptic inhibition by group II and III metabotropic glutamate receptors and uncouples the receptor from GTP-binding proteins
41. Changes in amino acid concentrations over time and space around an impact injury and their diffusion through the rat spinal cord
42. Application of the Cavalieri principle and vertical sections method to lung: Estimation of volume and pleural surface area
43. AIDA reduces glutamate release and attenuates mechanical allodynia after spinal cord injury
44. Changes in metabotropic glutamate receptor expression following spinal cord injury
45. Changes in exploratory behavior as a measure of chronic central pain following spinal cord injury
46. Group I metabotropic glutamate receptors in spinal cord injury: Roles in neuroprotection and the development of chronic central pain
47. Involvement of metabotropic glutamate receptors in excitatory amino acid and GABA release following spinal cord injury
48. A relationship between protein kinase C phosphorylation and calmodulin binding to metabotropic glutamate receptor subtype 7
49. Pre- and postsynaptic localization of a metabotropic glutamate receptor, mGluR2, in the rat brain: An immunohistochemical study with a monoclonal antibody
50. Requirement of metabotropic glutamate receptors for the generation of inflamamation-evoked hyperexcitability in rat spinal cord neurons
51. Role of metabotropic glutamate receptor subtype mGluR1 in brief nociception and central sensitization of primate STT cells
52. Groups II and III metabotropic glutamate receptors differentially modulate brief and prolonged nociception in primate STT cells
53. Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced
54. Presynaptic localization of a metabotropic glutamte receptor, mGluR7, in the primary afferent neurons: An immunohistochemical study in the rat
55. A new method of quantifying the extent of tissue loss following spinal cord injury in rat
56. The metabotropic glutamate receptors, mGluR2 and mGluR3, show unique postsynaptic, presynaptic and glial localizations
57. The metabotropic glutamate receptors: Structures and functions
58. Cyclosporin A treatment following spinal cord injury to the rat: Behavioral effects and stereological assessment of tissue sparing
59. β-Adrenergic regulation of synaptic NMDA receptors by cAMP-dependent protein kinase
60. Chronic pain in a community-based sample of men with spinal cord injury: Prevalence, severity, and relationship with impairment, disability, handicap and subjective well-being
61. 2+release from rat liver hepatocytes, permeabilized hepatocytes, and isolated mitochondria
62. Distinct presynaptic metabotropic glutamate receptors for L-AP4 and CCGI on GABAergic terminals: Pharmacological evidence using novel α-methyl derivative mGluR antagonists, MAP4 and MCCG, in rat thalamus in vivo
63. cAMP-dependent protein kinase inhibits mGluR2 coupling to G-proteins by direct receptor phosphorylation
64. Understanding chronic pain after spinal cord injury
65. Differential presynaptic localization of metabotropic glutamate receptor subtypes in the hippocampus
66. The effects of G-protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin
67. Capsaicin-induced sensitization of primate spinothalamic tract cells is prevented by a protein kinase C inhibitor
68. Inflammation alters the effects of mGlu receptor agonists on spinal nociceptive neurons
69. 2+currents in pyramidal neurons of the adult rat
70. Alteration in cAMP generation and G protein subunits following transient ischemia in gerbil hippocampus
71. Presynaptic calcium current modulation by a metabotropic glutamate receptor
72. L-AP4 inhibits calcium currents and synaptic transmission via a G-protein-coupled glutamate receptor
73. Pain following spinal cord injury: Animal models and mechanistic studies
74. Pharmacological evidence for an involvement of group II and group III mGluRs in the presynaptic regulation of excitatory synaptic responses in the CA1 region of rat hippocampal slices
75. Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain
76. mGlu5 receptors and nociceptive function. II. mGlu5 receptors functionally expressed on peripheral sensory neurons mediate inflammatory hyperalgesia
77. An in vitro model of ischemia: Metabolic and electrical alterations in the hippocampal slice
78. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation: Implications for the treatment of post-injury pain hypersensitivity states
79. Evidence for a role of metabotropic glutamate receptors in sustained nociceptive inputs to rat dorsal horn neurons
80. The involvement of metabotropic glutamate receptors and their intracellular signaling pathways in sustained nociceptive transmission in rat dorsal horn neurons
81. Behavioral and electrophysiological evidence supporting a role for group 1 metabotropic glutamate receptors in mediation of nociceptive inputs to the rat spinal cord
82. 1inhibits spinal nociceptive transmission