Activation of spinal group I metabotropic glutamate receptors in rats evokes local glutamate release and spontaneous nociceptive behaviors: Effects of 2-methyl-6-(phenylethynyl)-pyridine pretreatment

Neuroscience Letters

Volumn 327, Issue 3, 2002, Pages 198-202

  Lorrain, Daniel S ^a   Correa, Lucia ^a   Anderson, Jeffery ^a   Varney, Mark ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Metabotropic glutamate receptors; Microdialysis; Pain

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 3,5 DIHYDROXYPHENYLGLYCINE; GLUTAMIC ACID; METABOTROPIC RECEPTOR;

ANIMAL BEHAVIOR; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; MALE; MICRODIALYSIS; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN; WAKEFULNESS;

ANIMALS; BEHAVIOR, ANIMAL; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; EXTRACELLULAR SPACE; GLUTAMIC ACID; GLYCINE; MALE; MICRODIALYSIS; PAIN; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; RESORCINOLS; SPINAL CORD; TIME FACTORS;

EID: 0037178637     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(02)00393-2     Document Type: Article

References (20)

1. Role of group I metabotropic glutamate receptors in traumatic spinal cord white matter injury
2. Differential distribution of metabotropic glutamate receptors 1a, 1b, and 5 in the rat spinal cord
3. Distribution and developmental changes in metabotropic glutamate receptor messenger RNA expression in the rat lumbar spinal cord
4. Regulation of neurotransmitter release by metabotropic glutamate receptors
5. 5 metabotropic glutamate receptor activation in neonatal rat cultured dorsal root ganglia neurones
6. The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception
7. Hyperalgesia and allodynia induced by intrathecal (RS)-dihydroxyphenylglycine in rats
8. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist
9. Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice
10. Type I and II metabotropic glutamate receptors mediate depressor and bradycardic actions in the nucleus of the solitary tract of anesthetized rats
11. Evidence that DHPG-induced nociception depends on glutamate release from primary afferent C-fibers
12. Astrocyte heterogeneity: Endogenous amino acid levels and release evoked by non-N-methyl-D-aspartate receptor agonist and by potassium-induced swelling in type-1 and type-2 astrocytes
13. The spinal loop dialysis catheter; Characterization of use in the unanesthetized rat
14. The induction of pain: An integrative review
15. Metabotropic glutamate receptors - immunocytochemical and in situ hybridization analyses
16. Group I and II metabotropic glutamate receptor expression in cultured rat spinal cord astrocytes
17. NMDA evokes an L-NAME sensitive spinal release of glutamate and citrulline
18. 5 subtype positively modulate neuronal glutamate release in the rat forebrain in vitro
19. 5 receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP): Complementary in vitro and in vivo evidence
20. MGluR5 metabotropic glutamate receptor distribution in rat and human spinal cord: A developmental study