Knockdown of spinal metabotropic glutamate receptor 1 (mGluR1) alleviates pain and restores opioid efficacy after nerve injury in rats

British Journal of Pharmacology

Volumn 132, Issue 1, 2001, Pages 354-367

  Fundytus, Marian E ^a,b,c   Yashpal, Kiran ^c   Chabot, Jean Guy ^d   Osborne, Michael G ^c   Lefebvre, Celeste D ^c   Dray, Andy ^b   Henry, James L ^a   Coderre, Terence J ^c,e  

^a MCGILL UNIVERSITY   (Canada)

^b Astra Research Centre Montreal   (Canada)

^c CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^d MCGILL UNIVERSITY   (Canada)

^e UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Allodynia; Antisense oligonucleotide; Hyperalgesia; Knockdown; Metabotropic glutamate receptor; Nerve injury; Neuropathy; NMDA sensitivity; Opioid analgesia; Pain

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; GLUTAMATE RECEPTOR; GLYCINE DERIVATIVE; METABOTROPIC RECEPTOR; MISSENSE OLIGODEOXYNUCLEOTIDE; MORPHINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OLIGODEOXYNUCLEOTIDE DERIVATIVE; OPIATE; PHORBOL DIBUTYRATE; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ALLODYNIA; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG SENSITIVITY; HYPERALGESIA; NERVE INJURY; NEUROPATHY; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN;

EID: 0035150239     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703810     Document Type: Article

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