Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: Identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase

Journal of Medicinal Chemistry

Volumn 39, Issue 15, 1996, Pages 2990-3000

  Monn, James A ^a   Valli, Matthew J ^a   Johnson, Bryan G ^a   Salhoff, Craig R ^a   Wright, Rebecca A ^a   Howe, Trevor ^a   Bond, Ann ^a   Lodge, David ^a   Spangle, Larry A ^a   Paschal, Jonathan W ^a   Campbell, Jack B ^a   Griffey, Kelly ^a   Tizzano, Joseph P ^a   Schoepp, Darryle D ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 4 AMINOPYRROLIDINE 2,4 DICARBOXYLATE; 4 PHOSPHONOMETHYLPIPECOLIC ACID; ADENYLATE CYCLASE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CYCLIC AMP; FORSKOLIN; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR AGONIST; INOSITOL PHOSPHATE; KAINIC ACID; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BINDING AFFINITY; BRAIN CORTEX; COMPLEX PARTIAL SEIZURE; DOSE RESPONSE; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; INTRACEREBRAL DRUG ADMINISTRATION; ISOMER; NEUROPHARMACOLOGY; NONHUMAN; RAT; RECEPTOR BINDING; SEIZURE;

ADENYLATE CYCLASE; ANIMALS; ANIMALS, NEWBORN; ANTICONVULSANTS; CEREBRAL CORTEX; CYCLIC AMP; EXCITATORY AMINO ACID AGONISTS; FORSKOLIN; GLUTAMIC ACID; HUMANS; HYDROGEN BONDING; LIMBIC SYSTEM; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROLINE; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; SEIZURES; SPINAL CORD; STEREOISOMERISM;

EID: 8944234853     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9601765     Document Type: Article

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37. 2O)) with the material prepared by the method described in Scheme 1.