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Volumn 555, Issue 1-2 SPEC. ISS., 2004, Pages 121-131

Signal transduction pathways leading to cell cycle arrest and apoptosis induction in cancer cells by Allium vegetable-derived organosulfur compounds: A review

Author keywords

Allium vegetables; Chemoprevention; Organosulfur compounds

Indexed keywords

ACETYLCYSTEINE; AJOENE; ALLYL MERCAPTOCYSTEINE; ALLYL SULFIDE; DIALLYL DISULFIDE; DIALLYL TRISULFIDE; GARLIC EXTRACT; NONSTEROID ANTIINFLAMMATORY AGENT; ORGANOSULFUR DERIVATIVE; S ALLYLCYSTEINE; UNCLASSIFIED DRUG;

EID: 5144220818     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2004.04.016     Document Type: Review
Times cited : (165)

References (98)
  • 1
    • 0035126826 scopus 로고    scopus 로고
    • Historical perspective on the use of garlic
    • R.S. Rivlin Historical perspective on the use of garlic J. Nutr. 131 2001 9515 9545
    • (2001) J. Nutr. , vol.131 , pp. 9515-9545
    • Rivlin, R.S.1
  • 2
    • 0030029823 scopus 로고    scopus 로고
    • Therapeutic actions of garlic constituents
    • K.C. Agarwal Therapeutic actions of garlic constituents Med. Res. Rev. 16 1996 111 124
    • (1996) Med. Res. Rev. , vol.16 , pp. 111-124
    • Agarwal, K.C.1
  • 3
    • 0031748853 scopus 로고    scopus 로고
    • Changes in platelet function and susceptibility of lipoproteins to oxidation associated with administration of aged garlic extract
    • M. Steiner, and R.S. Lin Changes in platelet function and susceptibility of lipoproteins to oxidation associated with administration of aged garlic extract J. Cardiovasc. Pharmacol. 31 1998 904 908
    • (1998) J. Cardiovasc. Pharmacol. , vol.31 , pp. 904-908
    • Steiner, M.1    Lin, R.S.2
  • 4
    • 0035129721 scopus 로고    scopus 로고
    • Historical perspective on garlic and cardiovascular disease
    • K. Rahman Historical perspective on garlic and cardiovascular disease J. Nutr. 131 2001 977S 979S
    • (2001) J. Nutr. , vol.131
    • Rahman, K.1
  • 5
    • 0035119879 scopus 로고    scopus 로고
    • Aged garlic extract, a modulator of cardiovascular risk factors: A dose-finding study on the effects of AGE on platelet functions
    • M. Steiner, and W. Li Aged garlic extract, a modulator of cardiovascular risk factors: a dose-finding study on the effects of AGE on platelet functions J. Nutr. 131 2001 980S 984S
    • (2001) J. Nutr. , vol.131
    • Steiner, M.1    Li, W.2
  • 6
    • 0035126521 scopus 로고    scopus 로고
    • Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide (DAS) and related compounds from garlic
    • C.S. Yang, S.K. Chhabra, J.Y. Hong, and T.J. Smith Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide (DAS) and related compounds from garlic J. Nutr. 131 2001 1041S 1045S
    • (2001) J. Nutr. , vol.131
    • Yang, C.S.1    Chhabra, S.K.2    Hong, J.Y.3    Smith, T.J.4
  • 7
    • 0034921254 scopus 로고    scopus 로고
    • Mechanisms by which garlic and allyl sulfur compounds suppress carcinogen bioactivation. Garlic and carcinogenesis
    • J.A. Milner Mechanisms by which garlic and allyl sulfur compounds suppress carcinogen bioactivation. Garlic and carcinogenesis Adv. Exp. Med. Biol. 492 2001 69 81
    • (2001) Adv. Exp. Med. Biol. , vol.492 , pp. 69-81
    • Milner, J.A.1
  • 8
    • 0037301861 scopus 로고    scopus 로고
    • Garlic [Allium sativum]: A review of its potential use as an anti-cancer agent
    • M. Thomson, and M. Ali Garlic [Allium sativum]: a review of its potential use as an anti-cancer agent Curr. Cancer Drug. 3 2003 67 81
    • (2003) Curr. Cancer Drug. , vol.3 , pp. 67-81
    • Thomson, M.1    Ali, M.2
  • 9
    • 0026177249 scopus 로고
    • Garlic compounds modulate macrophage and T-lymphocyte functions
    • B.H. Lau, T. Yamasaki, and D.S. Gridley Garlic compounds modulate macrophage and T-lymphocyte functions Mol. Biother. 3 1991 103 107
    • (1991) Mol. Biother. , vol.3 , pp. 103-107
    • Lau, B.H.1    Yamasaki, T.2    Gridley, D.S.3
  • 10
    • 0033972788 scopus 로고    scopus 로고
    • The potential application of Allium sativum (garlic) for the treatment of bladder cancer
    • D.L. Lamm, and D.R. Riggs The potential application of Allium sativum (garlic) for the treatment of bladder cancer Urol. Clin. North Am. 27 2000 157 162 xi
    • (2000) Urol. Clin. North Am. , vol.27 , pp. 157-162
    • Lamm, D.L.1    Riggs, D.R.2
  • 11
    • 0029081239 scopus 로고
    • Anti-diabetic effects of onion and garlic sulfoxide amino acids in rats
    • C.G. Sheela, K. Kumud, and K.T. Augusti Anti-diabetic effects of onion and garlic sulfoxide amino acids in rats Planta Med. 61 1995 356 357
    • (1995) Planta Med. , vol.61 , pp. 356-357
    • Sheela, C.G.1    Kumud, K.2    Augusti, K.T.3
  • 12
    • 9044251597 scopus 로고    scopus 로고
    • Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin secretagogue, in diabetic rats
    • K.T. Augusti, and C.G. Sheela Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin secretagogue, in diabetic rats Experientia 52 1996 115 120
    • (1996) Experientia , vol.52 , pp. 115-120
    • Augusti, K.T.1    Sheela, C.G.2
  • 13
    • 0029615520 scopus 로고
    • In vivo radioprotection with garlic extract
    • S.P. Singh, S.K. Abraham, and P.C. Kesavan In vivo radioprotection with garlic extract Mutat. Res. 345 1995 147 153
    • (1995) Mutat. Res. , vol.345 , pp. 147-153
    • Singh, S.P.1    Abraham, S.K.2    Kesavan, P.C.3
  • 14
    • 0029933775 scopus 로고    scopus 로고
    • Radioprotection of mice following garlic pretreatment
    • S.P. Singh, S.K. Abraham, and P.C. Kesavan Radioprotection of mice following garlic pretreatment Br. J. Cancer Suppl. 27 1996 102 104
    • (1996) Br. J. Cancer Suppl. , vol.27 , pp. 102-104
    • Singh, S.P.1    Abraham, S.K.2    Kesavan, P.C.3
  • 16
    • 0034047349 scopus 로고    scopus 로고
    • Allylsulfide constituents of garlic volatile oil as antimicrobial agents
    • P. Avato, E. Tursil, C. Vitali, V. Miccolis, and V. Candido Allylsulfide constituents of garlic volatile oil as antimicrobial agents Phytomedicine 7 2000 239 243
    • (2000) Phytomedicine , vol.7 , pp. 239-243
    • Avato, P.1    Tursil, E.2    Vitali, C.3    Miccolis, V.4    Candido, V.5
  • 18
    • 0029932180 scopus 로고    scopus 로고
    • Aged garlic extract prolongs longevity and improves spatial memory deficit in senescence-accelerated mouse
    • T. Moriguchi, H. Saito, and N. Nishiyama Aged garlic extract prolongs longevity and improves spatial memory deficit in senescence-accelerated mouse Biol. Pharm. Bull. 19 1996 305 307
    • (1996) Biol. Pharm. Bull. , vol.19 , pp. 305-307
    • Moriguchi, T.1    Saito, H.2    Nishiyama, N.3
  • 19
    • 0030899549 scopus 로고    scopus 로고
    • Beneficial effects of aged garlic extract on learning and memory impairment in the senescence-accelerated mouse
    • N. Nishiyama, T. Moriguchi, and H. Saito Beneficial effects of aged garlic extract on learning and memory impairment in the senescence-accelerated mouse Exp. Gerontol. 32 1997 149 160
    • (1997) Exp. Gerontol. , vol.32 , pp. 149-160
    • Nishiyama, N.1    Moriguchi, T.2    Saito, H.3
  • 23
    • 0022039421 scopus 로고
    • The chemistry of garlic and onions
    • E. Block The chemistry of garlic and onions Sci. Am. 252 1985 114 119
    • (1985) Sci. Am. , vol.252 , pp. 114-119
    • Block, E.1
  • 24
    • 0020964874 scopus 로고
    • Onion and garlic oils inhibit tumor promotion
    • S. Belman Onion and garlic oils inhibit tumor promotion Carcinogenesis 4 1983 1063 1065
    • (1983) Carcinogenesis , vol.4 , pp. 1063-1065
    • Belman, S.1
  • 25
    • 0022512295 scopus 로고
    • Effects of allyl methyl trisulfide on glutathione S-transferase activity and BP-induced neoplasia in the mouse
    • V.L. Sparnins, A.W. Mott, G. Barany, and L.W. Wattenberg Effects of allyl methyl trisulfide on glutathione S-transferase activity and BP-induced neoplasia in the mouse Nutr. Cancer 8 1986 211 215
    • (1986) Nutr. Cancer , vol.8 , pp. 211-215
    • Sparnins, V.L.1    Mott, A.W.2    Barany, G.3    Wattenberg, L.W.4
  • 26
    • 0023221785 scopus 로고
    • Diallyl sulfide, a flavor component of garlic (Allium sativum), inhibits dimethylhydrazine-induced colon cancer
    • M.J. Wargovich Diallyl sulfide, a flavor component of garlic (Allium sativum), inhibits dimethylhydrazine-induced colon cancer Carcinogenesis 8 1987 487 489
    • (1987) Carcinogenesis , vol.8 , pp. 487-489
    • Wargovich, M.J.1
  • 27
    • 0024273970 scopus 로고
    • Chemoprevention of N-nitrosomethylbenzylamine-induced esophageal cancer in rats by the naturally occurring thioether, diallyl sulfide
    • M.J. Wargovich, C. Woods, V.W. Eng, L.C. Stephens, and K. Gray Chemoprevention of N-nitrosomethylbenzylamine-induced esophageal cancer in rats by the naturally occurring thioether, diallyl sulfide Cancer Res. 48 1988 6872 6875
    • (1988) Cancer Res. , vol.48 , pp. 6872-6875
    • Wargovich, M.J.1    Woods, C.2    Eng, V.W.3    Stephens, L.C.4    Gray, K.5
  • 28
    • 0025030412 scopus 로고
    • Chemoprevention of 1,2-dimethylhydrazine-induced colon cancer in mice by naturally occurring organosulfur compounds
    • H. Sumiyoshi, and M.J. Wargovich Chemoprevention of 1,2- dimethylhydrazine-induced colon cancer in mice by naturally occurring organosulfur compounds Cancer Res. 50 1990 5084 5087
    • (1990) Cancer Res. , vol.50 , pp. 5084-5087
    • Sumiyoshi, H.1    Wargovich, M.J.2
  • 29
    • 0027290648 scopus 로고
    • Chemoprevention of colon carcinogenesis by organosulfur compounds
    • B.S. Reddy, C.V. Rao, A. Rivenson, and G. Kelloff Chemoprevention of colon carcinogenesis by organosulfur compounds Cancer Res. 53 1993 3493 3498
    • (1993) Cancer Res. , vol.53 , pp. 3493-3498
    • Reddy, B.S.1    Rao, C.V.2    Rivenson, A.3    Kelloff, G.4
  • 30
    • 0026736766 scopus 로고
    • Enhancing effects of diallyl sulfide on hepatocarcinogenesis and inhibitory actions of the related diallyl disulfide on colon and renal carcinogenesis in rats
    • S. Takahashi, K. Hakoi, H. Yada, M. Hirose, N. Ito, and S. Fukushima Enhancing effects of diallyl sulfide on hepatocarcinogenesis and inhibitory actions of the related diallyl disulfide on colon and renal carcinogenesis in rats Carcinogenesis 13 1992 1513 1518
    • (1992) Carcinogenesis , vol.13 , pp. 1513-1518
    • Takahashi, S.1    Hakoi, K.2    Yada, H.3    Hirose, M.4    Ito, N.5    Fukushima, S.6
  • 31
    • 0029936481 scopus 로고    scopus 로고
    • Garlic and associated allyl sulfur components inhibit N-methyl-N-nitrosourea induced rat mammary carcinogenesis
    • E.M. Schaffer, J.Z. Liu, J. Green, C.A. Dangler, and J.A. Milner Garlic and associated allyl sulfur components inhibit N-methyl-N-nitrosourea induced rat mammary carcinogenesis Cancer Lett. 102 1996 199 204
    • (1996) Cancer Lett. , vol.102 , pp. 199-204
    • Schaffer, E.M.1    Liu, J.Z.2    Green, J.3    Dangler, C.A.4    Milner, J.A.5
  • 32
    • 0024378052 scopus 로고
    • Inhibition of N-nitrosodiethylamine carcinogenesis in mice by naturally occurring organosulfur compounds and monoterpenes
    • L.W. Wattenberg, V.L. Sparnins, and G. Barany Inhibition of N-nitrosodiethylamine carcinogenesis in mice by naturally occurring organosulfur compounds and monoterpenes Cancer Res. 49 1989 2689 2692
    • (1989) Cancer Res. , vol.49 , pp. 2689-2692
    • Wattenberg, L.W.1    Sparnins, V.L.2    Barany, G.3
  • 33
    • 0030761364 scopus 로고    scopus 로고
    • Inhibitory effects of diallyl disulfide or aspirin on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mammary carcinogenesis in rats
    • N. Suzui, S. Sugie, K.M. Rahman, M. Ohnishi, N. Yoshimi, K. Wakabayashi, and H. Mori Inhibitory effects of diallyl disulfide or aspirin on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mammary carcinogenesis in rats Jpn. J. Cancer Res. 88 1997 705 711
    • (1997) Jpn. J. Cancer Res. , vol.88 , pp. 705-711
    • Suzui, N.1    Sugie, S.2    Rahman, K.M.3    Ohnishi, M.4    Yoshimi, N.5    Wakabayashi, K.6    Mori, H.7
  • 35
    • 1842848678 scopus 로고    scopus 로고
    • Anticarcinogenic effect and modification of cytochrome P4502E1 by dietary garlic powder in diethylnitrosamine-initiated rat hepatocarcinogenesis
    • K.A. Park, S. Kweon, and H. Choi Anticarcinogenic effect and modification of cytochrome P4502E1 by dietary garlic powder in diethylnitrosamine-initiated rat hepatocarcinogenesis J. Biochem. Mol. Biol. 35 2002 615 622
    • (2002) J. Biochem. Mol. Biol. , vol.35 , pp. 615-622
    • Park, K.A.1    Kweon, S.2    Choi, H.3
  • 36
    • 0020076847 scopus 로고
    • Glutathione S-transferase activity: Enhancement by compounds inhibiting chemical carcinogenesis and by dietary constituents
    • V.L. Sparnins, P.L. Venegas, L.W. Wattenberg, and Glutathione S-transferase activity: enhancement by compounds inhibiting chemical carcinogenesis and by dietary constituents J. Natl. Cancer Inst. 68 1982 493 496
    • (1982) J. Natl. Cancer Inst. , vol.68 , pp. 493-496
    • Sparnins, V.L.1    Venegas, P.L.2    Wattenberg, L.W.3
  • 38
    • 0031569814 scopus 로고    scopus 로고
    • Glutathione S-transferases of female A/J mouse lung and their induction by anticarcinogenic organosulfides from garlic
    • X. Hu, and S.V. Singh Glutathione S-transferases of female A/J mouse lung and their induction by anticarcinogenic organosulfides from garlic Arch. Biochem. Biophys. 340 1997 279 286
    • (1997) Arch. Biochem. Biophys. , vol.340 , pp. 279-286
    • Hu, X.1    Singh, S.V.2
  • 39
    • 0035934441 scopus 로고    scopus 로고
    • Antimutagenic activity of organosulfur compounds from Allium is associated with phase II enzyme induction
    • D. Guyonnet, C. Belloir, M. Suschetet, M.H. Siess, and A.M. Le Bon Antimutagenic activity of organosulfur compounds from Allium is associated with phase II enzyme induction Mutat. Res. 495 2001 135 145
    • (2001) Mutat. Res. , vol.495 , pp. 135-145
    • Guyonnet, D.1    Belloir, C.2    Suschetet, M.3    Siess, M.H.4    Le Bon, A.M.5
  • 40
    • 0035732772 scopus 로고    scopus 로고
    • Relative activities of organosulfur compounds derived from onions and garlic in increasing tissue activities of quinone reductase and glutathione transferase in rat tissues
    • R. Munday, and C.M. Munday Relative activities of organosulfur compounds derived from onions and garlic in increasing tissue activities of quinone reductase and glutathione transferase in rat tissues Nutr. Cancer 40 2001 205 210
    • (2001) Nutr. Cancer , vol.40 , pp. 205-210
    • Munday, R.1    Munday, C.M.2
  • 41
    • 0012679602 scopus 로고    scopus 로고
    • Effects of garlic thioallyl derivatives on growth, glutathione concentration, and polyamine formation of human prostate carcinoma cells in culture
    • J.T. Pinto, C. Qiao, J. Xing, R.S. Rivlin, M.L. Protomastro, M.L. Weissler, Y. Tao, H. Thaler, and W.D. Heston Effects of garlic thioallyl derivatives on growth, glutathione concentration, and polyamine formation of human prostate carcinoma cells in culture Am. J. Clin. Nutr. 66 1997 398 405
    • (1997) Am. J. Clin. Nutr. , vol.66 , pp. 398-405
    • Pinto, J.T.1    Qiao, C.2    Xing, J.3    Rivlin, R.S.4    Protomastro, M.L.5    Weissler, M.L.6    Tao, Y.7    Thaler, H.8    Heston, W.D.9
  • 42
    • 0029936374 scopus 로고    scopus 로고
    • Chemopreventive effect of S-allylcysteine and its relationship to the detoxification enzyme glutathione S-transferase
    • S. Hatono, A. Jimenez, and M.J. Wargovich Chemopreventive effect of S-allylcysteine and its relationship to the detoxification enzyme glutathione S-transferase Carcinogenesis 17 1996 1041 1044
    • (1996) Carcinogenesis , vol.17 , pp. 1041-1044
    • Hatono, S.1    Jimenez, A.2    Wargovich, M.J.3
  • 44
    • 0036709597 scopus 로고    scopus 로고
    • Cellular glutathione and thiol metabolism
    • D.A. Dickinson, and H.J. Forman Cellular glutathione and thiol metabolism Biochem. Pharmacol. 64 2002 1019 1026
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 1019-1026
    • Dickinson, D.A.1    Forman, H.J.2
  • 45
    • 0030583242 scopus 로고    scopus 로고
    • Novel anti-carcinogenic activity of an organosulfide from garlic: Inhibition of H-RAS oncogene transformed tumor growth in vivo by diallyl disulfide is associated with inhibition of p21H-ras processing
    • S.V. Singh, R.R. Mohan, R. Agarwal, P.J. Benson, X. Hu, M.A. Rudy, H. Xia, A. Katoh, S.K. Srivastava, H. Mukhtar, V. Gupta, and H.A. Zaren Novel anti-carcinogenic activity of an organosulfide from garlic: inhibition of H-RAS oncogene transformed tumor growth in vivo by diallyl disulfide is associated with inhibition of p21H-ras processing Biochem. Biophys. Res. Commun. 225 1996 660 665
    • (1996) Biochem. Biophys. Res. Commun. , vol.225 , pp. 660-665
    • Singh, S.V.1    Mohan, R.R.2    Agarwal, R.3    Benson, P.J.4    Hu, X.5    Rudy, M.A.6    Xia, H.7    Katoh, A.8    Srivastava, S.K.9    Mukhtar, H.10    Gupta, V.11    Zaren, H.A.12
  • 46
    • 0035125669 scopus 로고    scopus 로고
    • Impact of garlic organosulfides on p21(H-ras) processing
    • S.V. Singh Impact of garlic organosulfides on p21(H-ras) processing J. Nutr. 131 2001 10465 10485
    • (2001) J. Nutr. , vol.131 , pp. 10465-10485
    • Singh, S.V.1
  • 47
    • 0842324788 scopus 로고    scopus 로고
    • Recycling the cell cycle: Cyclins revisited
    • A.W. Murray Recycling the cell cycle: cyclins revisited Cell 116 2004 221 234
    • (2004) Cell , vol.116 , pp. 221-234
    • Murray, A.W.1
  • 48
    • 0020961333 scopus 로고
    • Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division
    • T. Evans, E.T. Rosenthal, J. Youngblom, D. Distel, and T. Hunt Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division Cell 33 1983 389 396
    • (1983) Cell , vol.33 , pp. 389-396
    • Evans, T.1    Rosenthal, E.T.2    Youngblom, J.3    Distel, D.4    Hunt, T.5
  • 49
    • 0024425887 scopus 로고
    • Checkpoints: Controls that ensure the order of cell cycle events
    • L.H. Hartwell, and T.A. Weinert Checkpoints: controls that ensure the order of cell cycle events Science 246 1989 629 634
    • (1989) Science , vol.246 , pp. 629-634
    • Hartwell, L.H.1    Weinert, T.A.2
  • 50
    • 0030611095 scopus 로고    scopus 로고
    • Mitotic G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
    • C.Y. Peng, P.R. Graves, R.S. Thoma, Z. Wu, A.S. Shaw, and H. Piwnica-Worms Mitotic G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216 Science 277 1997 1501 1505
    • (1997) Science , vol.277 , pp. 1501-1505
    • Peng, C.Y.1    Graves, P.R.2    Thoma, R.S.3    Wu, Z.4    Shaw, A.S.5    Piwnica-Worms, H.6
  • 51
    • 0031028382 scopus 로고    scopus 로고
    • Nuclear localization of cyclin B1 mediates its biological activity and is regulated by phosphorylation
    • J. Li, A.N. Meyer, and D.J. Donoghue Nuclear localization of cyclin B1 mediates its biological activity and is regulated by phosphorylation Proc. Natl. Acad. Sci. U.S.A. 94 1997 502 507
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 502-507
    • Li, J.1    Meyer, A.N.2    Donoghue, D.J.3
  • 52
    • 0032525308 scopus 로고    scopus 로고
    • Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint
    • F. Toyoshima, T. Moriguchi, A. Wada, M. Fukuda, and E. Nishida Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint EMBO J. 17 1998 2728 2735
    • (1998) EMBO J. , vol.17 , pp. 2728-2735
    • Toyoshima, F.1    Moriguchi, T.2    Wada, A.3    Fukuda, M.4    Nishida, E.5
  • 53
    • 0031596406 scopus 로고    scopus 로고
    • Depressed p34cdc2 kinase activity and G2/M phase arrest induced by diallyl disulfide in HCT-15 cells
    • L.M. Knowles, and J.A. Milner Depressed p34cdc2 kinase activity and G2/M phase arrest induced by diallyl disulfide in HCT-15 cells Nutr. Cancer 30 1998 169 174
    • (1998) Nutr. Cancer , vol.30 , pp. 169-174
    • Knowles, L.M.1    Milner, J.A.2
  • 54
    • 0034130821 scopus 로고    scopus 로고
    • Diallyl disulfide inhibits p34(cdc2) kinase activity through changes in complex formation and phosphorylation
    • L.M. Knowles, and J.A. Milner Diallyl disulfide inhibits p34(cdc2) kinase activity through changes in complex formation and phosphorylation Carcinogenesis 21 2000 1129 1134
    • (2000) Carcinogenesis , vol.21 , pp. 1129-1134
    • Knowles, L.M.1    Milner, J.A.2
  • 55
    • 0028173798 scopus 로고
    • 2+ triggers premature inactivation of the cdc2 protein kinase in permeabilized sea urchin embryos
    • 2+ triggers premature inactivation of the cdc2 protein kinase in permeabilized sea urchin embryos Proc. Natl. Acad. Sci. U.S.A. 91 1994 6176 6180
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 6176-6180
    • Suprynowicz, F.A.1    Prusmack, C.2    Whalley, T.3
  • 56
    • 0030071542 scopus 로고    scopus 로고
    • Diallyl disulfide inhibits the proliferation of human tumor cells in culture
    • S.G. Sundaram, and J.A. Milner Diallyl disulfide inhibits the proliferation of human tumor cells in culture Biochim. Biophys. Acta 1315 1996 15 20
    • (1996) Biochim. Biophys. Acta , vol.1315 , pp. 15-20
    • Sundaram, S.G.1    Milner, J.A.2
  • 57
    • 0042920605 scopus 로고    scopus 로고
    • Diallyl disulfide induces ERK phosphorylation and alters gene expression profiles in human colon tumor cells
    • L.M. Knowles, and J.A. Milner Diallyl disulfide induces ERK phosphorylation and alters gene expression profiles in human colon tumor cells J. Nutr. 133 2003 2901 2906
    • (2003) J. Nutr. , vol.133 , pp. 2901-2906
    • Knowles, L.M.1    Milner, J.A.2
  • 58
    • 0034903749 scopus 로고    scopus 로고
    • Effects of the garlic compound diallyl disulfide on the metabolism, adherence and cell cycle of HT-29 colon carcinoma cells: Evidence of sensitive and resistant sub-populations
    • V. Robert, B. Mouille, C. Mayeur, M. Michaud, and F. Blachier Effects of the garlic compound diallyl disulfide on the metabolism, adherence and cell cycle of HT-29 colon carcinoma cells: evidence of sensitive and resistant sub-populations Carcinogenesis 22 2001 1155 1161
    • (2001) Carcinogenesis , vol.22 , pp. 1155-1161
    • Robert, V.1    Mouille, B.2    Mayeur, C.3    Michaud, M.4    Blachier, F.5
  • 59
    • 0034434222 scopus 로고    scopus 로고
    • Cell cycle arrest and differential gene expression in HT-29 cells exposed to an aqueous garlic extract
    • D.J. Frantz, B.G. Hughes, D.R. Nelson, B.K. Murray, and M.J. Christensen Cell cycle arrest and differential gene expression in HT-29 cells exposed to an aqueous garlic extract Nutr. Cancer 38 2000 255 264
    • (2000) Nutr. Cancer , vol.38 , pp. 255-264
    • Frantz, D.J.1    Hughes, B.G.2    Nelson, D.R.3    Murray, B.K.4    Christensen, M.J.5
  • 60
    • 0036257468 scopus 로고    scopus 로고
    • Antitumor activity of Z-ajoene, a natural compound purified from garlic: Antimitotic and microtubule-interaction properties
    • M. Li, J.R. Ciu, Y. Ye, J.M. Min, L.H. Zhang, K. Wang, M. Gares, J. Cros, M. Wright, and J. Leung-Tack Antitumor activity of Z-ajoene, a natural compound purified from garlic: antimitotic and microtubule-interaction properties Carcinogenesis 23 2002 573 579
    • (2002) Carcinogenesis , vol.23 , pp. 573-579
    • Li, M.1    Ciu, J.R.2    Ye, Y.3    Min, J.M.4    Zhang, L.H.5    Wang, K.6    Gares, M.7    Cros, J.8    Wright, M.9    Leung-Tack, J.10
  • 62
    • 5144234540 scopus 로고    scopus 로고
    • Oligosulfide chain lengh and allyl groups are critical structural determinants for antiproliferative activity of garlic-derived organosulfides against PC-3 human prostate cancer cells
    • K. Lew, D. Xiao, Y. Zeng, and S.V. Singh Oligosulfide chain lengh and allyl groups are critical structural determinants for antiproliferative activity of garlic-derived organosulfides against PC-3 human prostate cancer cells Proc. Am. Assoc. Cancer Res. 44 Suppl. 2003 197
    • (2003) Proc. Am. Assoc. Cancer Res. , vol.44 , pp. 197
    • Lew, K.1    Xiao, D.2    Zeng, Y.3    Singh, S.V.4
  • 63
    • 5144229511 scopus 로고    scopus 로고
    • Diallyl trisulfide, a garlic-derived organosulfide, causes G2/M arrest in PC-3 human prostate cancer cells by promoting proteasome-mediated degradation of Cdc25C phosphatase
    • D. Xiao, and S.V. Singh Diallyl trisulfide, a garlic-derived organosulfide, causes G2/M arrest in PC-3 human prostate cancer cells by promoting proteasome-mediated degradation of Cdc25C phosphatase Proc. Am. Assoc. Cancer Res. 44 Suppl. 2003 425
    • (2003) Proc. Am. Assoc. Cancer Res. , vol.44 , pp. 425
    • Xiao, D.1    Singh, S.V.2
  • 64
    • 0033173102 scopus 로고    scopus 로고
    • Increased acetylation of histones induced by diallyl disulfide and structurally related molecules
    • M.A. Lea, V.M. Randolph, and M. Patel Increased acetylation of histones induced by diallyl disulfide and structurally related molecules Int. J. Oncol. 15 1999 347 352
    • (1999) Int. J. Oncol. , vol.15 , pp. 347-352
    • Lea, M.A.1    Randolph, V.M.2    Patel, M.3
  • 65
    • 0035156867 scopus 로고    scopus 로고
    • Induction of histone acetylation in rat liver and hepatoma by organosulfur compounds including diallyl disulfide
    • M.A. Lea, and V.M. Randolph Induction of histone acetylation in rat liver and hepatoma by organosulfur compounds including diallyl disulfide Anticancer Res. 21 2001 2841 2845
    • (2001) Anticancer Res. , vol.21 , pp. 2841-2845
    • Lea, M.A.1    Randolph, V.M.2
  • 66
    • 0036437194 scopus 로고    scopus 로고
    • Induction of histone acetylation and inhibition of growth of mouse erythroleukemia cells by S-allylmercaptocysteine
    • M.A. Lea, M. Rasheed, V.M. Randolph, F. Khan, A. Shareef, and C. desBordes Induction of histone acetylation and inhibition of growth of mouse erythroleukemia cells by S-allylmercaptocysteine Nutr. Cancer 43 2002 90 102
    • (2002) Nutr. Cancer , vol.43 , pp. 90-102
    • Lea, M.A.1    Rasheed, M.2    Randolph, V.M.3    Khan, F.4    Shareef, A.5    Desbordes, C.6
  • 67
    • 3242755145 scopus 로고    scopus 로고
    • Diallyl disulfide (DADS) increases histone acetylation and p21waf1/cyp1 expression in human colon tumor cell lines
    • N. Druesne, A. Pagniez, C. Mayeur, M. Thomas, C. Cherbuy, P.H. Duee, P. Martel, and C. Chaumontet Diallyl disulfide (DADS) increases histone acetylation and p21waf1/cyp1 expression in human colon tumor cell lines Carcinogenesis 25 2004 1227 1236
    • (2004) Carcinogenesis , vol.25 , pp. 1227-1236
    • Druesne, N.1    Pagniez, A.2    Mayeur, C.3    Thomas, M.4    Cherbuy, C.5    Duee, P.H.6    Martel, P.7    Chaumontet, C.8
  • 68
    • 0038676409 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase activity by butyrate
    • J.R. Davie Inhibition of histone deacetylase activity by butyrate J. Nutr. 133 2003 2485S 2493S
    • (2003) J. Nutr. , vol.133
    • Davie, J.R.1
  • 69
    • 0031961995 scopus 로고    scopus 로고
    • Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: PRb is a critical determinant in blocking DNA replication and in preventing endoreduplication
    • A.B. Niculescu III, X. Chen, M. Smeets, L. Hengst, C. Prives, and S.I. Reed Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication Mol. Cell. Biol. 18 1998 629 643
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 629-643
    • Niculescu III, A.B.1    Chen, X.2    Smeets, M.3    Hengst, L.4    Prives, C.5    Reed, S.I.6
  • 70
    • 0034616946 scopus 로고    scopus 로고
    • Apoptotic pathways: Paper wraps stone blunts scissors
    • D.R. Green Apoptotic pathways: paper wraps stone blunts scissors Cell 102 2000 1 4
    • (2000) Cell , vol.102 , pp. 1-4
    • Green, D.R.1
  • 71
    • 0034953632 scopus 로고    scopus 로고
    • Apoptosis-regulating proteins as targets for drug discovery
    • J.C. Reed Apoptosis-regulating proteins as targets for drug discovery Trends Mol. Med. 7 2001 314 319
    • (2001) Trends Mol. Med. , vol.7 , pp. 314-319
    • Reed, J.C.1
  • 72
    • 0035736259 scopus 로고    scopus 로고
    • Organelle-specific initiation of cell death pathways
    • K.F. Ferri, and G. Kroemer Organelle-specific initiation of cell death pathways Nat. Cell Biol. 3 2001 255 263
    • (2001) Nat. Cell Biol. , vol.3 , pp. 255-263
    • Ferri, K.F.1    Kroemer, G.2
  • 74
    • 0034068601 scopus 로고    scopus 로고
    • Mitochondrial control of cell death
    • G. Kroemer, and J.C. Reed Mitochondrial control of cell death Nat. Med. 6 2000 513 519
    • (2000) Nat. Med. , vol.6 , pp. 513-519
    • Kroemer, G.1    Reed, J.C.2
  • 75
    • 0033179760 scopus 로고    scopus 로고
    • BCL-2 family members and the mitochondria in apoptosis
    • A. Gross, J.M. McDonnell, and S.J. Korsmeyer BCL-2 family members and the mitochondria in apoptosis Genes Dev. 13 1999 1899 1911
    • (1999) Genes Dev. , vol.13 , pp. 1899-1911
    • Gross, A.1    McDonnell, J.M.2    Korsmeyer, S.J.3
  • 76
    • 0030892234 scopus 로고    scopus 로고
    • Apoptosis by death factor
    • S. Nagata Apoptosis by death factor Cell 88 1997 355 365
    • (1997) Cell , vol.88 , pp. 355-365
    • Nagata, S.1
  • 77
    • 85009834484 scopus 로고    scopus 로고
    • Ajoene, an experimental anti-leukemic drug: Mechanism of cell death
    • V.M. Dirsch, D.S. Antlsperger, H. Hentze, and A.M. Vollmar Ajoene, an experimental anti-leukemic drug: mechanism of cell death Leukemia 16 2002 74 83
    • (2002) Leukemia , vol.16 , pp. 74-83
    • Dirsch, V.M.1    Antlsperger, D.S.2    Hentze, H.3    Vollmar, A.M.4
  • 78
    • 0029670590 scopus 로고    scopus 로고
    • New members of the Bcl-2 family and their protein partners
    • S.N. Farrow, and R. Brown New members of the Bcl-2 family and their protein partners Curr. Opin. Genet. Dev. 6 1996 45 49
    • (1996) Curr. Opin. Genet. Dev. , vol.6 , pp. 45-49
    • Farrow, S.N.1    Brown, R.2
  • 80
    • 0034734611 scopus 로고    scopus 로고
    • Effects of allyl sulfur compounds and garlic extract on the expression of Bcl-2, Bax, and p53 in non small cell lung cancer cell lines
    • Y.S. Hong, Y.A. Ham, J.H. Choi, and J. Kim Effects of allyl sulfur compounds and garlic extract on the expression of Bcl-2, Bax, and p53 in non small cell lung cancer cell lines Exp. Mol. Med. 32 2000 127 134
    • (2000) Exp. Mol. Med. , vol.32 , pp. 127-134
    • Hong, Y.S.1    Ham, Y.A.2    Choi, J.H.3    Kim, J.4
  • 82
    • 0036221283 scopus 로고    scopus 로고
    • Diallyl disulfide (DADS) induces the antitumorigenic NSAID-activated gene (NAG-1) by a p53-dependent mechanism in human colorectal HCT 116 cells
    • F.G. Bottone Jr., S.J. Baek, J.B. Nixon, and T.E. Eling Diallyl disulfide (DADS) induces the antitumorigenic NSAID-activated gene (NAG-1) by a p53-dependent mechanism in human colorectal HCT 116 cells J. Nutr. 132 2002 773 778
    • (2002) J. Nutr. , vol.132 , pp. 773-778
    • Bottone Jr., F.G.1    Baek, S.J.2    Nixon, J.B.3    Eling, T.E.4
  • 83
    • 0033533499 scopus 로고    scopus 로고
    • Phosphorylation and proteasome-dependent degradation of Bcl-2 in mitotic-arrested cells after microtubule damage
    • P. Chadebech, L. Brichese, V. Baldin, S. Vidal, and A. Valette Phosphorylation and proteasome-dependent degradation of Bcl-2 in mitotic-arrested cells after microtubule damage Biochem. Biophys. Res. Commun. 262 1999 823 827
    • (1999) Biochem. Biophys. Res. Commun. , vol.262 , pp. 823-827
    • Chadebech, P.1    Brichese, L.2    Baldin, V.3    Vidal, S.4    Valette, A.5
  • 85
    • 0031976715 scopus 로고    scopus 로고
    • Ajoene, a compound of garlic, induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor kappaB
    • V.M. Dirsch, A.L. Gerbes, and A.M. Vollmar Ajoene, a compound of garlic, induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor kappaB Mol. Pharmacol. 53 1998 402 407
    • (1998) Mol. Pharmacol. , vol.53 , pp. 402-407
    • Dirsch, V.M.1    Gerbes, A.L.2    Vollmar, A.M.3
  • 87
    • 0141842655 scopus 로고    scopus 로고
    • Reactive oxygen species-dependent c-Jun NH2-terminal kinase/c-Jun signaling cascade mediates neuroblastoma cell death induced by diallyl disulfide
    • G. Filomeni, K. Aquilano, G. Rotilio, and M.R. Ciriolo Reactive oxygen species-dependent c-Jun NH2-terminal kinase/c-Jun signaling cascade mediates neuroblastoma cell death induced by diallyl disulfide Cancer Res. 63 2003 5940 5949
    • (2003) Cancer Res. , vol.63 , pp. 5940-5949
    • Filomeni, G.1    Aquilano, K.2    Rotilio, G.3    Ciriolo, M.R.4
  • 88
    • 3342895063 scopus 로고    scopus 로고
    • Diallyl trisulfide-induced apoptosis in human prostate cancer cells is mediated by activation of c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2
    • D. Xiao, S.A. Choi, D.E. Johnson, V. Vogel, C.S. Johnson, D.L. Trump, Y. Lee, S.V. Singh, Diallyl trisulfide-induced apoptosis in human prostate cancer cells is mediated by activation of c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2, Oncogene 23 (2004) 5594-5606.
    • (2004) Oncogene , vol.23 , pp. 5594-5606
    • Xiao, D.1    Choi, S.A.2    Johnson, D.E.3    Vogel, V.4    Johnson, C.S.5    Trump, D.L.6    Lee, Y.7    Singh, S.V.8
  • 89
    • 0037473080 scopus 로고    scopus 로고
    • Ajoene-induced cell death in human promyeloleukemic cells does not require JNK but is amplified by the inhibition of ERK
    • D.S. Antlsperger, V.M. Dirsch, D. Ferreira, J.L. Su, M.L. Kuo, and A.M. Vollmar Ajoene-induced cell death in human promyeloleukemic cells does not require JNK but is amplified by the inhibition of ERK Oncogene 22 2003 582 589
    • (2003) Oncogene , vol.22 , pp. 582-589
    • Antlsperger, D.S.1    Dirsch, V.M.2    Ferreira, D.3    Su, J.L.4    Kuo, M.L.5    Vollmar, A.M.6
  • 90
    • 0029854544 scopus 로고    scopus 로고
    • Free radicals, proteins and DNA: Oxidative damage versus redox regulation
    • B. Halliwell Free radicals, proteins and DNA: oxidative damage versus redox regulation Biochem. Soc. Trans. 24 1996 1023 1027
    • (1996) Biochem. Soc. Trans. , vol.24 , pp. 1023-1027
    • Halliwell, B.1
  • 92
    • 2242445273 scopus 로고    scopus 로고
    • Role of glutaredoxin in metabolic oxidative stress. Glutaredoxin as a sensor of oxidative stress mediated by H2O2
    • J.J. Song, J.G. Rhee, M. Suntharalingam, S.A. Walsh, D.R. Spitz, and Y.J. Lee Role of glutaredoxin in metabolic oxidative stress. Glutaredoxin as a sensor of oxidative stress mediated by H2O2 J. Biol. Chem. 277 2002 46566 46575
    • (2002) J. Biol. Chem. , vol.277 , pp. 46566-46575
    • Song, J.J.1    Rhee, J.G.2    Suntharalingam, M.3    Walsh, S.A.4    Spitz, D.R.5    Lee, Y.J.6
  • 93
    • 0042068217 scopus 로고    scopus 로고
    • Differential role of glutaredoxin and thioredoxin in metabolic oxidative stress-induced activation of apoptosis signal-regulating kinase 1
    • J.J. Song, and Y.J. Lee Differential role of glutaredoxin and thioredoxin in metabolic oxidative stress-induced activation of apoptosis signal-regulating kinase 1 Biochem. J. 373 2003 845 853
    • (2003) Biochem. J. , vol.373 , pp. 845-853
    • Song, J.J.1    Lee, Y.J.2
  • 94
    • 0037941588 scopus 로고    scopus 로고
    • When calcium goes wrong: Genetic alterations of a ubiquitous signaling route
    • R. Rizzuto, and T. Pozzan When calcium goes wrong: genetic alterations of a ubiquitous signaling route Nat. Genet. 34 2003 135 141
    • (2003) Nat. Genet. , vol.34 , pp. 135-141
    • Rizzuto, R.1    Pozzan, T.2
  • 95
    • 0029970362 scopus 로고    scopus 로고
    • Diallyl disulfide induces apoptosis of human colon tumor cells
    • S.G. Sundaram, and J.A. Milner Diallyl disulfide induces apoptosis of human colon tumor cells Carcinogenesis 17 1996 669 673
    • (1996) Carcinogenesis , vol.17 , pp. 669-673
    • Sundaram, S.G.1    Milner, J.A.2
  • 96
    • 0031445546 scopus 로고    scopus 로고
    • Allyl sulfides from garlic suppress the in vitro proliferation of human A549 lung tumor cells
    • K. Sakamoto, L.D. Lawson, and J.A. Milner Allyl sulfides from garlic suppress the in vitro proliferation of human A549 lung tumor cells Nutr. Cancer 29 1997 152 156
    • (1997) Nutr. Cancer , vol.29 , pp. 152-156
    • Sakamoto, K.1    Lawson, L.D.2    Milner, J.A.3
  • 97
    • 0037205963 scopus 로고    scopus 로고
    • Role of Ca(2+) in diallyl disulfide-induced apoptotic cell death of HCT-15 cells
    • E.K. Park, K.B. Kwon, K.I. Park, B.H. Park, and E.C. Jhee Role of Ca(2+) in diallyl disulfide-induced apoptotic cell death of HCT-15 cells Exp. Mol. Med. 34 2002 250 257
    • (2002) Exp. Mol. Med. , vol.34 , pp. 250-257
    • Park, E.K.1    Kwon, K.B.2    Park, K.I.3    Park, B.H.4    Jhee, E.C.5


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