Antiproliferative effects of S-allylmercaptocysteine on colon cancer cells when tested alone or in combination with sulindac sulfide

Cancer Research

Volumn 61, Issue 2, 2001, Pages 725-731

  Shirin, Haim ^a,b   Pinto, John T ^c   Kawabata, Yuichi ^a   Soh, Jae Won ^a   Delohery, Thomas ^c   Moss, Steven F ^b   Murty, Vundavalli ^a   Rivlin, Richard S ^c   Holt, Peter R ^b   Weinstein, I Bernard ^a  

^a Columbia University ^*  (United States)

^b ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLYLMERCAPTOCYSTEINE; CASPASE 3; GARLIC EXTRACT; GLUTATHIONE; SULINDAC SULFIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INCIDENCE; CANCER PREVENTION; CARCINOGENESIS; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CHEMOPROPHYLAXIS; COLON CANCER; CONTROLLED STUDY; GROWTH INHIBITION; HUMAN; HUMAN CELL; MITOSIS; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASES; CELL CYCLE; CELL DIVISION; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; G2 PHASE; GARLIC; GLUTATHIONE; HT29 CELLS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; ISOENZYMES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KINETICS; MITOGEN-ACTIVATED PROTEIN KINASES; MITOSIS; PLANTS, MEDICINAL; PROTO-ONCOGENE PROTEINS C-BCL-2; SULINDAC; TUMOR CELLS, CULTURED;

EID: 0035863512     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Cancer Statistics 1999
2. Diet and high risk of stomach cancer in Shangdong Province
3. Vegetables, fruit, and colon cancer in the Iowa Women's Health Study
4. Effect of diallyl sulfide on rat liver microsomal nitrosamine metabolism and other monooxygenase activities
5. Modulation of rat hepatic cytochrome P450 activity by garlic organosulfur compounds
6. Chemoprevention of N-nitrosomethylbenzylamine-induced esophageal cancer in rats by naturally occurring thioether, diallyl sulfide
7. Inhibition of cytochrome P450 IIE1 by diallyl sulfide and its metabolites
8. Antitumorpromoting activity of garlic extracts
9. Diallyl disulfide inhibits the proliferation of human tumor cells in culture
10. Growth inhibition and modulation of cell markers of melanoma by S-allyl cysteine
11. Antiproliferative effect of the garlic compoundallyl cysteine on human neuroblastoma cells in vitro
12. Thioallyl compounds: Potent inhibitors of cell proliferation
13. S-allylmercaptocysteine inhibits cell proliferation and reduces the viability of erythroleukemia, breast, and prostate cancer cell lines
14. Redox regulation of fos and jun DNA-binding activity in vitro
15. Evolutionary conservation of function among mammalian, avian, and viral homologs of the Bcl-2 oncoprotein
16. Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent
17. Antineo-plastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis
18. Cytometry in cell necrobiology: Analysis of apoptosis and accidental cell death necrosis
19. Comparison of cellular and nuclear flow cytometric techniques for discriminating apoptotic sub-populations
20. 1to S transition in AGS gastric epithelial cells
21. Interphase cytogenetics of gastric and esophageal adenocarcinomas
22. Apoptosis in gastric epithelial cells is induced by Helicobacter pylori and accompanied by increased expression of Bak
23. Validated high-performance liquid chromatography-electrochemical method for determination of glutathione and glutathione disulfide in small tissue samples
24. The role of proteases during apoptosis
25. The anti-proliferative effect of sulindac and sulindac sulfide on HT-29 colon cancer cells: Alterations in tumor suppressor and cell cycle-regulatory proteins
26. Monoclonal antibodies to mitotic cells
27. cGMP mediates apoptosis induced by sulindac derivatives via activation of JNK1
28. Effects of garlic thioallyl derivatives on growth, glutathione concentration, and polyamine formation of human prostate carcinoma cells in culture
29. S-Allylmercaptocysteine, a stable thioallyl compound, induces apoptosis in erythroleukemia cell lines
30. Ajoene, a compound of garlic, induces apoptosis in human promyelocytic leukemia cells, accompanied by generation of reactive oxygen species and activation of nuclear factor B
31. Garlic constituents alter cell cycle progression and proliferation
32. Prostaglandin H synthetase expression is variable in human colorectal adenocarcinoma cell lines
33. Novel anticarcinogenic activity of an organosulfide from garlic: Inhibition of H-ras oncogene transformed tumor growth in vivo by diallyl disulfide is associated with inhibition of p21H-ras processing
34. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2
35. The stress-activated protein kinase subfamily of c-jun kinases
36. The role of c-jun N terminal kinase (JNK) in apoptosis induced by ultraviolet C and γ radiation. Duration of JNK activation may determine cell death and proliferation
37. Chemopreventive isothiocyanates induce apoptosis and caspase-3 like activity
38. Phenethylsiothiocyanate, a natural chemopreventive agent, activates c-Jun N-terminal kinase 1
39. Chemopreventive effect of S-allylcysteine and its relationship to the detoxification of enzyme glutathione S-transferase
40. Effects of organosulfur compounds from garlic and onion on benzo[a]pyrene-induced neoplasia and glutathione S-transferase activity in the mouse
41. Glutathione
42. Effects of non-steroidal anti-inflammatory drugs on glutathione S-transferase of the rat digestive tract
43. Sulindac sulfide, an aspirin like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells
44. Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest and p53 induction
45. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis
46. Lovastatin augments sulindac-induced apoptosis in colon cancer cells and potentiates chemopreventive effects of sulindac