Chemopreventive effect of S-allylcysteine and its relationship to the detoxification enzyme glutathione S-transferase

Carcinogenesis

Volumn 17, Issue 5, 1996, Pages 1041-1044

  Hatono, Shunso ^a   Jimenez, Arnie ^a   Wargovich, Michael J ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE TRANSFERASE; ORGANOSULFUR DERIVATIVE; S ALLYLCYSTEINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMOPROPHYLAXIS; COLON CANCER; CONTROLLED STUDY; CRYPT CELL; DETOXIFICATION; EXPERIMENTAL NEOPLASM; GARLIC; LIVER; MALE; NONHUMAN; ONION; PRIORITY JOURNAL; RAT; SMALL INTESTINE; TUMOR PROMOTION;

1,2-DIMETHYLHYDRAZINE; ANIMALS; ANTICARCINOGENIC AGENTS; CARCINOGENS; COLON; CYSTEINE; DIMETHYLHYDRAZINES; GLUTATHIONE TRANSFERASE; INTESTINE, SMALL; ISOENZYMES; LIVER; MALE; METABOLIC DETOXICATION, DRUG; RATS; RATS, INBRED F344;

EID: 0029936374     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.5.1041     Document Type: Article

References (24)

1. Bloc,E. (1985) The chemistry of garlic and onions. Sci. Am., 252, 114-119.
2. Fenwick,G.R. and Hanley,A.B. (1985) The genus Allium. Part 1. Crit. Rev. Food Sci. Nutr., 22, 199-271.
3. Wargovich,M.J. (1987) Diallyl sulfide, a flavor component of garlic (Allium sativum), inhibits dimethylhydrazine-induced colon cancer. Carcinogenesis, 8, 487-489.
4. Wargovich,M.J., Woods,C., Eng,V.W.S., Stephens,L.C. and Gray,K. (1988) Chemoprevention of N-nitrosomethylbenzylamine-induced esophageal cancer in rats by the naturally occurring thioether, diallyl sulfide. Cancer Res., 48, 6872-6875.
5. Goldberg,M.T. and Josephy,P.D. (1987) Studies on the mechanism of action of diallyl sulfide, an inhibitor of the genotoxic effects of cyclophosphamide. Can. J. Physiol. Pharmacol., 65, 467-471.
6. Belman,S. (1983) Onion and garlic oil inhibit tumor promotion. Carcinogenesis, 4, 1063-1065.
7. Sparnins,V.L., Mott,A.W., Barany,G. and Wattenberg,L.W. (1986) Effects of allyl methyl trisulfide on glutathione S-transferase activity and BP-induced neoplasia in the mouse. Nutr. Cancer. 8, 211-215.
8. Sparnins,V.L., Barany,G. and Wattenberg,L.W. (1988) Effects of organosulfur compounds from garlic and onion on benzo[a]pyrene-induced neoplasia and glutathione S-transferase activity in the mouse. Carcinogenesis, 9, 131-134.
9. Sumiyoshi,H. and Wargovich,M.J. (1990) Chemoprevention of 1,2-dimethylhydrazine-induced colon cancer in mice by naturally occurring organosulfur compounds. Cancer Res., 50, 5084-5087.
10. Jakoby,W.B. (1978) The glutathione S-transferases: a group of multifunctional detoxification proteins. Adv. Enzymol., 46, 383-414.
11. Chasseaud,L.F. (1979) The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents. Adv. Cancer Res., 29, 175-274.
12. Mannervik,B. (1985) The isoenzymes of glutathione transferase. Adv. Enzymol. Relat. Areas Mol. Biol., 57, 357-417.
13. Habig, W.H., Pabst,M.J. and Jakoby,W.B. (1974) Glutathione S-transferases: the first enzymatic step in mercapturic acid formation, J. Biol. Chem., 249, 7130-7139.
14. Sparnins,V.L., Venegas,P.L. and Wattenberg,L.W. (1982) Glutathione S-transferase activity: enhancement by compounds inhibiting chemical carcinogenesis and by dietary constituents. J. Natl Cancer Inst., 68, 493-496.
15. Morrow,C.S. and Cowan,K.H. (1990) Glutathione S-transferases and drug resistance. Cancer Cells, 2, 15-22.
16. Tew,K.D., Bomber,A.W. and Hoffman,S.J. (1988) Ethacrynic acid and piriprost as enhancers of cytotoxicity in drug resistant and sensitive cell lines. Cancer Res., 48, 3622-2625.
17. Wolf,C.R., Hayard,I.P., Lawrie,S.S., Buckton,K., McIntyre,M.A., Adams,D.J., Lewis,A.D., Scott,A.R.R. and Smyth,J.F. (1987) Cellular heterogeneity and drug resistance in two ovarian adenocarcinoma cell lines derived from a single patient. Int. J. Cancer, 39, 695-702.
18. Jakoby,W.B., Ketter,B. and Mannervik,B. (1984) Glutathione transferases: nomenclature. Biochem. Pharmacol., 33, 2539-2540.
19. Mannervik,B., Alin,P., Guthenberg,C., Jenson,H., Thair,M.K., Walholm,M. and Johnvall,H. (1985) Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties. Proc. Natl Acad. Sci. USA, 82, 7202-7206.
20. Bird,R.P. (1987) Observation and quantification of aberrant crypt in the murine colon treated with a colon carcinogen. Cancer Lett., 37, 147-151.
21. You,W.C., Blot,W.J., Chang,Y.S., Ershow,A., Yang,Z.T., An,Q., Henderson,B.E., Fraumeni,J.F. and Wang,T.G. (1989) Allium vegetables and reduced risk of stomach cancer. J. Natl Cancer Inst., 81, 162-164.
22. Buiatti,E. et al. (1989) A case-control study of gastric cancer and diet in Italy. Int. J. Cancer, 44, 611-616.
23. Carr,B.I. (1985) Chemical carcinogens and inhibitors of carcinogenesis in the human diet. Cancer, 55, 218-225.
24. Steinmetz,K.A., Kushi,L.H., Bostick,R.M., Folsom,A.R. and Potter,J.D. (1994) Vegetables, fruit, and colon cancer in the Iowa Women's Health Study. Am. J. Epidemiol., 139, 1-5.