Ajoene, an experimental anti-leukemic drug: Mechanism of cell death

Leukemia

Volumn 16, Issue 1, 2002, Pages 74-83

  Dirsch, V M ^a   Antlsperger, D S M ^a   Hentze, H ^b,c   Vollmar, A M ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF KONSTANZ   (Germany)

^c INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

Apoptosis; Caspases; HL 60; Mitochondria; Organosulfur compound

Indexed keywords

AJOENE; ANTILEUKEMIC AGENT; BENZYLOXYCARBONYLPHENYLALANYLALANYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 8; CASPASE INHIBITOR; CELL RECEPTOR; CYTOCHROME C; DNA FRAGMENT; ENZYME PRECURSOR; ETOPOSIDE; FAS ANTIGEN; GARLIC EXTRACT; ORGANOSULFUR DERIVATIVE; PROTEIN BCL X;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; BLOOD CELL; CELL DEATH; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME RELEASE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

AMINO ACID CHLOROMETHYL KETONES; ANTIGENS, CD95; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-X PROTEIN; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CYSTEINE PROTEINASE INHIBITORS; CYTOCHROME C GROUP; DISULFIDES; DNA FRAGMENTATION; DNA, NEOPLASM; ENZYME ACTIVATION; ENZYME PRECURSORS; FAS LIGAND PROTEIN; GENE EXPRESSION REGULATION, LEUKEMIC; HL-60 CELLS; HUMANS; INTRACELLULAR MEMBRANES; JURKAT CELLS; MEMBRANE GLYCOPROTEINS; MEMBRANE POTENTIALS; MITOCHONDRIA; NEOPLASM PROTEINS; NF-KAPPA B; OXIDATIVE STRESS; PERMEABILITY; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES;

EID: 85009834484     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402337     Document Type: Article

References (47)

1. Effects of organosulfur compounds from garlic and onions on benzo[alpyrene-induced neoplasia and glutathione S-transferase activity in the mouse
2. Chemoprevention of 1,2-dimethylhydrazine-induced colon cancer in mice by naturally occurring organosulfur compounds
3. A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure
4. Chemoprevention of colon carcinogenesis by organosulfur compounds
5. Effects of garlic thioallyl derivatives on growth, glutathione concentration, and polyamine formation of human prostate carcinoma cells in culture
6. Selective cytostatic and cytotoxic effects of glucosinolates hydrolysis products on human colon cancer cells in vitro
7. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells
8. Sallylmercaptocysteine, a stable thioallyl compound, induces apoptosis in erythroleukemia cell lines
9. Ajoene, a compound of garlic, induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor κB
10. 2-(allylthio)pyrazine suppresses the growth and proliferation of human promyelocytic leukemia (HL-60) cells via induction of apoptosis
11. Novel synthetic organosulfur compounds induce apoptosis of human leukemic cells
12. Effects of garlic extract and of three pure components isolated from it on human platelet aggregation, arachidonate metabolism, release reaction, and platelet ultrastructure
13. Induction of apoptosis by cancer chemotherapy
14. Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells
15. Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53
16. Sensitization of cancer cells treated with cytotoxic drugs to Fas mediated cytotoxicity
17. Functional CD95 ligand and CD95 death-inducing signaling complex in activation-induced cell death and doxorubicin-induced apoptosis in leukemic T cells
18. Apoptosis signaling in lymphocytes
19. Two CD95 (APO-1/Fas) signaling pathways
20. Drug-induced apoptosis is associated with enhanced Fas (APO-1/CD95) ligand expression but occurs independently of Fas (APO-1/CD95) signaling in human T-acute lymphatic leukemia cells
21. Comparison of apoptosis in wild-type and Fas-resistant cells: Chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions
22. FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation
23. Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction
24. Mitochondrial control of cell death
25. Biochemical pathways of caspase activation during apoptosis
26. L overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human acute myeloid leukemia
27. APO-1 (CD95)-dependent and -independent antigen receptor-induced apoptosis in human T and B cell lines
28. L-overexpressing chemotherapy-resistant tumor cells
29. L or Bcl-2
30. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
31. Interleukin-1 beta converting enzyme
32. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
33. FLICE is predominantly expressed as two functionally active isoforms, caspase 8/a and caspase 8/b
34. 1-Methyl-4-phenylpyridinium induces autocrine excitotoxicity protease activation, and neuronal apoptosis
35. Proteolytic activities that mediate apoptosis
36. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
37. Chemopreventive agent resveratrol, a natural product derived from grapes triggers CD95 signaling-dependent apoptosis in human tumor cells
38. Intracellular triggering of Fas, independently of FasL, as a new mechanism of antitumor ether lipid-induced apoptosis
39. Changes in susceptibility to Fas-mediated apoptosis during differentiation of HL-60 cells
40. The mitochondrion in cell death control: Certainties and incognita
41. Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis
42. Functional heterogeneity of an isolated mitochondrial population revealed by cytofluorometric analysis at the single organelle level
43. Bcl-2 family members and the mitochondria in apoptosis
44. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis
45. Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
46. Caspase-8 activation and Bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis
47. Four deaths and a funeral: From caspases to alternative mechanisms