Regulation of TLR2 expression by prostaglandins in brain glia

Journal of Immunology

Volumn 180, Issue 12, 2008, Pages 8400-8409

  Yoon, Hee Jung ^a   Jeon, Sae Bom ^a,b   Kim, In Hoo ^a   Park, Eun Jung ^a  

^a National Cancer Center   (South Korea)

^b Ajou University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; DELTA12 PROSTAGLANDIN J2; LIPOTEICHOIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; PROSTAGLANDIN; PROSTAGLANDIN D2; PROSTANOID RECEPTOR; ROSIGLITAZONE; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; 15 DEOXYPROSTAGLANDIN J2; 15-DEOXYPROSTAGLANDIN J2; AUTACOID; DRUG DERIVATIVE; IMMUNOLOGICAL ADJUVANT; LIGAND; PROSTAGLANDIN E2; TLR2 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GLIA CELL; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL LINE; DRUG ANTAGONISM; DRUG POTENTIATION; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; MICROGLIA; MOUSE; PERITONEUM MACROPHAGE; PHYSIOLOGY;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ARACHIDONIC ACID; CELL LINE, TRANSFORMED; CELLS, CULTURED; DINOPROSTONE; GENE EXPRESSION REGULATION; INFLAMMATION MEDIATORS; LIGANDS; MACROPHAGES, PERITONEAL; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED ICR; MICROGLIA; PHAGOCYTOSIS; PROSTAGLANDIN D2; PROSTAGLANDINS; TOLL-LIKE RECEPTOR 2;

EID: 50949127955     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.12.8400     Document Type: Article

References (73)

1. Medzhitov, R., P. Prcslon-Hurlburt, and C. A. Janeway, Jr. 1997. A human hornologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388: 394-397.
2. Aderem, A., and R. J. Ulevitch. 2000. Toll-like receptors in the induction of the innate immune response. Nature 406: 782-787.
3. Underhill, D. M., A. Ozinsky, A. M. Hajjar, A. Stevens, C. B. Wilson, M. Bassetti, and A. Aderem. 1999. The Toll-like receptor 2 is recruited to mac-rophage phagosomes and discriminates between pathogens. Nature 401: 811-815.
4. Sabroe, I., R. C. Read, M. K. Whyte, D. II. Dockrell, S. N. Vogel, and S. K. Dower. 2003. Toll-like receptors in health and disease: complex questions remain. J. Immunol. 171: 1630-1635.
5. Kawai, T., and S. Akira. 2007. TLR signaling. Semin. Immunol. 19: 24-32.
6. O'Neill, L. A. 2006. How Toll-like receptors signal: what we know and what we don't know. Curr. Opin. Immunol. 18: 3-9.
7. Trinchieri, G., and A. Sher. 2007. Cooperation of Toll-like receptor signals in innate immune defense. Nat. Rev. Immunol. 7: 179-190.
8. Kaisho, T., and S. Akira. 2006. Toll-like receptor function and signaling. J. Allergy Clin. Immunol. 117: 979-987.
9. Kobayashi, K., L. D. Hernandez, J. E. Galan, C. A. Janeway, Jr., R. Medzhitov, and R. A. Flavell. 2002. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 110: 191-202.
10. Nakagawa, R., T. Naka, H. Tsutsui, M. Fujimolo, A. Kimura, T. Abe, E. Seki, S. Sato, O. Takeuchi, K. Takeda, et al. 2002. SOCS-1 participates in negative regulation of LPS responses. Immunity 17: 677-687.
11. Zhang, G., and S. Ghosh. 2002. Negative regulation of Toll-like receptor-mediated signaling by Tollip. J. Biol. Chem. 277: 7059-7065.
12. Kobayashi, K. S., and R. A. Flavell. 2004. Shielding the double-edged sword: negative regulation of the innate immune system. J. Leukocyte Biol. 75: 428-433.
13. Saitoh, T., M. Yamamoto, M. Miyagishi, K. Taira, M. Nakanishi, T. Fujita, S. Akira, N. Yamamoto, and S. Yamaoka. 2005. A20 is a negative regulator of IFN regulatory factor 3 signaling. J. Immunol. 174: 1507-1512.
14. Tanaka, T., M. J. Grusby, and T. Kaisho. 2007. PDLIM2-mediated termination of transcription factor NF-KB activation by intranuclear sequestration and degradation of the p65 subunit. Nat. Immunol. 8: 584-591.
15. Ridet, J. L., S. K. Malhotra, A. Privat, and F. H. Gage. 1997. Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci. 20: 570-577.
16. Kigerl, K. A., W. Lai, S. Rivest, R. P. Hart, A. R. Satoskar, and P. G. Popovich. 2007. Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury. J. Neurochem. 102: 37-50.
17. Matyszak, M. K. 1998. Inflammation in the CNS: balance between immunolog-ical privilege and immune responses. Prog. Neurobiol. 56: 19-35.
18. Minghetti, L., and G. Levi. 1998. Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide. Prog. Neurobiol. 54: 99-125.
19. Straus, D. S., and C. K. Glass. 2001. Cyclopentenone prostaglandins: new insights on biological activities and cellular targets. Med. Res. Rev. 21: 185-210.
20. Hata, A. N., and R. M. Breyer. 2004. Pharmacology and signaling of prostaglan-din receptors: multiple roles in inflammation and immune modulation. Pharmacol. Ther. 103: 147-166.
21. 2 and its metabolites in leukocyte function. J. Leukocyte Biol. 81: 372-382.
22. Gilroy, D. W., P. R. Colville-Nash, D. Willis, J. Olivers, M. J. Paul-Clark, and D. A. Willoughby. 1999. Inducible cyclooxygenase may have anti-inflammatory properties. Nat. Med. 5: 698-701.
23. 2 metabolite generated during inflammatory processes. J. Biol. Chem. 277: 10459-10466.
24. 2 synthase in the control of delayed type hypersensitiv-ity. Proc. Katl.-Acad. Sci. USA 103: 5179-5184.
25. Gavett, S. H., S. L. Madison, P. C. Chulada, P. E. Scarborough, W. Qu, J. E. Boyle, H. F. Tiano, C. A. Lee, R. Langenbach, V. L. Roggli, and D. C. Zeldin. 1999. Allergic lung responses are increased in prostaglandin H synthase-deficient mice. J. Clin. Invest. 104: 721-732.
26. Peebles, R. S., Jr., K. Hashimoto, J. D. Morrow, R. Dworski, R. D. Collins, Y. Hashimoto, J. W. Christman, K. H. Kang, K. Jarzecka, J. Furlong, et al. 2002. Selective cyclooxygenase-1 and -2 inhibitors each increase allergic inflammation and airway hyperresponsiveness in mice. Am. J. Respir. Crit. Care Med. 165: 1154-1160.
27. 2 inhibits airway dendritic cell migration and function in steady state conditions by selective activation of the D prostanoid receptor 1. J. Immunol. 171: 3936-3940.
28. Hammad, H., M. Kool, T. Soullie, S. Narumiya, F. Trottein, H. C. Hoogsteden, and B. N. Lambrecht. 2007. Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells. J. Exp. Med. 204: 357-367.
29. 2 mediates neuronal protection via the DPI receptor. J. Neurochem. 92: 477-486.
30. 2 protects neonatal mouse brain from hypoxic ischemic injury. J. Neurosci. 27: 4303-4312.
31. 2. Proc. Natl. Acad. Sci. USA 96: 4668-4673.
32. Combs, C. K., D. E. Johnson, J. C. Karlo, S. B. Cannady, and G. E. Landreth. 2000. Inflammatory mechanisms in Alzheimer's disease: inhibition of β-amy-loid-stimulated proinflammatory responses and neurotoxicity by PPARγ agonists. J. Neurosci. 20: 558-567.
33. Heneka, M. T., T. Klockgether, and D. L. Feinstein. 2000. Peroxisome prolif-erator-activated receptor-γ ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo. J. Neurosci. 20: 6862-6867.
34. 2: the anti-inflammatory prostaglandin? Clin. Immunol. 114: 100-109.
35. Rehli, M. 2002. Of mice and men: species variations of Toll-like receptor expression. Trends Immunol. 23: 375-378.
36. Weiss, D. S., B. Raupach. K. Takeda, S. Akira, and A. Zychlinsky. 2004. Toll-like receptors are temporally involved in host defense. J. Immunol. 172: 4463-4469.
37. Jou, I., J. H. Lee, S. Y. Park, H. J. Yoon, E. H. Joe, and E. J. Park. 2006. Gangliosides trigger inflammatory responses via TLR4 in brain glia. Am. J. Pathol. 168: 1619-1630.
38. Yoon, H. J., S. B. Jeon, K. H. Seok, D. K. Choi, Y. J. Hong, and E. J. Park. 2008. Contribution of TLR2 in the initiation of gangliosides-triggered inflammatory signaling. Mol. Cells 25: 99-104.
39. Kielian, T., A. Haney, P. M. Mayes, S. Garg, and N. Esen. 2005. Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess. Infect. Immun. 73: 7428-7435.
40. Chen, K., P. Iribarren, J. Hu, J. Chen, W. Gong, E. H. Cho, S. Lockett, N. M. Dunlop, and J. M. Wang. 2006. Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid β peptide. J. Biol. Chem. 281: 3651-3659.
41. Lehnardt, S., P. Henneke, E. Lien, D. L. Kasper, J. J. Volpe, I. Bechmann, R. Nitsch, J. R. Weber, D. T. Golenbock, and T. Vartanian. 2006. A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyDS8 pathway in microglia. J. Immunol. 177: 583-592.
42. Hoffmann, O., J. S. Braun, D. Becker, A. Halle, D. Freyer, E. Dagand, S. Lehnardt, and J. R. Weber. 2007. TLR2 mediates neuroinflammation and neuronal damage. J. Immunol. 178: 6476-6481.
43. Jiang, D., J. Liang, J. Fan, S. Yu, S. Chen, Y. Luo, G. D. Prestwich, M. M. Mascarenhas, H. G. Garg, D. A. Quinn, et al. 2005. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat. Med. 11: 1173-1179.
44. Lehmann, J. M., L. B. Moore, T. A. Smith-Oliver, W. O. Wilkison, T. M. Willson, and S. A. Kliewer. 1995. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPAR γ). J. Biol. Chem. 270: 12953-12956.
45. Miyake, K. 2007. Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors. Semin. Immunol. 19: 3-10.
46. Han, J., and R. J. Ulevitch. 2005. Limiting inflammatory responses during activation of innate immunity. Nat. Immunol. 6: 1198-1205.
47. Miggin, S. M., and L. A. O'Neill. 2006. New insights into the regulation of TLR signaling. J. Leukocyte Biol. 80: 220-226.
48. Kanzler, H., F. J. Barrat, E. M. Hessel, and R. L. Coffman. 2007. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat. Med. 13: 552-559.
49. Streit, W. J., S. A. Walter, and N. A. Pennell. 1999. Reactive microgliosis. Prog. Neurobiol. 57: 563-581.
50. Bowman, C. C., A. Rasley, S. L. Tranguch, and I. Marriott. 2003. Cultured astrocytes express Toll-like receptors for bacterial products. Glia 43: 281-291.
51. Olson, J. K., and S. D. Miller. 2004. Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J. Immunol. 173: 3916-3924.
52. Lehnardt, S., C. Lachance, S. Patrizi, S. Lefebvre, P. L. Follett, F. E. Jensen, P. A. Rosenberg, J. J. Volpe, and T. Vartanian. 2002. The Toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS. J. Neurosci. 22: 2478-2486.
53. Tanga, F. Y., N. Nutile-McMenemy, and J. A. DeLeo. 2005. The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy. Proc. Natl. Acad. Sci. USA 102: 5856-5861.
54. Visintin, A., A. Mazzoni, J. H. Spitzer, D. H. Wyllie, S. K. Dower, and D. M. Segal. 2001. Regulation of Toll-like receptors in human monocytes and dendritic cells. J. Immunol. 166: 249-255.
55. Muzio, M., D. Bosisio, N. Polentarutti, G. D'Amico, A. Stoppacciaro, R. Mancinelli, C. van't Veer, G. Penton-Rol, L. P. Ruco, P. Allavena, and A. Mantovani. 2000. Differential expression and regulation of Toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J. Immunol. 164: 5998-6004.
56. Reis e Sousa, C. 2004. Toll-like receptors and dendritic cells: for whom the bug tolls. Semin. Immunol. 16: 27-34.
57. Iwasaki, A., and R. Medzhitov. 2004. Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 5: 987-995.
58. Wayman, N. S., Y. Hattori, M. C. McDonald, H. Mota-Filipe, S. Cuzzocrea, B. Pisano, P. K. Chatterjee, and C. Thiernermann. 2002. Ligands of the peroxisome proliferator-activated receptors (PPAR-γ and PPAR-α) reduce myocardial infarct size. FASEB J. 16: 1027-1040.
59. Murphy, G. J., and J. C. Holder. 2000. PPAR-γ agonists: therapeutic role in diabetes, inflammation and cancer. Trends Pharmacol. Sci. 21: 469-474.
60. 2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia. J. Biol. Chem. 278: 14747-14752.
61. Jiang, C., A. T. Ting, and B. Seed. 1998. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature 391: 82-86.
62. Ricote, M., A. C. Li, T. M. Willson, C. J. Kelly, and C. K. Glass. 1998. The peroxisome proliferator-activated receptor-γ is a negative regulator of macro-phage activation. Nature 391: 79-82.
63. Chawla, A., Y. Barak, L. Nagy, D. Liao, P. Tontonoz, and R. M. Evans. 2001. PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat. Med. 7: 48-52.
64. 2 ameliorates experimental autoimmune encephalomyelitis. J. Immunol. 168: 2508-2515.
65. Kim, O. S., E. J. Park, E. H. Joe, and I. Jou. 2002. JAK-STAT signaling mediates gangliosides-induced inflammatory responses in brain microglial cells. J. Biol. Chem. 277: 40594-40601.
66. Kim, H. Y., E. J. Park, E. H. Joe, and I. Jou. 2003. Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia. J. Immunol 171: 6072-6079.
67. Rossi, A., P. Kapahi, G. Natoli, T. Takahashi, Y. Chen, M. Karin, and M. G. Santoro. 2000. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IKB kinase. Nature 403: 103-108.
68. 2 inhibits multiple steps in the NF-KB signaling pathway. Proc. Natl. Acad. Sci. USA 97: 4844-4849.
69. 2. J. Biol. Chem. 278: 51251-51260.
70. 2 binds to and activates H-Ras. Proc. Natl. Acad. Sci. USA 100: 4772-4777.
71. 2 inhibits transcriptional activity of estrogen receptor-α via covalent modification of DNA-binding domain. Cancer Res. 67: 2595-2602.
72. Lawrence, T., D. A. Willoughby, and D. W. Gilroy. 2002. Anti-inflammatory lipid mediators and insights into the resolution of inflammation. Nat. Rev. 2: 787-795.
73. 2 and proliferator activation receptor-γ agonists. J. Immunol. 164: 1498-1504.