Inhibitors of the heme oxygenase - Carbon monoxide system: On the doorstep of the clinic?

Canadian Journal of Physiology and Pharmacology

Volumn 86, Issue 9, 2008, Pages 577-599

  Kinobe, Robert T ^a,b   Dercho, Ryan A ^a   Nakatsu, Kanji ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b JAMES COOK UNIVERSITY   (Australia)

Author keywords

Heme oxygenases; Imidazole based inhibitors and clinical applications; Metalloporphyrins

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; BILIRUBIN; BILIVERDIN; CARBON MONOXIDE; CHROMIUM MESOPORPHYRIN; FERROUS ION; HEME OXYGENASE; HEME OXYGENASE 1; HEME OXYGENASE 2; HEME OXYGENASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMIDAZOLE DERIVATIVE; IRON; METALLOPORPHYRIN; NONSTEROID ANTIINFLAMMATORY AGENT; PORPHYRIN DERIVATIVE; PROTOPORPHYRIN TIN; PROTOPORPHYRIN ZINC; QC 1; QC 10; QC 13; QC 9; UNCLASSIFIED DRUG; ZINC DEUTEROPORPHYRIN IX 2,4 BISETHYLENE GLYCOL;

ANIMAL CELL; ANIMAL MODEL; BACTERIAL INFECTION; CELL PROTECTION; DEGENERATIVE DISEASE; DRUG DISTRIBUTION; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE DELETION; HUMAN; HUMAN CELL; HYPERBILIRUBINEMIA; LUNG FIBROSIS; MOUSE; MYCOSIS; NEOPLASM; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW;

ANIMALS; CARBON MONOXIDE; ENZYME INHIBITORS; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HUMANS; IRON;

EID: 50849112415     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y08-066     Document Type: Review

References (297)

1. Abate, A., Zhao, H., Wong, R.J., and Stevenson, D.K. 2007. The role of Bach1 in the induction of heme oxygenase by tin mesoporphyrin. Biochem. Biophys. Res. Commun. 354: 757-763. doi:10.1016/j.bbrc.2007.01.050. PMID:17257585.
2. Adin, C.A., Croker, B.P., and Agarwal, A. 2005. Protective effects of exogenous bilirubin on ischemia-reperfusion injury in the isolated, perfused rat kidney. Am. J. Physiol. Renal Physiol. 288: F778-F784. doi:10.1152/ajprenal.00215.2004. PMID:15561977.
3. Akaike, T., Sato, K., Ijiri, S., Miyamoto, Y., Kohno, M., Ando, M., and Maeda, H. 1992. Bactericidal activity of alkyl peroxyl radicals generated by heme-iron-catalyzed decomposition of organic peroxides. Arch. Biochem. Biophys. 294: 55-63. doi:10.1016/0003-9861(92)90136-K. PMID:1312811.
4. Alam, J., and Den, Z. 1992. Distal AP-1 binding sites mediate basal level enhancement and TPA induction of the mouse heme oxygenase-1 gene. J. Biol. Chem. 267: 21894-21900. PMID:1400499.
5. Alam, J., Shibahara, S., and Smith, A. 1989. Transcriptional activation of the heme oxygenase gene by heme and cadmium in mouse hepatoma cells. J. Biol. Chem. 264: 6371-6375. PMID:2703493.
6. Alam, J., Stewart, D., Touchard, C., Boinapally, S., Choi, A.M., and Cook, J.L. 1999. Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J. Biol. Chem. 274: 26071-26078. doi:10.1074/jbc.274.37.26071. PMID:10473555.
7. Alam, J., Wicks, C., Stewart, D., Gong, P., Touchard, C., Otterbein, S., et al. 2000. Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells. Role of p38 kinase and Nrf2 transcription factor. J. Biol. Chem. 275: 27694-27702. PMID:10874044.
8. Alam, J., Igarashi, K., Immenschuh, S., Shibara, S., and Tyrrell, R.M. 2003. Regulation of heme oxygenase-1 gene transcription: recent advances and highlights from the International Conference (Uppsala, 2003) on Heme Oxygenase. Antioxid. Redox Signal. 6: 924-933. PMID:15345152.
9. Amersi, F., Shen, X.D., Anselmo, D., Melinek, J., Iyer, S., Southard, D.J., et al. 2002. Ex vivo exposure to carbon monoxide prevents hepatic ischemia/reperfusion injury through p38 MAP kinase pathway. Hepatology, 35: 815-823. doi:10.1053/jhep.2002.32467. PMID:11915027.
10. Anderson, K.E., Simionatto, C.S., Drummond, G.S., and Kappas, A. 1984. Tissue distribution and disposition of tin-protoporphyrin, a potent competitive inhibitor of heme oxygenase. J. Pharmacol. Exp. Ther. 228: 327-333. PMID:6546399.
11. Anwar, A.A., Li, F.Y., Leake, D.S., Ishii, T., Mann, G.E., and Siow, R.C. 2005. Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: role of mitogen-activated protein kinases and Nrf2. Free Radic. Biol. Med. 39: 227-236. doi:10.1016/j.freeradbiomed.2005.03.012. PMID:15964514.
12. Appleton, S.D., Chretien, M.L., McLaughlin, B.E., Vreman, H.J., Stevenson, D.K., Nakatsu, K., et al. 1999. Selective inhibition of heme oxygenase, without inhibition of nitric oxide synthase or soluble guanylyl cyclase, by metalloporphyrins at low concentrations. Drug Metab. Dispos. 27: 1214-1219. PMID:10497150.
13. Araujo, J.A., Meng, L., Tward, A.D., Hancock, W.W., Zhai, Y., Lee, A., et al. 2003. Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse. J. Immunol. 171: 1572-1580. PMID:12874251.
14. Atzori, L., Chua, F., Dunsmore, S.E., Willis, D., Barbarisi, M., McAnulty, R.J., and Laurent, G.J. 2004. Attenuation of bleomycin-induced pulmonary fibrosis in mice using the heme oxygenase inhibitor Zn-deuteroporphyrin IX-2,4-bisethylene glycol. Thorax, 59: 217-223. doi:10.1136/thx.2003.008979. PMID:14985557.
15. Balla, J., Jacob, H.S., Balla, G., Nath, K., Eaton, J.W., and Vercellotti, G.M. 1993. Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage. Proc. Natl. Acad. Sci. U.S.A. 90: 9285-9289. doi:10.1073/pnas.90.20.9285. PMID:8415693.
16. Baranano, D.E., Rao, M., Ferris, C.D., and Snyder, S.H. 2002. Biliverdin reductase: a major physiologic cytoprotectant. Proc. Natl. Acad. Sci. U.S.A. 99: 16093-16098. doi:10.1073/pnas.252626999. PMID:12456881.
17. Basuroy, S., Bhattacharya, S., Tcheranova, D., Qu, Y., Regan, R.F., Leffler, C.W., and Perfenova, H. 2006. HO-2 provides endogenous protection against oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells. Am. J. Physiol. Cell Physiol. 291: C897-C908. doi:10.1152/ajpcell.00032.2006. PMID:16822952.
18. Benallaoua, M., Francois, M., Batteux, F., Thelier, N., Shyy, J.Y., Fitting, C., et al. 2007. Pharmacologic induction of heme oxygenase 1 reduces acute inflammatory arthritis in mice. Arthritis Rheum. 56: 2585-2594. doi:10.1002/art.22749. PMID:17665394.
19. Benaron, D.A., and Bowen, F.W. 1991. Variation of initial serum bilirubin rise in newborn infants with type of illness. Lancet, 338: 78-81. doi:10.1016/0140-6736(91)90074-Y. PMID:1676469.
20. Berberat, P.O., Dambrauskas, Z., Gulbinas, A., Giese, T., Giese, N., Kunzli, B., et al. 2005. Inhibition of heme oxygenase-1 increases responsiveness of pancreatic cancer cells to anticancer treatment. Clin. Cancer Res. 11: 3790-3798. doi:10.1158/1078-0432.CCR-04-2159. PMID:15897578.
21. Bilban, M., Haschemi, A., Wegiel, B., Chin, B.Y., Wagner, O., and Otterbein, L.E. 2007. Heme oxygenase and carbon monoxide initiate homeostatic signaling. J. Mol. Med. 86: 267-279. doi:10.1007/s00109-007-0276-0. PMID:18034222.
22. Boehning, D., Moon, C., Sharma, S., Hurt, K.J., Hester, L.D., Ronnett, G.V., et al. 2003. Carbon monoxide neurotransmission activated by CK2 phosphorylation of heme oxygenase-2. Neuron, 40: 129-137. doi:10.1016/S0896-6273(03)00596-8. PMID:14527438.
23. Boehning, D., Sedaghat, L., Sedlak, T.W., and Snyder, S.H. 2004. Heme oxygenase-2 is activated by calcium-calmodulin. J. Biol. Chem. 279: 30927-30930. doi:10.1074/jbc.C400222200. PMID:15175337.
24. Braggins, P.E., Trakshel, G.M., Kutty, R.K., and Maines, M.D. 1986. Characterization of two heme oxygenase isoforms in rat spleen: comparison with the hematin-induced and constitutive isoforms of the liver. Biochem. Biophys. Res. Commun. 141: 528-533. doi:10.1016/S0006-291X(86)80205-4. PMID:3099789.
25. Burnett, A.L., Johns, D.G., Kriegsfeld, L.J., Klein, S.L., Calvin, D.C., Demas, G.E., et al. 1998. Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2. Nat. Med. 4: 84-87. doi:10.1038/nm0198-084. PMID:9427611.
26. Caignan, G.A., Deshmukh, R., Wilks, A., Zeng, Y., Huang, H.W., Moenne-Loccoz, P., et al. 2002. Oxidation of heme to β- and δ-biliverdin by Pseudomonas aeruginosa heme oxygenase as a consequence of an unusual seating of the heme. J. Am. Chem. Soc. 124: 14879-14892. doi:10.1021/ja0274960. PMID:12475329.
27. Camhi, S.L., Alam, J., Otterbein, L., Sylevester, S.L., and Choi, A.M. 1995. Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation. Am. J. Respir. Cell Mol. Biol. 13: 387-398. PMID:7546768.
28. Carraway, M.S., Ghio, A.J., Suliman, H.B., Carter, J.D., Whorton, A.R., and Piantadosi, C.A. 2002. Carbon monoxide promotes hypoxic pulmonary vascular remodeling. Am. J. Physiol. Lung Cell. Mol. Physiol. 282: L693-L702. PMID:11880294.
29. Cary, S.P., and Marletta, M.A. 2001. The case of CO signaling: why the jury is still out. J. Clin. Invest. 107: 1071-1073. doi:10.1172/JCI12823. PMID:11342568.
30. Cerne, D., Ledinski, G., Kager, G., Greilberger, J., Wang, X., and Jurgens, G. 2000. Comparison of laboratory parameters as risk factors for the presence and the extent of coronary or carotid atherosclerosis: the significance of apolipoprotein B to apolipoprotein all ratio. Clin. Chem. Lab. Med. 38: 529-538. doi:10.1515/CCLM.2000.078. PMID:10987202.
31. Chakder, S., Rathi, S., Ma, X.L., and Rattan, S. 1996. Heme oxygenase inhibitor zinc protoporphyrin IX causes an activation of nitric oxide synthase in the rabbit internal anal sphincter. J. Pharmacol. Exp. Ther. 277: 1376-1382. PMID:8667200.
32. Chakrabarty, A., Emerson, M.R., and LeVine, S.M. 2003. Heme oxygenase-1 in SJL mice with experimental allergic encephalomyelitis. Mult. Scler. 9: 372-381. doi:10.1191/1352458503ms928oa. PMID:12926842.
33. Chang, E.F., Wong, R.J., Vreman, H.J., Igarashi, T., Galo, E., Sharp, F.R., et al. 2003. Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury. J. Neurosci. 23: 3689-3696. PMID:12736340.
34. Chang, K.W., Lee, T.C., Yeh, W.I., Chung, M.Y., Liu, C.J., Chin, L.Y., and Lin, S.C. 2004. Polymorphism in heme oxygenase-1 (HO-1) promoter is related to the risk of oral squamous cell carcinoma occurring on male areca chewers. Br. J. Cancer, 91: 1551-1555. doi:10.1038/sj.bjc.6602186. PMID:15365571.
35. Chauveau, C., Remy, S., Royer, P.J., Hill, M., Tanguy-Royer, S., Hubert, F.X., et al. 2005. Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression. Blood, 106: 1694-1702. doi:10.1182/blood-2005-02-0494. PMID:15920011.
36. Chen, K., and Maines, M.D. 2000. Nitric oxide induces heme oxygenase-1 via mitogen-activated protein kinases ERK and p38. Cell Mol. Biol. (Noisy-le-grand), 46: 609-617. PMID:10872747.
37. Chen, J., and Regan, R.F. 2004. Heme oxygenase-2 gene deletion increases astrocyte vulnerability to hemin. Biochem. Biophys. Res. Commun. 318: 88-94. doi:10.1016/j.bbrc.2004.03.187. PMID:15110757.
38. Chen, G.G., Liu, Z.M., Vlantis, A.C., Tse, G.M., Leung, B.C., and van Hasselt, C.A. 2004. Heme oxygenase-1 protects against apoptosis induced by tumor necrosis factor-alpha and cycloheximide in papillary thyroid carcinoma cells. J. Cell. Biochem. 92: 1246-1256. doi:10.1002/jcb.20157. PMID:15258907.
39. Chen, J.C., Huang, K.C., and Lin, W.W. 2006. HMG-CoA reductase inhibitors upregulate heme oxygenase-1 expression in murine RAW264.7 macrophages via ERK, p38 MAPK and protein kinase G pathways. Cell. Signal. 18: 32-39. doi:10.1016/j.cellsig.2005.03.016. PMID:16214041.
40. Cherrington, J.M., Strawn, L.M., and Shawver, L.K. 2000. New paradigms for the treatment of cancer: the role of antiangiogenesis agents. Adv. Cancer Res. 79: 1-38. doi:10.1016/S0065-230X(00)79001-4. PMID:10818676.
41. Choi, A.M., and Dolinay, T. 2005. "Therapeutic" carbon monoxide may be a reality soon. Am. J. Respir. Crit. Care Med. 171: 1318-1319. PMID:15914570.
42. Choi, B.M., Kim, Y.M., Jeong, Y.R., Pae, H.O., Song, C.E., Park, J.E., et al. 2004. Induction of heme oxygenase-1 is involved in anti-proliferative effects of paclitaxel on rat vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 321: 132-137. doi:10.1016/j.bbrc.2004.06.120. PMID:15358225.
43. Cisowski, J., Loboda, A., Jozkowicz, A., Chen, S., Agarwal, A., and Dulak, J. 2005. Role of heme oxygenase-1 in hydrogen peroxide-induced VEGF synthesis: effect of HO-1 knockout. Biochem. Biophys. Res. Commun. 326: 670-676. doi:10.1016/j.bbrc.2004.11.083. PMID:15596152.
44. Clark, J.E., Green, C.J., and Motterlini, R. 1997. Involvement of the heme oxygenase-carbon monoxide pathway in keratinocyte proliferation. Biochem. Biophys. Res. Commun. 241: 215-220. doi:10.1006/bbrc.1997.7742. PMID:9425252.
45. Clark, J.E., Foresti, R., Green, C.J., and Motterlini, R. 2000. Dynamics of haem oxygenase-1 expression and bilirubin production in cellular protection against oxidative stress. Biochem. J. 348: 615-619. doi:10.1042/0264- 6021:3480615. PMID:10839994.
46. Clark, J.E., Naughton, P., Shurey, S., Green, C.J., Johnson, T.R., Mann, B.E., et al. 2003. Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule. Circ. Res. 93: e2-e8. doi:10.1161/01.RES. 0000084381.86567.08. PMID:12842916.
47. Cuturi, M.C., Christoph, F., Woo, J., Iyer, S., Brouard, S., Heslan, J.M., et al. 1999. RDP1258, a new rationally designed immunosuppressive peptide, prolongs allograft survival in rats: analysis of its mechanism of action. Mol. Med. 5: 820-832. PMID:10666482.
48. Deininger, M.H., Meyermann, R., Trautmann, K., Duffner, F., Grote, E.H., Wickboldt, J., and Schluesener, H.J. 2000. Heme oxygenase (HO)-1 expressing macrophages/microglial cells accumulate during oligodendroglioma progression. Brain Res. 882: 1-8. doi:10.1016/S0006-8993(00)02594-4. PMID:11056178.
49. Denagel, D.C., Verity, A.N., Madden, F.E., Yang, C.O., Sangameswaran, L., and Johnson, R.M. 1998. Identification of non-porphyrin inhibitors of heme oxygenase-1. Neuroscience, 24: 2058.
50. Deng, Y.M., Wu, B.J., Witting, P.K., and Stocker, R. 2004. Probucol protects against smooth muscle cell proliferation by upregulating heme oxygenase-1. Circulation, 110: 1855-1860. doi:10.1161/01.CIR.0000142610. 10530.25. PMID:15364806.
51. Dennery, P.A. 2005. Metalloporphyrins for the treatment of neonatal jaundice. Curr. Opin. Pediatr. 17: 167-169. doi:10.1097/01.mop. 0000156270.25640.5a. PMID:15800405.
52. Dennery, P.A., Visner, G., Weng, Y.H., Nguyen, X., Lu, F., Zander, D., and Yang, G. 2003. Resistance to hyperoxia with heme oxygenase-1 disruption: role of iron. Free Radic. Biol. Med. 34: 124-133. doi:10.1016/S0891- 5849(02)01295-9. PMID:12498987.
53. Dercho, R.A., Nakatsu, K., Wong, R.J., Stevenson, D.K., and Vreman, H.J. 2006. Determination of in vivo carbon monoxide production in laboratory animals via exhaled air. J. Pharmacol. Toxicol. Methods, 54: 288-295. doi:10.1016/j.vascn.2006.01.004. PMID:16540352.
54. Deshane, J., Chen, S., Caballero, S., Grochot-Przeczek, A., Was, H., Calzi, S., et al. 2007. Stromal cell-derived factor 1 promotes angiogenesis via a heme oxygenase 1-dependent mechanism. J. Exp. Med. 204: 605-618. doi:10.1084/jem.20061609. PMID:17339405.
55. Ding, Y., Zhang, Y.Z., Furuyama, K., Ogawa, K., Igarashi, K., and Shibahara, S. 2006. Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines. FEBS J. 273: 5333-5346. doi:10.1111/j.1742-4658.2006.05526.x. PMID:17064313.
56. Doi, K., Akaike, T., Fujii, S., Tanaka, S., Ikebe, N., Beppu, T., et al. 1999. Induction of haem oxygenase-1 nitric oxide and ischaemia in experimental solid tumours and implications for tumour growth. Br. J. Cancer, 80: 1945-1954. doi:10.1038/sj.bjc.6690624. PMID:10471043.
57. Domachowske, J.B. 1997. The role of nitric oxide in the regulation of cellular iron metabolism. Biochem. Mol. Med. 60: 1-7. doi:10.1006/bmme.1996.2557. PMID:9066977.
58. Doré, S., Takahashi, M., Ferris, C.D., Zakhary, R., Hester, L.D., Guastella, D., and Snyder, S.H. 1999a. Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury. Proc. Natl. Acad. Sci. U.S.A. 96: 2445-2450. doi:10.1073/pnas.96.5.2445. PMID:10051662.
59. Doré, S., Sampei, K., Goto, S., Alkayed, N.J., Guastella, D., Blackshaw, S., et al. 1999b. Heme oxygenase-2 is neuroprotective in cerebral ischemia. Mol. Med. 5: 656-663. PMID:10602774.
60. Doré, S., Goto, S., Sampei, K., Blackshaw, S., Hester, L.D., Ingi, T., et al. 2000. Heme oxygenase-2 acts to prevent neuronal death in brain cultures and following transient cerebral ischemia. Neuroscience, 99: 587-592. doi:10.1016/S0306-4522(00)00216-5. PMID:10974422.
61. Drummond, G.S., and Kappas, A. 1981. Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation. Proc. Natl. Acad. Sci. U.S.A. 78: 6466-6470. doi:10.1073/pnas.78.10.6466. PMID:6947237.
62. Dugue, B., and Meunier, B. 1985. How can iron salts mediate the degradation of nucleos(t)ides by elliptinium acetate via free-radicals? Biochem. Biophys. Res. Commun. 133: 15-22. doi:10.1016/0006-291X(85) 91835-2. PMID:3000372.
63. Dulak, J., Jozkowicz, A., Foresti, R., Kasza, A., Frick, M., Huk, I., et al. 2002. Heme oxygenase activity modulates vascular endothelial growth factor synthesis in vascular smooth muscle cells. Antioxid. Redox Signal. 4: 229-240. doi:10.1089/152308602753666280. PMID:12006174.
64. Durante, W., Christodoulides, N., Cheng, K., Peyton, K.J., Sunahara, R.K., and Schafer, A.I. 1997. cAMP induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle. Am. J. Physiol. 273: H317-H323. PMID:9249506.
65. Durante, W., Peyton, K.J., and Schafer, A.I. 1999. Platelet-derived growth factor stimulates heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 19: 2666-2672. PMID:10559009.
66. Elbashir, S.M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., and Tuschl, T. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature, 411: 494-498. doi:10.1038/35078107. PMID:11373684.
67. Elbirt, K.K., Whitmarsh, A.J., Davis, R.J., and Bonkovsky, H.L. 1998. Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. Role of mitogen-activated protein kinases. J. Biol. Chem. 273: 8922-8931. doi:10.1074/jbc.273.15.8922. PMID:9535875.
68. Ewing, J.F., Haber, S.N., and Maines, M.D. 1992. Normal and heat-induced patterns of expression of heme oxygenase-1 (HSP32) in rat brain: hyperthermia causes rapid induction of mRNA and protein. J. Neurochem. 58: 1140-1149. doi:10.1111/j.1471-4159.1992.tb09373.x. PMID:1737989.
69. Exner, M., Minar, E., Wagner, O., and Schillinger, M. 2004. The role of heme oxygenase-1 promoter polymorphisms in human disease. Free Radic. Biol. Med. 37: 1097-1104. doi:10.1016/j.freeradbiomed.2004.07.008. PMID:15451051.
70. Fang, J., Sawa, T., Akaike, T., Akuta, T., Sahoo, S.K., Khaled, G., et al. 2003. In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor. Cancer Res. 63: 3567-3574. PMID:12839943.
71. Fang, J., Sawa, T., Akaike, T., Greish, K., and Maeda, H. 2004. Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin. Int. J. Cancer, 109: 1-8. doi:10.1002/ijc.11644. PMID:14735461.
72. Farrera, J.A., Jauma, A., Ribo, J.M., Peire, M.A., Parellada, P.P., Roques-Choua, S., et al. 1994. The antioxidant role of bile pigments evaluated by chemical tests. Bioorg. Med. Chem. 2: 181-185. doi:10.1016/S0968- 0896(00)82013-1. PMID:7922130.
73. Fondevila, C., Shen, X.D., Tsuchiyashi, S., Yamashita, K., Csizmadia, E., Lassman, C., et al. 2004. Biliverdin therapy protects rat livers from ischemia and reperfusion injury. Hepatology, 40: 1333-1341. doi:10.1002/hep.20480. PMID:15565657.
74. Foresti, R., Clark, J.E., Green, C.J., and Motterlini, R. 1997. Thiol compounds interact with nitric oxide in regulating heme oxygenase-1 induction in endothelial cells. Involvement of superoxide and peroxynitrite anions. J. Biol. Chem. 272: 18411-18417. doi:10.1074/jbc.272.29.18411. PMID:9218484.
75. Fort, F.L., and Gold, J. 1989. Phototoxicity of tin protoporphyrin, tin mesoporphyrin, and tin diiododeuteroporphyrin under neonatal phototherapy conditions. Pediatrics, 84: 1031-1037. PMID:2531365.
76. Francis, S.E., Sullivan, D.J., Jr., and Goldberg, D.E. 1997. Hemoglobin metabolism in the malaria parasite Plasmodium falciparum. Annu. Rev. Microbiol. 51: 97-123. doi:10.1146/annurev.micro.51.1.97. PMID:9343345.
77. Friedman, J., Lad, L., Deshmukh, R., Li, H., Wilks, A., and Poulos, T.L. 2003. Crystal structures of the NO- and CO-bound heme oxygenase from Neisseriae meningitidis. Implications for O2 activation. J. Biol. Chem. 278: 34654-34659. doi:10.1074/jbc.M302985200. PMID:12819228.
78. Furchgott, R.F., and Jothianandan, D. 1991. Endothelium-dependent and -independent vasodilation involving cyclic GMP: relaxation induced by nitric oxide, carbon monoxide and light. Blood Vessels, 28: 52-61. PMID:1848126.
79. Furci, L.M., Lopes, P., Eakanunkul, S., Zhong, S., MacKerell, A.D., Jr., and Wilks, A. 2007. Inhibition of the bacterial heme oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: novel antimicrobial targets. J. Med. Chem. 50: 3804-3813. doi:10.1021/ jm0700969. PMID:17629261.
80. Galbraith, R.A., Drummond, G.S., and Kappas, A. 1992. Suppression of bilirubin production in the Crigler-Najjar type I syndrome: studies with the heme oxygenase inhibitor tin-mesoporphyrin. Pediatrics, 89: 175-182. PMID:1734381.
81. Ginsburg, H., Famin, O., Zhang, J., and Krugliak, M. 1998. Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action. Biochem. Pharmacol. 56: 1305-1313. doi:10.1016/S0006-2952(98)00184-1. PMID:9825729.
82. Gong, P., Hu, B., Stewart, D., Ellerbe, M., Figueroa, Y.G., Blank, V., et al. 2001. Cobalt induces heme oxygenase-1 expression by a hypoxia-inducible factor-independent mechanism in Chinese hamster ovary cells: regulation by Nrf2 and MafG transcription factors. J. Biol. Chem. 276: 27018-27025. doi:10.1074/jbc.M103658200. PMID:11356853.
83. Goodman, A.I., Choudhury, M., da Silva, J.L., Schwartzman, M.L., and Abraham, N.G. 1997. Overexpression of the heme oxygenase gene in renal cell carcinoma. Proc. Soc. Exp. Biol. Med. 214: 54-61. PMID:9012361.
84. Gorman, D., Drewry, A., Huang, Y.L., and Sames, C. 2003. The clinical toxicology of carbon monoxide. Toxicology, 187: 25-38. doi:10.1016/S0300-483X(03)00005-2. PMID:12679050.
85. Goto, S., Sampei, K., Alkayed, N.J., Doré, S., and Koehler, R.C. 2003. Characterization of a new double-filament model of focal cerebral ischemia in heme oxygenase-2 deficient mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285: R222-R230. PMID:12663258.
86. Grosser, N., Abate, A., Oberle, S., Vreman, H.J., Dennery, P.A., Becker, J.C., et al. 2003. Heme oxygenase-1 induction may explain the antioxidant profile of aspirin. Biochem. Biophys. Res. Commun. 308: 956-960. doi:10.1016/S0006-291X(03)01504-3. PMID:12927812.
87. Grosser, N., Erdmann, K., Hemmerle, A., Berndt, G., Hinkelmann, U., Smith, G., and Schroder, H. 2004. Rosuvastatin upregulates the antioxidant defense protein heme oxygenase-1. Biochem. Biophys. Res. Commun. 325: 871-876. doi:10.1016/j.bbrc.2004.10.123. PMID:15541371.
88. Grundemar, L., and Ny, L. 1997. Pitfalls using metalloporphyrins in carbon monoxide research. Trends Pharmacol. Sci. 18: 193-195. PMID:9226997.
89. Halliwell, B., and Gutteridge, G.M. 1992. Biologically relevant metal ion-dependent hydroxyl radical generation. An update. FEBS Lett. 307: 108-112. doi:10.1016/0014-5793(92)80911-Y. PMID:1322323.
90. Hamilton, A.J., and Baulcombe, D.C. 1999. A species of small antisense RNA in posttranscriptional gene silencing in plants. Science, 286: 950-952. doi:10.1126/science.286.5441.950. PMID:10542148.
91. Hara, E., Takahashi, K., Tominaga, T., Kumabe, T., Kayama, T., Suzuki, H., et al. 1996. Expression of heme oxygenase and inducible nitric oxide synthase mRNA in human brain tumors. Biochem. Biophys. Res. Commun. 224: 153-158. doi:10.1006/bbrc.1996.0999. PMID:8694803.
92. Harada, T., Koi, H., Kubota, T., and Aso, T. 2004. Haem oxygenase augments porcine granulosa cell apoptosis in vitro. J. Endocrinol. 181: 191-205. doi:10.1677/joe.0.1810191. PMID:15072579.
93. Hentze, M.W., and Kuhn, L.C. 1996. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc. Natl. Acad. Sci. U.S.A. 93: 8175-8182. doi:10.1073/pnas.93.16.8175. PMID:8710843.
94. Heykants, J., Van Peer, A., Lavrijsen, K., Meuldermans, W., Woestenborghs, R., and Cauwenbergh, G. 1990. Pharmacokinetics of oral antifungals and their clinical implications. Br. J. Clin. Pract. Suppl. 71: 50-56. PMID:1965419.
95. Hill, M., Pereira, V., Chauveau, C., Zagani, R., Remy, S., Tesson, L., et al. 2005. Heme oxygenase-1 inhibits rat and human breast cancer cell proliferation: mutual cross inhibition with indoleamine 2,3-dioxygenase. FASEB J. 19: 1957-1968. doi:10.1096/fj.05-3875com. PMID:16319139.
96. Hill-Kapturczak, N., Thamilselvan, V., Liu, F., Nick, H.S., and Agarwal, A. 2001. Mechanism of heme oxygenase-1 gene induction by curcumin in human renal proximal tubule cells. Am. J. Physiol. Renal Physiol. 281: F851-F859. PMID:11592943.
97. Hirai, H., Kubo, H., Yamaya, M., Nakayama, K., Numasaki, M., Kobayashi, S., et al. 2003. Microsatellite polymorphism in heme oxygenase-1 gene promoter is associated with susceptibility to oxidant-induced apoptosis in lymphoblastoid cell lines. Blood, 102: 1619-1621. doi:10.1182/blood-2002-12-3733. PMID:12730098.
98. Hirai, K., Sasahira, T., Ohmori, H., Fujii, K., and Kuniyasu, H. 2007. Inhibition of heme oxygenase-1 by zinc protoporphyrin IX reduces tumor growth of LL/2 lung cancer in C57BL mice. Int. J. Cancer, 120: 500-505. doi:10.1002/ijc.22287. PMID:17066448.
99. Ho, I.C., Yih, L.H., Kao, C.Y., and Lee, T.C. 2000. Tin-protoporphyrin potentiates arsenite-induced DNA strand breaks, chromatid breaks and kinetochore-negative micronuclei in human fibroblasts. Mutat. Res. 452: 41-50. PMID:10894889.
100. Hoetzel, A., Dolinay, T., Schmidt, R., Choi, A.M., and Ryter, S.W. 2007. Carbon monoxide in sepsis. Antioxid. Redox Signal. 9: 2013-2026. doi:10.1089/ars.2007.1762. PMID:17822362.
101. Hokamaki, J., Kawano, H., Yoshimura, M., Soejima, H., Miyamoto, S., Kajiwara, I., et al. 2004. Urinary biopyrrins levels are elevated in relation to severity of heart failure. J. Am. Coll. Cardiol. 43: 1880-1885. doi:10.1016/j.jacc.2004.01.028. PMID:15145115.
102. Hou, C.C., Hung, S.L., Kao, S.H., Chen, T.H., and Lee, H.M. 2005. Celecoxib induces heme-oxygenase expression in glomerular mesangial cells. Ann. N. Y. Acad. Sci. 1042: 235-245. doi:10.1196/annals.1338.026. PMID:15965068.
103. Hsu, H.Y., Chu, L.C., Hua, K.F., and Chao, L.K. 2008. Heme oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytes. J. Cell. Physiol. 215: 603-612. doi:10.1002/jcp.21206. PMID:18357586.
104. Huang, F.P., Xi, G., Keep, R.F., Hua, Y., Nemoianu, A., and Hoff, J.T. 2002. Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products. J. Neurosurg. 96: 287-293. PMID:11838803.
105. Ignarro, L.J., Ballot, B., and Woods, K.S. 1984. Regulation of soluble guanylate cyclase activity by porphyrins and metalloporphyrins. J. Biol. Chem. 259: 6201-6207. PMID:6144676.
106. Immenschuh, S., Iwahara, S., Satoh, H., Nell, C., Katz, N., and Muller-Eberhard, U. 1995. Expression of the mRNA of heme-binding protein 23 is coordinated with that of heme oxygenase-1 by heme and heavy metals in primary rat hepatocytes and hepatoma cells. Biochemistry, 34: 13407-13411. doi:10.1021/bi00041a018. PMID:7577927.
107. Immenschuh, S., Hinke, V., Ohlmann, A., Gifhorn-Katz, S., Katz, N., Jungermann, K., and Kietzmann, T. 1998. Transcriptional activation of the haem oxygenase-1 gene by cGMP via a cAMP response element/activator protein-1 element in primary cultures of rat hepatocytes. Biochem. J. 334: 141-146. PMID:9693113.
108. Ishizaka, N., Ishizaka, Y., Takahashi, E., Yamakado, M., and Hashimoto, H. 2001. High serum bilirubin level is inversely associated with the presence of carotid plaque. Stroke, 32: 580-583. PMID:11157203.
109. Iwen, P.C., and Miller, N.G. 1986. Enhancement of ketoconazole penetration across the blood-brain barrier of mice by dimethyl sulfoxide. Antimicrob. Agents Chemother. 30: 617-618. PMID:3789696.
110. Johnson, R.A., Colombari, E., Colombari, D.S., Lavesa, M., Talman, W.T., and Nasjletti, A. 1997. Role of endogenous carbon monoxide in central regulation of arterial pressure. Hypertension, 30: 962-967. PMID:9336401.
111. Jozkowicz, A., Was, H., and Dulak, J. 2007. Heme oxygenase-1 in tumors: is it a false friend? Antioxid. Redox Signal. 9: 2099-2117. doi:10.1089/ars.2007.1659. PMID:17822372.
112. Juan, S.H., Cheng, T.H., Lin, H.C., Chu, Y.L., and Lee, W.S. 2005. Mechanism of concentration-dependent induction of heme oxygenase-1 by resveratrol in human aortic smooth muscle cells. Biochem. Pharmacol. 69: 41-48. doi:10.1016/j.bcp.2004.09.015. PMID:15588712.
113. Kajimura, M., Goda, N., and Suematsu, M. 2002. Organ design for generation and reception of CO: lessons from the liver. Antioxid. Redox Signal. 4: 633-637. doi:10.1089/15230860260220139. PMID:12230875.
114. Kangas, E., Teittinen, K., Vilkko, P., and Utriainen, S. 1999. Bilirubin and peripheral vascular disease. Br. J. Surg. 86: 713. doi:10.1046/j.1365-2168.1999.1104e.x. PMID:10361355.
115. Kappas, A., and Drummond, G.S. 1986. Control of heme metabolism with synthetic metalloporphyrins. J. Clin. Invest. 77: 335-339. doi:10.1172/JCI112309. PMID:3511095.
116. Kappas, A., Drummond, G.S., and Galbraith, R.A. 1993. Prolonged clinical use of a heme oxygenase inhibitor: hematological evidence for an inducible but reversible iron-deficiency state. Pediatrics, 91: 537-539. PMID:8441555.
117. Kaur, H., Hughes, M.N., Green, C.J., Naughton, P., Foresti, R., and Motterlini, R. 2003. Interaction of bilirubin and biliverdin with reactive nitrogen species. FEBS Lett. 543: 113-119. doi:10.1016/S0014-5793(03) 00420-4. PMID:12753916.
118. Kawashima, A., Oda, Y., Yachie, A., Koizumi, S., and Nakanishi, I. 2002. Heme oxygenase-1 deficiency: the first autopsy case. Hum. Pathol. 33: 125-130. doi:10.1053/hupa.2002.30217. PMID:11823983.
119. Keino, H., Nagae, H., Mimura, S., Watanabe, K., and Kashiwamata, S. 1990. Dangerous effects of tin-protoporphyrin plus photo-irradiation on neonatal rats. Eur. J. Pediatr. 149: 278-279. doi:10.1007/BF02106294. PMID:2303077.
120. Keyse, S.M., and Tyrrell, R.M. 1989. Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proc. Natl. Acad. Sci. U.S.A. 86: 99-103. doi:10.1073/pnas.86.1.99. PMID:2911585.
121. Kim, Y.S., and Doré, S. 2005. Catalytically inactive heme oxygenase-2 mutant is cytoprotective. Free Radic. Biol. Med. 39: 558-564. doi:10.1016/j.freeradbiomed.2005.04.009. PMID:16043027.
122. Kinobe, R., Ji, Y., and Nakatsu, K. 2004. Peroxynitrite-mediated inactivation of heme oxygenases. BMC Pharmacol. 4: 26-34. doi:10.1186/1471-2210-4-26. PMID:15498099.
123. Kinobe, R.T., Vlahakis, J.Z., Vreman, H.Z., Stevenson, D.K., Brien, J.F., Szarek, W.A., and Nakatsu, K. 2006a. Selectivity of imidazole-dioxolane compounds for in vitro inhibition of microsomal haem oxygenase isoforms. Br. J. Pharmacol. 147: 307-315. doi:10.1038/sj.bjp.0706555. PMID:16331285.
124. Kinobe, R.T., Dercho, R.A., Vlahakis, J.Z., Brien, J.F., Szarek, W.A., and Nakatsu, K. 2006b. Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs. J. Pharmacol. Exp. Ther. 319: 277-284. doi:10.1124/jpet.106.102699. PMID:16807364.
125. Kinobe, R.T., Ji, Y., Vlahakis, J.Z., Motterlini, R., Brien, J.F., Szarek, W.A., and Nakatsu, K. 2007. Effectiveness of novel imidazole-dioxolane heme oxygenase inhibitors in renal proximal tubule epithelial cells. J. Pharmacol. Exp. Ther. 323: 763-770. doi:10.1124/jpet.107.119800. PMID:17761847.
126. Kirkby, K., Baylis, C., Agarwal, A., Croker, B., Archer, L., and Adin, C. 2007. Intravenous bilirubin provides incomplete protection against renal ischemia-reperfusion injury in vivo. Am. J. Physiol. Renal Physiol. 292: F888-F894. doi:10.1152/ajprenal.00064.2006. PMID:17032942.
127. Kitamura, Y., Kakimura, J., Matsuoka, Y., Nomura, Y., Gebicke-Haerter, P.J., and Taniguchi, T. 1999. Activators of peroxisome proliferator-activated receptor-gamma (PPARgamma) inhibit inducible nitric oxide synthase expression but increase heme oxygenase-1 expression in rat glial cells. Neurosci. Lett. 262: 129-132. doi:10.1016/S0304-3940(99)00055-5. PMID:10203248.
128. Koeppen, A.H., Dickson, A.C., and Smith, J. 2004. Heme oxygenase in experimental intracerebral hemorrhage: the benefit of tin-mesoporphyrin. J. Neuropathol. Exp. Neurol. 63: 587-597. PMID:15217087.
129. Koiso, Y., Nakajima, O., Matsumura, D., Fujimoto, Y., and Hashimoto, Y. 2000. Chemical control of cell differentiation of human myeloleukemia K562 cell line. Yakugaku Zasshi, 120: 104-112. PMID:10655786.
130. Krijgsman, B., Papadakis, J.A., Ganotakis, E.S., Mikhailidis, D.P., and Hamilton, G. 2002. The effect of peripheral vascular disease on the serum levels of natural anti-oxidants: bilirubin and albumin. Int. Angiol. 21: 44-52. PMID:11941273.
131. Kumar, S., Guha, M., Choubey, V., Mait, P., Srivastava, K., Puri, S.K., and Bandyopadhyay, U. 2008. Bilirubin inhibits Plasmodium falciparum growth through the generation of reactive oxygen species. Free Radic. Biol. Med. 44: 602-613. doi:10.1016/j.freeradbiomed.2007.10.057. PMID:18070610.
132. Kutty, R.K., Nagineni, C.N., Kutty, G., Hooks, J.J., Chader, G.J., and Wiggert, B. 1994. Increased expression of heme oxygenase-1 in human retinal pigment epithelial cells by transforming growth factor-beta. J. Cell. Physiol. 159: 371-378. doi:10.1002/jcp.1041590221. PMID:8163576.
133. Ladan, H., Nitzan, Y., and Malik, Z. 1993. The antibacterial activity of haemin compared with cobalt, zinc and magnesium protoporphyrin and its effect on potassium loss and ultrastructure of Staphylococcus aureus. FEMS Microbiol. Lett. 112: 173-177. doi:10.1111/j.1574-6968.1993.tb06444.x. PMID:8405959.
134. Land, E.J., McDonagh, A.F., McGarvey, D.J., and Truscott, T.G. 1988. Photophysical studies of tin(IV)-protoporphyrin: potential phototoxicity of a
135. Lavrovsky, Y., Schwartzman, M.L., Levere, R.D., Kappas, A., and Abraham, N.G. 1994. Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase 1 gene. Proc. Natl. Acad. Sci. U.S.A. 91: 5987-5991. doi:10.1073/pnas.91.13.5987. PMID:8016102.
136. Lee, T.S., and Chau, L.Y. 2002. Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Nat. Med. 8: 240-246. doi:10.1038/nm0302-240. PMID:11875494.
137. Lew, V.L., Macdonald, L., Ginsburg, H., Krugliak, M., and Tiffert, T. 2004. Excess haemoglobin digestion by malaria parasites: a strategy to prevent premature host cell lysis. Blood Cells Mol. Dis. 32: 353-359. doi:10.1016/j.bcmd.2004.01.006. PMID:15121091.
138. Li, X., and Clark, J.D. 2000. Heme oxygenase type 2 plays a role in formalin-induced nociception. Pain, 86: 75-80. doi:10.1016/S0304-3959(00) 00238-4. PMID:10779663.
139. Li, X., Angst, M.S., and Clark, J.D. 2001. A murine model of opioid-induced hyperalgesia. Brain Res. Mol. Brain Res., 86: 56-62. doi:10.1016/S0169-328X(00)00260-6. PMID:11165371.
140. Li, X., and Clark, J.D. 2003. Heme oxygenase type 2 participates in the development of chronic inflammatory and neuropathic pain. J. Pain, 4: 101-107. doi:10.1054/jpai.2003.18. PMID:14622721.
141. Liang, D., Li, X., Lighthall, G., and Clark, J.D. 2003. Heme oxygenase type 2 modulates behavioral and molecular changes during chronic exposure to morphine. Neuroscience, 121: 999-1005. doi:10.1016/S0306-4522(03)00483-4. PMID:14580950.
142. Lin, Q.S., Weis, S., Yang, G., Weng, Y.H., Helston, R., Risk, K., et al. 2007. Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress. J. Biol. Chem. 282: 20621-20633. doi:10.1074/jbc.M607954200. PMID:17430897.
143. Lin, Q.S., Weis, S., Yang, G., Zhuang, T., Abate, A., and Dennery, P.A. 2008. Catalytic inactive heme oxygenase-1 protein regulates its own expression in oxidative stress. Free Radic. Biol. Med. 44: 847-855. doi:10.1016/j.freeradbiomed.2007.11.012. PMID:18154739.
144. Linden, D.J., Narasimhan, K., and Gurfel, D. 1993. Protoporphyrins modulate voltage-gated Ca current in AtT-20 pituitary cells. J. Neurophysiol. 70: 2673-2677. PMID:7907135.
145. Liu, N., Wang, X., McCoubrey, W.K., Jr., and Maines, M.D. 2000. Developmentally regulated expression of two transcripts for heme oxygenase-2 with a first exon unique to rat testis: control by corticosterone of the oxygenase protein expression. Gene, 241: 175-183. doi:10.1016/S0378- 1119(99)00439-4. PMID:10607912.
146. Liu, X.M., Chapman, G.B., Wang, H., and Durante, W. 2002. Adenovirus-mediated heme oxygenase-1 gene expression stimulates apoptosis in vascular smooth muscle cells. Circulation, 105: 79-84. doi:10.1161/hc0102.101369. PMID:11772880.
147. Liu, Z.M., Chen, G.G., Ng, E.K., Leung, W.K., Sung, J.J., and Chung, S.C. 2004. Upregulation of heme oxygenase-1 and p21 confers resistance to apoptosis in human gastric cancer cells. Oncogene, 23: 503-513. doi:10.1038/sj.onc.1207173. PMID:14647439.
148. Luo, D., and Vincent, S.R. 1994. Metalloporphyrins inhibit nitric oxide-dependent cGMP formation in vivo. Eur. J. Pharmacol. 267: 263-267. doi:10.1016/0922-4106(94)90149-X. PMID:7522180.
149. Lyall, F., Barber, A., Myatt, L., Bulmer, J.N., and Robson, S.C. 2000. Hemeoxygenase expression in human placenta and placental bed implies a role in regulation of trophoblast invasion and placental function. FASEB J. 14: 208-219. PMID:10627295.
150. Maines, M.D. 1988. Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J. 2: 2557-2568. PMID:3290025.
151. Maines, M.D., and Abrahamsson, P.A. 1996. Expression of heme oxygenase-1 (HSP32) in human prostate: normal, hyperplastic, and tumor tissue distribution. Urology, 47: 727-733. doi:10.1016/S0090-4295(96)00010-6. PMID:8650873.
152. Maines, M.D., and Ewing, J.F. 1996. Stress response of the rat testis: in situ hydridization and immunohistochemical analysis of heme oxygenase-1 (HSP32) induction by hyperthermia. Biol. Reprod. 54: 1070-1079. doi:10.1095/biolreprod54.5.1070. PMID:8722628.
153. Malik, Z., Ladan, H., Nitzan, Y., and Ehrenberg, B. 1990. The bactericidal activity of a deuteroporphyrin-hemin mixture on grampositive bacteria. A microbiological and spectroscopic study. J. Photochem. Photobiol. B, 6: 419-430. doi:10.1016/1011-1344(90)85115-D. PMID:2120409.
154. Marks, G.S. 1987. The 1986 Upjohn award lecture. Interaction of chemicals with hemoproteins: implications for the mechanism of action of porphyrinogenic drugs and nitroglycerin. Can. J. Physiol. Pharmacol. 65: 1111-1119. PMID:3113708.
155. Martasek, P., Solangi, K., Goodman, A.I., Levere, R.D., Chernick, R.D., and Abraham, N.G. 1988. Properties of human kidney heme oxygenase: inhibition by synthetic heme analogues and metalloporphyrins. Biochem. Biophys. Res. Commun. 157: 480-487. doi:10.1016/S0006-291X(88)80274-2. PMID:3202858.
156. Martinez, J.C., Garcia, H., Otheguy, L., Drummond, G.S., and Kappas, A. 2001. Treatment of hyperbilirubinemia pharmacologic approach SnMP(tin-mesoporphyrin). J. Perinatol. 21: S101-S107. doi:10.1038/sj.jp.7210655. PMID:11803428.
157. Mayerhofer, M., Florian, S., Krauth, M.T., Aichberger, K.J., Bilban, M., Marculescu, R., et al. 2004. Identification of heme oxygenase-1 as a novel BCR/ABL-dependent survival factor in chronic myeloid leukemia. Cancer Res. 64: 3148-3154. doi:10.1158/0008-5472.CAN-03-1200. PMID:15126353.
158. McCarter, S.D., Scott, J.R., Lee, P.J., Zhang, X., Choi, A.M., McLean, C.A., et al. 2003. Cotransfection of heme oxygenase-1 prevents the acute inflammation elicited by a second adenovirus. Gene Ther. 10: 1629-1635. doi:10.1038/sj.gt.3302063. PMID:12923561.
159. McCarty, M.F. 2007. "Iatrogenic Gilbert syndrome"-a strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubin. Med. Hypotheses, 69: 974-994. doi:10.1016/j.mehy.2006.12.069. PMID:17825497.
160. McDonagh, A.F., and Assisi, F. 1972. The ready isomerization of bilirubin IX- in aqueous solution. Biochem. J. 129: 797-800. PMID:4659001.
161. Miralem, T., Hu, Z., Torno, M.D., Lelli, K.M., and Maines, M.D. 2005. Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells. J. Biol. Chem. 280: 17084-17092. doi:10.1074/jbc.M413121200. PMID:15741166.
162. Mitrione, S.M., Villalon, P., Lutton, J.D., Levere, R.D., and Abraham, N.G. 1988. Inhibition of human adult and fetal heme oxygenase by new synthetic heme analogues. Am. J. Med. Sci. 296: 180-186. doi:10.1097/00000441- 198809000-00006. PMID:3177434.
163. Morioka, I., Wong, R.J., Abate, A., Vreman, H.J., Contag, C.H., and Stevenson, D.K. 2006. Systemic effects of orally-administered zinc and tin (IV) metalloporphyrins on heme oxygenase expression in mice. Pediatr. Res. 59: 667-672. doi:10.1203/01.pdr.0000215088.71481.a6. PMID:16627879.
164. Morita, Y., Takahashi, H., Kamihata, H., Yamamoto, Y., Hara, K., and Iwasaka, T. 2001. Urinary excretion of biopyrrins, oxidative metabolites of bilirubin, increases after spasm provocation tests in patients with coronary spastic angina. Int. J. Cardiol. 80: 243-250. doi:10.1016/S0167-5273(01) 00517-4. PMID:11578721.
165. Motterlini, R., Foresti, R., Bassi, R., and Green, C.J. 2000. Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic. Biol. Med. 28: 1303-1312. doi:10.1016/S0891-5849(00)00294-X. PMID:10889462.
166. Motterlini, R., Sawle, P., Hammad, J., Bains, S., Alberto, R., Foresti, R., and Green, C.J. 2005. CORM-A1: a new pharmacologically active carbon monoxide-releasing molecule. FASEB J. 19: 284-286. PMID:15556971.
167. Nagai, H., Kitagaki, K., Kuwabara, K., and Koda, A. 1992. Anti-inflammatory properties of zinc protoporphyrin disodium (Zn-PP-2Na). Agents Actions, 37: 273-283. doi:10.1007/BF02028120. PMID:1295376.
168. Nakao, A., Otterbein, L.E., Overhaus, M., Sarady, J.K., Tsung, A., Kimizuka, K., et al. 2004. Biliverdin protects the functional integrity of a transplanted syngeneic small bowel. Gastroenterology, 127: 595-606. doi:10.1053/j.gastro.2004.05.059. PMID:15300591.
169. Nakao, A., Neto, J.S., Kanno, S., Stolz, D.B., Kimizuka, K., Liu, F., et al. 2005. Protection against ischemia/reperfusion injury in cardiac and renal transplantation with carbon monoxide, biliverdin and both. Am. J. Transplant. 5: 282-291. doi:10.1111/j.1600-6143.2004.00695.x. PMID:15643987.
170. Namiranian, K., Koehler, R.C., Sapirstein, A., and Doré, S. 2005. Stroke outcomes in mice lacking the genes for neuronal heme oxygenase-2 and nitric oxide synthase. Curr. Neurovasc. Res. 2: 23-27. doi:10.2174/1567202052773517. PMID:16181097.
171. Nath, K.A., Vercellotti, G.M., Grande, J.P., Miyoshi, H., Paya, C.V., Manivel, J.C., et al. 2001. Heme protein-induced chronic renal inflammation: suppressive effect of induced heme oxygenase-1. Kidney Int. 59: 106-117. doi:10.1046/j.1523-1755.2001.00471.x. PMID:11135063.
172. Ndisang, J.F., and Wang, R. 2003. Alterations in heme oxygenase/carbon monoxide system in pulmonary arteries in hypertension. Exp. Biol. Med. (Maywood), 228: 557-563. PMID:12709586.
173. Ning, W., Song, R., Li, C., Park, E., Mohsenin, A., Choi, A.M., and Choi, M.E. 2002. TGF-beta1 stimulates HO-1 via the p38 mitogen-activated protein kinase in A549 pulmonary epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 283: L1094-L1102. PMID:12376363.
174. Noodt, B.B., Berg, K., Stokke, T., Peng, Q., and Nesland, J.M. 1996. Apoptosis and necrosis induced with light and 5-amino-laevulinic acid-derived protoporphyrin IX. Br. J. Cancer, 74: 22-29. PMID:8679453.
175. Novogrodsky, A., Suthanthiran, M., and Stenzel, K.H. 1989. Immune stimulatory properties of metalloporphyrins. J. Immunol. 143: 3981-3987. PMID:2512345.
176. Ny, L., Andersson, K.E., and Grundemar, L. 1995. Inhibition by zinc protoporphyrin-IX of receptor-mediated relaxation of the rat aorta in a manner distinct from inhibition of haem oxygenase. Br. J. Pharmacol. 115: 186-190. PMID:7647974.
177. Ono, K., Mannami, T., and Iwai, N. 2003. Association of a promoter variant of the haeme oxygenase-1 gene with hypertension in women. J. Hypertens. 21: 1497-1503. doi:10.1097/00004872-200308000-00013. PMID:12872043.
178. Otterbein, L., Sylvester, S.L., and Choi, A.M. 1995. Hemoglobin provides protection against lethal endotoxemia in rats: the role of heme oxygenase-1. Am. J. Respir. Cell Mol. Biol. 13: 595-601. PMID:7576696.
179. Otterbein, L.E., Bach, F.H., Alam, J., Soares, M., Tao, L.H., Wysk, M., et al. 2000. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat. Med. 6: 422-428. doi:10.1038/74680. PMID:10742149.
180. Pamplona, A., Ferreira, A., Balla, J., Jeney, V., Balla, G., Epiphanio, S., et al. 2007. Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria. Nat. Med. 13: 703-710. doi:10.1038/nm1586. PMID:17496899.
181. Papadakis, J.A., Ganotakis, E.S., Jagroop, I.A., Mikhailidis, D.P., and Winder, A.F. 1999. Effect of hypertension and its treatment on lipid, lipoprotein(a), fibrinogen, and bilirubin levels in patients referred for dyslipidemia. Am. J. Hypertens. 12: 673-681. doi:10.1016/S0895-7061(99) 00049-7. PMID:10411364.
182. Payne, S.M. 1993. Iron acquisition in microbial pathogenesis. Trends Microbiol. 1: 66-69. doi:10.1016/0966-842X(93)90036-Q. PMID:8044465.
183. Pendrak, M.L., Chao, M.P., Yan, S.S., and Roberts, D.D. 2004. Heme oxygenase in Candida albicans is regulated by hemoglobin and is necessary for metabolism of exogenous heme and hemoglobin to alpha-biliverdin. J. Biol. Chem. 279: 3426-3433. doi:10.1074/jbc.M311550200. PMID:14615478.
184. Pimstone, N.R., Engel, P., Tenhunen, R., Seitz, P.T., Marver, H.S., and Schmid, R. 1971. Inducible heme oxygenase in the kidney: a model for the homeostatic control of hemoglobin catabolism. J. Clin. Invest. 50: 2042-2050. doi:10.1172/JCI106697. PMID:4398936.
185. Platel, D.F., Mangou, F., and Tribouley-Duret, J. 1999. Role of glutathione in the detoxification of ferriprotoporphyrin IX in chloroquine resistant Plasmodium berghei. Mol. Biochem. Parasitol. 98: 215-223. doi:10.1016/S0166-6851(98)00170-4. PMID:10080390.
186. Platt, J.L., and Nath, K.A. 1998. Heme oxygenase: protective gene or Trojan horse. Nat. Med. 4: 1364-1365. doi:10.1038/3947. PMID:9846569.
187. Poss, K.D., and Tonegawa, S. 1997. Reduced stress defense in heme oxygenase 1-deficient cells. Proc. Natl. Acad. Sci. U.S.A. 94: 10925-10930. doi:10.1073/pnas.94.20.10925. PMID:9380736.
188. Poss, K.D., Thomas, M.J., Ebralidze, A.K., O'Dell, T.J., and Tonegawa, S. 1995. Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice. Neuron, 15: 867-873. doi:10.1016/0896-6273(95)90177-9. PMID:7576635.
189. Qiu, S., Adema, C.M., and Lane, T. 2005. A computational study of off-target effects of RNA interference. Nucleic Acids Res. 33: 1834-1847. doi:10.1093/nar/gki324. PMID:15800213.
190. Qu, Y., Chen, J., Benvenisti-Zarom, L., Ma, X., and Regan, R.F. 2005. Effect of targeted deletion of the heme oxygenase-2 gene on hemoglobin toxicity in the striatum. J. Cereb. Blood Flow Metab. 25: 1466-1475. doi:10.1038/sj.jcbfm.9600143. PMID:15902196.
191. Qu, Y., Chen-Roetling, J., Benvenisti-Zarom, L., and Regan, R.F. 2007. Attenuation of oxidative injury after induction of experimental intracerebral hemorrhage in heme oxygenase-2 knockout mice. J. Neurosurg. 106: 428-435. doi:10.3171/jns.2007.106.3.428. PMID:17367065.
192. Raju, V.S., and Maines, M.D. 1994. Coordinated expression and mechanism of induction of HSP32 (heme oxygenase-1) mRNA by hyperthermia in rat organs. Biochim. Biophys. Acta, 1217: 273-280. PMID:8148372.
193. Raju, V.S., McCoubrey, W.K., Jr., and Maines, M.D. 1997. Regulation of heme oxygenase-2 by glucocorticoids in neonatal rat brain: characterization of a functional glucocorticoid response element. Biochim. Biophys. Acta, 1351: 89-104. PMID:9116047.
194. Ratliff, M., Zhu, W., Deshmukh, R., Wilks, A., and Stojiljkovic, I. 2001. Homologues of neisserial heme oxygenase in gram-negative bacteria: degradation of heme by the product of the pigA gene of Pseudomonas aeruginosa. J. Bacteriol. 183: 6394-6403. doi:10.1128/JB.183.21.6394-6403.2001. PMID:11591684.
195. Reddi, E., Jori, G., and Rubaltelli, F.F. 1991. Photochemical and photosensitizing properties of monomeric and dimeric Sn(IV)-protoporphyrin. J. Photochem. Photobiol. B, 8: 159-167. doi:10.1016/1011-1344(91)80054-L. PMID:1904917.
196. Regan, R.F., Chen, J., and Benvenisti-Zarom, L. 2004. Heme oxygenase-2 gene deletion attenuates oxidative stress in neurons exposed to extracellular hemin. BMC Neurosci. 5: 34-41. doi:10.1186/1471-2202-5-34. PMID:15377391.
197. Ridley, K.A., Rock, J.D., Li, Y., and Ketley, J.M. 2006. Heme utilization in Campylobacter jejuni. J. Bacteriol. 188: 7862-7875. doi:10.1128/JB.00994-06. PMID:16980451.
198. Rodrigues, C.M., Sola, S., Silva, R., and Brites, D. 2000. Bilirubin and amyloid-beta peptide induce cytochrome c release through mitochondrial membrane permeabilization. Mol. Med. 6: 936-946. PMID:11147571.
199. Rogers, B., Yakopson, V., Teng, Z.P., Guo, Y., and Regan, R.F. 2003. Heme oxygenase-2 knockout neurons are less vulnerable to hemoglobin toxicity. Free Radic. Biol. Med. 35: 872-881. doi:10.1016/S0891-5849(03)00431-3. PMID:14556851.
200. Roman, G., Riley, J.G., Vlahakis, J.Z., Kinobe, R.T., Brien, J.F., Nakatsu, K., and Szarek, W.A. 2007. Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring. Bioorg. Med. Chem. 15: 3225-3234. doi:10.1016/j.bmc.2007.02.034. PMID:17339115.
201. Ryter, S.W., and Choi, A.M. 2005. Heme oxygenase-1: redox regulation of a stress protein in lung and cell culture models. Antioxid. Redox Signal. 7: 80-91. doi:10.1089/ars.2005.7.80. PMID:15650398.
202. Ryter, S.W., and Choi, A.M. 2006. Therapeutic applications of carbon monoxide in lung disease. Curr. Opin. Pharmacol. 6: 257-262. doi:10.1016/j.coph.2006.03.002. PMID:16580257.
203. Ryter, S.W., and Tyrrell, R.M. 2000. The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties. Free Radic. Biol. Med. 28: 289-309. doi:10.1016/S0891-5849(99)00223-3. PMID:11281297.
204. Ryter, S.W., Alam, J., and Choi, A.M. 2006. Heme oxygenase-1/ carbon monoxide: from basic science to therapeutic applications. Physiol. Rev. 86: 583-650. doi:10.1152/physrev.00011.2005. PMID:16601269.
205. Sahni, S.K., Rydkina, E., Sahni, A., Joshi, S.G., and Silverman, D.J. 2005. Potential roles for regulatory oxygenases in rickettsial pathogenesis. Ann. N. Y. Acad. Sci. 1063: 207-214. doi:10.1196/annals.1355.033. PMID:16481516.
206. Santos, R., Buisson, N., Knight, S., Dancis, A., Camadro, J.M., and Lesuisse, F. 2003. Haemin uptake and use as an iron source by Candida albicans: role of CaHMX1-encoded haem oxygenase. Microbiology, 149: 579-588. doi:10.1099/mic.0.26108-0. PMID:12634327.
207. Sarady, J.K., Zuckerbraun, B.S., Bilban, M., Wagner, O., Usheva, A., Liu, F., et al. 2004. Carbon monoxide protection against endotoxic shock involves reciprocal effects on iNOS in the lung and liver. FASEB J. 18: 854-856. PMID:15001560.
208. Sardana, M.K., and Kappas, A. 1987. Dual control mechanism for heme oxygenase: tin(IV)-protoporphyrin potently inhibits enzyme activity while markedly increasing content of enzyme protein in liver. Proc. Natl. Acad. Sci. U.S.A. 84: 2464-2468. doi:10.1073/pnas.84.8.2464. PMID:3470805.
209. Sawa, T., Nakao, M., Akaike, T., Ono, K., and Maeda, H. 1999. Alkylperoxyl radical-scavenging activity of various flavonoids and other phenolic compounds: implications for the anti-tumor-promoter effect of vegetables. J. Agric. Food Chem. 47: 397-402. doi:10.1021/jf980765e. PMID:10563906.
210. Scapagnini, G., Foresti, R., Calabrese, V., Giuffrida Stella, A.M., Green, C.J., and Motterlini, R. 2002. Caffeic acid phenethyl ester and curcumin: a novel class of heme oxygenase-1 inducers. Mol. Pharmacol. 61: 554-561. doi:10.1124/mol.61.3.554. PMID:11854435.
211. Schacter, B.A., and Kurz, P. 1982. Alterations in hepatic and splenic microsomal electron transport system components, drug metabolism, heme oxygenase activity, and cytochrome P-450 turnover in Murphy-Sturm lymphosarcoma-bearing rats. Cancer Res. 42: 3557-3564. PMID:6809310.
212. Schipper, H.M., Chertkow, H., Mehindate, K., Frankel, D., Melmed, C., and Bergman, H. 2000. Evaluation of heme oxygenase-1 as a systemic biological marker of sporadic AD. Neurology, 54: 1297-1304. PMID:10746601.
213. Schmidt, R. 2007. Cobalt protoporphyrin as a potential therapeutic agent? FASEB J. 21: 2639. doi:10.1096/fj.07-0904ltr. PMID:17766326.
214. Schuller, D.J., Wilks, A., Ortiz de Montellano, P.R., and Poulos, T.L. 1999. Crystal structure of human heme oxygenase-1. Nat. Struct. Biol. 6: 860-867. doi:10.1038/12319. PMID:10467099.
215. Schuller, D.J., Zhu, W., Stojiljkovic, I., Wilks, A., and Poulos, T.L. 2001. Crystal structure of heme oxygenase from the gram-negative pathogen Neisseria meningitidis and a comparison with mammalian heme oxygenase-1. Biochemistry, 40: 11552-11558. doi:10.1021/bi0110239. PMID:11560504.
216. Sedlak, T.W., and Snyder, S.H. 2004. Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle. Pediatrics, 113: 1776-1782. doi:10.1542/peds.113.6.1776. PMID:15173506.
217. Shan, Y., Lambrecht, R.W., Hong, L.T., and Bonkovsky, H.L. 1999. Effects of phenylarsine oxide on expression of heme oxygenase-1 reporter constructs in transiently transfected cultures of chick embryo liver cells. Arch. Biochem. Biophys. 372: 224-229. doi:10.1006/abbi.1999.1490. PMID:10600159.
218. Shibahara, S., Yoshida, T., and Kikuchi, G. 1979. Mechanism of increase of heme oxygenase activity induced by hemin in cultured pig alveolar macrophages. Arch. Biochem. Biophys. 197: 607-617. doi:10.1016/0003- 9861(79)90285-6. PMID:507831.
219. Shimomura, H., Ogawa, H., Takazoe, K., Soejima, H., Miyamoto, S., Sakamoto, T., et al. 2002. Comparison of urinary biopyrrin levels in acute myocardial infarction (after reperfusion therapy) versus stable angina pectoris and their usefulness in predicting subsequent cardiac events. Am. J. Cardiol. 90: 108-111. doi:10.1016/S0002-9149(02)02430-X. PMID:12106837.
220. Shiraishi, F., Curtis, L.M., Truong, L., Poss, K., Visner, G.A., Madsen, K., et al. 2000. Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis. Am. J. Physiol. Renal Physiol. 278: F726-F736. PMID:10807584.
221. Siner, J.M., Jiang, G., Cohen, Z.I., Shan, P., Zhang, X., Lee, C.G., et al. 2007. VEGF-induced heme oxygenase-1 confers cytoprotection from lethal hyperoxia in vivo. FASEB J. 21: 1422-1432. doi:10.1096/fj.06-6661com. PMID:17264168.
222. Siow, R.C., Ishii, T., Sato, H., Taketani, S., Leake, D.S., Sweiry, J.H., et al. 1995. Induction of the antioxidant stress proteins heme oxygenase-1 and MSP23 by stress agents and oxidized LDL in cultured vascular smooth muscle cells. FEBS Lett. 368: 239-242. doi:10.1016/0014-5793(95)00650-X. PMID:7628613.
223. Skaar, E.P., Gaspar, A.H., and Schneewind, O. 2004. IsdG and IsdI, heme-degrading enzymes in the cytoplasm of Staphylococcus aureus. J. Biol. Chem. 279: 436-443. doi:10.1074/jbc.M307952200. PMID:14570922.
224. Smith, M.L., Norden, B., Edlund, U., Romeo, P.H., Rosa, J., and Paul, K.G. 1986. A 13C-NMR study of mutant hemoglobins with altered oxygen affinity. FEBS Lett. 202: 337-339. doi:10.1016/0014-5793(86)80713-X. PMID:3720952.
225. Smith, A., Alam, J., Escriba, P.V., and Morgan, W.T. 1993. Regulation of heme oxygenase and metallothionein gene expression by the heme analogs, cobalt-, and tin-protoporphyrin. J. Biol. Chem. 268: 7365-7371. PMID:8463269.
226. Song, R., Kubo, M., Morse, D., Zhou, Z., Zhang, X., Dauber, J.H., et al. 2003. Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and antiapoptotic effects. Am. J. Pathol. 163: 231-242. PMID:12819027.
227. Song, R., Mahidhara, R.S., Zhou, Z., Hoffman, R.A., Seol, D.W., Flavell, R.A., et al. 2004. Carbon monoxide inhibits T lymphocyte proliferation via caspase-dependent pathway. J. Immunol. 172: 1220-1226. PMID:14707100.
228. Srivastava, P., and Pandy, V.C. 1995. Heme oxygenase and related indices in chloroquine-resistant and -sensitive strains of Plasmodium berghei. Int. J. Parasitol. 25: 1061-1064. doi:10.1016/0020-7519(95)00013-R. PMID:8847167.
229. Srivastava, P., Puri, S.K., Dutta, G.P., and Pandy, V.C. 1992. Status of oxidative stress and antioxidant defences during Plasmodium knowlesi infection and chloroquine treatment in Macaca mulatta. Int. J. Parasitol. 22: 243-245. doi:10.1016/0020-7519(92)90109-X. PMID:1316884.
230. Srivastava, P., Pandey, V.C., Misra, A.P., Gupta, P., Raj, K., and Bhaduri, A.P. 1998. Potential inhibitors of plasmodial heme oxygenase; an innovative approach for combating chloroquine resistant malaria. Bioorg. Med. Chem. 6: 181-187. doi:10.1016/S0968-0896(97)10013-X. PMID:9547941.
231. Stevenson, D.K., Watson, E.M., Hintz, S.R., Kim, C.B., and Vreman, H.J. 1987. Tin protoporphyrin inhibits carbon monoxide production in suckling mice. Biol. Neonate, 51: 40-44. PMID:3828416.
232. Stewart, R.D. 1976. Proceedings: The effect of carbon monoxide on humans. J. Occup. Med. 18: 304-309. doi:10.1097/00043764-197605000-00004. PMID:778353.
233. Stocker, R. 2004. Antioxidant activities of bile pigments. Antioxid. Redox Signal. 6: 841-849. PMID:15345144.
234. Stocker, R., and Peterhans, E. 1989. Antioxidant properties of conjugated bilirubin and biliverdin: biologically relevant scavenging of hypochlorous acid. Free Radic. Res. Commun. 6: 57-66. doi:10.3109/10715768909073428. PMID:2542140.
235. Stocker, R., Yamamoto, Y., McDonagh, A.F., Glazer, A.N., and Ames, B.N. 1987. Bilirubin is an antioxidant of possible physiological importance. Science, 235: 1043-1046. doi:10.1126/science.3029864. PMID:3029864.
236. Stone, J.R., and Marletta, M.A. 1994. Soluble guanylate cyclase from bovine lung: activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states. Biochemistry, 33: 5636-5640. doi:10.1021/bi00184a036. PMID:7910035.
237. Suits, M.D., Pal, G.P., Nakatsu, K., Matte, A., Cygler, M., and Jia, Z. 2005. Identification of an Escherichia coli O157:H7 heme oxygenase with tandem functional repeats. Proc. Natl. Acad. Sci. U.S.A. 102: 16955-16960. doi:10.1073/pnas.0504289102. PMID:16275907.
238. Sunamura, M., Duda, D.G., Ghattas, M.H., Lozonschi, L., Motoi, F., Yamauchi, J., et al. 2003. Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer. Angiogenesis, 6: 15-24. doi:10.1023/A: 1025803600840. PMID:14517400.
239. Suttner, D.M., and Dennery, P.A. 1999. Reversal of HO-1 related cytoprotection with increased expression is due to reactive iron. FASEB J. 13: 1800-1809. PMID:10506583.
240. Tacchini, L., Dansi, P., Matteucci, E., and Desiderio, M.A. 2001. Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells. Carcinogenesis, 22: 1363-1371. doi:10.1093/carcin/22.9.1363. PMID:11532856.
241. Takahashi, K., Hara, E., Suzuki, H., Sasano, H., and Shibahara, S. 1996. Expression of heme oxygenase isozyme mRNAs in the human brain and induction of heme oxygenase-1 by nitric oxide donors. J. Neurochem. 67: 482-489. PMID:8764571.
242. Taketani, S., Kohno, H., Yoshinaga, T., and Tokunaga, R. 1989. The human 32-kDa stress protein induced by exposure to arsenite and cadmium ions is heme oxygenase. FEBS Lett. 245: 173-176. doi:10.1016/0014-5793(89)80215-7. PMID:2924920.
243. Tenhunen, R., Marver, H.S., and Schmid, R. 1969. Microsomal heme oxygenase. Characterization of the enzyme. J. Biol. Chem. 244: 6388-6394. PMID:4390967.
244. Tenhunen, R., Marver, H.S., and Schmid, R. 1970. The enzymatic catabolism of hemoglobin: stimulation of microsomal heme oxygenase by hemin. J. Lab. Clin. Med. 75: 410-421. PMID:4392030.
245. Teran, F.J., Johnson, R.A., Stevenson, B.K., Peyton, K.J., Jackson, K.E., Appleton, S.D., et al. 2005. Heme oxygenase-derived carbon monoxide promotes arteriolar endothelial dysfunction and contributes to salt-induced hypertension in Dahl salt-sensitive rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288: R615-R622. PMID:15528397.
246. Terry, C.M., Clikeman, J.A., Hoidal, J.R., and Callahan, K.S. 1998. Effect of tumor necrosis factor-alpha and interleukin-1 alpha on heme oxygenase-1 expression in human endothelial cells. Am. J. Physiol. 274: H883-H891. PMID:9530200.
247. Terry, C.M., Clikeman, J.A., Hoidal, J.R., and Callahan, K.S. 1999. TNF-alpha and IL-1alpha induce heme oxygenase-1 via protein kinase C, Ca2+, and phospholipase A2 in endothelial cells. Am. J. Physiol. 276: H1493-H1501. PMID:10330231.
248. Thom, S.R., Weaver, L.K., and Hampson, N.B. 2005. "Therapeutic" carbon monoxide may be toxic. Am. J. Respir. Crit. Care Med. 171: 1318. PMID:15914571.
249. Tiribelli, C., and Ostrow, J.D. 1996. New concepts in bilirubin and jaundice: report of the Third International Bilirubin Workshop, April 6-8, 1995, Trieste, Italy. Hepatology, 24: 1296-1311. doi:10.1002/hep.510240551. PMID:8903413.
250. Torisu-Itakura, H., Furue, M., Kuwano, M., and Ono, M. 2000. Co-expression of thymidine phosphorylase and heme oxygenase-1 in macrophages in human malignant vertical growth melanomas. Jpn. J. Cancer Res. 91: 906-910. PMID:11011118.
251. Tschugguel, W., Stonek, F., Zhegu, Z., Dietrich, W., Schneeberger, C., Stimpfl, T., et al. 2001. Estrogen increases endothelial carbon monoxide, heme oxygenase 2, and carbon monoxide-derived cGMP by a receptor-mediated system. J. Clin. Endocrinol. Metab. 86: 3833-3839. doi:10.1210/jc.86.8.3833. PMID:11502820.
252. Tsuji, M.H., Yanagawa, T., Iwasa, S., Tabuchi, K., Onizawa, K., Bannai, S., et al. 1999. Heme oxygenase-1 expression in oral squamous cell carcinoma as involved in lymph node metastasis. Cancer Lett. 138: 53-59. doi:10.1016/S0304-3835(98)00372-3. PMID:10378773.
253. Tulis, D.A., Durante, W., Peyton, K.J., Evans, A.J., and Schafer, A.I. 2001. Heme oxygenase-1 attenuates vascular remodeling following balloon injury in rat carotid arteries. Atherosclerosis, 155: 113-122. doi:10.1016/S0021-9150(00)00552-9. PMID:1 1223432.
254. Undem, B.J., Ellis, J.L., Meeker, S., Fischer, A., and Canning, B.J. 1996. Inhibition by zinc protoporphyrin-IX of vasoactive intestinal peptide-induced relaxations of guinea pig isolated trachea. J. Pharmacol. Exp. Ther. 278: 964-970. PMID:8768754.
255. Vile, G.F., and Tyrrell, R.M. 1993. Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin. J. Biol. Chem. 268: 14678-14681. PMID:8325845.
256. Vile, G.F., Basu-Modak, S., Waltner, C., and Tyrrell, R.M. 1994. Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 91: 2607-2610. doi:10.1073/pnas.91.7.2607. PMID:8146161.
257. Vitek, L., Jirsa, M., Brodanova, M., Kalab, M., Marecek, Z., Danzig, V., et al. 2002. Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels. Atherosclerosis, 160: 449-456. doi:10.1016/S0021-9150(01)00601-3. PMID:11849670.
258. Vlahakis, J.Z., Kinobe, R.T., Bowers, R.J., Brien, J.F., Nakatsu, K., and Szarek, W.A. 2005. Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors. Bioorg. Med. Chem. Lett. 15: 1457-1461. doi:10.1016/j.bmcl.2004.12.075. PMID:15713406.
259. Vlahakis, J.Z., Kinobe, R.T., Bowers, R.J., Brien, J.F., Nakatsu, K., and Szarek, W.A. 2006. Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors. J. Med. Chem. 49: 4437-4441. doi:10.1021/jm0511435. PMID:16821802.
260. Vogt, B.A., Alam, J., Croatt, A.J., Vercellotti, G.M., and Nath, K.A. 1995. Acquired resistance to acute oxidative stress. Possible role of heme oxygenase and ferritin. Lab. Invest. 72: 474-483. PMID:7723286.
261. Von Burg, R. 1999. Carbon monoxide. J. Appl. Toxicol. 19: 379-386. doi:10.1002/(SICI)1099-1263(199909/10)19:5〈379::AID-JAT563〉3.0.CO;2- 8. PMID:10513684.
262. Vreman, H.J., Ekstrand, B.C., and Stevenson, D.K. 1993. Selection of metalloporphyrin heme oxygenase inhibitors based on potency and photoreactivity. Pediatr. Res. 33: 195-200. PMID:8433895.
263. Vulapalli, S.R., Chen, Z., Chua, B.H., Wang, T., and Liang, C.S. 2002. Cardioselective overexpression of HO-1 prevents I/R-induced cardiac dysfunction and apoptosis. Am. J. Physiol. Heart Circ. Physiol. 283: H688-H694. PMID:12124217.
264. Wagener, F.E., de Witte, T., and Abraham, N.G. 1997. Heme induces the expression of adhesion molecules ICAM-1, VCAM-1, and E selectin in vascular endothelial cells. Proc. Soc. Exp. Biol. Med. 216: 456-463. PMID:9402154.
265. Wagener, F.A., Eggert, A., Boerman, O.C., Oyen, W.J., Verhofstad, A., Abraham, N.D., et al. 2001. Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase. Blood, 98: 1802-1811. doi:10.1182/blood.V98.6.1802. PMID:11535514.
266. Wagner, J.R., Motchnik, P.A., Stocker, R., Sies, H., and Ames, B.N. 1993. The oxidation of blood plasma and low density lipoprotein components by chemically generated singlet oxygen. J. Biol. Chem. 268: 18502-18506. PMID:8360151.
267. Wagner, C.T., Durante, W., Christodoulides, N., Hellums, J.D., and Schafer, A.I. 1997. Hemodynamic forces induce the expression of heme oxygenase in cultured vascular smooth muscle cells. J. Clin. Invest. 100: 589-596. doi:10.1172/JCI119569. PMID:9239406.
268. Wagner, K.R., Hua, Y., de Courten-Myers, G.M., Broderick, J.P., Nishimura, R.N., Lu, S.Y., and Dwyer, B.E. 2000. Tin-mesoporphyrin, a potent heme oxygenase inhibitor, for treatment of intracerebral hemorrhage: in vivo and in vitro studies. Cell Mol. Biol. (Noisy-le-grand), 46: 597-608. PMID:10872746.
269. Walker, K.A., Kertesz, D.J., Rotstein, D.M., Swinney, D.C., Berry, P.W., So, O.Y., et al. 1993. Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. J. Med. Chem. 36: 2235-2237. doi:10.1021/jm00067a022. PMID:8340925.
270. Wandersman, C., and Delepelaire, P. 2004. Bacterial iron sources: from siderophores to hemophores. Annu. Rev. Microbiol. 58: 611-647. doi:10.1146/annurev.micro.58.030603.123811. PMID:15487950.
271. Wang, J., and Doré, S. 2007. Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage. Brain, 130: 1643-1652. doi:10.1093/brain/awm095. PMID:17525142.
272. Wang, R., Wu, L., and Wang, Z. 1997. The direct effect of carbon monoxide on KCa channels in vascular smooth muscle cells. Pflugers Arch. 434: 285-291. doi:10.1007/s004240050398. PMID:9178628.
273. Wardman, P., and Candeias, P. 1996. Fenton chemistry: an introduction. Radiat. Res. 145: 523-531. doi:10.2307/3579270. PMID:8619017.
274. Was, H., Cichon, T., Smolarczyk, R., Rudnicka, D., Stopa, M., Chevalier, C., et al. 2006. Overexpression of heme oxygenase-1 in murine melanoma: increased proliferation and viability of tumor cells, decreased survival of mice. Am. J. Pathol. 169: 2181-2198. doi:10.2353/ajpath.2006.051365. PMID:17148680.
275. Watkins, C.C., Boehning, D., Kaplin, A.L., Rao, M., Ferris, C.D., and Snyder, S.H. 2004. Carbon monoxide mediates vasoactive intestinal polypeptide-associated nonadrenergic/noncholinergic neurotransmission. Proc. Natl. Acad. Sci. U.S.A. 101: 2631-2635. doi:10.1073/pnas.0308695100. PMID:14983060.
276. Weber, C.M., Eke, B.C., and Maines, M.D. 1994. Corticosterone regulates heme oxygenase-2 and NO synthase transcription and protein expression in rat brain. J. Neurochem. 63: 953-962. PMID:7519667.
277. Wegele, R., Tasler, R., Zeng, Y., Rivera, M., and Frankkenberg-Dinkel, N. 2004. The heme oxygenase(s)-phytochrome system of Pseudomonas aeruginosa. J. Biol. Chem. 279: 45791-45802. doi:10.1074/jbc. M408303200. PMID:15310749.
278. Weng, Y.H., Yang, G., Weis, S., and Dennery, P.A. 2003. Interaction between heme oxygenase-1 and -2 proteins. J. Biol. Chem. 278: 50999-51005. doi:10.1074/jbc.M307644200. PMID:14514669.
279. Wiesel, P., Patel, A.P., Carvajal, I.M., Wang, Z.Y., Pellacani, A., Maemura, K., et al. 2001. Exacerbation of chronic renovascular hypertension and acute renal failure in heme oxygenase-1-deficient mice. Circ. Res. 88: 1088-1094. doi:10.1161/hh1001.091521. PMID:11375280.
280. Wilks, A., and Schmitt, M.P. 1998. Expression and characterization of a heme oxygenase (Hmu O) from Corynebacterium diphtheriae. Iron acquisition requires oxidative cleavage of the heme macrocycle. J. Biol. Chem. 273: 837-841. doi:10.1074/jbc.273.2.837. PMID:9422739.
281. Williams, S.E., Wootton, P., Mason, H.S., Bould, J., Iles, D.E., Riccardi, D., et al. 2004. Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel. Science, 306: 2093-2097. doi:10.1126/science.1105010. PMID:15528406.
282. Wu, L., and Wang, R. 2005. Carbon monoxide: endogenous production, physiological functions, and pharmacological applications. Pharmacol. Rev. 57: 585-630. doi:10.1124/pr.57.4.3. PMID:16382109.
283. Xu, C., Yuan, X., Pan, Z., Shen, G., Kim, J.H., Yu, S., et al. 2006. Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2. Mol. Cancer Ther. 5: 1918-1926. doi:10.1158/1535-7163.MCT-05-0497.PMID:16928811.
284. Xue, L., Farrugia, G., Miller, S.M., Ferris, C.D., Snyder, S.H., and Szurszewski, J.H. 2000. Carbon monoxide and nitric oxide as coneurotransmitters in the enteric nervous system: evidence from genomic deletion of biosynthetic enzymes. Proc. Natl. Acad. Sci. U.S.A. 97: 1851-1855. doi:10.1073/pnas.97.4.1851. PMID:10677545.
285. Yachie, A., Niida, Y., Wada, T., Igarashi, N., Kaneda, H., Toma, T., et al. 1999. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J. Clin. Invest. 103: 129-135. doi:10.1172/JCI4165. PMID:9884342.
286. Yamada, N., Yamaya, M., Okinaga, S., Nakayama, K., Sekizawa, K., Shibahara, S., and Sasaki, H. 2000. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am. J. Hum. Genet. 66: 187-195. doi:10.1086/302729. PMID:10631150.
287. Yanagawa, T., Omura, K., Harada, H., Nakaso, K., Iwasa, S., Koyama, Y., et al. 2004. Heme oxygenase-1 expression predicts cervical lymph node metastasis of tongue squamous cell carcinomas. Oral Oncol. 40: 21-27. doi:10.1016/S1368-8375(03)00128-3. PMID:14662411.
288. Yet, S.F., Pellacani, A., Patterson, C., Tan, L., Folta, S.C., Foster, L., et al. 1997. Induction of heme oxygenase-1 expression in vascular smooth muscle cells. A link to endotoxic shock. J. Biol. Chem. 272: 4295-4301. doi:10.1074/jbc.272.7.4295. PMID:9020147.
289. Yet, S.F., Tian, R., Layne, M.D., Wang, Z.Y., Maemura, K., Solovyeva, M., et al. 2001. Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. Circ. Res. 89: 168-173. doi:10.1161/hh1401.093314. PMID:11463724.
290. Yet, S.F., Layne, M.D., Liu, X., Chen, Y.H., Ith, B., Sibinga, N.E., and Perrella, M.A. 2003. Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling. FASEB J. 17: 1759-1761. PMID:12958201.
291. Yoon, S.S., Macdonald, S.C., and Parrish, R.G. 1998. Deaths from unintentional carbon monoxide poisoning and potential for prevention with carbon monoxide detectors. JAMA, 279: 685-687. doi:10.1001/jama.279.9.685. PMID:9496987.
292. Yoshida, T., Maulik, N., Ho, Y.S., Alam, J., and Das, D.K. 2001. H(mox-1) constitutes an adaptive response to effect antioxidant cardioprotection: A study with transgenic mice heterozygous for targeted disruption of the Heme oxygenase-1 gene. Circulation, 103: 1695-1701. PMID:11273999.
293. Zakhary, R., Poss, K.D., Jaffrey, S.R., Ferris, C.D., Tonegawa, S., and Snyder, S.H. 1997. Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide. Proc. Natl. Acad. Sci. U.S.A. 94: 14848-14853. doi:10.1073/pnas.94.26.14848. PMID:9405702.
294. Zhang, X., Shan, P., Jiang, D., Noble, P.W., Abraham, N.G., Kappas, A., and Lee, P.J. 2003. Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis. J. Biol. Chem. 279: 10677-10684. doi:10.1074/jbc.M312941200. PMID:14688267.
295. Zhou, H., Lu, F., Latham, C., Zander, D.S., and Visner, G.A. 2004. Heme oxygenase-1 expression in human lungs with cystic fibrosis and cytoprotective effects against Pseudomonas aeruginosa in vitro. Am. J. Respir. Crit. Care Med. 170: 633-640. doi:10.1164/rccm.200311-1607OC. PMID:15184199.
296. Zhu, W., Wilks, A., and Stojiljkovic, I. 2000. Degradation of heme in gram-negative bacteria: the product of the hemO gene of Neisseriae is a heme oxygenase. J. Bacteriol. 182: 6783-6790. doi:10.1128/JB.182.23.6783- 6790.2000. PMID:11073924.
297. Zwerina, J., Tzima, S., Hayer, S., Redlick, K., Hoffmann, O., Hanslik-Schnabel, B., et al. 2005. Heme oxygenase 1 (HO-1) regulates osteoclastogenesis and bone resorption. FASEB J. 19: 2011-2013. PMID:16234431.