Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors

Journal of Medicinal Chemistry

Volumn 49, Issue 14, 2006, Pages 4437-4441

  Vlahakis, Jason Z ^a   Kinobe, Robert T ^a   Bowers, Raymond J ^a   Brien, James F ^a   Nakatsu, Kanji ^a   Szarek, Walter A ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 DIOXOLANE DERIVATIVE; 2 [2 (4 CHLORPHENYL)ETHYL] 2 [(1H IMIDAZOL 1 YL)METHYL] 4 METHYL 1,3 DIOXOLANE; AMINOTHIOPHENOL; AZALANSTAT; CYTOCHROME P450 2E1; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; HEME OXYGENASE INHIBITOR; IMIDAZOLE DERIVATIVE; METALLOPORPHYRIN; PHENOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG POTENCY; ENZYME INHIBITION; ENZYME SPECIFICITY; LIVER MICROSOME; NONHUMAN; RAT; SPLEEN;

ANIMALS; CYTOSOL; DIOXOLANES; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HUMANS; IMIDAZOLES; ISOENZYMES; MICROSOMES; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33745845157     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0511435     Document Type: Article

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