Treatment of hyperbilirubinemia pharmacologic approach SnMP (tin-mesoporphyrin)

Journal of Perinatology

Volumn 21, Issue , 2001, Pages S101-S103

  Martínez, Jorge César ^a   García, Horacio O ^a   Otheguy, Lydia E ^a   Drummond, George S ^b   Kappas, Attallah ^b  

^a Hospital Materno Infantil Ramon Sarda   (Argentina)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILE PIGMENT; BILIRUBIN; HEME DERIVATIVE; HEME OXYGENASE; HEME OXYGENASE INHIBITOR; MACROCYCLIC COMPOUND; MESOPORPHYRIN TIN; METALLOPORPHYRIN; PORPHYRIN; PYRROLE DERIVATIVE; VINYL DERIVATIVE;

ARGENTINA; BILIARY EXCRETION; BILIRUBIN BLOOD LEVEL; BLOOD TOXICITY; BRAIN INJURY; CHEMICAL MODIFICATION; CLINICAL TRIAL; CONFERENCE PAPER; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG TOLERANCE; ENZYME INHIBITION; ERYTHEMA; EXCHANGE BLOOD TRANSFUSION; FOLLOW UP; GESTATIONAL AGE; HEALTH EDUCATION; HEALTH PRACTITIONER; HEALTH PROGRAM; HIGH RISK POPULATION; HOSPITAL DISCHARGE; HUMAN; INFORMED CONSENT; MOTHER CHILD RELATION; NEWBORN; NEWBORN DISEASE; NEWBORN JAUNDICE; NEWBORN PERIOD; NOMOGRAM; OUTCOMES RESEARCH; PEDIATRICIAN; PHARMACOLOGICAL PARAMETERS; PHOTOTHERAPY; POSTNATAL CARE; PREDICTION; PREGNANCY;

ENZYME INHIBITORS; HEME OXYGENASE (DECYCLIZING); HUMANS; INFANT, NEWBORN; JAUNDICE, NEONATAL; MESOPORPHYRINS; METALLOPORPHYRINS;

EID: 0035680604     PISSN: 07438346     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jp.7210655     Document Type: Note

References (15)

1. Kernicterus in otherwise healthy, breast-fed term newborns
2. Hospital readmission due to neonatal hyperbilirubinemia
3. Early discharge from the newborn nursery - Effect on scheduling of follow-up visits by pediatricians
4. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase
5. Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation
6. Control of hyperbilirubinemia in glucose-6-phosphate dehydrogenase deficient newborns using an inhibitor of bilirubin production, Sn-mesoporphyrin
7. Reduction of the C2 and C4 vinyl groups of Sn-protoporphyrin to form Sn-mesoporphyrin markedly enhances the ability of the metalloporphyrin to inhibit in vivo heme catabolism
8. Control of jaundice in preterm newborns by an inhibitor of bilirubin production: Studies with tin-mesoporphyrin
9. Sn-protoporphyrin lowers serum bilirubin levels, decreases biliary bilirubin output, enhances biliary heme excretion and potently inhibits hepatic heme oxygenase activity in normal human subjects
10. Control of heme metabolism with synthetic metalloporphyrins
11. Control of severe hyperbilirubinemia in full-term newborns with the inhibitor of bilirubin production Sn-mesoporphyrin
12. Sn-protoporphyrin use in the management of hyperbilirubinemia in term newborns with direct Coombs-positive ABO incompatibility
13. Direct comparison of Sn-mesoporphtyrin, an inhibitor of bilirubin production, and phototherapy in controlling hyperbilirubinemia in term and near-term newborns
14. Hyperbilirubinemia in the breastfed-newborn: A controlled trial of four interventions
15. Jaundice, terminating breast-feeding and the vulnerable child