Heme oxygenase-1 mediates the anti-inflammatory effect of curcumin within LPS-stimulated human monocytes

Journal of Cellular Physiology

Volumn 215, Issue 3, 2008, Pages 603-612

  Hsu, Hsien Yeh ^a,c   Chu, Li Chieh ^a   Hua, Kuo Feng ^a   Chao, Louis Kuoping ^b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI CITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CURCUMIN; HEME OXYGENASE 1; HYDROGEN PEROXIDE; INTERLEUKIN 1; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C ALPHA; PROTEIN KINASE C DELTA; SMALL INTERFERING RNA; ANTIINFLAMMATORY AGENT; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; BIOLOGICAL MODEL; CELL CULTURE; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; MACROPHAGE; METABOLISM; SECRETION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; CURCUMIN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEME OXYGENASE-1; HUMANS; INTERLEUKIN-1; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MODELS, BIOLOGICAL; MONOCYTES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE C-DELTA; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 42949162968     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21206     Document Type: Article

References (38)

1. Abuarqoub H, Foresti R, Green CJ, Motterlini R. 2006. Heme oxygenase-1 mediates the antiinflammatory actions of 2′-hydroxychalcone in RAW 264.7 murine macrophages. Am J Physiol Cell Physiol 290:1092-1099.
2. Alam J, Wicks C, Stewart D, Gong P, Touchard C, Otterbein S, Choi AM, Burow ME, Tou J. 2000. Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells. Role of p38 kinase and Nrf2 transcription factor. J Biol Chem 275:27694-27702.
3. Ammon HPT, Wahl MA. 1991. Pharmacology of Curcuma longa. Planta Med 57:1-7.
4. Andreadi CK, Howells LM, Atherfold PA, Manson MM. 2006. Involvement of Nrf2, p38, B-Raf, and nuclear factor-kappaB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols. Mol Pharmacol 69:1033-1040.
5. Balogun E, Hoque M, Gong P, Killeen E, Green CJ, Foresti R, Alam J, Motterlini R. 2003a. Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem J 371:887-895.
6. Balogun E, Foresti R, Green CJ, Motterlini R. 2003b. Changes in temperature modulate heme oxygenase-1 induction by Curcumin in renal epithelial cells. Biochem Biophys Res Commun 308:950-955.
7. Chan WH, Wu CC, Yu JS. 2003. Curcumin inhibits UV irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermoid carcinoma A431 cells. J Cell Biochem 90:327-338.
8. 2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages. Biochem Pharmacol 69:1839-1851.
9. Drechsler Y, Dolganiuc A, Norkina O, Romics L, Li W, Kodys K, Bach FH, Mandrekar P, Szabo G. 2006. Heme oxygenase-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38 MAPK activation in monocytes. J Immunol 177:2592-2600.
10. Gaedeke J, Noble NA, Border WA. 2005. Curcumin blocks fibrosis in anti-Thy 1 glomerulonephritis through up-regulation of heme oxygenase 1. Kidney Int 68:2042-2049.
11. Hegazi RA, Rao KN, Mayle A, Sepulveda AR, Otterbein LE, Plevy SE. 2005. Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway. J Exp Med 202:1703-1713.
12. Hsu HY, Wen MH. 2002. Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression. J Biol Chem 277:22131-22139.
13. Kim HY, Park EJ, Joe EH, Jou I. 2003. Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia. J Immunol 171:6072-6079.
14. Lee TS, Chau LY. 2002. Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Nat Med 8:240-246.
15. Lee TS, Tsai HL, Chau LY. 2003. Induction of heme oxygenase-1 expression in murine macrophages is essential for the anti-inflammatory effect of low dose 15-deoxy-Delta 12,14-prostaglandin J2. J Biol Chem 278:19325-19330.
16. Lee TS, Chang CC, Zhu Y, Shyy JY. 2004. Simvastatin induces heme oxygenase-1: A novel mechanism of vessel protection. Circulation 110:1296-1302.
17. Liby K, Hock T, Yore MM, Suh N, Place AE, Risingsong R, Williams CR, Royce DB, Honda T, Honda Y, Gribble GW, Hill-Kapturczak N, Agarwal A, Sporn MB. 2005. The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling. Cancer Res 65:4789-4798.
18. Maines MD. 1997. The heme oxygenase system: A regulator of second messenger gases. Annu Rev Pharmacol Toxicol 37:517-554.
19. Martin D, Rojo Al, Salinas M, Diaz R, Gallardo G, Alam J, De Galarreta CM, Cuadrado A. 2004. Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol. J Biol Chem 279:8919-8929.
20. McNally SJ, Harrison EM, Ross JA, Garden OJ, Wigmore SJ. 2006. Curcumin induces heme oxygenase-1 in hepatocytes and is protective in simulated cold preservation and warm reperfusion injury. Transplantation 81:623-626.
21. McNally SJ, Harrison EM, Ross JA, Garden OJ, Wigmore SJ. 2007. Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition. Int J Mol Med 19:165-172.
22. Motterlini R, Foresti R, Bassi R, Green CJ. 2000. Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic Biol Med 28:1303-1312.
23. Ogborne RM, Rushworth SA, O'Connell MA. 2005. Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells. Arterioscler Thromb Vasc Biol 25:2100-2105.
24. Oh GS, Pae HO, Lee BS, Kim BN, Kim JM, Kim HR, Jeon SB, Jeon WK, Chae HJ, Chung HT. 2006. Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in R AW264.7 macrophages stimulated with lipopolysaccharide. Free Radic Biol Med 41:106-119.
25. Ricchetti GA, Williams LM, Foxwell BM. 2004. Heme oxygenase 1 expression induced by IL-10 requires STAT-3 and phosphoinositol-3 kinase and is inhibited by lipopolysaccharide. J Leukoc Biol 76:719-726.
26. Rojo AI, Salina M, Salazar M, Takahashi S, Suske G, Calvo V, de Sagarra MR, Cuadrado A. 2006. Regulation of heme oxygenase-1 gene expression through the phosphatidylinositol 3-kinase/PKC-zeta pathway and Sp1. Free Radic Biol Med 41:247-261.
27. Rushworth SA, Chen XL, Mackman N, Ogborne RM, O'Connell MA. 2005. Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C. J Immunol 175:4408-4415.
28. Rushworth SA, Ogborne RM, Charalambos CA, O'Connell MA. 2006. Role of protein kinase C delta in Curcumin-induced antioxidant response element-mediated gene expression in human monocytes. Biochem Biophys Res Commun 341:1007-1016.
29. Scapagnini G, Foresti R, Calabrese V, Giuffrida Stella AM, Green CJ, Motterlini R. 2002. Caffeic acid phenethyl ester and Curcumin: A novel class of heme oxygenase-1 inducers. Mol Pharmacol 61:554-561.
30. Scapagnini G, Colombrita C, Amadio M, D'Agata V, Arcelli E, Sapienza M, Quattrone A, Calabrese V. 2006. Curcumin activates defensive genes and protects neurons against oxidative stress. Antioxid Redox Signal 8:395-403.
31. Sharma RA, Gescher AJ, Steward WP. 2005. Curcumin: The story so far. Eur J Cancer 41:1955-1968.
32. Shi M, Cai Q, Yao L, Mao Y, Ming Y, Ouyang G. 2006. Antiproliferation and apoptosis induced by Curcumin in human ovarian cancer cells. Cell Biol Int 30:221-226.
33. Shoskes D, Lapierre C, Cruz-Corerra M, Muruve N, Rosario R, Fromkin B, Braun M, Copley J. 2005. Beneficial effects of the bioflavonoids Curcumin and quercetin on early function in cadaveric renal transplantation: A randomized placebo controlled trial. Transplantation 80:1556-1559.
34. Silva G, Cunha A, Gregoire IP, Seldon MP, Soares MP. 2006. The antiapoptotic effect of heme oxygenase-1 in endothelial cells involves the degradation of p38{alpha} MAPK isoform. J Immunol 177:1894-1903.
35. Swarnakar S, Ganguly K, Kundu P, Banerjee A, Maity P, Sharma AV. 2005. Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. J Biol Chem 280:9409-9415.
36. Taille C, El-Benna J, Lanone S, Dang MC, Ogier-Denis E, Aubier M, Boczkowski J. 2004. Induction of heme oxygenase-1 inhibits NAD(P)H oxidase activity by down-regulating cytochrome b558 expression via the reduction of heme availability. J Biol Chem 279:28681-28688.
37. Terry CM, Clikeman JA, Hoidal JR, Callahan KS. 1999. TNF-alpha and IL-1alpha induce heme oxygenase-1 via protein kinase C, Ca2+, and phospholipase A2 in endothelial cells. Am J Physiol 276:1493-1501.
38. Weber WM, Hunsaker LA, Abcouwer SF, Deck LM, Vander Jagt DL. 2005. Anti-oxidant activities of Curcumin and related enones. Bioorg Med Chem 13:3811-3820.