메뉴 건너뛰기




Volumn 51, Issue 9, 2008, Pages 801-807

Aβ-binding molecules: Possible application as imaging probes and as anti-aggregation agents

Author keywords

A binding; A inhibitor; Bifunctional candidate; Core structure; Hydrophobic and aromatic interaction

Indexed keywords

AGGLOMERATION; ARSENIC COMPOUNDS; AZO DYES; BINDING ENERGY; BIOCHEMISTRY; CHEMOTHERAPY; CHLORINE COMPOUNDS; DRUG DELIVERY; DRUG DOSAGE; HEALTH; MOLECULES; OLIGOMERS; POLYMERS;

EID: 49749097494     PISSN: 10069291     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11426-008-0075-7     Document Type: Article
Times cited : (8)

References (58)
  • 1
    • 0034701238 scopus 로고    scopus 로고
    • The origins of Alzheimer disease: A is for amyloid
    • Selkoe D J. The origins of Alzheimer disease: A is for amyloid. JAMA, 2000, 283: 1615-1617
    • (2000) JAMA , vol.283 , pp. 1615-1617
    • Selkoe, D.J.1
  • 3
    • 0030908095 scopus 로고    scopus 로고
    • Models of amyloid seeding in Alzheimer's disease and scrapie: Mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins
    • Harper J D, Lansbury P T Jr. Models of amyloid seeding in Alzheimer's disease and scrapie: Mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins. Annu Rev Biochem, 1997, 66: 385-407
    • (1997) Annu Rev Biochem , vol.66 , pp. 385-407
    • Harper, J.D.1    Lansbury Jr, P.T.2
  • 4
    • 0024990330 scopus 로고
    • Neurotrophic and neurotoxic effects of amyloid beta protein: Reversal by tachykinin neuropeptides
    • Yankner B A, Duffy L K, Kirschner D A. Neurotrophic and neurotoxic effects of amyloid beta protein: Reversal by tachykinin neuropeptides. Science, 1990, 250: 279-282
    • (1990) Science , vol.250 , pp. 279-282
    • Yankner, B.A.1    Duffy, L.K.2    Kirschner, D.A.3
  • 6
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
    • Walsh D M, Klyubin I, Fadeeva J V, Cullen W K, Anwyl R, Wolfe M S, Rowan M J, Selkoe D J. Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo. Nature, 2002, 416: 535-539
    • (2002) Nature , vol.416 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3    Cullen, W.K.4    Anwyl, R.5    Wolfe, M.S.6    Rowan, M.J.7    Selkoe, D.J.8
  • 7
    • 0042838303 scopus 로고    scopus 로고
    • Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss
    • Gong Y S, Chang L, Viola K L, Lacor P N, Lambert M P, Finch C E, Krafft G A, Klein W L. Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc Natl Acad Sci USA, 2003, 100:10417-10422
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10417-10422
    • Gong, Y.S.1    Chang, L.2    Viola, K.L.3    Lacor, P.N.4    Lambert, M.P.5    Finch, C.E.6    Krafft, G.A.7    Klein, W.L.8
  • 8
    • 0036591852 scopus 로고    scopus 로고
    • Formation of hydrogen peroxide and hydroxyl radicals from Aβ and R-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease
    • Tabner B J, Turnbull S, El Agnaf O M, Allsop D. Formation of hydrogen peroxide and hydroxyl radicals from Aβ and R-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease. Free Radical Biol Med, 2002, 32: 1076-1083
    • (2002) Free Radical Biol Med , vol.32 , pp. 1076-1083
    • Tabner, B.J.1    Turnbull, S.2    El Agnaf, O.M.3    Allsop, D.4
  • 10
    • 0034319190 scopus 로고    scopus 로고
    • Molecular mechanism of neurodegeneration induced by Alzheimer's beta-amyloid protein: Channel formation and disruption of calcium homeostasis
    • Kawahara M, Kuroda J. Molecular mechanism of neurodegeneration induced by Alzheimer's beta-amyloid protein: Channel formation and disruption of calcium homeostasis. Brain Res Bull, 2000, 53: 389-397
    • (2000) Brain Res Bull , vol.53 , pp. 389-397
    • Kawahara, M.1    Kuroda, J.2
  • 11
    • 0032731763 scopus 로고    scopus 로고
    • Brain inflammation in Alzheimer disease and the therapeutic implications
    • McGeer E G, McGeer P L. Brain inflammation in Alzheimer disease and the therapeutic implications. Curr Pharm Design, 1999, 5: 821-836
    • (1999) Curr Pharm Design , vol.5 , pp. 821-836
    • McGeer, E.G.1    McGeer, P.L.2
  • 12
    • 0037038822 scopus 로고    scopus 로고
    • Neuroinflammation and anti-inflammatory therapy for Alzheimer's disease
    • Moore A H, O'Banion M K. Neuroinflammation and anti-inflammatory therapy for Alzheimer's disease. Adv Drug Delivery Rev, 2002, 54: 1627-1656
    • (2002) Adv Drug Delivery Rev , vol.54 , pp. 1627-1656
    • Moore, A.H.1    O'Banion, M.K.2
  • 13
    • 0036242449 scopus 로고    scopus 로고
    • Advances in the development of Abeta-related therapeutic strategies for Alzheimer's disease
    • Barrow C J. Advances in the development of Abeta-related therapeutic strategies for Alzheimer's disease. Drug News Perspect, 2002, 15:102-109
    • (2002) Drug News Perspect , vol.15 , pp. 102-109
    • Barrow, C.J.1
  • 14
    • 33745027879 scopus 로고    scopus 로고
    • Molecular mechanisms for Alzheimer's disease: Implications for neuroimaging and therapeutics
    • Masters C L, Cappai R, Barnham K J, Villemagne V L. Molecular mechanisms for Alzheimer's disease: Implications for neuroimaging and therapeutics. J Neurochem, 2006, 97: 1700-1725
    • (2006) J Neurochem , vol.97 , pp. 1700-1725
    • Masters, C.L.1    Cappai, R.2    Barnham, K.J.3    Villemagne, V.L.4
  • 15
    • 4644283049 scopus 로고    scopus 로고
    • PET imaging of amyloid in Alzheimer's disease
    • Nordberg A. PET imaging of amyloid in Alzheimer's disease. Lancet Neurol, 2004, 3: 519-527
    • (2004) Lancet Neurol , vol.3 , pp. 519-527
    • Nordberg, A.1
  • 16
    • 0348142000 scopus 로고    scopus 로고
    • Alzheimer's disease: Neuropathologic findings and recent advances in imaging
    • Norfray J F, Provenzale J M. Alzheimer's disease: Neuropathologic findings and recent advances in imaging. Am J Roentgenol, 2004, 182:3-13
    • (2004) Am J Roentgenol , vol.182 , pp. 3-13
    • Norfray, J.F.1    Provenzale, J.M.2
  • 18
    • 0035902875 scopus 로고    scopus 로고
    • Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain
    • Klunk W E, Wang Y M, Huang G F, Debnath M L, Holt D P, Mathis C A. Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain. Life Sci, 2001, 69:1471-1484
    • (2001) Life Sci , vol.69 , pp. 1471-1484
    • Klunk, W.E.1    Wang, Y.M.2    Huang, G.F.3    Debnath, M.L.4    Holt, D.P.5    Mathis, C.A.6
  • 19
    • 2342446265 scopus 로고    scopus 로고
    • Imaging β-amyloid plaques and neurofibrillary tangles in the aging human brain
    • Mathis C A, Wang Y, Klunk W E. Imaging β-amyloid plaques and neurofibrillary tangles in the aging human brain. Curr Pharm Design, 2004, 10: 1469-1492
    • (2004) Curr Pharm Design , vol.10 , pp. 1469-1492
    • Mathis, C.A.1    Wang, Y.2    Klunk, W.E.3
  • 20
    • 0033857342 scopus 로고    scopus 로고
    • X-34, a fluorescent derivative of congo red. A novel histochemical stain for Alzheimer's disease pathology
    • Styren S D, Hamilton R L, Styren G C, Klunk W E. X-34, a fluorescent derivative of congo red. A novel histochemical stain for Alzheimer's disease pathology. J Histochem Cytochem, 2000, 48: 1223-1232
    • (2000) J Histochem Cytochem , vol.48 , pp. 1223-1232
    • Styren, S.D.1    Hamilton, R.L.2    Styren, G.C.3    Klunk, W.E.4
  • 22
    • 0142011533 scopus 로고    scopus 로고
    • Dimethylamino-fluorenes: Ligands for detecting β-amyloid plaques in the brain
    • Lee C W, Kung M P, Hou C, Kung H F. Dimethylamino-fluorenes: Ligands for detecting β-amyloid plaques in the brain. Nucl Med Biol, 2003, 30: 573-580
    • (2003) Nucl Med Biol , vol.30 , pp. 573-580
    • Lee, C.W.1    Kung, M.P.2    Hou, C.3    Kung, H.F.4
  • 23
    • 13844305879 scopus 로고    scopus 로고
    • Biphenyls labeled with technetium 99m for imaging β-amyloid plaques in the brain
    • Zhuang Z P, Kung M P, Hou C, Plössl K, Kung H F. Biphenyls labeled with technetium 99m for imaging β-amyloid plaques in the brain. Nucl Med Biol, 2005, 32: 171-184
    • (2005) Nucl Med Biol , vol.32 , pp. 171-184
    • Zhuang, Z.P.1    Kung, M.P.2    Hou, C.3    Plössl, K.4    Kung, H.F.5
  • 27
    • 0036668810 scopus 로고    scopus 로고
    • Benzofuran derivatives as Aβ-aggregate-specific imaging agents for Alzheimer's disease
    • Ono M, Kung M P, Hou C, Kung H F. Benzofuran derivatives as Aβ-aggregate-specific imaging agents for Alzheimer's disease. Nucl Med Biol, 2002, 29: 633-642
    • (2002) Nucl Med Biol , vol.29 , pp. 633-642
    • Ono, M.1    Kung, M.P.2    Hou, C.3    Kung, H.F.4
  • 28
    • 0035893245 scopus 로고    scopus 로고
    • Binding characteristics of radiofluorinated 6-dialkylamino-2- naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease
    • 1-5
    • Agdeppa E D, Kepe V, Liu J, Flores-Torres S, Satyamurthy N, Petric A, Cole G M, Small G W, Huang S C, Barrio J R. Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease. J Neurosci, 2001, 21:RC189 1-5
    • (2001) J Neurosci , vol.21 , pp. 189
    • Agdeppa, E.D.1    Kepe, V.2    Liu, J.3    Flores-Torres, S.4    Satyamurthy, N.5    Petric, A.6    Cole, G.M.7    Small, G.W.8    Huang, S.C.9    Barrio, J.R.10
  • 29
    • 31444448867 scopus 로고    scopus 로고
    • Design, synthesis, and structure-activity relationship of novel thiophene derivatives for β-amyloid plaque imaging
    • Chandra R, Kung M P, Kung H F. Design, synthesis, and structure-activity relationship of novel thiophene derivatives for β-amyloid plaque imaging. Bioorg Med Chem Lett, 2006, 16: 1350-1352
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 1350-1352
    • Chandra, R.1    Kung, M.P.2    Kung, H.F.3
  • 30
    • 34249029282 scopus 로고    scopus 로고
    • New diphenylacetylenes as probes for positron emission tomographic imaging of amyloid plaques
    • Chandra R, Oya S, Kung M P, Hou C, Jin L W, Kung H F. New diphenylacetylenes as probes for positron emission tomographic imaging of amyloid plaques. J Med Chem, 2007, 50: 2415-2423
    • (2007) J Med Chem , vol.50 , pp. 2415-2423
    • Chandra, R.1    Oya, S.2    Kung, M.P.3    Hou, C.4    Jin, L.W.5    Kung, H.F.6
  • 31
    • 34447502169 scopus 로고    scopus 로고
    • Quick assembly of 1,4-diphenyltriazoles as probes targeting β-amyloid aggregates in alzheimer's disease
    • Qu W, Kung M P, Hou C, Oya S, Kung H F. Quick assembly of 1,4-diphenyltriazoles as probes targeting β-amyloid aggregates in alzheimer's disease. J Med Chem, 2007, 50: 3380-3387
    • (2007) J Med Chem , vol.50 , pp. 3380-3387
    • Qu, W.1    Kung, M.P.2    Hou, C.3    Oya, S.4    Kung, H.F.5
  • 32
    • 14844303913 scopus 로고    scopus 로고
    • Evidence for the presence of three distinct binding sites for the Thioflavin T class of Alzheimer's disease PET imaging agents on β-amyloid peptide fibrils
    • Lockhart A, Ye L, Judd D B, Merritt A T, Lowe P N, Morgenstern J L, Hong G, Gee A D, Brown J. Evidence for the presence of three distinct binding sites for the Thioflavin T class of Alzheimer's disease PET imaging agents on β-amyloid peptide fibrils. J Biol Chem, 2005, 280: 7677-7684
    • (2005) J Biol Chem , vol.280 , pp. 7677-7684
    • Lockhart, A.1    Ye, L.2    Judd, D.B.3    Merritt, A.T.4    Lowe, P.N.5    Morgenstern, J.L.6    Hong, G.7    Gee, A.D.8    Brown, J.9
  • 33
    • 21244490033 scopus 로고    scopus 로고
    • Multiple ligand binding sites on Aβ(1-40) fibrils
    • LeVine H. Multiple ligand binding sites on Aβ(1-40) fibrils. Amyloid, 2005, 12: 5-14
    • (2005) Amyloid , vol.12 , pp. 5-14
    • Levine, H.1
  • 34
    • 0345415139 scopus 로고    scopus 로고
    • 2-dialkylamino-6-acylmalononitrile substituted naphthalenes (DDNP analogs): Novel diagnostic and therapeutic tools in Alzheimer's disease
    • Agdeppa E D, Kepe V, Liu J, Small G W, Huang S C, Petric A, Satyamurthy N, Barrio J R. 2-dialkylamino-6-acylmalononitrile substituted naphthalenes (DDNP analogs): Novel diagnostic and therapeutic tools in Alzheimer's disease. Mol Imaging Biol, 2003, 5: 404-417
    • (2003) Mol Imaging Biol , vol.5 , pp. 404-417
    • Agdeppa, E.D.1    Kepe, V.2    Liu, J.3    Small, G.W.4    Huang, S.C.5    Petric, A.6    Satyamurthy, N.7    Barrio, J.R.8
  • 35
    • 11144222595 scopus 로고    scopus 로고
    • The binding of thioflavin-T to amyloid fibrils: Localization and implications
    • Krebs M R H, Bromley E H C, Donald A M. The binding of thioflavin-T to amyloid fibrils: Localization and implications. J Struct Biol, 2005, 149: 30-37
    • (2005) J Struct Biol , vol.149 , pp. 30-37
    • Krebs, M.R.H.1    Bromley, E.H.C.2    Donald, A.M.3
  • 36
    • 33646167218 scopus 로고    scopus 로고
    • QSAR and primary docking studies of trans-stilbene (TSB) series of imaging agents for β-amyloid plaques
    • Chen X J. QSAR and primary docking studies of trans-stilbene (TSB) series of imaging agents for β-amyloid plaques. J Mol Struc-Theochem, 2006, 763: 83-89
    • (2006) J Mol Struc-Theochem , vol.763 , pp. 83-89
    • Chen, X.J.1
  • 37
    • 0141642253 scopus 로고    scopus 로고
    • Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: Implications for the prevention and therapeutics of Alzheimer's disease
    • Ono K, Yoshiike Y, Takashima A, Hasegawa K, Naiki H, Yamada M. Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: Implications for the prevention and therapeutics of Alzheimer's disease. J Neurochem, 2003, 87: 172-181
    • (2003) J Neurochem , vol.87 , pp. 172-181
    • Ono, K.1    Yoshiike, Y.2    Takashima, A.3    Hasegawa, K.4    Naiki, H.5    Yamada, M.6
  • 38
    • 1542364225 scopus 로고    scopus 로고
    • Curcumin has potent anti-amyloidogenic effects for Alzheimer's β-amyloid fibrils in vitro
    • Ono K, Hasegawa K, Naiki H, Yamada M. Curcumin has potent anti-amyloidogenic effects for Alzheimer's β-amyloid fibrils in vitro. J Neurosci Res, 2004, 75: 742-750
    • (2004) J Neurosci Res , vol.75 , pp. 742-750
    • Ono, K.1    Hasegawa, K.2    Naiki, H.3    Yamada, M.4
  • 39
    • 20044370990 scopus 로고    scopus 로고
    • Curcumin inhibits formation of amyloid β oligomers and fibrils, binds plaques, and reduces amyloid in vivo
    • Yang F S, Lim G P, Begum A N. Curcumin inhibits formation of amyloid β oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem, 2005, 280: 5892-5901
    • (2005) J Biol Chem , vol.280 , pp. 5892-5901
    • Yang, F.S.1    Lim, G.P.2    Begum, A.N.3
  • 42
    • 33750955461 scopus 로고    scopus 로고
    • Synthesis and characterization of styrylchromone derivatives as β-amyloid imaging agents
    • Ono M, Maya Y, Haratake M, Nakayama M. Synthesis and characterization of styrylchromone derivatives as β-amyloid imaging agents. Bioorg Med Chem, 2007, 15: 444-450
    • (2007) Bioorg Med Chem , vol.15 , pp. 444-450
    • Ono, M.1    Maya, Y.2    Haratake, M.3    Nakayama, M.4
  • 43
    • 34547697123 scopus 로고    scopus 로고
    • Structure-activity relationship of chalcones and related derivatives as ligands for detecting of β-amyloid plaques in the brain
    • Ono M, Hori M, Haratake M, Tomiyama T, Mori H, Nakayama M. Structure-activity relationship of chalcones and related derivatives as ligands for detecting of β-amyloid plaques in the brain. Bioorg Med Chem, 2007, 15: 6388-6396
    • (2007) Bioorg Med Chem , vol.15 , pp. 6388-6396
    • Ono, M.1    Hori, M.2    Haratake, M.3    Tomiyama, T.4    Mori, H.5    Nakayama, M.6
  • 44
    • 33749265462 scopus 로고    scopus 로고
    • Curcumin and dehydrozingerone derivatives: Synthesis, radiolabeling, and evaluation for β-Amyloid plaque imaging
    • Ryu E K, Choe Y S, Lee K H, Choi Y, Kim B T. Curcumin and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for β-Amyloid plaque imaging. J Med Chem, 2006, 49: 6111-6119
    • (2006) J Med Chem , vol.49 , pp. 6111-6119
    • Ryu, E.K.1    Choe, Y.S.2    Lee, K.H.3    Choi, Y.4    Kim, B.T.5
  • 45
    • 49749137474 scopus 로고    scopus 로고
    • Synthesis and evaluation of RS-0406 derivatives for beta-amyloid plaque and neurofibrillary tangle imaging
    • Lee I, Choe YS, Kim D H, Lee K H, Choi Y, Choi JY, Kim B T. Synthesis and evaluation of RS-0406 derivatives for beta-amyloid plaque and neurofibrillary tangle imaging. J Label Compd Radio Pharm, 2007, 50: S409
    • (2007) J Label Compd Radio Pharm , vol.50 , pp. 409
    • Lee, I.1    Choe, Y.S.2    Kim, D.H.3    Lee, K.H.4    Choi, Y.5    Choi, J.Y.6    Kim, B.T.7
  • 46
    • 0036135139 scopus 로고    scopus 로고
    • A possible role for π-stacking in the selfassembly of amyloid fibrils
    • Gazit E. A possible role for π-stacking in the selfassembly of amyloid fibrils. FASEB J, 2002, 16: 77-83
    • (2002) FASEB J , vol.16 , pp. 77-83
    • Gazit, E.1
  • 49
    • 0031766850 scopus 로고    scopus 로고
    • Molecular simulation of the primary and secondary structures of the Aβ(1-42) peptide of Alzheimer's disease
    • Mage P P. Molecular simulation of the primary and secondary structures of the Aβ(1-42) peptide of Alzheimer's disease. Med Res Rev, 1998, 18: 403-430
    • (1998) Med Res Rev , vol.18 , pp. 403-430
    • Mage, P.P.1
  • 50
    • 0035968743 scopus 로고    scopus 로고
    • Aspirin and nonsteroidal anti-inflammatory drugs inhibit amyloid-β aggregation
    • Thomas T, Nadackal G T, Thomas K. Aspirin and nonsteroidal anti-inflammatory drugs inhibit amyloid-β aggregation. Neuroreport, 2001, 12: 3263-3267
    • (2001) Neuroreport , vol.12 , pp. 3263-3267
    • Thomas, T.1    Nadackal, G.T.2    Thomas, K.3
  • 52
    • 27144513779 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects for Alzheimer's β-amyloid fibrils in vitro
    • Hirohata M, Ono K, Naiki H, Yamada M. Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects for Alzheimer's β-amyloid fibrils in vitro. Neuropharmacology, 2005, 49: 1088-1099
    • (2005) Neuropharmacology , vol.49 , pp. 1088-1099
    • Hirohata, M.1    Ono, K.2    Naiki, H.3    Yamada, M.4
  • 53
    • 0036860355 scopus 로고    scopus 로고
    • Amyloid binding ligands as Alzheimer's disease therapies
    • Lee V M Y. Amyloid binding ligands as Alzheimer's disease therapies. Neurobiol Aging, 2002, 23: 1039-1042
    • (2002) Neurobiol Aging , vol.23 , pp. 1039-1042
    • Lee, V.M.Y.1
  • 54
    • 48849104834 scopus 로고    scopus 로고
    • Molecules that target beta-amyloid
    • Stains C I, Mondal K, Ghosh I. Molecules that target beta-amyloid. ChemMedChem, 2007, 2: 1674-1692
    • (2007) ChemMedChem , vol.2 , pp. 1674-1692
    • Stains, C.I.1    Mondal, K.2    Ghosh, I.3
  • 55
  • 56
    • 0036170625 scopus 로고    scopus 로고
    • Development of technetium-99m-based CNS receptor ligands: Have there been any advances?
    • Johannsen B, Pietzsch H J. Development of technetium-99m-based CNS receptor ligands: have there been any advances? Eur J Nucl Med, 2002, 29: 263-275
    • (2002) Eur J Nucl Med , vol.29 , pp. 263-275
    • Johannsen, B.1    Pietzsch, H.J.2
  • 57
    • 13844305879 scopus 로고    scopus 로고
    • Biphenyls labeled with technetium 99m for imaging β-amyloid plaques in the brain
    • Zhuang Z P, Kung M P, Hou C, Ploessl K, Kung H F. Biphenyls labeled with technetium 99m for imaging β-amyloid plaques in the brain. Nucl Med Biol, 2005, 32: 171-184
    • (2005) Nucl Med Biol , vol.32 , pp. 171-184
    • Zhuang, Z.P.1    Kung, M.P.2    Hou, C.3    Ploessl, K.4    Kung, H.F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.