Imaging sigma receptors: Applications in drug development

Current Pharmaceutical Design

Volumn 13, Issue 1, 2007, Pages 51-72

  Lee Collier, Thomas ^a   Waterhouse, Rikki N ^b   Kassiou, Michael ^c  

^a Siemens Molecular Imaging Biomarker Research   (United States)

^b Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Drug development; PET; Radioligand; Radiotracer; Sigma receptors; SPECT

Indexed keywords

1 (2 HYDROXYETHYL) 4 (4 IODOPHENOXYMETHYL)PIPERIDINE I 123; 1 (3 CHLORO 4 CYCLOHEXYLPHENYL) 3 (HEXAHYDRO 1 AZEPINYL)PROPENE; 1 (3,4 DIMETHOXYPHENETHYL) 4 (3 PHENYLPROPYL)PIPERAZINE; 1 CYCLOPROPYLMETHYL 4 [2 (4 FLUOROPHENYL) 2 OXOETHYL]PIPERIDINE; 2 [4 METHOXY 3 (2 PHENYLETHOXY)PHENYL] N,N DIPROPYLETHYLAMINE; 4 [2 (4 CYANOPHENYL) 2 OXOETHYL] 1 (CYCLOPROPYLMETHYL)PIPERIDINE; ALPHA (4 FLUOROPHENYL) 4 (5 FLUORO 2 PYRIMIDINYL) 1 PIPERAZINEBUTANOL; CLOZAPINE; EDM 57445; ELIPRODIL; HALOPERIDOL; IFENPRODIL; IGMESINE; METHADONE; N (4' FLUOROBENZYL) 4 (3 BROMOPHENYL)ACETAMIDE F 18; N (N BENZYLPIPERIDIN 4 YL) 2 FLUOROBENZAMIDE F 18; N [2 (1' PIPERIDINYL)ETHYL] 3 IODO 4 METHOXYBENZAMIDE I 123; N [2 (1' PIPERIDINYL)ETHYL] 3 IODO 4 METHOXYBENZAMIDE I 125; N ALLYLNORMETAZOCINE; N CYCLOHEXYL N ETHYL 3 (3 CHLORO 4 CYCLOHEXYLPHENYL) 2 PROPENYLAMINE; NALTREXONE; OPC 14523; PANAMESINE; PLACEBO; PRASTERONE; RADIOPHARMACEUTICAL AGENT; REMOXIPRIDE; SIGMA OPIATE RECEPTOR; SIGMA RECEPTOR LIGAND; SSR 125047; UNCLASSIFIED DRUG; UNINDEXED DRUG; VPI 013;

BREAST CANCER; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; DEMENTIA; DIAGNOSTIC VALUE; DOSE RESPONSE; DRUG CLEARANCE; DRUG DEPENDENCE; DRUG DOSE INCREASE; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG RESEARCH; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ELECTROCONVULSIVE THERAPY; ENDOCRINE DISEASE; EXTRAPYRAMIDAL SYMPTOM; GASTROINTESTINAL DISEASE; HUMAN; IC 50; IMMUNOPATHOLOGY; MAJOR DEPRESSION; MENTAL DISEASE; MOLECULAR IMAGING; MONOTHERAPY; MOTOR DYSFUNCTION; NEUROLOGIC DISEASE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROSTATE TUMOR; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVIEW; RHEUMATOID ARTHRITIS; SCHIZOPHRENIA; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STROKE;

ANIMALS; ANTINEOPLASTIC AGENTS; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; DEPRESSION; DRUG DESIGN; GONADAL STEROID HORMONES; HUMANS; LIGANDS; MOLECULAR STRUCTURE; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; PSYCHOTROPIC DRUGS; RADIOPHARMACEUTICALS; RECEPTORS, SIGMA; SCHIZOPHRENIA; SUBSTANCE-RELATED DISORDERS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TUMOR MARKERS, BIOLOGICAL;

EID: 33846162759     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161207779313740     Document Type: Review

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