Structure-activity relationship of chalcones and related derivatives as ligands for detecting of β-amyloid plaques in the brain

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 19, 2007, Pages 6388-6396

  Ono, Masahiro ^a   Hori, Miyuki ^a   Haratake, Mamoru ^a   Tomiyama, Takami ^b   Mori, Hiroshi ^b   Nakayama, Morio ^a  

^a NAGASAKI UNIVERSITY   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Amyloid plaque; Alzheimer's disease; Imaging; PET; SPECT

Indexed keywords

1 (5 IODO 2 THIENYL) 3 (4 DIMETHYLAMINOPHENYL) 2 PROPEN 1 ONE; 4 DIMETHYLAMINO 4' IODOCHALCONE; AMYLOID BETA PROTEIN; CHALCONE DERIVATIVE; IODINE 125; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN; CONTROLLED STUDY; DRUG DESIGN; DRUG DISTRIBUTION; DRUG SCREENING; DRUG SYNTHESIS; DRUG UPTAKE; MOUSE; NONHUMAN; SENILE PLAQUE; STRUCTURE ACTIVITY RELATION;

ALZHEIMER DISEASE; ANIMALS; BINDING, COMPETITIVE; BRAIN; CHALCONES; DISEASE MODELS, ANIMAL; LIGANDS; MICE; SENILE PLAQUES; STRUCTURE-ACTIVITY RELATIONSHIP;

MUS;

EID: 34547697123     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.06.055     Document Type: Article

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