메뉴 건너뛰기




Volumn 38, Issue 7-8, 2008, Pages 1119-1139

Cholesterol and non-cholesterol sterol transporters: ABCG5, ABCG8 and NPC1L1: A review

Author keywords

ABCG5; ABCG8; NPC1L1; Sterol transporters; Xenosterols

Indexed keywords

ATP BINDING CASSETTE TRANSPORTER G5; ATP BINDING CASSETTE TRANSPORTER G8; CARRIER PROTEIN; EZETIMIBE; NIEMAN PICK C1 LIKE 1 PROTEIN; PHYTOSTEROL;

EID: 48749087791     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250802007930     Document Type: Review
Times cited : (60)

References (138)
  • 4
    • 17844410923 scopus 로고    scopus 로고
    • Dose-comparison study of the combination of ezetimibe and simvastatin (Vytorin) versus atorvastatin in patients with hypercholesterolemia: The Vytorin Versus Atorvastatin (VYVA) study
    • Ballantyne CM, Abate N, Yuan Z, King TR, Palmisano J. 2005. Dose-comparison study of the combination of ezetimibe and simvastatin (Vytorin) versus atorvastatin in patients with hypercholesterolemia: The Vytorin Versus Atorvastatin (VYVA) study. American Heart Journal 149(3):464-473.
    • (2005) American Heart Journal , vol.149 , Issue.3 , pp. 464-473
    • Ballantyne, C.M.1    Abate, N.2    Yuan, Z.3    King, T.R.4    Palmisano, J.5
  • 9
    • 0016366624 scopus 로고
    • Beta-sitosterolaemia and xanthomatosis. A newly described lipid storage disease in two sisters
    • Bhattacharyya AK, Connor WE. 1974. Beta-sitosterolaemia and xanthomatosis. A newly described lipid storage disease in two sisters. Journal of Clinical Investigation 53(4):1033-1043.
    • (1974) Journal of Clinical Investigation , vol.53 , Issue.4 , pp. 1033-1043
    • Bhattacharyya, A.K.1    Connor, W.E.2
  • 10
    • 0032913411 scopus 로고    scopus 로고
    • Percent cholesterol absorption in normal women and men quantified with dual stable isotopic tracers and negative ion mass spectrometry
    • Bosner MS, Lange LG, Stenson WF, Ostlund Jr RE. 1999. Percent cholesterol absorption in normal women and men quantified with dual stable isotopic tracers and negative ion mass spectrometry. Journal of Lipid Research 40(2):302-308.
    • (1999) Journal of Lipid Research , vol.40 , Issue.2 , pp. 302-308
    • Bosner, M.S.1    Lange, L.G.2    Stenson, W.F.3    Ostlund Jr, R.E.4
  • 11
    • 34548148209 scopus 로고    scopus 로고
    • NPC1L1 (Niemann-Pick C1-like 1) mediates sterol-specific unidirectional transport of non-esterified cholesterol in McArdle-RH7777 hepatoma cells
    • Brown JM, Rudel LL, Yu L. 2007. NPC1L1 (Niemann-Pick C1-like 1) mediates sterol-specific unidirectional transport of non-esterified cholesterol in McArdle-RH7777 hepatoma cells. Biochemistry Journal 406:273-283.
    • (2007) Biochemistry Journal , vol.406 , pp. 273-283
    • Brown, J.M.1    Rudel, L.L.2    Yu, L.3
  • 13
    • 8344245251 scopus 로고    scopus 로고
    • ATP-binding cassette transporter G8 gene as a determinant of apolipoprotein B-100 kinetics in overweight men. Arteriosclererosis
    • Chan DC, Watts GF, Barrett PH, Whitfield AJ, Van Bockxmeer FM. 2004. ATP-binding cassette transporter G8 gene as a determinant of apolipoprotein B-100 kinetics in overweight men. Arteriosclererosis. Thrombosis and Vascular Biology 24(11):2188-2191.
    • (2004) Thrombosis and Vascular Biology , vol.24 , Issue.11 , pp. 2188-2191
    • Chan, D.C.1    Watts, G.F.2    Barrett, P.H.3    Whitfield, A.J.4    Van Bockxmeer, F.M.5
  • 14
    • 45349087988 scopus 로고    scopus 로고
    • Variation in Niemann-Pick C1-like 1 gene as a determinant of apolipoprotein B-100 kinetics and response to statin therapy in centrally obese men
    • Oxford, Epub ahead of print] doi: 10.1111/j.1365-2265.2007. 03144.X
    • Chan DC, Watts GF, Wang J, Hegele RA, Van Bockxmeer FM, Barrett PH. 2007. Variation in Niemann-Pick C1-like 1 gene as a determinant of apolipoprotein B-100 kinetics and response to statin therapy in centrally obese men. Clinical Endocrinology (Oxford) [Epub ahead of print] doi: 10.1111/j.1365-2265.2007. 03144.X.
    • (2007) Clinical Endocrinology
    • Chan, D.C.1    Watts, G.F.2    Wang, J.3    Hegele, R.A.4    Van Bockxmeer, F.M.5    Barrett, P.H.6
  • 16
    • 0034655917 scopus 로고    scopus 로고
    • Evidence for a Niemann-Pick C (NPC) gene family: Identification and characterization of NPC1L1
    • Davies JP, Levy B, Ioannou YA. 2000. Evidence for a Niemann-Pick C (NPC) gene family: Identification and characterization of NPC1L1. Genomics 65(2):137-145.
    • (2000) Genomics , vol.65 , Issue.2 , pp. 137-145
    • Davies, J.P.1    Levy, B.2    Ioannou, Y.A.3
  • 17
    • 16844376244 scopus 로고    scopus 로고
    • Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia
    • Davies JP, Scott C, Oishi K, Liapis A, Ioannou YA. 2005. Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia. Journal of Biology and Chemistry 280(13):12710-12720.
    • (2005) Journal of Biology and Chemistry , vol.280 , Issue.13 , pp. 12710-12720
    • Davies, J.P.1    Scott, C.2    Oishi, K.3    Liapis, A.4    Ioannou, Y.A.5
  • 18
    • 0035572836 scopus 로고    scopus 로고
    • Ezetimibe, a potent cholesterol absorption inhibitor, inhibits the development of atherosclerosis in ApoE knockout mice. Arteriosclererosis
    • Davis Jr HR, Compton DS, Hoos L, Tetzloff G. 2001. Ezetimibe, a potent cholesterol absorption inhibitor, inhibits the development of atherosclerosis in ApoE knockout mice. Arteriosclererosis. Thrombosis and Vascular Biology 21(12):2032-2038.
    • (2001) Thrombosis and Vascular Biology , vol.21 , Issue.12 , pp. 2032-2038
    • Davis Jr, H.R.1    Compton, D.S.2    Hoos, L.3    Tetzloff, G.4
  • 20
  • 22
    • 0024268092 scopus 로고
    • The brown protein of Drosophila melanogaster is similar to the white protein and to components of active transport complexes
    • Dreesen TD, Johnson DH, Henikoff S. 1988. The brown protein of Drosophila melanogaster is similar to the white protein and to components of active transport complexes. Molecular Cell Biology 8(12):5206-5215.
    • (1988) Molecular Cell Biology , vol.8 , Issue.12 , pp. 5206-5215
    • Dreesen, T.D.1    Johnson, D.H.2    Henikoff, S.3
  • 24
    • 3042522984 scopus 로고    scopus 로고
    • Cholesterol absorption is mainly regulated by the jejunal and ileal ATP-binding cassette sterol efflux transporters Abcg5 and Abcg8 in mice
    • Duan LP, Wang HH, Wang DQ. 2004. Cholesterol absorption is mainly regulated by the jejunal and ileal ATP-binding cassette sterol efflux transporters Abcg5 and Abcg8 in mice. Journal of Lipid Research 45(7):1312-1323.
    • (2004) Journal of Lipid Research , vol.45 , Issue.7 , pp. 1312-1323
    • Duan, L.P.1    Wang, H.H.2    Wang, D.Q.3
  • 26
    • 10044226295 scopus 로고    scopus 로고
    • Stanol esters decrease plasma cholesterol independently of intestinal ABC sterol transporters and Niemann-Pick C1-like 1 protein gene expression
    • Field FJ, Born E, Mathur SN. 2004. Stanol esters decrease plasma cholesterol independently of intestinal ABC sterol transporters and Niemann-Pick C1-like 1 protein gene expression. Journal of Lipid Research 45(12):2252-2259.
    • (2004) Journal of Lipid Research , vol.45 , Issue.12 , pp. 2252-2259
    • Field, F.J.1    Born, E.2    Mathur, S.N.3
  • 29
    • 30944446042 scopus 로고    scopus 로고
    • Hepatic expression of ABC transporters G5 and G8 does not correlate with biliary cholesterol secretion in liver transplant patients
    • Geuken E, Visser DS, Leuvenink HG, De Jong KP, Peeters PM, Slooff MJ, Kuipers F, Porte RJ. 2005. Hepatic expression of ABC transporters G5 and G8 does not correlate with biliary cholesterol secretion in liver transplant patients. Hepatology 42(5):1166-1174.
    • (2005) Hepatology , vol.42 , Issue.5 , pp. 1166-1174
    • Geuken, E.1    Visser, D.S.2    Leuvenink, H.G.3    De Jong, K.P.4    Peeters, P.M.5    Slooff, M.J.6    Kuipers, F.7    Porte, R.J.8
  • 33
    • 0022529021 scopus 로고
    • Abnormal metabolism of shellfish sterols in a patient with sitosterolemia and xanthomatosis
    • Gregg RE, Connor WE, Lin DS, Brewer Jr HB. 1986. Abnormal metabolism of shellfish sterols in a patient with sitosterolemia and xanthomatosis. Journal of Clinical Investigation 77(6):1864-1872.
    • (1986) Journal of Clinical Investigation , vol.77 , Issue.6 , pp. 1864-1872
    • Gregg, R.E.1    Connor, W.E.2    Lin, D.S.3    Brewer Jr, H.B.4
  • 36
    • 7744236073 scopus 로고    scopus 로고
    • Cholesterol metabolism and its implications for therapeutic interventions in patients with hypercholesterolaemia
    • Gylling H. 2004. Cholesterol metabolism and its implications for therapeutic interventions in patients with hypercholesterolaemia. International Journal of Clinical Practice 58(9):859-866.
    • (2004) International Journal of Clinical Practice , vol.58 , Issue.9 , pp. 859-866
    • Gylling, H.1
  • 38
    • 0033804429 scopus 로고    scopus 로고
    • Comparison of the effects of plant sterol ester and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low-fat diet
    • Hallikainen MA, Sarkkinen ES, Gylling H, Erkkila AT, Uusitupa MI. 2000. Comparison of the effects of plant sterol ester and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low-fat diet. European Journal of Clinical Nutrition 54(9):715-725.
    • (2000) European Journal of Clinical Nutrition , vol.54 , Issue.9 , pp. 715-725
    • Hallikainen, M.A.1    Sarkkinen, E.S.2    Gylling, H.3    Erkkila, A.T.4    Uusitupa, M.I.5
  • 40
    • 33845872811 scopus 로고    scopus 로고
    • In vivo responsiveness to ezetimibe correlates with Niemann-Pick C1-like-1 (NPC1L1) binding affinity: Comparison of multiple species NPC1L1 orthologs
    • Hawes BE, O'Neill K A, Yao X, Crona JH, Davis Jr HR, Graziano MP, Altmann SW. 2007. In vivo responsiveness to ezetimibe correlates with Niemann-Pick C1-like-1 (NPC1L1) binding affinity: Comparison of multiple species NPC1L1 orthologs. Molecular Pharmacology 71(1):19-29.
    • (2007) Molecular Pharmacology , vol.71 , Issue.1 , pp. 19-29
    • Hawes, B.E.1    O'Neill, K.A.2    Yao, X.3    Crona, J.H.4    Davis Jr, H.R.5    Graziano, M.P.6    Altmann, S.W.7
  • 41
    • 33846667507 scopus 로고    scopus 로고
    • Sterolins ABCG5 and ABCG8: Regulators of whole body dietary sterols
    • Hazard SE, Patel SB. 2007. Sterolins ABCG5 and ABCG8: Regulators of whole body dietary sterols. Pflugers Archives 453(5):745-752.
    • (2007) Pflugers Archives , vol.453 , Issue.5 , pp. 745-752
    • Hazard, S.E.1    Patel, S.B.2
  • 42
    • 24144438622 scopus 로고    scopus 로고
    • NPC1L1 haplotype is associated with inter-individual variation in plasma low-density lipoprotein response to ezetimibe. Lipids
    • Hegele RA, Guy J, Ban MR, Wang J. 2005. NPC1L1 haplotype is associated with inter-individual variation in plasma low-density lipoprotein response to ezetimibe. Lipids, Health and Disease 4:16.
    • (2005) Health and Disease , vol.4 , pp. 16
    • Hegele, R.A.1    Guy, J.2    Ban, M.R.3    Wang, J.4
  • 43
    • 0027729980 scopus 로고
    • Comparison of intestinal absorption of cholesterol with different plant sterols in man
    • Heinemann T, Axtmann G, Von Bergmann K. 1993. Comparison of intestinal absorption of cholesterol with different plant sterols in man. European Journal of Clinical Investigation 23(12):827-831.
    • (1993) European Journal of Clinical Investigation , vol.23 , Issue.12 , pp. 827-831
    • Heinemann, T.1    Axtmann, G.2    Von Bergmann, K.3
  • 47
    • 1642506259 scopus 로고    scopus 로고
    • ATP binding cassette transporter G5 and G8 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin
    • Kajinami K, Brousseau ME, Nartsupha C, Ordovas JM, Schaefer EJ. 2004a. ATP binding cassette transporter G5 and G8 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin. Journal of Lipid Research 45(4):653-656.
    • (2004) Journal of Lipid Research , vol.45 , Issue.4 , pp. 653-656
    • Kajinami, K.1    Brousseau, M.E.2    Nartsupha, C.3    Ordovas, J.M.4    Schaefer, E.J.5
  • 48
    • 3242736602 scopus 로고    scopus 로고
    • Interactions between common genetic polymorphisms in ABCG5/G8 and CYP7A1 on LDL cholesterol-lowering response to atorvastatin
    • Kajinami K, Brousseau ME, Ordovas JM, Schaefer EJ. 2004b. Interactions between common genetic polymorphisms in ABCG5/G8 and CYP7A1 on LDL cholesterol-lowering response to atorvastatin. Atherosclerosis 175(2):287-293.
    • (2004) Atherosclerosis , vol.175 , Issue.2 , pp. 287-293
    • Kajinami, K.1    Brousseau, M.E.2    Ordovas, J.M.3    Schaefer, E.J.4
  • 50
    • 34548644843 scopus 로고    scopus 로고
    • Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane
    • Knopfel M, Davies JP, Duong PT, Kvaerno L, Carreira EM, Phillips MC, Ioannou YA, Hauser H. 2007. Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane. Biochimica et Biophysica Acta 1771(9):1140-1147.
    • (2007) Biochimica et Biophysica Acta , vol.1771 , Issue.9 , pp. 1140-1147
    • Knopfel, M.1    Davies, J.P.2    Duong, P.T.3    Kvaerno, L.4    Carreira, E.M.5    Phillips, M.C.6    Ioannou, Y.A.7    Hauser, H.8
  • 55
    • 11144257009 scopus 로고    scopus 로고
    • Increased fecal neutral sterol loss upon liver X-receptor activation is independent of biliary sterol secretion in mice
    • Kruit JK, Plosch T, Havinga R, Boverhof R, Groot PH, Groen AK, Kuipers F. 2005. Increased fecal neutral sterol loss upon liver X-receptor activation is independent of biliary sterol secretion in mice. Gastroenterology 128(1):147-156.
    • (2005) Gastroenterology , vol.128 , Issue.1 , pp. 147-156
    • Kruit, J.K.1    Plosch, T.2    Havinga, R.3    Boverhof, R.4    Groot, P.H.5    Groen, A.K.6    Kuipers, F.7
  • 56
    • 34548620629 scopus 로고    scopus 로고
    • Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles
    • Labonte ED, Howles PN, Granholm NA, Rojas JC, Davies JP, Ioannou YA, Hui DY. 2007. Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles. Biochimica et Biophysica Acta 1771(9):1132-1139.
    • (2007) Biochimica et Biophysica Acta , vol.1771 , Issue.9 , pp. 1132-1139
    • Labonte, E.D.1    Howles, P.N.2    Granholm, N.A.3    Rojas, J.C.4    Davies, J.P.5    Ioannou, Y.A.6    Hui, D.Y.7
  • 57
    • 23244465200 scopus 로고    scopus 로고
    • New insights into the genetic regulation of intestinal cholesterol absorption
    • Lammert F, Wang DQ. 2005. New insights into the genetic regulation of intestinal cholesterol absorption. Gastroenterology 129(2):718-734.
    • (2005) Gastroenterology , vol.129 , Issue.2 , pp. 718-734
    • Lammert, F.1    Wang, D.Q.2
  • 59
    • 0034980709 scopus 로고    scopus 로고
    • Fine mapping of a gene responsible for regulating dietary cholesterol absorption; founder effects underlie cases of phytosterolaemia in multiple communities
    • Lee MH, Gordon D, Ott J, Lu K, Ose L, Miettinen T, Gylling H, Stalenhoef AF, Pandya A, Hidaka H, et al. 2001a. Fine mapping of a gene responsible for regulating dietary cholesterol absorption; founder effects underlie cases of phytosterolaemia in multiple communities. European Journal of Human Genetics 9(5):375-384.
    • (2001) European Journal of Human Genetics , vol.9 , Issue.5 , pp. 375-384
    • Lee, M.H.1    Gordon, D.2    Ott, J.3    Lu, K.4    Ose, L.5    Miettinen, T.6    Gylling, H.7    Stalenhoef, A.F.8    Pandya, A.9    Hidaka, H.10
  • 61
    • 0017688818 scopus 로고
    • Plant sterols as cholesterol-lowering agents: Clinical trials in patients with hypercholesterolemia and studies of sterol balance
    • Lees AM, Mok HY, Lees RS, McCluskey MA, Grundy SM. 1977. Plant sterols as cholesterol-lowering agents: Clinical trials in patients with hypercholesterolemia and studies of sterol balance. Atherosclerosis 28(3):325-338.
    • (1977) Atherosclerosis , vol.28 , Issue.3 , pp. 325-338
    • Lees, A.M.1    Mok, H.Y.2    Lees, R.S.3    McCluskey, M.A.4    Grundy, S.M.5
  • 62
    • 0034915332 scopus 로고    scopus 로고
    • Two genes that map to the STSL locus cause sitosterolaemia: Genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively
    • Lu K, Lee MH, Hazard S, Brooks-Wilson A, Hidaka H, Kojima H, Ose L, Stalenhoef AF, Mietinnen T, Bjorkhem I, et al. 2001. Two genes that map to the STSL locus cause sitosterolaemia: Genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively. American Journal of Human Genetics 69(2):278-290.
    • (2001) American Journal of Human Genetics , vol.69 , Issue.2 , pp. 278-290
    • Lu, K.1    Lee, M.H.2    Hazard, S.3    Brooks-Wilson, A.4    Hidaka, H.5    Kojima, H.6    Ose, L.7    Stalenhoef, A.F.8    Mietinnen, T.9    Bjorkhem, I.10
  • 63
    • 0036198630 scopus 로고    scopus 로고
    • Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8
    • Lu K, Lee MH, Yu H, Zhou Y, Sandell SA, Salen G, Patel SB. 2002. Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8. Journal of Lipid Research 43(4):565-578.
    • (2002) Journal of Lipid Research , vol.43 , Issue.4 , pp. 565-578
    • Lu, K.1    Lee, M.H.2    Yu, H.3    Zhou, Y.4    Sandell, S.A.5    Salen, G.6    Patel, S.B.7
  • 64
    • 0029112257 scopus 로고
    • Sterol absorption and sterol balance in phytosterolemia evaluated by deuterium-labeled sterols: Effect of sitostanol treatment
    • Lutjohann D, Bjorkhem I, Beil UF, Von Bergmann K. 1995. Sterol absorption and sterol balance in phytosterolemia evaluated by deuterium-labeled sterols: Effect of sitostanol treatment. Journal of Lipid Research 36(8):1763-1773.
    • (1995) Journal of Lipid Research , vol.36 , Issue.8 , pp. 1763-1773
    • Lutjohann, D.1    Bjorkhem, I.2    Beil, U.F.3    Von Bergmann, K.4
  • 65
    • 0030762693 scopus 로고    scopus 로고
    • Phytosterolaemia: Diagnosis, characterization and therapeutical approaches
    • Lutjohann D, Von Bergmann K. 1997. Phytosterolaemia: Diagnosis, characterization and therapeutical approaches. Annals of Medicine 29(3):181-184.
    • (1997) Annals of Medicine , vol.29 , Issue.3 , pp. 181-184
    • Lutjohann, D.1    Von Bergmann, K.2
  • 67
    • 0018841909 scopus 로고
    • Phytosterolaemia, xanthomatosis and premature atherosclerotic arterial disease: A case with high plant sterol absorption, impaired sterol elimination and low cholesterol synthesis
    • Miettinen TA. 1980. Phytosterolaemia, xanthomatosis and premature atherosclerotic arterial disease: A case with high plant sterol absorption, impaired sterol elimination and low cholesterol synthesis. European Journal of Clinical Investigation 10(1):27-35.
    • (1980) European Journal of Clinical Investigation , vol.10 , Issue.1 , pp. 27-35
    • Miettinen, T.A.1
  • 69
    • 0025156823 scopus 로고
    • Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population
    • Miettinen TA, Tilvis RS, Kesaniemi YA. 1990. Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population. American Journal of Epidemiology 131(1):20-31.
    • (1990) American Journal of Epidemiology , vol.131 , Issue.1 , pp. 20-31
    • Miettinen, T.A.1    Tilvis, R.S.2    Kesaniemi, Y.A.3
  • 73
    • 33750525151 scopus 로고    scopus 로고
    • Co-expression of human ABCG5 and ABCG8 in insect cells generates an androstan stimulated membrane ATPase activity
    • Muller M, Klein I, Kopacsi S, Remaley AT, Rajnavolgyi E, Sarkadi B, Varadi A. 2006. Co-expression of human ABCG5 and ABCG8 in insect cells generates an androstan stimulated membrane ATPase activity. FEBS Letters 580(26):6139-6144.
    • (2006) FEBS Letters , vol.580 , Issue.26 , pp. 6139-6144
    • Muller, M.1    Klein, I.2    Kopacsi, S.3    Remaley, A.T.4    Rajnavolgyi, E.5    Sarkadi, B.6    Varadi, A.7
  • 75
    • 0034107086 scopus 로고    scopus 로고
    • Soy sterol esters and beta-sitostanol ester as inhibitors of cholesterol absorption in human small bowel
    • Normen L, Dutta P, Lia A, Andersson H. 2000. Soy sterol esters and beta-sitostanol ester as inhibitors of cholesterol absorption in human small bowel. American Journal of Clinical Nutrition 71(4):908-913.
    • (2000) American Journal of Clinical Nutrition , vol.71 , Issue.4 , pp. 908-913
    • Normen, L.1    Dutta, P.2    Lia, A.3    Andersson, H.4
  • 78
    • 11244310636 scopus 로고    scopus 로고
    • Common sequence variations in ABCG8 are related to plant sterol metabolism in healthy volunteers
    • Plat J, Bragt MC, Mensink RP. 2005. Common sequence variations in ABCG8 are related to plant sterol metabolism in healthy volunteers. Journal of Lipid Research 46(1):68-75.
    • (2005) Journal of Lipid Research , vol.46 , Issue.1 , pp. 68-75
    • Plat, J.1    Bragt, M.C.2    Mensink, R.P.3
  • 82
    • 0034056801 scopus 로고    scopus 로고
    • Vegetable oils high in phytosterols make erythrocytes less deformable and shorten the life span of stroke-prone spontaneously hypertensive rats
    • Ratnayake WM, L'Abbe MR, Mueller R, Hayward S, Plouffe L, Hollywood R, Trick K. 2000. Vegetable oils high in phytosterols make erythrocytes less deformable and shorten the life span of stroke-prone spontaneously hypertensive rats. Journal of Nutrition 130(5):1166-1178.
    • (2000) Journal of Nutrition , vol.130 , Issue.5 , pp. 1166-1178
    • Ratnayake, W.M.1    L'Abbe, M.R.2    Mueller, R.3    Hayward, S.4    Plouffe, L.5    Hollywood, R.6    Trick, K.7
  • 84
    • 7044235261 scopus 로고    scopus 로고
    • ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: Impact on hepatic cholesterol homeostasis
    • Repa JJ, Buhman KK, Farese Jr RV, Dietschy JM, Turley SD. 2004. ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: Impact on hepatic cholesterol homeostasis. Hepatology 40(5):1088-1097.
    • (2004) Hepatology , vol.40 , Issue.5 , pp. 1088-1097
    • Repa, J.J.1    Buhman, K.K.2    Farese Jr, R.V.3    Dietschy, J.M.4    Turley, S.D.5
  • 85
    • 0036851863 scopus 로고    scopus 로고
    • The liver X-receptor gene team: Potential new players in atherosclerosis
    • Repa JJ, Mangelsdorf DJ. 2002. The liver X-receptor gene team: Potential new players in atherosclerosis. Nature Medicine 8(11):1243-1248.
    • (2002) Nature Medicine , vol.8 , Issue.11 , pp. 1243-1248
    • Repa, J.J.1    Mangelsdorf, D.J.2
  • 86
    • 0037790917 scopus 로고    scopus 로고
    • The enzymes, regulation, and genetics of bile acid synthesis
    • Russell DW. 2003. The enzymes, regulation, and genetics of bile acid synthesis. Annual Reviews in Biochemistry 72:137-174.
    • (2003) Annual Reviews in Biochemistry , vol.72 , pp. 137-174
    • Russell, D.W.1
  • 88
    • 0021856672 scopus 로고
    • Increased plasma cholestanol and 5 alpha-saturated plant sterol derivatives in subjects with sitosterolemia and xanthomatosis
    • Salen G, Kwiterovich Jr PO, Shefer S, Tint GS, Horak I, Shore V, Dayal B, Horak E. 1985. Increased plasma cholestanol and 5 alpha-saturated plant sterol derivatives in subjects with sitosterolemia and xanthomatosis. Journal of Lipid Research 26(2):203-209.
    • (1985) Journal of Lipid Research , vol.26 , Issue.2 , pp. 203-209
    • Salen, G.1    Kwiterovich Jr, P.O.2    Shefer, S.3    Tint, G.S.4    Horak, I.5    Shore, V.6    Dayal, B.7    Horak, E.8
  • 95
    • 0142074236 scopus 로고    scopus 로고
    • A missense mutation in the Abcg5 gene causes phytosterolemia in SHR, stroke-prone SHR, and WKY rats
    • Scoggan KA, Gruber H, Lariviere K. 2003. A missense mutation in the Abcg5 gene causes phytosterolemia in SHR, stroke-prone SHR, and WKY rats. Journal of Lipid Research. 44(5):911-916.
    • (2003) Journal of Lipid Research , vol.44 , Issue.5 , pp. 911-916
    • Scoggan, K.A.1    Gruber, H.2    Lariviere, K.3
  • 96
    • 0014083967 scopus 로고
    • Absorption of cholesterol from a micellar solution: Intestinal perfusion studies in man
    • Simmonds WJ, Hofmann AF, Theodor E. 1967. Absorption of cholesterol from a micellar solution: Intestinal perfusion studies in man. Journal of Clinical Investigation 46(5):874-890.
    • (1967) Journal of Clinical Investigation , vol.46 , Issue.5 , pp. 874-890
    • Simmonds, W.J.1    Hofmann, A.F.2    Theodor, E.3
  • 98
    • 0037422545 scopus 로고    scopus 로고
    • Role of ABC transporters in secretion of cholesterol from liver into bile
    • Small DM. 2003. Role of ABC transporters in secretion of cholesterol from liver into bile. Proceedings of the National Academy of Sciences, USA 100(1):4-6.
    • (2003) Proceedings of the National Academy of Sciences, USA , vol.100 , Issue.1 , pp. 4-6
    • Small, D.M.1
  • 99
    • 1542618335 scopus 로고    scopus 로고
    • Annexin 2-caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transport
    • Smart EJ, De Rose RA, Farber SA. 2004. Annexin 2-caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transport. Proceedings of the National Academy of Sciences, USA 101(10):3450-3455.
    • (2004) Proceedings of the National Academy of Sciences, USA , vol.101 , Issue.10 , pp. 3450-3455
    • Smart, E.J.1    De Rose, R.A.2    Farber, S.A.3
  • 100
    • 0022181816 scopus 로고
    • Membrane lipid composition and cellular function
    • Spector AA, Yorek MA. 1985. Membrane lipid composition and cellular function. Journal of Lipid Research 26(9):1015-1035.
    • (1985) Journal of Lipid Research , vol.26 , Issue.9 , pp. 1015-1035
    • Spector, A.A.1    Yorek, M.A.2
  • 101
    • 14344250452 scopus 로고    scopus 로고
    • Sterol transporters: Targets of natural sterols and new lipid lowering drugs
    • Sudhop T, Lutjohann D, Von Bergmann K. 2005. Sterol transporters: Targets of natural sterols and new lipid lowering drugs. Pharmacology and Therapy 105(3):333-341.
    • (2005) Pharmacology and Therapy , vol.105 , Issue.3 , pp. 333-341
    • Sudhop, T.1    Lutjohann, D.2    Von Bergmann, K.3
  • 102
    • 0018653503 scopus 로고
    • Purine transport by malpighian tubules of pteridine-deficient eye color mutants of Drosophila melanogaster
    • Sullivan DT, Bell LA, Paton DR, Sullivan MC. 1979. Purine transport by malpighian tubules of pteridine-deficient eye color mutants of Drosophila melanogaster. Biochemistry and Genetics 17(5-6):565-573.
    • (1979) Biochemistry and Genetics , vol.17 , Issue.5-6 , pp. 565-573
    • Sullivan, D.T.1    Bell, L.A.2    Paton, D.R.3    Sullivan, M.C.4
  • 103
    • 34250173805 scopus 로고    scopus 로고
    • Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8
    • Sumi K, Tanaka T, Uchida A, Magoori K, Urashima Y, Ohashi R, Ohguchi H, Okamura M, Kudo H, Daigo K, et al. 2007. Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8. Molecular Cell Biology 27(12):4248-4260.
    • (2007) Molecular Cell Biology , vol.27 , Issue.12 , pp. 4248-4260
    • Sumi, K.1    Tanaka, T.2    Uchida, A.3    Magoori, K.4    Urashima, Y.5    Ohashi, R.6    Ohguchi, H.7    Okamura, M.8    Kudo, H.9    Daigo, K.10
  • 104
    • 36148987225 scopus 로고    scopus 로고
    • Cholesterol and plant sterol efflux from cultured intestinal epithelial cells is mediated by ATP-binding cassette transporters
    • Tachibana S, Hirano M, Hirata T, Matsuo M, Ikeda I, Ueda K, Sato R. 2007. Cholesterol and plant sterol efflux from cultured intestinal epithelial cells is mediated by ATP-binding cassette transporters. Bioscience, Biotechnology and Biochemistry 71(8):1886-1895.
    • (2007) Bioscience, Biotechnology and Biochemistry , vol.71 , Issue.8 , pp. 1886-1895
    • Tachibana, S.1    Hirano, M.2    Hirata, T.3    Matsuo, M.4    Ikeda, I.5    Ueda, K.6    Sato, R.7
  • 106
    • 0024697812 scopus 로고
    • Cloning and characterization of the scarlet gene of Drosophila melanogaster
    • Tearle RG, Belote JM, McKeown M, Baker BS, Howells AJ. 1989. Cloning and characterization of the scarlet gene of Drosophila melanogaster. Genetics 122(3):595-606.
    • (1989) Genetics , vol.122 , Issue.3 , pp. 595-606
    • Tearle, R.G.1    Belote, J.M.2    McKeown, M.3    Baker, B.S.4    Howells, A.J.5
  • 108
    • 0026722821 scopus 로고
    • Lipoprotein receptors and steroidogenesis in adrenocortical cells
    • Toth IE. 1992. Lipoprotein receptors and steroidogenesis in adrenocortical cells. Journal of Steroid Biochemistry and Molecular Biology 43(5):395-402.
    • (1992) Journal of Steroid Biochemistry and Molecular Biology , vol.43 , Issue.5 , pp. 395-402
    • Toth, I.E.1
  • 111
    • 0031705365 scopus 로고    scopus 로고
    • Gender-related differences in bile acid and sterol metabolism in outbred CD-1 mice fed low- and high-cholesterol diets
    • Turley SD, Schwarz M, Spady DK, Dietschy JM. 1998. Gender-related differences in bile acid and sterol metabolism in outbred CD-1 mice fed low- and high-cholesterol diets. Hepatology 28(4):1088-1094.
    • (1998) Hepatology , vol.28 , Issue.4 , pp. 1088-1094
    • Turley, S.D.1    Schwarz, M.2    Spady, D.K.3    Dietschy, J.M.4
  • 113
    • 33846864235 scopus 로고    scopus 로고
    • Cholesterol feeding strongly reduces hepatic VLDL-triglyceride production in mice lacking the liver X-receptor alpha
    • Van der Veen JN, Havinga R, Bloks VW, Groen AK, Kuipers F. 2007. Cholesterol feeding strongly reduces hepatic VLDL-triglyceride production in mice lacking the liver X-receptor alpha. Journal of Lipid Research 48(2):337-347.
    • (2007) Journal of Lipid Research , vol.48 , Issue.2 , pp. 337-347
    • Van der Veen, J.N.1    Havinga, R.2    Bloks, V.W.3    Groen, A.K.4    Kuipers, F.5
  • 115
    • 0034003105 scopus 로고    scopus 로고
    • Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663
    • Van Heek M, Farley C, Compton DS, Hoos L, Alton KB, Sybertz EJ, Davis HR, Jr. 2000. Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663. British Journal of Pharmacology 129(8):1748-1754.
    • (2000) British Journal of Pharmacology , vol.129 , Issue.8 , pp. 1748-1754
    • Van Heek, M.1    Farley, C.2    Compton, D.S.3    Hoos, L.4    Alton, K.B.5    Sybertz, E.J.6    Davis Jr., H.R.7
  • 116
    • 0034776367 scopus 로고    scopus 로고
    • Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function
    • Van Heek M, Farley C, Compton DS, Hoos L, Davis HR. 2001. Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function. British Journal of Pharmacology 134(2):409-417.
    • (2001) British Journal of Pharmacology , vol.134 , Issue.2 , pp. 409-417
    • Van Heek, M.1    Farley, C.2    Compton, D.S.3    Hoos, L.4    Davis, H.R.5
  • 118
    • 34548686115 scopus 로고    scopus 로고
    • The sterol transporting heterodimer ABCG5/ABCG8 requires bile salts to mediate cholesterol efflux
    • Vrins C, Vink E, Vandenberghe KE, Frijters R, Seppen J, Groen AK. 2007. The sterol transporting heterodimer ABCG5/ABCG8 requires bile salts to mediate cholesterol efflux. FEBS Letters 581(24):4616-4620.
    • (2007) FEBS Letters , vol.581 , Issue.24 , pp. 4616-4620
    • Vrins, C.1    Vink, E.2    Vandenberghe, K.E.3    Frijters, R.4    Seppen, J.5    Groen, A.K.6
  • 120
    • 14244262377 scopus 로고    scopus 로고
    • Compound heterozygosity for two non-synonymous polymorphisms in NPC1L1 in a non-responder to ezetimibe
    • Wang J, Williams CM, Hegele RA. 2005. Compound heterozygosity for two non-synonymous polymorphisms in NPC1L1 in a non-responder to ezetimibe. Clinical Genetics 67(2):175-177.
    • (2005) Clinical Genetics , vol.67 , Issue.2 , pp. 175-177
    • Wang, J.1    Williams, C.M.2    Hegele, R.A.3
  • 125
    • 33748796068 scopus 로고    scopus 로고
    • How does cholesterol affect the way Hedgehog works?
    • Wendler F, Franch-Marro X, Vincent JP. 2006. How does cholesterol affect the way Hedgehog works? Development 133(16):3055-3061.
    • (2006) Development , vol.133 , Issue.16 , pp. 3055-3061
    • Wendler, F.1    Franch-Marro, X.2    Vincent, J.P.3
  • 126
    • 0036733732 scopus 로고    scopus 로고
    • Biliary cholesterol secretion by the twinned sterol half-transporters ABCG5 and ABCG8
    • Wittenburg H, Carey MC. 2002. Biliary cholesterol secretion by the twinned sterol half-transporters ABCG5 and ABCG8. Journal of Clinical Investigation 110(5):605-609.
    • (2002) Journal of Clinical Investigation , vol.110 , Issue.5 , pp. 605-609
    • Wittenburg, H.1    Carey, M.C.2
  • 127
    • 24644511633 scopus 로고    scopus 로고
    • Association of a lithogenic Abcg5/Abcg8 allele on Chromosome 17 (Lith9) with cholesterol gallstone formation in PERA/EiJ mice
    • Wittenburg H, Lyons MA, Li R, Kurtz U, Mossner J, Churchill GA, Carey MC, Paigen B. 2005. Association of a lithogenic Abcg5/Abcg8 allele on Chromosome 17 (Lith9) with cholesterol gallstone formation in PERA/EiJ mice. Mammalian Genome 16(7):495-504.
    • (2005) Mammalian Genome , vol.16 , Issue.7 , pp. 495-504
    • Wittenburg, H.1    Lyons, M.A.2    Li, R.3    Kurtz, U.4    Mossner, J.5    Churchill, G.A.6    Carey, M.C.7    Paigen, B.8
  • 128
    • 31844452256 scopus 로고    scopus 로고
    • Inhibition of intestinal cholesterol absorption by ezetimibe is a novel therapeutic target for fatty liver
    • Yamagishi S, Nakamura K, Matsui T, Sato T, Takeuchi M. 2006. Inhibition of intestinal cholesterol absorption by ezetimibe is a novel therapeutic target for fatty liver. Medical Hypotheses 66(4):844-844.
    • (2006) Medical Hypotheses , vol.66 , Issue.4 , pp. 844-844
    • Yamagishi, S.1    Nakamura, K.2    Matsui, T.3    Sato, T.4    Takeuchi, M.5
  • 129
    • 33846421597 scopus 로고    scopus 로고
    • Niemann-Pick C1-like 1 overexpression facilitates ezetimibe-sensitive cholesterol and beta-sitosterol uptake in CaCo-2 cells
    • Yamanashi Y, Takada T, Suzuki H. 2007. Niemann-Pick C1-like 1 overexpression facilitates ezetimibe-sensitive cholesterol and beta-sitosterol uptake in CaCo-2 cells. Journal of Pharmacology and Experimental Therapy 320(2):559-564.
    • (2007) Journal of Pharmacology and Experimental Therapy , vol.320 , Issue.2 , pp. 559-564
    • Yamanashi, Y.1    Takada, T.2    Suzuki, H.3
  • 130
    • 0022389171 scopus 로고
    • Cholesterol and the cell membrane
    • Yeagle PL. 1985. Cholesterol and the cell membrane. Biochimica et Biophysica Acta 822(3-4):267-287.
    • (1985) Biochimica et Biophysica Acta , vol.822 , Issue.3-4 , pp. 267-287
    • Yeagle, P.L.1
  • 135
    • 0036733630 scopus 로고    scopus 로고
    • Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol
    • Yu L, Li-Hawkins J, Hammer RE, Berge KE, Horton JD, Cohen JC, Hobbs HH. 2002b. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. Journal of Clinical Investigation 110(5):671-680.
    • (2002) Journal of Clinical Investigation , vol.110 , Issue.5 , pp. 671-680
    • Yu, L.1    Li-Hawkins, J.2    Hammer, R.E.3    Berge, K.E.4    Horton, J.D.5    Cohen, J.C.6    Hobbs, H.H.7
  • 138
    • 0038614979 scopus 로고    scopus 로고
    • Stimulation of cholesterol excretion by the liver X-receptor agonist requires ATP-binding cassette transporters G5 and G8
    • Yu L, York J, Von Bergmann K, Lutjohann D, Cohen JC, Hobbs HH. 2003b. Stimulation of cholesterol excretion by the liver X-receptor agonist requires ATP-binding cassette transporters G5 and G8. Journal of Biology and Chemistry 278(18):15565-15570.
    • (2003) Journal of Biology and Chemistry , vol.278 , Issue.18 , pp. 15565-15570
    • Yu, L.1    York, J.2    Von Bergmann, K.3    Lutjohann, D.4    Cohen, J.C.5    Hobbs, H.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.