메뉴 건너뛰기




Volumn 58, Issue 9, 2004, Pages 859-866

Cholesterol metabolism and its implications for therapeutic interventions in patients with hypercholesterolaemia

Author keywords

Cardiovascular diseases; Cholesterol absorption; Cholesterol synthesis; Therapy

Indexed keywords

ATORVASTATIN; CHOLESTEROL; EZETIMIBE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIVER X RECEPTOR ALPHA; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; RESIN; RETINOID X RECEPTOR; SCAVENGER RECEPTOR; SIMVASTATIN; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

EID: 7744236073     PISSN: 13685031     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1742-1241.2004.00351.x     Document Type: Review
Times cited : (42)

References (52)
  • 1
    • 0031658523 scopus 로고    scopus 로고
    • Prevention of coronary heart disease in clinical practice. Summary of recommendations of the second joint task force of European and other societies on coronary prevention
    • Wood D, De Backer G, Faergeman O et al. Prevention of coronary heart disease in clinical practice. Summary of recommendations of the second joint task force of European and other societies on coronary prevention. J Hypertens 1998; 16: 1407-14.
    • (1998) J. Hypertens. , vol.16 , pp. 1407-1414
    • Wood, D.1    De Backer, G.2    Faergeman, O.3
  • 2
    • 0003775049 scopus 로고    scopus 로고
    • 2001 Heart and Stroke Statistical Update
    • American Heart Association. Dallas, Tex: American Heart Association
    • American Heart Association. 2001 Heart and Stroke Statistical Update. Dallas, Tex: American Heart Association, 2000.
    • (2000)
  • 3
    • 0035023281 scopus 로고    scopus 로고
    • The value of lipid lowering in patients with coronary heart disease
    • Karnik R. The value of lipid lowering in patients with coronary heart disease. J Clin Basic Cardiol 2001; 4: 31-4.
    • (2001) J. Clin. Basic Cardiol. , vol.4 , pp. 31-34
    • Karnik, R.1
  • 4
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
    • Scandinavian Simvastatin Survival Study Group
    • Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S). Lancet 1994; 344: 1383-9.
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 5
    • 0032487931 scopus 로고    scopus 로고
    • Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels
    • The Long-Term Intervention with Pravastatin in Ischaemic Disease (Lipid) Study Group
    • The Long-Term Intervention with Pravastatin in Ischaemic Disease (Lipid) Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-57.
    • (1998) N. Engl. J. Med. , vol.339 , pp. 1349-1357
  • 6
    • 0342981862 scopus 로고    scopus 로고
    • The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and recurrent events trial investigators
    • Sacks FM, Pfeffer MA, Moye LA et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and recurrent events trial investigators. N Engl J Med 1996; 335: 1001-9.
    • (1996) N. Engl. J. Med. , vol.335 , pp. 1001-1009
    • Sacks, F.M.1    Pfeffer, M.A.2    Moye, L.A.3
  • 7
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
    • West of Scotland Coronary Prevention Study Group
    • Shepherd J, Cobbe SM, Ford I et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med 1995; 333 1301-7.
    • (1995) N. Engl. J. Med. , vol.333 , pp. 1301-1307
    • Shepherd, J.1    Cobbe, S.M.2    Ford, I.3
  • 8
    • 0032572086 scopus 로고    scopus 로고
    • Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: Results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study
    • Downs JR, Clearfield M, Weis S et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA 1998; 279: 1615-22.
    • (1998) JAMA , vol.279 , pp. 1615-1622
    • Downs, J.R.1    Clearfield, M.2    Weis, S.3
  • 9
    • 0037840242 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: A randomised placebo-controlled trial
    • for the Heart Protection Study Collaborative Group
    • Collins R, Armitage J, Parish S et al. for the Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial. Lancet 2003; 361: 2005-16.
    • (2003) Lancet , vol.361 , pp. 2005-2016
    • Collins, R.1    Armitage, J.2    Parish, S.3
  • 10
    • 0025183769 scopus 로고
    • Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B
    • Brown G, Albers JJ, Fisher LD et al. Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B. N Engl J Med 1990; 323: 1289-98.
    • (1990) N. Engl. J. Med. , vol.323 , pp. 1289-1298
    • Brown, G.1    Albers, J.J.2    Fisher, L.D.3
  • 11
    • 0027322190 scopus 로고
    • Retardation and arrest of progression or regression of coronary artery disease: A review
    • Vos J, De Feyter PJ, Simoons ML et al. Retardation and arrest of progression or regression of coronary artery disease: a review. Prog Cardiovasc Dis 1993; 35: 435-54.
    • (1993) Prog. Cardiovasc. Dis. , vol.35 , pp. 435-454
    • Vos, J.1    De Feyter, P.J.2    Simoons, M.L.3
  • 12
    • 0035978089 scopus 로고    scopus 로고
    • Clinical reality of coronary prevention guidelines: A comparison of EUROASPIRE I and II in nine countries. European action on secondary prevention by intervention to reduce events
    • II.Group
    • Euroaspire I, II.Group. Clinical reality of coronary prevention guidelines: a comparison of EUROASPIRE I and II in nine countries. European action on secondary prevention by intervention to reduce events. Lancet 2001; 357: 995-1001.
    • (2001) Lancet , vol.357 , pp. 995-1001
    • Euroaspire, I.1
  • 13
    • 0037126526 scopus 로고    scopus 로고
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report. Circulation 2002; 106: 3143-421.
    • (2002) Circulation , vol.106 , pp. 3143-3421
  • 14
    • 0030945970 scopus 로고    scopus 로고
    • Adherence to National Cholesterol Education Program treatment goals in postmenopausal women with heart disease. The Heart and Estrogen/Progestin Replacement Study (HERS)
    • for the HERS Research Group
    • Schrott HG, Bittner V, Vittinghoff E et al. for the HERS Research Group. Adherence to National Cholesterol Education Program treatment goals in postmenopausal women with heart disease. The Heart and Estrogen/Progestin Replacement Study (HERS). JAMA 1997; 277: 1281-6.
    • (1997) JAMA , vol.277 , pp. 1281-12786
    • Schrott, H.G.1    Bittner, V.2    Vittinghoff, E.3
  • 15
    • 0034733885 scopus 로고    scopus 로고
    • The undertreatment of LDL-cholesterol: Addressing the challenge
    • Pearson TA. The undertreatment of LDL-cholesterol: addressing the challenge. Int J Cardiol 2000; 74(Suppl. 1): S23-S28.
    • (2000) Int. J. Cardiol. , vol.74 , Issue.SUPPL. 1
    • Pearson, T.A.1
  • 16
    • 0030951706 scopus 로고    scopus 로고
    • Theoretical considerations of what regulates low-density lipoprotein and high-density lipoprorein cholesterol
    • Dietschy JM. Theoretical considerations of what regulates low-density lipoprotein and high-density lipoprorein cholesterol. Am J Clin Nutr 1997; 65(Suppl.): 1581S-1589S.
    • (1997) Am. J. Clin. Nutr. , vol.65 , Issue.SUPPL.
    • Dietschy, J.M.1
  • 17
    • 0031888994 scopus 로고    scopus 로고
    • Lipoprotein metabolism
    • Beisiegel U. Lipoprotein metabolism. Eur Heart J 1998; 19(Suppl. A): A20-A23.
    • (1998) Eur. Heart J. , vol.19 , Issue.SUPPL. A
    • Beisiegel, U.1
  • 18
    • 33749964463 scopus 로고
    • Lipid and lipoprotein metabolism
    • Rifkind BM, ed. New York, NY: Marcel Dekker, Inc
    • Brewer HB Jr. Lipid and lipoprotein metabolism. In: Rifkind BM, ed. Drug Treatment of Hyperlipidemia. New York, NY: Marcel Dekker, Inc., 1991.
    • (1991) Drug Treatment of Hyperlipidemia
    • Brewer Jr., H.B.1
  • 19
    • 0038626745 scopus 로고
    • Origin, metabolic fate, and metabolic function of plasma lipoproteins
    • Steinberg D, Olefsky JM, eds. New York, NY: Churchill Livingstone
    • Havel RJ. Origin, metabolic fate, and metabolic function of plasma lipoproteins. In: Steinberg D, Olefsky JM, eds. Hypercholesterolemia and Atherosclerosis: Pathogenesis and Prevention. New York, NY: Churchill Livingstone, 1987.
    • (1987) Hypercholesterolemia and Atherosclerosis: Pathogenesis and Prevention
    • Havel, R.J.1
  • 20
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002; 109: 1125-31.
    • (2002) J. Clin. Invest. , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 21
    • 0037450981 scopus 로고    scopus 로고
    • Liver X receptors and the control of cholesterol homeostasis: Potential therapeutic targets for the treatment of atherosclerosis
    • Millatt LJ, Bocher V, Fruchart J, Staels B. Liver X receptors and the control of cholesterol homeostasis: potential therapeutic targets for the treatment of atherosclerosis. Biochim Biophys Acta 2003; 1631: 107-18.
    • (2003) Biochim. Biophys. Acta , vol.1631 , pp. 107-118
    • Millatt, L.J.1    Bocher, V.2    Fruchart, J.3    Staels, B.4
  • 22
    • 0034795381 scopus 로고    scopus 로고
    • Molecular mechanisms of sterol absorptions
    • Chen HC. Molecular mechanisms of sterol absorptions. J Nutr 2001; 131: 2603-5.
    • (2001) J. Nutr. , vol.131 , pp. 2603-2605
    • Chen, H.C.1
  • 23
    • 0030947679 scopus 로고    scopus 로고
    • Established and emerging strategies for inhibition of cholesterol absorption
    • Homan R, Krause BR. Established and emerging strategies for inhibition of cholesterol absorption. Curr Pharm Des 1997; 3: 29-44.
    • (1997) Curr. Pharm. Des. , vol.3 , pp. 29-44
    • Homan, R.1    Krause, B.R.2
  • 24
    • 0035458853 scopus 로고    scopus 로고
    • Dietary cholesterol absorption; more than just bile
    • Lu K, Lee M, Patel SB. Dietary cholesterol absorption; more than just bile. Trends Endocrinol Metab 2001; 12: 314-20.
    • (2001) Trends Endocrinol. Metab. , vol.12 , pp. 314-320
    • Lu, K.1    Lee, M.2    Patel, S.B.3
  • 25
    • 0032913411 scopus 로고    scopus 로고
    • Percent cholesterol absorption in normal women and men quantified with dual stable isotopic tracers and negative ion mass spectrometry
    • Bosner MS, Lange LG, Stenson WF, Ostlund RE Jr. Percent cholesterol absorption in normal women and men quantified with dual stable isotopic tracers and negative ion mass spectrometry. J Lipid Res 1999; 40: 302-8.
    • (1999) J. Lipid Res. , vol.40 , pp. 302-308
    • Bosner, M.S.1    Lange, L.G.2    Stenson, W.F.3    Ostlund Jr., R.E.4
  • 26
    • 0000778664 scopus 로고    scopus 로고
    • Regulation of bile acid synthesis
    • Chiang JYL. Regulation of bile acid synthesis. Front Biosci 1998; 3: 176-93.
    • (1998) Front Biosci. , vol.3 , pp. 176-193
    • Chiang, J.Y.L.1
  • 27
    • 0035289931 scopus 로고    scopus 로고
    • Intestinal lipid absorption and transport
    • Phan CT, Tso P. Intestinal lipid absorption and transport. Front Biosci 2001; 6: 299-319.
    • (2001) Front Biosci. , vol.6 , pp. 299-319
    • Phan, C.T.1    Tso, P.2
  • 28
    • 13144253097 scopus 로고    scopus 로고
    • Biliary cholesterol excretion: A novel mechanism that regulates dietary cholesterol absorption
    • Sehayek E, Ono JG, Shefer S et al. Biliary cholesterol excretion: a novel mechanism that regulates dietary cholesterol absorption. Proc Natl Acad Sci USA 1998; 95: 10194-9.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10194-10199
    • Sehayek, E.1    Ono, J.G.2    Shefer, S.3
  • 30
    • 0034686663 scopus 로고    scopus 로고
    • Intestinal absorption of cholesterol is mediated by a saturable, inhibitable transporter
    • Hernandez M, Montenegro J, Steiner M et al. Intestinal absorption of cholesterol is mediated by a saturable, inhibitable transporter. Biochim Biophys Acta 2000; 1486: 232-42.
    • (2000) Biochim. Biophys. Acta , vol.1486 , pp. 232-242
    • Hernandez, M.1    Montenegro, J.2    Steiner, M.3
  • 31
    • 0141869052 scopus 로고    scopus 로고
    • Scavenger receptor class B type I (SR-BI) in pig enterocytes: Trafficking from the brush border to lipid droplets during fat absorption
    • Hansen GH, Niels-Christiansen LL, Immerdal L, Danielsen EM. Scavenger receptor class B type I (SR-BI) in pig enterocytes: trafficking from the brush border to lipid droplets during fat absorption. Gut 2003; 52: 1424-31.
    • (2003) Gut , vol.52 , pp. 1424-1431
    • Hansen, G.H.1    Niels-Christiansen, L.L.2    Immerdal, L.3    Danielsen, E.M.4
  • 32
    • 10744221008 scopus 로고    scopus 로고
    • Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption
    • Altmann SW, Davis Hr Jr, Zhu L-J et al. Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science 2004; 303: 1201-4.
    • (2004) Science , vol.303 , pp. 1201-1204
    • Altmann, S.W.1    Davis Jr., H.R.2    Zhu, L.-J.3
  • 33
    • 18844464080 scopus 로고    scopus 로고
    • A novel therapeutic approach to dyslipidemia
    • Clearfield MB. A novel therapeutic approach to dyslipidemia. JAOA 2003; 103(Suppl. 1): S16-S20.
    • (2003) JAOA , vol.103 , Issue.SUPPL. 1
    • Clearfield, M.B.1
  • 34
    • 0032881850 scopus 로고    scopus 로고
    • Charting the fate of the "good cholesterol": Identification and characterization of the high-density lipoprotein receptor SR-BI
    • Krieger M. Charting the fate of the "good cholesterol": identification and characterization of the high-density lipoprotein receptor SR-BI. Annu Rev Biochem 1999; 68: 523-58.
    • (1999) Annu. Rev. Biochem. , vol.68 , pp. 523-558
    • Krieger, M.1
  • 35
    • 0001776585 scopus 로고    scopus 로고
    • The role of the exogenous pathway in hypercholesterolemia
    • Shepherd J. The role of the exogenous pathway in hypercholesterolemia. Eur Heart J Suppl 2001; 3(Suppl. E): E2-E5.
    • (2001) Eur. Heart J. Suppl. , vol.3 , Issue.SUPPL. E
    • Shepherd, J.1
  • 37
    • 0038342948 scopus 로고    scopus 로고
    • Effect of a statin on hepatic apolipoprotein B-100 secretion and plasma campesterol levels in the metabolic syndrome
    • Watts GF, Chan DC, Barrett PHR, O'Neill FH, Thompson GR. Effect of a statin on hepatic apolipoprotein B-100 secretion and plasma campesterol levels in the metabolic syndrome. Int J Obes 2003; 27: 862-5.
    • (2003) Int. J. Obes. , vol.27 , pp. 862-865
    • Watts, G.F.1    Chan, D.C.2    Barrett, P.H.R.3    O'Neill, F.H.4    Thompson, G.R.5
  • 38
    • 0242721947 scopus 로고    scopus 로고
    • Synthesis and absorption markers of cholesterol in serum and lipoproteins during a large dose of statin treatment
    • Miettinen TA, Gylling H. Synthesis and absorption markers of cholesterol in serum and lipoproteins during a large dose of statin treatment. Eur J Clin Invest 2003; 33: 976-82.
    • (2003) Eur. J. Clin. Invest. , vol.33 , pp. 976-982
    • Miettinen, T.A.1    Gylling, H.2
  • 39
    • 0032943037 scopus 로고    scopus 로고
    • Effect of 3-hydroxy-3-methylglutaryl coenzyme, a reductase inhibitor on sterol absorption in hypercholesterolemic subjects
    • Ntanios FY, Jones PJ, Frohlich JJ. Effect of 3-hydroxy-3-methylglutaryl coenzyme, a reductase inhibitor on sterol absorption in hypercholesterolemic subjects. Metabolism 1999; 48 68-73.
    • (1999) Metabolism , vol.48 , pp. 68-73
    • Ntanios, F.Y.1    Jones, P.J.2    Frohlich, J.J.3
  • 40
    • 0037169565 scopus 로고    scopus 로고
    • Scavenger receptor class B type I is expressed in cultured keratinocytes and epidermis. Regulation in response to changes in cholesterol homeostasis and barrier requirements
    • Tsuruoka H, Khovidhunkit W, Brown BE, Fluhr JW, Elias PM, Feingold KR. Scavenger receptor class B type I is expressed in cultured keratinocytes and epidermis. Regulation in response to changes in cholesterol homeostasis and barrier requirements. J Biol Chem 2002; 277: 2916-22.
    • (2002) J. Biol. Chem. , vol.277 , pp. 2916-2922
    • Tsuruoka, H.1    Khovidhunkit, W.2    Brown, B.E.3    Fluhr, J.W.4    Elias, P.M.5    Feingold, K.R.6
  • 41
    • 0037687369 scopus 로고    scopus 로고
    • Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice
    • Kosters A, Frijters RJ, Schaap FG et al. Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice. J Hepatol 2003; 38: 710-6.
    • (2003) J. Hepatol. , vol.38 , pp. 710-716
    • Kosters, A.1    Frijters, R.J.2    Schaap, F.G.3
  • 42
    • 0035092261 scopus 로고    scopus 로고
    • Mechanisms for cholesterol homeostasis in rat jejunal mucosa: Effects of cholesterol, sitosterol, and lovastatin
    • Nguyen LB, Shefer S, Salen G, Tint GS, Ruiz F, Bullock J. Mechanisms for cholesterol homeostasis in rat jejunal mucosa: effects of cholesterol, sitosterol, and lovastatin. J Lipid Res 2001; 42 195-200.
    • (2001) J. Lipid Res. , vol.42 , pp. 195-200
    • Nguyen, L.B.1    Shefer, S.2    Salen, G.3    Tint, G.S.4    Ruiz, F.5    Bullock, J.6
  • 43
    • 0037044454 scopus 로고    scopus 로고
    • Inhibition of intestinal cholesterol absorption by ezetimibe in humans
    • Sudhop T, Lutjohann D, Kodal A et al. Inhibition of intestinal cholesterol absorption by ezetimibe in humans. Circulation 2002; 106: 1943-8.
    • (2002) Circulation , vol.106 , pp. 1943-1948
    • Sudhop, T.1    Lutjohann, D.2    Kodal, A.3
  • 44
    • 0019504745 scopus 로고
    • Influence of dietary cholesterol, saturated and unsaturated lipid on 3-hydroxy-3-methylglutaryl CoA reductase activity in rabbit intestine and liver
    • Stange EF, Alavi M, Schneider A, Ditschuneit H, Poley JR. Influence of dietary cholesterol, saturated and unsaturated lipid on 3-hydroxy-3-methylglutaryl CoA reductase activity in rabbit intestine and liver. J Lipid Res 1981; 22: 47-56.
    • (1981) J. Lipid Res. , vol.22 , pp. 47-56
    • Stange, E.F.1    Alavi, M.2    Schneider, A.3    Ditschuneit, H.4    Poley, J.R.5
  • 45
    • 0032526825 scopus 로고    scopus 로고
    • Dietary cholesterol regulates hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression in rats primarily at the level of translation
    • Chambers CM, Ness GC. Dietary cholesterol regulates hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression in rats primarily at the level of translation. Arch Biochem Biophys 1998; 354: 317-22.
    • (1998) Arch. Biochem. Biophys. , vol.354 , pp. 317-322
    • Chambers, C.M.1    Ness, G.C.2
  • 46
    • 0034723758 scopus 로고    scopus 로고
    • The lipid treatment assessment project (L-TAP): A multicenter survey to evaluate the percentages of dyslipidemic patients receiving lipid-lowering therapy and achieving low-density lipoprotein cholesterol goals
    • Pearson TA, Laurora I, Chu H, Kafonek S. The lipid treatment assessment project (L-TAP): a multicenter survey to evaluate the percentages of dyslipidemic patients receiving lipid-lowering therapy and achieving low-density lipoprotein cholesterol goals. Arch Intern Med 2000; 160: 459-67.
    • (2000) Arch. Intern. Med. , vol.160 , pp. 459-467
    • Pearson, T.A.1    Laurora, I.2    Chu, H.3    Kafonek, S.4
  • 47
    • 0034960884 scopus 로고    scopus 로고
    • Assessment of hypercholesterolemia control in a managed care organization
    • Straka RJ, Taheri R, Cooper SL, Tan AW, Smith AC. Assessment of hypercholesterolemia control in a managed care organization. Pharmacotherapy 2001; 21: 818-27.
    • (2001) Pharmacotherapy , vol.21 , pp. 818-827
    • Straka, R.J.1    Taheri, R.2    Cooper, S.L.3    Tan, A.W.4    Smith, A.C.5
  • 48
    • 0032507494 scopus 로고    scopus 로고
    • Baseline serum cholestanol as predictor of recurrent coronary events in subgroup of Scandinavian Simvastatin Survival Study. Finnish 4S Investigators
    • Miettinen TA, Gylling H, Strandberg T, Sarna S. Baseline serum cholestanol as predictor of recurrent coronary events in subgroup of Scandinavian Simvastatin Survival Study. Finnish 4S Investigators. BMJ 1998; 316: 1127-30.
    • (1998) BMJ , vol.316 , pp. 1127-1130
    • Miettinen, T.A.1    Gylling, H.2    Strandberg, T.3    Sarna, S.4
  • 49
    • 0035034225 scopus 로고    scopus 로고
    • Determinants of variable response to statin treatment in patients with refractory familial hypercholesterolemia
    • O'Neill FH, Patel DD, Knight BL et al. Determinants of variable response to statin treatment in patients with refractory familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 2001; 21: 832-7.
    • (2001) Arterioscler. Thromb. Vasc. Biol. , vol.21 , pp. 832-837
    • O'Neill, F.H.1    Patel, D.D.2    Knight, B.L.3
  • 50
    • 0035996367 scopus 로고    scopus 로고
    • Ineffective decrease of serum cholesterol by simvastatin in a subgroup of hypercholesterolemic coronary patients
    • Miettinen TA, Gylling H. Ineffective decrease of serum cholesterol by simvastatin in a subgroup of hypercholesterolemic coronary patients. Atherosclerosis 2002; 164: 147-52.
    • (2002) Atherosclerosis , vol.164 , pp. 147-152
    • Miettinen, T.A.1    Gylling, H.2
  • 51
    • 0037526450 scopus 로고    scopus 로고
    • Preventing coronary events by optimal control of blood pressure and lipids in patients with the metabolic syndrome
    • Wong ND, Pio JR. Franklin SS, L'Italien GJ, Kamath TV, Williams GR. Preventing coronary events by optimal control of blood pressure and lipids in patients with the metabolic syndrome. Am J Cardiol 2003; 91: 1421-6.
    • (2003) Am. J. Cardiol. , vol.91 , pp. 1421-1426
    • Wong, N.D.1    Pio, J.R.2    Franklin, S.S.3    L'Italien, G.J.4    Kamath, T.V.5    Williams, G.R.6
  • 52
    • 0041827050 scopus 로고    scopus 로고
    • Emerging non-statin LDL-lowering therapies for dyslipidemia and atherosclerosis
    • Shah PK. Emerging non-statin LDL-lowering therapies for dyslipidemia and atherosclerosis. Rev Cardiovasc Med 2003; 4: 136-41.
    • (2003) Rev. Cardiovasc. Med. , vol.4 , pp. 136-141
    • Shah, P.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.