ABCG5 and ABCG8 are expressed in gallbladder epithelial cells

Biochemical and Biophysical Research Communications

Volumn 307, Issue 4, 2003, Pages 1021-1028

  Tauscher, Aimee ^a,b   Kuver, Rahul ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cholesterol; Gallstones; Nuclear hormone receptors; Oxysterols; sitosterol

Indexed keywords

ABC TRANSPORTER; CHOLESTEROL; COMPLEMENTARY DNA; HORMONE RECEPTOR; LIGAND; LIVER X RECEPTOR ALPHA; MESSENGER RNA; PROTEIN ABCG 5; PROTEIN ABCG 8; RECEPTOR SUBTYPE; RETINOID X RECEPTOR; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ARTICLE; BILE; CELL CULTURE; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOG; EPITHELIUM CELL; GALLBLADDER EPITHELIUM; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

MURINAE;

EID: 0038782335     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)01296-8     Document Type: Article

References (33)

1. Neiderhiser D., Harmon C., Roth H. Absorption of cholesterol by the gallbladder. J. Lipid Res. 17:1976;117-124.
2. Jacyna M., Ross P., Bakar M., Hopwood D., Bouchier I. Characteristics of cholesterol absorption by human gallbladder: relevance to cholesterolosis. J. Clin. Pathol. 40:1987;524-529.
3. Corradini S., Ripani C., Guardia P., Giovannelli L., Elisei W., Cantafora A., Pisanelli M., Tebala G., Nuzzo G., Corsi A., Attili A., Capocaccia L., Zipar V. The human gallbladder increases cholesterol solubility in bile by differential lipid absorption: a study using a new in vitro model of isolated intra-arterially perfused gallbladder. Hepatology. 28:1998;314-322.
4. Chen Q., Amaral J., Biancani P., Behar J. Excess membrane cholesterol alters gallbladder muscle contractility and membrane fluidity. Gastroenterology. 116:1999;678-685.
5. Hayashi A., Lee S.P. Bi-directional transport of cholesterol between gallbladder epithelial cells and model bile. Am. J. Physiol. 271:1996;G410-G414.
6. Lee J., Shirk A., Oram J.F., Lee S.P., Kuver R. Polarized cholesterol and phospholipid efflux in cultured gall-bladder epithelial cells: evidence for an ABCA1-mediated pathway. Biochem. J. 364:2002;475-484.
7. Lee J., Tauscher A., Seo D.W., Oram J.F., Kuver R. Cultured gallbladder epithelial cells synthesize apolipoproteins A-I and E. Am. J. Physiol. 2003;. in press (doi:10.1152/ajpgi.00101.2003).
8. Yu L., Hammer R.E., Li-Hawkins J., von Bergmann K., Lutjohann D., Cohen J.C., Hobbs H.H. Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proc. Natl. Acad. Sci. USA. 99:2002;16237-16242.
9. Yu L., Li-Hawkins J., Hammer R.E., Berge K.E., Horton J.D., Cohen J.C., Hobbs H.H. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J. Clin. Invest. 110:2002;671-680.
10. Wittenburg H., Carey M.C. Biliary cholesterol secretion by the twinned sterol half-transporters ABCG5 and ABCG8. J. Clin. Invest. 110:2002;605-609.
11. Berge K., Tian H., Graf G., Yu L., Grishin N., Schultz J., Kwiterovich P., Shan B., Barnes R., Hobbs H.H. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science. 290:2000;1771-1775.
12. Lee M.H., Lu K., Hazard S., Yu H., Shulenin S., Hidaka H., Kojima H., Allikmets R., Sakuma N., Pegoraro R., Srivastava A.K., Salen G., Dean M., Patel S.B. Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Nat. Genet. 27:2001;79-83.
13. Salen G., Patel S., Batta A.K. Sitosterolemia. Cardiovasc. Drug Rev. 20:2002;255-270.
14. Repa J.J., Berge K.E., Pomajzl C., Richardson J.A., Hobbs H.H., Mangelsdorf D.J. Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. J. Biol. Chem. 277:2002;18793-18800.
15. Yu L., York J., von Bergmann K., Lutjohann D., Cohen J.C., Hobbs H.H. Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8. J. Biol. Chem. 278:2003;15565-15570.
16. Kuver R., Savard C.E., Osborne W.R.A., Lee S.P. Isolation and long-term culture of gallbladder epithelial cells from wild-type and CF mice. In Vitro Cell Dev. Biol. 33:1997;104-109.
17. Oda D., Lee S.P., Hayashi A. Long-term culture and partial characterization of dog gallbladder epithelial cells. Lab. Invest. 64:1991;682-692.
18. Kuver R., Lee S.P., Savard C., Oda D. PGE generates intracellular cAMP and accelerates mucin secretion by cultured dog gallbladder epithelial cells. Am. J. Physiol. 267:1994;G998-G1003.
19. Kuver R., Klinkspoor J.H., Osborne W.R.A., Lee S.P. Mucous granule exocytosis and CFTR expression in gallbladder epithelium. Glycobiology. 10:2000;149-157.
20. Klinkspoor J.H., Kuver R., Savard C.E., Oda D., Azzouz H., Tytgat G., Groen A.K., Lee S.P. Model bile and bile salts accelerate mucin secretion by cultured dog gallbladder epithelial cells. Gastroenterology. 109:1995;264-274.
21. Weggemans R.M., Zock P.L., Tai E.S., Ordovas J.M., Molhuizen H.O., Katan M.B. ATP binding cassette G5 C1950G polymorphism may affect blood cholesterol concentrations in humans. Clin. Genet. 62:2002;226-229.
22. Heimer S., Langmann T., Moehle C., Mauerer R., Dean M., Beil F.U., von Bergmann K., Schmitz G. Mutations in the human ATP-binding cassette transporters ABCG5 and ABCG8 in sitosterolemia. Hum. Mutat. 20:2002;151.
23. Panzenboeck U., Balazs Z., Sovic A., Hrzenjak A., Levak-Frank S., Wintersperger A., Malle E., Sattler W. ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells. J. Biol. Chem. 277:2002;42781-42789.
24. Zheng P., Horwitz A., Waelde C., Smith J. Stably transfected ABCA1 antisense cell line has decreased ABCA1 mRNA and cAMP-induced cholesterol efflux to apolipoprotein AI and HDL. Biochim. Biophys. Acta. 1534:2001;121-128.
25. Repa J.J., Turley S., Lobaccaro J.-M., Medina J., Li L., Lustig K., Shan B., Heyman R., Dietschy J., Mangelsdorf D.J. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science. 289:2000;1524-1529.
26. Chawla A., Repa J.J., Evans R., Mangelsdorf D.J. Nuclear receptors and lipid physiology: opening the X-Files. Science. 294:2001;1866-1870.
27. Repa J.J., Mangelsdorf D.J. The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Annu. Rev. Cell Dev. Biol. 16:2000;459-481.
28. Graf G.A., Li W.P., Gerard R.D., Gelissen I., White A., Cohen J.C., Hobbs H.H. Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface. J. Clin. Invest. 110:2002;659-669.
29. Francis G., Knopp R., Oram J.F. Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier disease. J. Clin. Invest. 96:1995;78-87.
30. Oram J.F., Lawn R., Garvin M., Wade D. ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages. J. Biol. Chem. 275:2000;34508-34511.
31. Salen G., Ahrens E.H. Jr., Grundy S.M. Metabolism of beta-sitosterol in man. J. Clin. Invest. 49:1970;952-967.
32. Albrecht C., Elliott J.I., Sardini A., Litman T., Stieger B., Meier P.J., Higgins C.F. Functional analysis of candidate ABC transporter proteins for sitosterol transport. Biochim. Biophys. Acta. 1567:2002;133-142.
33. Kipp H., Pichetshote N., Arias I.M. Transporters on demand: Intrahepatic pools of canalicular ATP binding cassette transporters in rat liver. J. Biol. Chem. 276:2001;7218-7224.