Diosgenin-induced biliary cholesterol secretion in mice requires Abcg8

Hepatology

Volumn 41, Issue 1, 2005, Pages 141-150

  Kosters, Astrid ^a,c   Frijters, Raoul J J M ^a   Kunne, Cindy ^a   Vink, Edwin ^a   Schneiders, Marit S ^a   Schaap, Frank G ^a   Nibbering, Catherina P ^a   Patel, Shailendra B ^b   Groen, Albert K ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER A1; ABC TRANSPORTER G5; ABC TRANSPORTER G8; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLESTEROL ACYLTRANSFERASE; CYTOCHROME P450; DIOSGENIN; EARLY GROWTH RESPONSE FACTOR 1; GLUCOSE 6 PHOSPHATASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LIM PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; ORGANIC ANION TRANSPORTER; PHYTOSTEROL; PREGNANE X RECEPTOR; RNA; SOMATOMEDIN BINDING PROTEIN 1; STEROL CARRIER PROTEIN 2; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG;

ABCG8 GENE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE SECRETION; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DIET; DRUG MECHANISM; FEMALE; GENE; GENE EXPRESSION; GENE IDENTIFICATION; HEPATOBILIARY SYSTEM; LIPID ANALYSIS; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SECRETION;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BILIARY TRACT; CHOLESTEROL; DIOSGENIN; FEMALE; KINETICS; LIPOPROTEINS; MALE; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT;

EID: 11244264036     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.20540     Document Type: Article

References (39)

1. Soccio RE, Breslow JL. Intracellular cholesterol transport. Arterioscler Thromb Vasc Biol 2004;24:1150-1160.
2. Ory DS. The Niemann-Pick disease genes: regulators of cellular cholesterol homeostasis. Trends Cardiovasc Med 2004;14:66-72.
3. Salen G, Shefer S, Nguyen L, Ness GC, Tint GS, Shore V. Sitosterolemia. J Lipid Res 1992;33:945-955.
4. Bhattacharyya AK, Connor WE. Beta-sitosterolemia and xanthomatosis. A newly described lipid storage disease in two sisters. J Clin Invest 1974;53:1033-1043.
5. Lu K, Lee MH, Hazard S, Brooks-Wilson A, Hidaka H, Kojima H, et al. Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively. Am J Hum Genet 2001;69:278-290.
6. Yu L, Li-Hawkins J, Hammer RE, Berge KE, Horton JD, Cohen JC, et al. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J Clin Invest 2002;110:671-680.
7. Yu L, Hammer RE, Li-Hawkins J, von Bergmann K, Lutjohann D, Cohen JC, et al. Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proc Natl Acad Sci U S A 2002;99:16237-16242.
8. Klett EL, Lu K, Kosters A, Vink E, Lee MH, Altenburg M, et al. A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. BMC Med 2004;2:5.
9. Plosch T, Bloks VW, Terasawa Y, Berdy S, Siegler K, Van Der SF, et al. Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor. Gastroenterology 2004;126:290-300.
10. Kosters A, Frijters RJ, Schaap FG, Vink E, Plosch T, Ottenhoff R, et al. Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice. J Hepatol 2003;38:710-716.
11. Cayen MN, Ferdinandi ES, Greselin E, Dvornik D. Studies on the disposition of diosgenin in rats, dogs, monkeys and man. Atherosclerosis 1979;33:71-87.
12. Cayen MN, Dvornik D. Effect of diosgenin on lipid metabolism in rats. J Lipid Res 1979;20:162-174.
13. Nervi F, Marinovic I, Rigotci A, Ulloa N. Regulation of biliary cholesterol secretion. Functional relationship between the canalicular and sinusoidal cholesterol secretory pathways in the rat. J Clin Invest 1988;82:1818-1825.
14. Nibbering CP, Groen AK, Ottenhoff R, Brouwers JF, vanBerge-Henegouwen GP, van Erpecum KJ. Regulation of biliary cholesterol secretion is independent of hepatocyte canalicular membrane lipid composition: a study in the diosgenin-fed rat model. J Hepatol 2001;35:164-169.
15. Klett EL, Lu K, Kosters A, Vink E, Lee MH, Altenburg M, et al. A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. BMC Med 2004;2:5.
16. Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem 1974;20:470-475.
17. Vreken P, van Lint AE, Bootsma AH, Overmars H, Wanders RJ, van Gennip AH. Rapid diagnosis of organic acidemias and fatty-acid oxidation defects by quantitative electrospray tandem-MS acyl-carnitine analysis in plasma. Adv Exp Med Biol 1999;466:327-337.
18. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-159.
19. Houten SM, Schneiders MS, Wanders RJ, Waterham HR. Regulation of isoprenoid/cholesterol biosynthesis in cells from mevalonate kinase-deficient patients. J Biol Chem 2003;278:5736-5743.
20. van Wijland MJ, de Waart DR, Groen AK. Biliary anionic peptide fraction/calcium binding protein inhibits apolipoprotein A-I-mediated cholesterol efflux from cultured cells. Biochem Biophys Res Commun 2001;287:1-4.
21. Fell DA. Metabolic control analysis: a survey of its theoretical and experimental development. Biochem J 1992;286:313-330.
22. Tauscher A, Kuver R. ABCG5 and ABCG8 are expressed in gallbladder epithelial cells. Biochem Biophys Res Commun 2003;307:1021-1028.
23. Wang DQ, Tazuma S, Cohen DE, Carey MC. Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouse. Am J Physiol Gastrointest Liver Physiol 2003;285:G494-G502.
24. Marzolo MP, Rigotti A, Nervi F. Secretion of biliary lipids from the hepatocyte. HEPATOLOGY 1990;12:134S-141S.
25. Mohrmann K, Gerez L, Oorschot V, Klumperman J, van der SP. Rab4 function in membrane recycling from early endosomes depends on a membrane to cytoplasm cycle. J Biol Chem 2002;277:32029-32035.
26. Rojas R, Ruiz WG, Leung SM, Jou TS, Apodaca G. Cdc42-dependent modulation of tight junctions and membrane protein traffic in polarized Madin-Darby canine kidney cells. Mol Biol Cell 2001;12:2257-2274.
27. Jacob R, Heine M, Alfalah M, Naim HY. Distinct cytoskeletal tracks direct individual vesicle populations to the apical membrane of epithelial cells. Curr Biol 2003;13:607-612.
28. Lee MH, Lu K, Patel SB. Genetic basis of sitosterolemia. Curr Opin Lipidol 2001;12:141-149.
29. Lu K, Lee MH, Patel SB. Dietary cholesterol absorption; more than just bile. Trends Endocrinol Metab 2001;12:314-320.
30. Robins SJ, Fasulo JM. High density lipoproteins, but not other lipoproteins, provide a vehicle for sterol transport to bile. J Clin Invest 1997;99:380-384.
31. Robins SJ, Fasulo JM. Delineation of a novel hepatic route for the selective transfer of unesterified sterols from high-density lipoproteins to bile: studies using the perfused rat liver. HEPATOLOCY 1999;29:1541-1548.
32. Wang DQ, Carey MC. Susceptibility to murine cholesterol gallstone formation is not affected by partial disruption of the HDL receptor SR-BI. Biochim Biophys Acta 2002;1583:141-150.
33. Nervi F, Bronfman M, Allalon W, Depiereux E, Del Pozo R. Regulation of biliary cholesterol secretion in the rat. Role of hepatic cholesterol esterification. J Clin Invest 1984;74:2226-2237.
34. Puglielli L, Amigo L, Arrese M, Nunez L, Rigotti A, Garrido J, et al. Protective role of biliary cholesterol and phospholipid lamellae against bile acid-induced cell damage. Gastroenterology 1994;107:244-254.
35. Rendic S, Di Carlo FJ. Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metab Rev 1997;29:413-580.
36. Horton JD, Shah NA, Warrington JA, Anderson NN, Park SW, Brown MS, et al. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc Natl Acad Sci U S A 2003;100:12027-12032.
37. Rawson RB. Control of lipid metabolism by regulated intramembrane proteolysis of sterol regulatory element binding proteins (SREBPs). Biochem Soc Symp 2003;70:221-231.
38. Anderson RG. Joe Goldstein and Mike Brown: from cholesterol homeostasis to new paradigms in membrane biology. Trends Cell Biol 2003;13:534-539.
39. Yabe D, Brown MS, Goldstein JL. Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Nad Acad Sci U S A 2002;99:12753-12758.