Clinical Manifestations of Cerebral Amyloid Angiopathy-Related Inflammation

Annals of Neurology

Volumn 55, Issue 2, 2004, Pages 250-256

  Eng, Jessica A ^a   Frosch, Matthew P ^a   Choi, Kyungchan ^a   Rebeck, G William ^a   Greenberg, Steven M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CORTICOSTEROID; CYCLOPHOSPHAMIDE;

ADULT; AGE; AGED; ARTICLE; BLOOD VESSEL; BRAIN HEMORRHAGE; CLINICAL ARTICLE; CLINICAL FEATURE; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ASSOCIATION; EVIDENCE BASED MEDICINE; FEMALE; FOLLOW UP; GIANT CELL; HUMAN; HUMAN TISSUE; IMMUNIZATION; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOTHERAPY; INFLAMMATION; MALE; NEURORADIOLOGY; PRIORITY JOURNAL; SEIZURE; STROKE; VASCULAR AMYLOIDOSIS; WHITE MATTER;

ADRENAL CORTEX HORMONES; AGE FACTORS; AGED; AMYLOID BETA-PROTEIN; APOLIPOPROTEINS E; BRAIN; CEREBRAL AMYLOID ANGIOPATHY; CEREBRAL HEMORRHAGE; COGNITION DISORDERS; CYCLOPHOSPHAMIDE; FEMALE; GENOTYPE; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATION; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; RISK FACTORS; SEIZURES; TREATMENT OUTCOME;

EID: 10744225948     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.10810     Document Type: Article

References (43)

1. McGeer PL, McGeer EG. The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res Brain Res Rev 1995;21:195-218.
2. In't Veld BA, Ruitenberg A, Hofman A, et al. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. N Engl J Med 2001;345:1515-1521.
3. Stewart WF, Kawas C, Corrada M, Metter EJ. Risk of Alzheimer's disease and duration of NSAID use. Neurology 1997;48:626-632.
4. Schenk D, Barbour R, Dunn W, et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999;400:173-177.
5. Bacskai BJ, Kajdasz ST, Christie RH, et al. Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat Med 2001;7:369-372.
6. McLaurin J, Cecal R, Kierstead ME, et al. Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis. Nat Med 2002;8:1263-1269.
7. Schenk D. Opinion: amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning. Nat Rev Neurosci 2002;3:824-828.
8. Orgogozo JM, Gilman S, Dartigues JF, et al. Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization. Neurology 2003;61:46-54.
9. Yamada M, Itoh Y, Shintaku M, et al. Immune reactions associated with cerebral amyloid angiopathy. Stroke 1996;27:1155-1162.
10. Uchihara T, Akiyama H, Kondo H, Ikeda K. Activated microglial cells are colocalized with perivascular deposits of amyloid-beta protein in Alzheimer's disease brain. Stroke 1997;28:1948-1950.
11. Maat-Schieman ML, van Duinen SG, Rozemuller AJ, et al. Association of vascular amyloid beta and cells of the mononuclear phagocyte system in hereditary cerebral hemorrhage with amyloidosis (Dutch) and Alzheimer disease. J Neuropathol Exp Neurol 1997;56:273-284.
12. Vinters HV, Natte R, Maat-Schieman ML, et al. Secondary microvascular degeneration in amyloid angiopathy of patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA-D). Acta Neuropathol 1998;95:235-244.
13. Shin Y, Cho HS, Rebeck GW, Greenberg SM. Vascular changes in Iowa-type hereditary cerebral amyloid angiopathy. Ann NY Acad Sci 2002;977:245-251.
14. Probst A, Ulrich J. Amyloid angiopathy combined with granulomatous angiitis of the central nervous system: report on two patients. Clin Neuropathol 1985;4:250-259.
15. Le Coz P, Mikol J, Ferrand J, et al. Granulomatous angiitis and cerebral amyloid angiopathy presenting as a mass lesion. Neuropathol Appl Neurobiol 1991;17:149-155.
16. Powers JM, Stein BM, Torres RA. Sporadic cerebral amyloid angiopathy with giant cell reaction. Acta Neuropathol 1990;81:95-98.
17. Vonsattel JP, Myers RH, Hedley-Whyte ET, et al. Cerebral amyloid angiopathy without and with cerebral hemorrhages: a comparative histological study. Ann Neurol 1991;30:637-649.
18. Mandybur TI, Balko G. Cerebral amyloid angiopathy with granulomatous angiitis ameliorated by steroid-cytoxan treatment. Clin Neuropharm 1992;15:241-247.
19. Anders KH, Wang ZZ, Kornfeld M, et al. Giant cell arteritis in association with cerebral amyloid angiopathy: immunohistochemical and molecular studies. Hum Pathol 1997;28:1237-1246.
20. Fountain NB, Eberhard DA. Primary angiitis of the central nervous system associated with cerebral amyloid angiopathy: report of two cases and review of the literature. Neurology 1996;46:190-197.
21. Shintaku M, Osawa K, Toki J, et al. A case of granulomatous angiitis of the central nervous system associated with amyloid angiopathy. Acta Neuropathol 1986;70:340-342.
22. Pfeifer M, Boncristiano S, Bondolfi L, et al. Cerebral hemorrhage after passive anti-Abeta immunotherapy. Science 2002;298:1379.
23. O'Donnell HC, Rosand J, Knudsen KA, et al. Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage. N Engl J Med 2000;342:240-245.
24. Greenberg SM, Rebeck GW, Vonsattel JPV, et al. Apolipoprotein E e4 and cerebral hemorrhage associated with amyloid angiopathy. Ann Neurol 1995;38:254-259.
25. Greenberg SM, Vonsattel JP, Stakes JW, et al. The clinical spectrum of cerebral amyloid angiopathy: presentations without lobar hemorrhage. Neurology 1993;43:2073-2079.
26. Smith EE, Eng JA, Rosand J, Greenberg SM. Presence of leukoaraiosis predicts recurrent lobar hemorrhage. Stroke (abs) 2003;34:242.
27. Pfeifer LA, White LR, Ross GW, et al. Cerebral amyloid angiopathy and cognitive function: the HAAS autopsy study. Neurology 2002;58:1629-1634.
28. Olichney JM, Hansen LA, Hofstetter CR, et al. Cerebral infarction in Alzheimer's disease is associated with severe amyloid angiopathy and hypertension. Arch Neurol 1995;52:702-708.
29. Cadavid D, Mena H, Koeller K, Frommelt RA. Cerebral beta amyloid angiopathy is a risk factor for cerebral ischemic infarction. A case control study in human brain biopsies. J Neuropathol Exp Neurol 2000;59:768-773.
30. Haglund M, Englund E. Cerebral amyloid angiopathy, white matter lesions and Alzheimer encephalopathy: a histopathological assessment. Dement Geriatr Cogn Disord 2002;14:161-166.
31. Gray F, Vinters HV, Le Noan H, et al. Cerebral amyloid angiopathy and granulomatous angiitis: immunohistochemical study using antibodies to the Alzheimer A4 peptide. Hum Pathol 1990;21:1290-1293.
32. Winkler DT, Bondolfi L, Herzig MC, et al. Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy. J Neurosci 2001;21:1619-1627.
33. Kolodny EH, Rebeiz JJ, Caviness VSJ, Richardson EPJ. Granulomatous angiitis of the central nervous system. Arch Neurol 1968;19:510-524.
34. Schmechel DE, Saunders AM, Strittmatter WJ, et al. Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc Natl Acad Sci USA 1993;90:9649-9653.
35. Rebeck GW, Reiter JS, Strickland DK, Hyman BT. Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron 1993;11:575-580.
36. Holtzman DM, Bales KR, Tenkova T, et al. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 2000;97:2892-2897.
37. Premkumar DR, Cohen DL, Hedera P, et al. Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease. Am J Pathol 1996;148:2083-2095.
38. Wisniewski T, Frangione B. Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid. Neurosci Lett 1992;135:235-238.
39. Cho HS, Hyman BT, Greenberg SM, Rebeck GW. Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation. J Neuropathol Exp. Neurol 2001;60:342-349.
40. Barger SW, Harmon AD. Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature 1997;388:878-881.
41. McGeer PL, Walker DG, Pitas RE, et al. Apolipoprotein E4 (ApoE4) but not ApoE3 or ApoE2 potentiates beta-amyloid protein activation of complement in vitro. Brain Res 1997;749:135-138.
42. Nicoll JA, Wilkinson D, Holmes C, et al. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat Med 2003;9:448-452.
43. Greenberg SM, Bacskai BJ, Hyman BT. Alzheimer disease's double-edged vaccine. Nat Med 2003;9:389-390.