Mapping and characterization of quantitative trait loci for non-insulin- dependent diabetes mellitus with an improved genetic map in the Otsuka Long- Evans Tokushima Fatty rat

Mammalian Genome

Volumn 10, Issue 3, 1999, Pages 249-258

  Wei, Suwen ^a   Wei, Kaichun ^a   Moralejo, Daniel H ^a   Ogino, Tomoe ^a   Koike, George ^b   Jacob, Howard J ^b   Sugiura, Kenkichi ^c   Sasaki, Yoshiyuki ^c   Yamada, Takahisa ^a   Matsumoto, Kozo ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CHROMOSOME 11; CHROMOSOME 14; CHROMOSOME 7; CHROMOSOME 8; GENE MAPPING; GENETIC ANALYSIS; GLUCOSE BLOOD LEVEL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; QUANTITATIVE TRAIT; RAT;

ANIMALS; BODY WEIGHT; CHROMOSOME MAPPING; CROSSES, GENETIC; DIABETES MELLITUS, TYPE 2; GENOTYPE; HOMOZYGOTE; LOD SCORE; QUANTITATIVE TRAIT, HERITABLE; RATS; RATS, INBRED F344; RATS, INBRED OLETF;

EID: 0032805994     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003359900982     Document Type: Article

References (42)

1. Affholter JA, Hsieh CL, Francke U, Roth RA (1990) Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes. Mol Endocrinol 4, 1125-1135
2. 2 crosses. Genome Res 7, 434-440
3. fa associated with variability in insulin production and susceptibility to NIDDM. Genomics 41, 332-344
4. Copeman JB, Cucca F, Hearne CM, Cornall RJ, Reed PW et al. (1995) Linkage disequilibrium mapping of a type I diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33. Nat Genet 9, 80-85
5. Galli J, Li L-S, Glaser A, Osteson C-G, Jiao H et al. (1996) Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nat Genet 12, 31-37
6. Gauguier D, Froguel P, Parent V, Bernard C, Bihoreau M-T et al. (1996) Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat. Nat Genet 12, 38-43
7. Gilbert DA, O'Brien JS, O'Brien SI (1988) Chromosomal mapping of lysosomal enzyme structural genes in the domestic cat. Genomics 2, 329-336
8. Hanis CL, Boerwinkle E, Chakraborty R, Ellsworth DL, Concannon P et al. (1996) A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nat Genet 13, 161-166
9. Henry RR, Wallace P, Olfesky JM (1986) Effects of weight loss on mechanisms of hyperglycemia in obese non-insulin-dependent diabetes mellitus. Diabetes 35, 990-998
10. Inagaki N, Gonoi T, Clement JP, Namba N, Inazawa J et al. (1995) Reconstruction of IKATP: an inward rectifier subunit plus the sulfonylurea receptor. Science 270, 1166-1170
11. Inoue H, Iannotti CA, Welling CM, Veile R, Donis-Keller H (1997) Human cholecystokinin type A receptor gene: cytogenetic localization, physical mapping, and identification of two missense variants in patients with obesity and non-insulin-dependent diabetes mellitus (NIDDM). Genomics 42, 331-335
12. Jacob HJ, Brown DM, Bunker RK, Daly MJ, Dzau VJ et al. (1995) A genetic linkage map of the laboratory rat, Rattus norvegicus. Nat Genet 9, 63-69
13. Kawano K, Hirashima T, Mori S, Kurosumi M, Saitoh Y (1991) A new rat strain with non-insulin-dependent diabetes mellitus, "OLETF". Rat News Lett 25, 24-26
14. Kawano K, Hirashima T, Mori S, Saitoh Y, Kurosumi M et al. (1992) Spontaneous long-term hyperglycemic rat with diabetic complications, Otsuka Long-Evans Tokushima Fatty (OLETF) strain. Diabetes 41, 1422-1428
15. Lander ES, Botstein D (1989) Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121, 185-199
16. Lander ES, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11, 241-247
17. Lander ES, Green P, Abrahamson J, Barlow A, Daley M et al. (1987) MAPMAKER: An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1, 174-181
18. Li Z, Pinson SRM, Park WD, Paterson AH, Stansel JW (1997) Epistasis for three grain yield components in rice (Oryza saliva L.). Genetics 145, 453-465
19. Lincoln SE, Lander ES (1992) Systematic detection of errors in genetic linkage data. Genomics 14, 604-610
20. Mahtani MM, Widen E, Lehto M, Thomas J, McCarthy M et al. (1996) Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nat Genet 14, 90-94
21. Morahan G, Huang D, Tait BD, Colman PG, Harrison LC (1996) Markers on distal chromosome 2q linked to insulin-dependent diabetes mellitus. Science 272, 1811-1813
22. Moralejo DH, Ogino T, Zhu M, Toide K, Wei S et al. (1998a) A major quantitative trait locus co-localizing with cholecystokinin type A receptor gene influences poor pancreatic proliferation in a spontaneously diabetogenic rat. Mamm Genome, 9, 794-798
23. Moralejo DH, Wei S, Wei K, Weksler-Zangen S, Koike G et al. (1998b) Identification of quantitative trait loci for non-insulin-dependent diabetes mellitus that interact with body weight in the Otsuka Long-Evans Tokushima Fatty rat. Proc Assoc Am Physicians 110, 545-558
24. Nistico L, Buzzetti R, Pritchard LE, Van der Auwera B, Giovannini C et al. (1996) The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Hum Mol Genet 5, 1075-1080
25. Okauchi N, Mizuno A, Yoshimoto S, Zhu M, Sano T (1995a) Is caloric restriction effective in preventing diabetes mellitus in the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus? Diabetes Res Clin Pract 27, 97-106
26. Okauchi N, Mizuno A, Zhu M, Ishida K, Sato T et al. (1995b) Effects of obesity and inheritance on the development of non-insulin-dependent diabetes mellitus in Otsuka-Long-Evans-Tokushima Fatty rats. Diabetes Res Clin Pract 29, 1-10
27. Paterson AH, Lander ES, Hewitt JD, Peterson S, Lincoln SE et al. (1988) Resolution of quantitative traits into mendelian factors by using a complete linkage map of restriction fragment length polymorphisms. Nature 335, 721-726
28. Povoski SP, Zhou W, Longnecker DS, Jensen RT, Mantey SA et al. (1994) Stimulation of in vivo pancreatic growth in the rat is mediated specifically by way of cholecystokinin-A receptors. Gastroenterology 107, 1135-1146
29. Rushakoff RA, Goldfme ID, Bekkaria LJ, Mathur A, Brand RJ et al. (1993) Reduced postprandial cholecystokinin (CCK) secretion in patients with noninsulin-dependent diabetes mellitus: evidence for a role for CCK in regulating postprandial hyperglycemia. J Clin Endocrinol Metab 76, 489-493
30. Scarpignato C, Varga G, Dobronyi I, Papp M (1989) Effect of a new potent CCK antagonist, lorglumide, on caerulein and bombesin induced pancreatic secretion and growth in the rat. Br J Pharmacol 96, 661-669
31. Sellar GC, Oghene K, Boyle S, Bickmore WA, Whitehead AS (1994) Organization of the region encompassing the human serum amyloid (SAA) gene family on chromosome 11p15.1. Genomics 23, 492-495
32. Shima K, Shi K, Sano T, Iwami T, Mizuno A et al. (1993) Is exercise training effective in preventing diabetes mellitus in the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus? Metabolism 42, 971-977
33. Takiguchi S, Takata Y, Funakoshi A, Miyasaka K, Kataoka K et al. (1997) Disrupted cholecystokinin type-A receptor (CCKAR) gene in OLETF rats. Gene 197, 169-175
34. Tamimi R, Steingrimsson E, Copeland NG, Dyer-Montgomery K, Lee JE et al. (1996) The NEUROD gene maps to human chromosome 2q32 and mouse chromosome 2. Genomics 34, 418-421
35. The expert committee on the diagnosis and classification of diabetes mellitus (1997) Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 20, 1183-1197
36. Thomas PM, Cote GJ, Wohllk N, Haddad B, Mathew PM et al. (1995) Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy. Science 268, 426-429
37. Todd JA, Aitman TJ, Cornall RJ, Ghosh S, Hall JRS et al. (1991) Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Nature 351, 542-547
38. Uger RH (1995) Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Diabetes 44, 863-870
39. Wing RR, Epstein LH, Paternostro-Bayles M, Kriska A, Nowalk MP et al. (1988) Exercise in a behavioural weight control programme for obese patients with type 2 (non-insulin-dependent) diabetes. Diabetologia 31, 902-909
40. Yamada J, Kuramoto T, Serikawa T (1994) A rat genetic linkage map and comparative maps for mouse or human homologous rat genes. Mamm Genome 5, 63-83
41. Yamagata K, Oda N, Kaisaki PJ, Menzel S, Furuta H et al. (1996) Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3). Nature 384, 455-458
42. Zhu M, Noma Y, Mizuno A, Sano T, Shima K (1996) Poor capacity for proliferation of pancreatic β-cells in Otsuka-Long-Evans-Tokushima Fatty rat: a model of spontaneous NIDDM. Diabetes 45, 941-946