Maternal environment and genotype interact to establish diabesity in mice

Genome Research

Volumn 10, Issue 10, 2000, Pages 1568-1578

  Reifsnyder, P C ^a   Churchill, G ^a   Leiter, E H ^a  

^a JACKSON LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST MILK; GLUCOSE; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY GROWTH; BODY WEIGHT; CHROMOSOME 1; CHROMOSOME 12; CHROMOSOME 14; CHROMOSOME 17; CHROMOSOME 2; CHROMOSOME 5; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENE LOCUS; GENOTYPE; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; LACTATION; MALE; MOTHER; MOUSE; MOUSE STRAIN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; QUANTITATIVE TRAIT; WEIGHT GAIN;

ANIMAL; CHROMOSOME SEGREGATION; CROSSES, GENETIC; DIABETES MELLITUS, NON-INSULIN-DEPENDENT; FEMALE; GENES, DOMINANT; GENETIC MARKERS; GENOTYPE; LACTATION; MALE; MATERNAL-FETAL EXCHANGE; MICE; MICE, INBRED NOD; MICE, OBESE; PENETRANCE; PREGNANCY; QUANTITATIVE TRAIT, HERITABLE; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0033787384     PISSN: 10889051     EISSN: None     Source Type: Journal    
DOI: 10.1101/gr.147000     Document Type: Article

References (31)

1. Androgens, the metabolic syndrome, and non-insulin dependent diabetes mellitus
2. Empirical threshold value for quantitative trait mapping
3. Limits to prediction of phenotype from knowledge of genotypes
4. Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans
5. Rapid maturational growth as a predictor of NIDDM in NZO male mice
6. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
7. A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2
8. Genetic analysis of obese diabetes in the TSOD mouse
9. Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
10. Genetic localization of interacting modifiers affecting severity in a murine model of polycystic kidney disease
11. Nutritional and biochemical properties of human milk. Part I: General aspects, proteins, and carbohydrates
12. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
13. A major effect QTL determined by multiple genes in epileptic EL mice
14. The polygenetics of diabesity in mice
15. Non-insulin dependent diabetes genes in mice: Deleterious synergism by both parental genomes contributes to diabetogenic thresholds
16. Gestational obesity accentuates obesity in obesity-prone progeny
17. Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families
18. Overview of QTL mapping software and introduction to MapManager QT
19. Controversial topics series: Milk proteins and diabetes
20. Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse Chromosome 3
21. Gene-environment interactions in the pathogenesis of type 2 diabetes mellitus: Lessons learned from the Pima Indians
22. A perspective on the New Zealand obese mouse
23. Interaction between BTBR and C57BL/6J genomes produces an insulin resistance syndrome in (BTBR x C57BL/6J) F1 mice
24. Subcongenic analysis of the Idd13 locus in NOD/Lt mice: Evidence for several susceptibility genes including a possible diabetogenic role for β2-microglobulin
25. The interpretation of interaction in contingency tables
26. Evidence for a major gene for type II diabetes and linkage analyses with selected candidate genes in Mexican-Americans
27. Detection of obesity QTLs on mouse chromosome 1 and 7 by selective DNA pooling
28. Genetic analysis of late-onset type 2 diabetes in a mouse model of human complex trait
29. Breast feeding and obesity: Cross sectional study
30. Gene-environment interaction: A significant diet-dependent obesity locus demonstrated in a congenic segment on mouse chromosome 7
31. Notes on the theory of association of attributes in statistics