Genetic analysis of late-onset type 2 diabetes in a mouse model of human complex trait

Diabetes

Volumn 48, Issue 5, 1999, Pages 1168-1174

  Ueda, Hironori ^a   Ikegami, Hiroshi ^a,c   Kawaguchi, Yoshihiko ^a   Fujisawa, Tomomi ^a   Yamato, Eiji ^a   Shibata, Masao ^b   Ogihara, Toshio ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b AICHI GAKUIN UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR FACTOR I;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME 11; CHROMOSOME 14; CHROMOSOME 6; EPIDIDYMIS FAT; FEMALE; GENE CONTROL; INBRED STRAIN; INSULIN RELEASE; INSULIN SENSITIVITY; MALE; MOUSE; MULTIFACTORIAL INHERITANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ADIPOSE TISSUE; AMINO ACID SEQUENCE; ANIMALS; BLOOD GLUCOSE; CHROMOSOME MAPPING; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; EPIDIDYMIS; FEMALE; HEPATOCYTE NUCLEAR FACTOR 1-BETA; HUMANS; INSULIN; INSULIN RESISTANCE; LONGITUDINAL STUDIES; MALE; MICE; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; ORGAN SIZE; TRANSCRIPTION FACTORS;

EID: 0032913371     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.5.1168     Document Type: Article

References (37)

1. Warram JH, Rich SS, Krolewski AS: Epidemiology and genetics of diabetes mellitus. In Joslin's Diabetes Mellitus. Kahn C, Weir G, Eds. Philadelphia, Lea and Febiger, 1994, p. 201-215
2. Rich, SS: Mapping genes in diabetes: genetic epidemiological perspective. Diabetes 39:777-781, 1990
3. Newman B, Selby JV, King MC, Slemenda C, Fabsitz R, Friedman GD: Concordance for type 2 (non-insulin-dependent) diabetes mellitus in male twins. Diabetologia 30:763-768, 1987
4. Yamagata K, Oda N, Kaisaki PJ, Menzel S, Furuta H, Vaxillaire M, Southam L, Cox RD, Lathrop GM, Boriraj VV, Chen X, Cox NJ, Oda Y, Yano H, Le Beau MM, Yamada S, Nishigori H, Takeda J, Fajans SS, Hattersley AT, Iwasaki N, Hansen T, Pedersen O, Polonsky KS, Turner RC, Velho G, Chevre JC, Froguel P, Bell GI: Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3). Nature 384:455-458, 1996
5. Yamagata K, Furuta H, Oda N, Kaisaki PJ, Menzel S, Cox NJ, Fajans SS, Signorini S, Stoffel M, Bell GI: Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1). Nature 384:458-460, 1996
6. Steiner D, Tager H, Chan S, Nanjo K, Sanke T, Rubenstein A: Lessons learned from molecular biology of insulin-gene mutations. Diabetes Care 13:600-609, 1990
7. Taylor S: Molecular mechanisms of insulin resistance-lessons from patients with mutations in the insulin receptor gene. Diabetes 41:1473-1490, 1992
8. Vionnet N, Stoffel M, Takeda J, Yasuda K, Bell GI, Zouali H, Lesage S, Velho G, Iris F, Passa P, Froguel P, Cohen D: Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus. Nature 356:721-722, 1992
9. Hanis C, Boerwinkle E, Chakraborty R, Ellsworth D, Concannon P, Stirling B, Morrison V, Wapelhorst B, Spielman R, Gogolin-Ewens K, Shephard J, Williams S, Risch N, Hinds D, Iwasaki N, Ogata M, Omori Y, Petzold C, Rietzsch H, Schoder HE, Schulze J, Cox N, Menzel S, Boriraj V, Chen X, Lim L, Lindner T, Mereu L, Wang YQ, Xiang K, Yamagata K, Yang Y, Bell GI: A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nat Genet 13:161-166, 1996
10. Mahtani MM, Widen E, Lehto M, Thomas J, McCarthy M, Brayer J, Bryant B, Chan G, Daly M, Carol F, Kanninen T, Kirby A, Kruglyak L, Munnelly K, Parkkonen M, Reeve-Daly MP, Weaver A, Brettin T, Duyk G, Lander ES, Groop LC: Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nat Genet 14:90-94, 1996
11. Ji L, Malecki M, Warram JH, Yang Y, Rich SS, Krolewski AS: New susceptibility locus for NIDDM is localized to human chromosome 20q. Diabetes 46:876-881, 1997
12. Zouali H, Hani EH, Philippi A, Vionnet N, Beckmann JS, Demenais F, Froguel P: A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene. Hum Mol Genet 6:1401-1408, 1997
13. Bell GI, Xiang KS, Newman MV, Wu SH, Wright LG, Fajans SS, Spielman RS, Cox NJ: Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q. Proc Natl Acad Sci U S A 88:1484-1488, 1991
14. Leiter EH, Reifsnyder PC, Flurkey K, Partke HJ, Junger E, Herberg L: NIDDM genes in mice: deleterious synergism by both parental genomes contributes to diabetogenic thresholds. Diabetes 47:1287-1295, 1998
15. Shibata M, Yasuda B: New experimental congenital diabetic mice (NSY mice). Tohoku J Exp Med 130:139-142, 1980
16. Ueda H, Ikegami H, Yamato E, Fu J, Fukuda M, Shen GQ, Kawaguchi Y, Takekawa K, Fujioka Y, Fujisawa T, Nakagawa Y, Hamada Y, Shibata M, Ogihara T: The NSY mouse: a new animal model of spontaneous NTDDM with moderate obesity. Diabetologia 38:503-508, 1995
17. Lander ES, Botstein D: Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121:185-199, 1989
18. Lander ES, Green P, Abrahamson J, Barlow A, Daly MJ, Lincoln SE, Newburg L: MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1:174-181, 1987
19. Paterson AH, Lander ES, Hewitt JD, Peterson S, Lincoln SE, Tanksley SD: Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphisms. Nature 335:721-726, 1988
20. Lincoln SE, Daly MJ, Lander ES: Mapping genes controlling quantitative traits with MAPMAKER/QTL 1.1. Cambridge, MA, Whitehead Institute, 1992 (Tech. Rep., 2nd edition)
21. Lander ES, Kruglyak L: Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247, 1995
22. Rey-Campos J, Chouard T, Yaniv M, Cereghini S: vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1. EMBO J 10:1445-1457, 1991
23. De Simone V, De Magistris L, Lazzaro D, Gerstner J, Monaci P, Nicosia A, Cortese R: LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia EMBO J 10:1435-1443, 1991
24. Mendel DB, Hansen LP, Graves MK, Conley PB, Crabtree GR: HNF-1a and HNF-1b (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro. Genes Dev 5:1042-1056, 1991
25. Karolyi IJ, Guenet JL, Rey-Campos J, Camper SA: The gene coding for variant hepatic nuclear factor 1 (Tcf2), maps between the Edp-1 and Erba genes on mouse chromosome 11. Mamm Genome 3:184-185, 1992
26. Horikawa Y, Iwasaki N, Hara M, Furuta H, Hinokio Y, Cockburn BN, Lindner T, Yamagata K, Ogata M, Tomonaga O, Kuroki H, Kasahara T, Iwamoto Y, Bell GI: Mutation in heptocyte nuclear factor-1β gene (TCF2) associated with MODY. Nat Genet 17:384-385, 1997
27. Lander ES, Schork NJ: Genetic dissection of complex traits. Science 265:2037-2048, 1994
28. Hattori M, Yamato E, Matsumoto E, Itoh N, Toyonaga T, Petruzzelli M, Fukuda M, Kobayashi M, Chapman VM: Occurrence of pretype I diabetes and type II diabetes mellitus in BC1 [(NODxMus spretus) F1xNOD] mice. In Lessons from Animal Diabetes VI. Shafrir E, Eds. Boston, Birkhauser, 1996, p. 83-95
29. Makino S, Kunimoto K, Muraoka Y, Mizushima Y, Katagiri K, Tochino Y: Breeding of a nonobese, diabetic strain of mice. Exp Anim 29:1-13, 1980
30. Iwasaki N, Oda N, Ogata M, Hara M, Hinokio Y, Oda Y, Yamagata K, Kanematsu S, Ohgawara H, Omori Y, Bell GI: Mutations in the heptocyte nuclear factor-1α/MODY3 gene in Japanese subjects with early- and late-onset NIDDM. Diabetes 46:1504-1508, 1997
31. Nishigori H, Yamada S, Kohama T, Tomura H, Sho K, Horikawa Y, Bell GI, Takeuchi T, Takeda J: Frameshift mutation, A263fsinsGG, in the hepatocyte nuclear factor-1β gene associated with diabetes and renal dysfunction. Diabetes 47:1354-1355, 1998
32. Todd JA, Aitman TJ, Cornall RJ, Ghosh S, Hall JRS, Hearne CM, Knight AM, Love JM, McAleer MA, Prins JB, Rodrigues N, Lathlop M, Pressey A, DeLarato NH, Peterson LB, Wicker LS: Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Nature 351:542-547, 1991
33. Wicker LS, Todd JA, Peterson LB: Genetic control of autoimmune diabetes in the NOD mouse. Annu Rev Immunol 13:179-200, 1995
34. Wagener D, Sacks J, LaPorte R, MacGregor J: The Pittsburgh study of insulin-dependent diabetes mellitus: risk for diabetes among relatives of IDDM. Diabetes 31:136-144, 1982
35. Rich SS, Panter SS, Goetz FC, Hedlund B, Barbosa J: Shared genetic susceptibility of type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus: contributions of HLA and haptoglobin. Diabetologia 34:350-355, 1991
36. Galli J, Li LS, Glaser A, Otenson CG, Jiao H, Fakhrai-Rad H, Jacob HJ, Lander ES, Luthman H: Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nat Genet 12:31-37, 1996
37. Gauguier D, Froguel P, Parent V, Bernard C, Bihoreau MT, Portha B, James MR, Penicaud L, Lathrop M, Ktorza A: Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat. Nat Genet 12:38-43, 1996