Obesity QTLs on mouse chromosomes 2 and 17

Genomics

Volumn 43, Issue 3, 1997, Pages 249-257

  Taylor, Benjamin A ^a   Phillips, Sandra J ^a  

^a JACKSON LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; CHROMOSOME 17; CHROMOSOME 2; GENE LOCATION; GENE LOCUS; GENETIC LINKAGE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; SCORING SYSTEM;

EID: 0031214118     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1997.4835     Document Type: Article

References (35)

1. Allison, D. B., Heshka, S., Neale, M. C., Lykken, D. T., and Heymsfield, S. B. (1994). A genetic analysis of relative weight among 4,020 twin pairs, with an emphasis on sex effects. Health Psychol. 13: 362-365.
2. Ashworth, A. (1993). Two acetyl-CoA acetyltransferase genes located in the t-complex region of mouse chromosome 17 partially overlap the Tcp-1 and Tcp-1x genes. Genomics 18: 195-198.
3. Barlow, D. P., Stoger, R., Herrmann, B. G., Saito, K., and Schweifer, N. (1991). The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus. Nature 349: 84-87.
4. Bouchard, C., and Perusse, L. (1996). Current status of the human obesity gene map. Obes. Res. 4: 81-90.
5. Bultman, S. J., Michaud, E. J., and Woychik, R. P. (1992). Molecular characterization of the mouse agouti locus. Cell 71: 1195-1204.
6. Coleman, D. L., and Eicher, E. M. (1990). Fat (fat) and tubby (tub): Two autosomal recessive mutations causing obesity syndromes in the mouse. J. Hered. 81: 424-427.
7. Darvasi, A., and Soller, M. (1994). Selective DNA pooling for determination of linkage between a molecular marker and a quantitative trait locus. Genetics 138: 1365-1373.
8. Davis, R. C., Ben-Zeev, O., Martin, D., and Doolittle, M. H. (1990). Combined lipase deficiency in the mouse. Evidence of impaired lipase processing and secretion. J. Biol. Chem. 265: 17960-17966.
9. Dietrich, W. F., Miller, J. C., Steen, R. G., Merchant, M., Damron, D., Nahf, R., Gross, A., Joyce, D. C., Wessel, M., Dredge, R. D., Marquis, A., Stein, L. D., Goodman, N., Page, D. C., and Lander, E. S. (1994). A genetic map of the mouse with 4,006 simple sequence length polymorphisms. Nature Genet. 7: 220-245.
10. Drudik, D. K., Pomp, D., Zeng, Z.-B., and Eisen, E. J. (1995). Identification of major genes controlling body weight and fat percentage on mouse chromosome 2. J. An. Sci. 73: S110.
11. Fabsitz, R. R., Sholinsky, P., and Carmelli, D. (1994). Genetic influences on adult weight gain and maximum body mass index in male twins. Am. J. Epidemiol. 140: 711-720.
12. Khanuja, B., Cheah, Y. C., Hunt, M., Nishina, P. M., Wang, D. Q., Chen, H. W., Billheimer, J. T., Carey, M. C., and Paigen, B. (1995). Lith 1, a major gene affecting cholesterol gallstone formation among inbred strains of mice. Proc. Natl. Acad. Sci. USA 92: 7729-7733.
13. Kleyn, P. W., Fan, W., Kovats, S. G., Lee, J. J., Pulido, J. C., Wu, Y., Berkemeier, L. R., Misumi, D. J., Holmgren, L., Charlat, O., Woolf, E. A., Tayber, O., Brody, T., Shu, P., Hawkins, F., Kennedy, B., Baldini, L., Ebeling, C., Alperin, G. D., Deeds, J., Lakey, N. D., Culpepper, J., Chen, H., Glucksmann-Kuis, M. A., Carlson, G. A., Duyk, G. M., and Moore, K. J. (1996). Identification and characterization of the mouse obesity gene tubby: A member of a novel gene family. Cell 85: 281-290.
14. Lander, E., and Kruglyak, L. (1995). Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results. Nature Genet. 11: 241-247.
15. Lander, E. S., and Botstein, D. (1989). Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121: 185-199.
16. Lander, E. S., Green, P., Abrahamson, J., Barlow, A., Daly, M. J., Lincoln, S. E., and Newburg, L. (1987). MAPMAKER: An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1: 174-181.
17. Miller, M. W., Duhl, D. M. J., Vrieling, H., Cordes, S. P., Ollmann, M. M., Winkes, B. M., and Barsh, G. S. (1993). Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev. 7: 454-467.
18. Naggert, J. K., Fricker, L. D., Varlamov, O., Nishina, P. M., Rouille, Y., Steiner, D. F., Carroll, R. J., Paigen, B. J., and Leiter, E. H. (1995). Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nature Genet. 10: 135-142.
19. Noben-Trauth, K., Naggert, J. K., North, M. A., and Nishina, P. M. (1996). A candidate gene for the mouse mutation tubby. Nature 380: 534-538.
20. Norman, R. A., Bogardus, C., and Ravussin, E. (1995). Linkage between obesity and a marker near the tumor necrosis factor-alpha locus in Pima Indians. J. Clin. Invest. 96: 158-162.
21. Paterniti, J. R. J., Brown, W. V., Ginsberg, H. N., and Artzt, K. (1983). Combined lipase deficiency (cld): A lethal mutation on chromosome 17 of the mouse. Science 221: 167-169.
22. Perusse, L., Despres, J. P., Lemieux, S., Rice, T., Rao, D. C., and Bouchard, C. (1996). Familial aggregation of abdominal visceral fat level: Results from the Quebec Family Study. Metabolism 45: 378-382.
23. Rice, T., Perusse, L., Bouchard, C., and Rao, D. C. (1996). Familial clustering of abdominal visceral fat and total fat mass: The Quebec Family Study. Obes. Res. 4: 253-261.
24. Siracusa, L. D., Morgan, J. L., Fisher, J. K., Abbott, C. M., and Peters, J. (1996). Mouse chromosome 2. Mamm. Genome 6: S51-S63.
25. Sorensen, T. I. (1995). The genetics of obesity. Metabolism 44: 4-6.
26. Taylor, B. A., and Meier, H. (1975). Mapping the adrenal lipid depletion gene of the AKR/J mouse strain. Genet. Res. 26: 307-312.
27. Taylor, B. A., and Phillips, S. J. (1996). Detection of obesity QTLs on mouse chromosomes 1 and 7 by selective DNA pooling. Genomics 34: 389-398.
28. Wang, G.-L., and Paterson, A. H. (1994). Assessment of DNA pooling strategies for mapping of QTLs. Theor. Appl. Genet. 88: 355-361.
29. Warden, C. H., Fisler, J. S., Pace, M. J., Svenson, K. L., and Lusis, A. J. (1993). Coincidence of genetic loci for plasma cholesterol levels and obesity in a multifactorial mouse model. J. Clin. Chem. 92: 773-779.
30. Warden, C. H., Fisler, J. S., Shoemaker, S. M., Wen, P. Z., Svenson, K. L., Pace, M. J., and Lusis, A. J. (1995). Identification of four chromosomal loci determining obesity in a multifactorial mouse model. J. Clin. Invest. 95: 1545-1552.
31. West, D. B., Goudey-Lefevre, J., York, B., and Truett, G. E. (1994a). Dietary obesity linked to genetic loci on chromosomes 9 and 15. J. Clin. Invest. 94: 1410-1416.
32. West, D. B., Truett, G. E., LeFevre, J., and York, B. (1994b). Quantitative trait loci on chromosomes 9 and 1 controlling mesenteric adipose depot size in the mouse. Obesity 18: 105S.
33. West, D. B., Waguespack, J., York, J., Goudey-Lefevre, J., and Price, R. A. (1994c). Genetics of dietary obesity in AKR/J × SWR/J mice: Segregation of the trait and identification of a linked locus on chromosome 4. Mamm. Genome 5: 546-552.
34. Wilson, A. F., Elston, R. C., Tran, L. D., and Siervogel, R. M. (1991). Use of the robust sib-pair method to screen for single-locus, multiple-locus, and pleiotropic effects: Application to traits related to hypertension. Am. J. Hum. Genet. 48: 862-872.
35. Zhang, Y., Proenca, R., Maffel, M., Barone, M., Leopold, L., and Friedman, J. M. (1994). Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432.