Major quantitative trait locus on chromosome 2 for glucose tolerance in diabetic SMXA-5 mouse established from non-diabetic SM/J and A/J strains

Diabetologia

Volumn 49, Issue 3, 2006, Pages 486-495

  Kobayashi, M ^a,b   Io, F ^a   Kawai, T ^a   Kumazawa, M ^a   Ikegami, H ^b   Nishimura, M ^c   Ohno, T ^c   Horio, F ^a,d  

^a NAGOYA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d CHUBU UNIVERSITY   (Japan)

Author keywords

Congenic; Glucose tolerance; Hyperinsulinaemia; Obesity; QTL; Recombinant inbred; Type 2 diabetes

Indexed keywords

ALLELE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY MASS; CHROMOSOME 2; CONGENIC ANIMAL; CONTROLLED STUDY; DIABETOGENESIS; FEMALE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC TRAIT; GENOME ANALYSIS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; IMPAIRED GLUCOSE TOLERANCE; LIPID DIET; MALE; MOUSE; MOUSE STRAIN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; QUANTITATIVE TRAIT LOCUS MAPPING;

ANIMALS; BLOOD GLUCOSE; BODY MASS INDEX; CHROMOSOMES, MAMMALIAN; DIABETES MELLITUS; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; MALE; MICE; MICE, INBRED STRAINS; OBESITY; PHENOTYPE; QUANTITATIVE TRAIT LOCI;

EID: 33244465359     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-005-0121-3     Document Type: Article

References (49)

1. Warm JH, Rich SS, Krolewski AS (1994) Epidemiology and genetics of diabetes mellitus. In: Kahn C, Weir G (eds) Joslin's diabetes mellitus. Lea and Febiger, Philadelphia, Pennsylvania, pp 201-215
2. Galli J, Li LS, Glaser A et al (1996) Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nat Genet 12:31-37
3. Gauguier D, Froguel P, Parent V et al (1996) Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat. Nat Genet 12:38-43
4. Kanemoto N, Hishigaki H, Miyakita A et al (1998) Genetic dissection of 'OLETF', a rat model for non-insulin-dependent diabetes mellitus. Mamm Genome 9:419-425
5. Moralejo DH, Ogino T, Zhu M et al (1998) A major quantitative trait locus co-localizing with cholecystokinin type A receptor gene influences poor pancreatic proliferation in a spontaneously diabetogenic rat. Mamm Genome 9:794-798
6. Wei S, Wei K, Moralejo DH et al (1999) Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat. Mamm Genome 10:249-258
7. Sugiura K, Miyake T, Taniguchi Y et al (1999) Identification of novel non-insulin-dependent diabetes mellitus susceptibility loci in the Otsuka Long-Evans Tokushima fatty rat by MQM-mapping method. Mamm Genome 10:1126-1131
8. Masuyama T, Fuse M, Yokoi N et al (2003) Genetic analysis for diabetes in a new rat model of nonobese type 2 diabetes, spontaneously diabetic torii rat. Biochem Biophys Res Commun 304:196-206
9. Ueda H, Ikegami H, Kawaguchi Y et al (1999) Genetic analysis of late-onset type 2 diabetes in a mouse model of human complex trait. Diabetes 48:1168-1174
10. Leiter EH, Reifsnyder PC, Flurkey K, Partke HJ, Junger E, Herberg L (1998) NIDDM genes in mice: deleterious synergism by both parental genomes contributes to diabetogenic thresholds. Diabetes 47:1287-1295
11. Plum L, Giesen K, Kluge R et al (2002) Characterisation of the mouse diabetes susceptibility locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat. Diabetologia 45:823-830
12. Hirayama I, Yi Z, Izumi S et al (1999) Genetic analysis of obese diabetes in the TSOD mouse. Diabetes 48:1183-1191
13. Shike T, Hirose S, Kobayashi M, Funabiki K, Shirai T, Tomino Y (2001) Susceptibility and negative epistatic loci contributing to type 2 diabetes and related phenotypes in a KK/Ta mouse model. Diabetes 50:1943-1948
14. y allele on quantitative regulation. Mamm Genome 9:506-510
15. y mice. Eur J Endocrinol 139:654-661
16. Kim JH, Sen S, Avery CS et al (2001) Genetic analysis of a new mouse model for non-insulin-dependent diabetes. Genomics 74:273-286
17. Nishimura M, Hirayama N, Serikawa T et al (1995) The SMXA: a new set of recombinant inbred strain of mice consisting of 26 substrains and their genetic profile. Mamm Genome 6:850-857
18. Anunciado RV, Horio F, Ohno T, Tanaka S, Nishimura M, Namikawa T (2000) Characterization of hyperinsulinemic recombinant inbred (RI) strains (SMXA-5 and SMXA-9) derived from normoinsulinemic SM/J and A/J mice. Exp Anim 49:83-90
19. Kobayashi M, Ohno T, Tsuji A, Nishimura M, Horio F (2003) Combinations of nondiabetic parental genomes elicit impaired glucose tolerance in mouse SMXA recombinant inbred strains. Diabetes 52:180-186
20. Kobayashi M, Io F, Kawai T, Nishimura M, Ohno T, Horio F (2004) SMXA-5 mouse as a diabetic model susceptible to feeding a high-fat diet. Biosci Biotechnol Biochem 68:226-230
21. Markel P, Shu P, Ebeling C et al (1997) Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains. Nat Genet 17:280-284
22. Reeves PG, Nielsen FH, Fahey GC Jr (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123:1939-1951
23. Ohno T, Katoh J, Kikkawa Y, Yonekawa H, Nishimura M (2003) Improved strain distribution patterns of SMXA recombinant inbred strains by microsatellite markers. Exp Anim 52:415-417
24. Silver LM (1995) Genetic markers. In: Silver LM (ed.) Mouse genetics. Oxford University Press, New York, pp 184-190
25. Manly KF, Olson JM (1999) Overview of QTL mapping software and introduction to map manager QT. Mamm Genome 10:327-334
26. Manly KF, Cudmore RH Jr, Meer JM (2001) Map Manager QTX, cross-platform software for genetic mapping. Mamm Genome 12:930-932
27. Churchill GA, Doerge RW (1994) Empirical threshold values for quantitative trait mapping. Genetics 138:963-971
28. Doerge RW, Churchill GA (1996) Permutation tests for multiple loci affecting a quantitative character. Genetics 142:285-294
29. Lynch M, Walsh B (1997) Mapping and characterizing QTLs: inbred line crosses. In: Genetics and analysis of quantitative traits. Sinauer Associates, Sunderland, Massachusetts, pp 431-489
30. Lander E, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247
31. Mehrabian M, Wen PZ, Fisler J, Davis RC, Lusis AJ (1998) Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model. J Clin Invest 101:2485-2496
32. Estrada-Smith D, Castellani LW, Wong H et al (2004) Dissection of multigenic obesity traits in congenic mouse strains. Mamm Genome 15:14-22
33. Stoehr JP, Nadler ST, Schueler KI et al (2000) Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci. Diabetes 49:1946-1954
34. Stoehr JP, Byers JE, Clee SM et al (2004) Identification of major quantitative trait loci controlling body weight variation in ob/ob mice. Diabetes 53:245-249
35. Young TL, Penny L, Woods MO et al (1999) A fifth locus for Bardet-Biedl syndrome maps to chromosome 2q31. Am J Hum Genet 64:900-904
36. Beales PL, Katsanis N, Lewis RA et al (2001) Genetic and mutational analyses of a large multiethnic Bardet-Biedl cohort reveal a minor involvement of BBS6 and delineate the critical intervals of other loci. Am J Hum Genet 68:606-616
37. Zouali H, Hani EH, Philippi A et al (1997) A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene. Hum Mol Genet 6:1401-1408
38. Hunt SC, Abkevich V, Hensel CH et al (2001) Linkage of body mass index to chromosome 20 in Utah pedigrees. Hum Genet 109:279-285
39. Permutt MA, Wasson J, Love-Gregory L et al (2002) Searching for type 2 diabetes genes on chromosome 20. Diabetes 51 (Suppl 3):S308-S315
40. Kovács P, van den Brandt J, Klöting I (2000) Genetic dissection of the syndrome X in the rat. Biochem Biophys Res Commun 269:660-665
41. Lehmann JM, Kliewer SA, Moore LB et al (1997) Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem 272:3137-3140
42. Peet DJ, Turley SD, Ma W et al (1998) Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell 93:693-704
43. Cao G, Liang Y, Broderick CL et al (2003) Antidiabetic action of a liver X receptor agonist mediated by inhibition of hepatic gluconeogenesis. J Biol Chem 278:1131-1136
44. Stulnig TM, Steffensen KR, Gao H et al (2002) Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue. Mol Pharmacol 62:1299-1305
45. Laffitte BA, Chao LC, Li J et al (2003) Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci USA 100:5419-5424
46. Dalen KT, Ulven SM, Bamberg K, Gustafsson JA, Nebb HI (2003) Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha. J Biol Chem 278:48283-48291
47. Brockmann GA, Kratzsch J, Haley CS, Renne U, Schwerin M, Karle S (2000) Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F2 variance of growth and obesity in DU6i x DBA/2 mice. Genome Res 10:1941-1957
48. Anunciado RV, Ohno T, Mori M et al (2000) Distribution of body weight, blood insulin and lipid levels in the SMXA recombinant inbred strains and the QTL analysis. Exp Anim 49:217-224
49. Anunciado RV, Nishimura M, Mori M et al (2003) Quantitative trait locus analysis of serum insulin, triglyceride, total cholesterol and phospholipid levels in the (SM/J x A/J)F2 mice. Exp Anim 52:37-42