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Volumn 4, Issue 4, 2007, Pages 253-266

Therapeutic vaccines: challenges of chronic viral infections

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; DNA; DNA VACCINE; HEPATITIS B CORE ANTIGEN; HEPATITIS B CORE ANTIGEN KANAMYCIN KINASE FUSION PROTEIN; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE; HEPATITIS B(E) ANTIGEN; HEPATITIS C VACCINE; HYBRID PROTEIN; INTERFERON; INTERLEUKIN 2; LAMIVUDINE; NONSTRUCTURAL PROTEIN; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 4A; PLACEBO; RECOMBINANT ALPHA2B INTERFERON; RECOMBINANT GLYCOPROTEIN E1; RECOMBINANT GLYCOPROTEIN E2; RECOMBINANT PROTEIN; RETROVIRUS VECTOR; RIBAVIRIN; T LYMPHOCYTE PEPTIDE; VIRUS DNA; VIRUS PROTEIN; VIRUS VECTOR;

EID: 46949111529     PISSN: 17406773     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddstr.2008.02.004     Document Type: Review
Times cited : (6)

References (155)
  • 1
    • 0033160040 scopus 로고    scopus 로고
    • Syphilization: human experimentation in the search for a syphilis vaccine in the nineteenth century
    • Sherwood J. Syphilization: human experimentation in the search for a syphilis vaccine in the nineteenth century. J. Hist. Med. Allied Sci. 54 (1999) 364-386
    • (1999) J. Hist. Med. Allied Sci. , vol.54 , pp. 364-386
    • Sherwood, J.1
  • 2
    • 0033231470 scopus 로고    scopus 로고
    • Vaccination against the major infectious diseases
    • Plotkin S.A. Vaccination against the major infectious diseases. C. R. Acad. Sci. III 322 (1999) 943-951
    • (1999) C. R. Acad. Sci. III , vol.322 , pp. 943-951
    • Plotkin, S.A.1
  • 3
    • 46949105588 scopus 로고
    • Vaccine therapy in bronchial asthma
    • Bergquist G. Vaccine therapy in bronchial asthma. Acta Allergol. 9 (1955) 97-106
    • (1955) Acta Allergol. , vol.9 , pp. 97-106
    • Bergquist, G.1
  • 4
    • 43849104724 scopus 로고    scopus 로고
    • Ahlen, G. et al. (2007) In vivo electroporation enhances the immunogenicity of hepatitis C virus nonstructural3/4A DNA by increased local DNA uptake, protein expression, inflammation, and infiltration of CD3+ cells. J. Immunol. 179, 4741-4753.
    • Ahlen, G. et al. (2007) In vivo electroporation enhances the immunogenicity of hepatitis C virus nonstructural3/4A DNA by increased local DNA uptake, protein expression, inflammation, and infiltration of CD3+ cells. J. Immunol. 179, 4741-4753.
  • 5
    • 2042522699 scopus 로고    scopus 로고
    • DNA vaccines against human immunodeficiency virus type 1 in the past decade
    • Giri M., et al. DNA vaccines against human immunodeficiency virus type 1 in the past decade. Clin. Microbiol. Rev. 17 (2004) 370-389
    • (2004) Clin. Microbiol. Rev. , vol.17 , pp. 370-389
    • Giri, M.1
  • 6
    • 0025833973 scopus 로고
    • HLA class I-restricted human cytotoxic T cells recognize endogenously synthesized hepatitis B virus nucleocapsid antigen
    • Bertoletti A., et al. HLA class I-restricted human cytotoxic T cells recognize endogenously synthesized hepatitis B virus nucleocapsid antigen. Proc. Natl. Acad. Sci. U. S. A. 88 (1991) 10445-10449
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 10445-10449
    • Bertoletti, A.1
  • 7
    • 0023683917 scopus 로고
    • Functional modulation of hepatitis B core antigen-specific T lymphocytes by an autoreactive T cell clone
    • Ferrari C., et al. Functional modulation of hepatitis B core antigen-specific T lymphocytes by an autoreactive T cell clone. J. Immunol. 141 (1988) 1155-1160
    • (1988) J. Immunol. , vol.141 , pp. 1155-1160
    • Ferrari, C.1
  • 8
    • 0025245580 scopus 로고
    • Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection
    • Ferrari C., et al. Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection. J. Immunol. 145 (1990) 3442-3449
    • (1990) J. Immunol. , vol.145 , pp. 3442-3449
    • Ferrari, C.1
  • 9
    • 0029067476 scopus 로고
    • Activation of a heterogeneous hepatitis B (HB) core and e antigen-specific CD4+ T-cell population during seroconversion to anti-HBe and anti-HBs in hepatitis B virus infection
    • Jung M.C., et al. Activation of a heterogeneous hepatitis B (HB) core and e antigen-specific CD4+ T-cell population during seroconversion to anti-HBe and anti-HBs in hepatitis B virus infection. J. Virol. 69 (1995) 3358-3368
    • (1995) J. Virol. , vol.69 , pp. 3358-3368
    • Jung, M.C.1
  • 10
    • 0031307884 scopus 로고    scopus 로고
    • Pathobiology of acute and chronic hepatitis B virus infection: an introduction
    • Milich D.R. Pathobiology of acute and chronic hepatitis B virus infection: an introduction. J. Viral Hepat. 4 Suppl. 2 (1997) 25-30
    • (1997) J. Viral Hepat. , vol.4 , Issue.SUPPL. 2 , pp. 25-30
    • Milich, D.R.1
  • 11
    • 0029944276 scopus 로고    scopus 로고
    • Viral cross talk: intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver
    • Guidotti L.G., et al. Viral cross talk: intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 4589-4594
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 4589-4594
    • Guidotti, L.G.1
  • 12
    • 0030021968 scopus 로고    scopus 로고
    • Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes
    • Guidotti L.G., et al. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity 4 (1996) 25-36
    • (1996) Immunity , vol.4 , pp. 25-36
    • Guidotti, L.G.1
  • 13
    • 9544232506 scopus 로고    scopus 로고
    • Long-lasting memory T cell responses following self-limited acute hepatitis B
    • Penna A., et al. Long-lasting memory T cell responses following self-limited acute hepatitis B. J. Clin. Invest. 98 (1996) 1185-1194
    • (1996) J. Clin. Invest. , vol.98 , pp. 1185-1194
    • Penna, A.1
  • 14
    • 0029838758 scopus 로고    scopus 로고
    • The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response
    • Rehermann B., et al. The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response. Nat. Med. 2 (1996) 1104-1108
    • (1996) Nat. Med. , vol.2 , pp. 1104-1108
    • Rehermann, B.1
  • 15
    • 34250005419 scopus 로고    scopus 로고
    • Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients
    • Fu J., et al. Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients. Gastroenterology 132 (2007) 2328-2339
    • (2007) Gastroenterology , vol.132 , pp. 2328-2339
    • Fu, J.1
  • 16
    • 16244385911 scopus 로고    scopus 로고
    • Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection
    • Stoop J.N., et al. Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology 41 (2005) 771-778
    • (2005) Hepatology , vol.41 , pp. 771-778
    • Stoop, J.N.1
  • 17
    • 20644471859 scopus 로고    scopus 로고
    • Predominant T-helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B
    • Penna A., et al. Predominant T-helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B. Hepatology 25 (1997) 1022-1027
    • (1997) Hepatology , vol.25 , pp. 1022-1027
    • Penna, A.1
  • 18
    • 0026767691 scopus 로고
    • Lack of protective immunity against reinfection with hepatitis C virus
    • Farci P., et al. Lack of protective immunity against reinfection with hepatitis C virus. Science 258 (1992) 135-140
    • (1992) Science , vol.258 , pp. 135-140
    • Farci, P.1
  • 19
    • 0028087985 scopus 로고
    • Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization
    • Farci P., et al. Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 7792-7796
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 7792-7796
    • Farci, P.1
  • 20
    • 0028968636 scopus 로고
    • Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant
    • Weiner A., et al. Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 2755-2759
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 2755-2759
    • Weiner, A.1
  • 21
    • 0020174651 scopus 로고
    • A possible immunodominant epitope recognized by murine T lymphocytes immune to different myoglobins
    • Berkower I., et al. A possible immunodominant epitope recognized by murine T lymphocytes immune to different myoglobins. Proc. Natl. Acad. Sci. U. S. A. 79 (1982) 4723-4727
    • (1982) Proc. Natl. Acad. Sci. U. S. A. , vol.79 , pp. 4723-4727
    • Berkower, I.1
  • 22
    • 0022455844 scopus 로고
    • Immunodominance in the T-cell response to multiple non-H-2 histocompatibility antigens. II. Observation of a hierarchy among dominant antigens
    • Wettstein P.J. Immunodominance in the T-cell response to multiple non-H-2 histocompatibility antigens. II. Observation of a hierarchy among dominant antigens. Immunogenetics 24 (1986) 24-31
    • (1986) Immunogenetics , vol.24 , pp. 24-31
    • Wettstein, P.J.1
  • 23
    • 0019992666 scopus 로고
    • Immunodominance in the immune response to "multiple" histocompatibility antigens
    • Wettstein P.J., and Bailey D.W. Immunodominance in the immune response to "multiple" histocompatibility antigens. Immunogenetics 16 (1982) 47-58
    • (1982) Immunogenetics , vol.16 , pp. 47-58
    • Wettstein, P.J.1    Bailey, D.W.2
  • 24
    • 0029151623 scopus 로고
    • Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection
    • Diepolder H.M., et al. Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet 346 (1995) 1006-1007
    • (1995) Lancet , vol.346 , pp. 1006-1007
    • Diepolder, H.M.1
  • 25
    • 10244225383 scopus 로고    scopus 로고
    • Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response
    • Missale G., et al. Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response. J. Clin. Invest. 98 (1996) 706-714
    • (1996) J. Clin. Invest. , vol.98 , pp. 706-714
    • Missale, G.1
  • 26
    • 0042844701 scopus 로고    scopus 로고
    • Evidence that clearance of hepatitis C virus RNA after alpha-interferon therapy in dialysis patients is sustained after renal transplantation
    • Kamar N., et al. Evidence that clearance of hepatitis C virus RNA after alpha-interferon therapy in dialysis patients is sustained after renal transplantation. J. Am. Soc. Nephrol. 14 (2003) 2092-2098
    • (2003) J. Am. Soc. Nephrol. , vol.14 , pp. 2092-2098
    • Kamar, N.1
  • 27
    • 33644520948 scopus 로고    scopus 로고
    • Therapy of hepatitis C: from empiricism to eradication
    • Pawlotsky J.M. Therapy of hepatitis C: from empiricism to eradication. Hepatology 43 2 Suppl. 1 (2006) S207-S220
    • (2006) Hepatology , vol.43 , Issue.2 SUPPL. 1
    • Pawlotsky, J.M.1
  • 28
    • 34250013090 scopus 로고    scopus 로고
    • HCV findings presented at EASL: long-term follow-up and the criteria of a cure
    • Lang L. HCV findings presented at EASL: long-term follow-up and the criteria of a cure. Gastroenterology 132 (2007) 2282-2283
    • (2007) Gastroenterology , vol.132 , pp. 2282-2283
    • Lang, L.1
  • 29
    • 23944485662 scopus 로고    scopus 로고
    • Evasion of intracellular host defence by hepatitis C virus
    • Gale Jr. M., and Foy E.M. Evasion of intracellular host defence by hepatitis C virus. Nature 436 (2005) 939-945
    • (2005) Nature , vol.436 , pp. 939-945
    • Gale Jr., M.1    Foy, E.M.2
  • 30
    • 0037687422 scopus 로고    scopus 로고
    • Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease
    • Foy E., et al. Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science 300 (2003) 1145-1148
    • (2003) Science , vol.300 , pp. 1145-1148
    • Foy, E.1
  • 31
    • 14544280209 scopus 로고    scopus 로고
    • Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF
    • Li K., et al. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 2992-2997
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 2992-2997
    • Li, K.1
  • 32
    • 27144440476 scopus 로고    scopus 로고
    • Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    • Meylan E., et al. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437 (2005) 1167-1172
    • (2005) Nature , vol.437 , pp. 1167-1172
    • Meylan, E.1
  • 33
    • 33749177118 scopus 로고    scopus 로고
    • The hepatitis C virus and immune evasion: non-structural 3/4A transgenic mice are resistant to lethal tumour necrosis factor {alpha} mediated liver disease
    • Frelin L., et al. The hepatitis C virus and immune evasion: non-structural 3/4A transgenic mice are resistant to lethal tumour necrosis factor {alpha} mediated liver disease. Gut 55 (2006) 1475-1483
    • (2006) Gut , vol.55 , pp. 1475-1483
    • Frelin, L.1
  • 34
    • 10744232784 scopus 로고    scopus 로고
    • Impaired clearance of virus-infected hepatocytes in transgenic mice expressing the hepatitis C virus polyprotein
    • Disson O., et al. Impaired clearance of virus-infected hepatocytes in transgenic mice expressing the hepatitis C virus polyprotein. Gastroenterology 126 (2004) 859-872
    • (2004) Gastroenterology , vol.126 , pp. 859-872
    • Disson, O.1
  • 35
    • 0346100572 scopus 로고    scopus 로고
    • Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A
    • Duong F.H., et al. Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A. Gastroenterology 126 (2004) 263-277
    • (2004) Gastroenterology , vol.126 , pp. 263-277
    • Duong, F.H.1
  • 36
    • 0036835773 scopus 로고    scopus 로고
    • Hepatitis C virus replicons: potential role for drug development
    • Bartenschlager R. Hepatitis C virus replicons: potential role for drug development. Nat. Rev. Drug Discov. 1 (2002) 911-916
    • (2002) Nat. Rev. Drug Discov. , vol.1 , pp. 911-916
    • Bartenschlager, R.1
  • 37
    • 4043148744 scopus 로고    scopus 로고
    • Hepatitis C virus mutation affects proteasomal epitope processing
    • Seifert U., et al. Hepatitis C virus mutation affects proteasomal epitope processing. J. Clin. Invest. 114 (2004) 250-259
    • (2004) J. Clin. Invest. , vol.114 , pp. 250-259
    • Seifert, U.1
  • 38
    • 0029792293 scopus 로고    scopus 로고
    • Differential cytotoxic T-lymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients
    • Rehermann B., et al. Differential cytotoxic T-lymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients. J. Virol. 70 (1996) 7092-7102
    • (1996) J. Virol. , vol.70 , pp. 7092-7102
    • Rehermann, B.1
  • 39
    • 30944431676 scopus 로고    scopus 로고
    • Relation between viral fitness and immune escape within the hepatitis C virus protease
    • Soderholm J., et al. Relation between viral fitness and immune escape within the hepatitis C virus protease. Gut 55 (2006) 266-274
    • (2006) Gut , vol.55 , pp. 266-274
    • Soderholm, J.1
  • 40
    • 33845381987 scopus 로고    scopus 로고
    • A complete mutational fitness map of the hepatitis C virus nonstructural 3 protease: relation to recognition by cytotoxic T lymphocytes
    • Soderholm J., and Sallberg M. A complete mutational fitness map of the hepatitis C virus nonstructural 3 protease: relation to recognition by cytotoxic T lymphocytes. J. Infect. Dis. 194 (2006) 1724-1728
    • (2006) J. Infect. Dis. , vol.194 , pp. 1724-1728
    • Soderholm, J.1    Sallberg, M.2
  • 41
    • 23944467250 scopus 로고    scopus 로고
    • Adaptive immune responses in acute and chronic hepatitis C virus infection
    • Bowen D.G., and Walker C.M. Adaptive immune responses in acute and chronic hepatitis C virus infection. Nature 436 (2005) 946-952
    • (2005) Nature , vol.436 , pp. 946-952
    • Bowen, D.G.1    Walker, C.M.2
  • 42
    • 21344442371 scopus 로고    scopus 로고
    • Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C
    • Cox A.L., et al. Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C. Hepatology 42 (2005) 104-112
    • (2005) Hepatology , vol.42 , pp. 104-112
    • Cox, A.L.1
  • 43
    • 21344442507 scopus 로고    scopus 로고
    • Cellular immune selection with hepatitis C virus persistence in humans
    • Cox A.L., et al. Cellular immune selection with hepatitis C virus persistence in humans. J. Exp. Med. 201 (2005) 1741-1752
    • (2005) J. Exp. Med. , vol.201 , pp. 1741-1752
    • Cox, A.L.1
  • 44
    • 0036116355 scopus 로고    scopus 로고
    • Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities
    • Lauer G.M., et al. Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities. J. Virol. 76 (2002) 6104-6113
    • (2002) J. Virol. , vol.76 , pp. 6104-6113
    • Lauer, G.M.1
  • 45
    • 0030067167 scopus 로고    scopus 로고
    • Hepatitis B virus transgenic mice: models of viral immunobiology and pathogenesis
    • Chisari F.V. Hepatitis B virus transgenic mice: models of viral immunobiology and pathogenesis. Curr. Top. Microbiol. Immunol. 206 (1996) 149-173
    • (1996) Curr. Top. Microbiol. Immunol. , vol.206 , pp. 149-173
    • Chisari, F.V.1
  • 46
    • 0035863924 scopus 로고    scopus 로고
    • Overcoming T cell tolerance to the hepatitis B virus surface antigen in hepatitis B virus-transgenic mice
    • Sette A.D., et al. Overcoming T cell tolerance to the hepatitis B virus surface antigen in hepatitis B virus-transgenic mice. J. Immunol. 166 (2001) 1389-1397
    • (2001) J. Immunol. , vol.166 , pp. 1389-1397
    • Sette, A.D.1
  • 47
    • 13944265920 scopus 로고    scopus 로고
    • Immune tolerance split between hepatitis B virus precore and core proteins
    • Chen M., et al. Immune tolerance split between hepatitis B virus precore and core proteins. J. Virol. 79 (2005) 3016-3027
    • (2005) J. Virol. , vol.79 , pp. 3016-3027
    • Chen, M.1
  • 48
    • 6944244922 scopus 로고    scopus 로고
    • A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen
    • Chen M.T., et al. A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 14913-14918
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 14913-14918
    • Chen, M.T.1
  • 49
    • 0025147370 scopus 로고
    • Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?
    • Milich D.R., et al. Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?. Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 6599-6603
    • (1990) Proc. Natl. Acad. Sci. U. S. A. , vol.87 , pp. 6599-6603
    • Milich, D.R.1
  • 50
    • 0030008076 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection
    • Rehermann B., et al. Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection. J. Clin. Invest. 97 (1996) 1655-1665
    • (1996) J. Clin. Invest. , vol.97 , pp. 1655-1665
    • Rehermann, B.1
  • 51
    • 0029101242 scopus 로고
    • Nucleic acid vaccination primes hepatitis B virus surface antigen-specific cytotoxic T lymphocytes in nonresponder mice
    • Schirmbeck R., et al. Nucleic acid vaccination primes hepatitis B virus surface antigen-specific cytotoxic T lymphocytes in nonresponder mice. J. Virol. 69 (1995) 5929-5934
    • (1995) J. Virol. , vol.69 , pp. 5929-5934
    • Schirmbeck, R.1
  • 52
    • 0028299207 scopus 로고
    • Immunization with soluble hepatitis B virus surface protein elicits murine H-2 class I-restricted CD8+ cytotoxic T lymphocyte responses in vivo
    • Schirmbeck R., et al. Immunization with soluble hepatitis B virus surface protein elicits murine H-2 class I-restricted CD8+ cytotoxic T lymphocyte responses in vivo. J. Immunol. 152 (1994) 1110-1119
    • (1994) J. Immunol. , vol.152 , pp. 1110-1119
    • Schirmbeck, R.1
  • 53
    • 0033050827 scopus 로고    scopus 로고
    • Specific vaccine therapy in chronic hepatitis B: induction of T cell proliferative responses specific for envelope antigens
    • Couillin I., et al. Specific vaccine therapy in chronic hepatitis B: induction of T cell proliferative responses specific for envelope antigens. J. Infect. Dis. 180 (1999) 15-26
    • (1999) J. Infect. Dis. , vol.180 , pp. 15-26
    • Couillin, I.1
  • 54
    • 0031866296 scopus 로고    scopus 로고
    • Immunotherapy of chronic hepatitis B by anti HBV vaccine
    • Pol S., et al. Immunotherapy of chronic hepatitis B by anti HBV vaccine. Acta Gastroenterol. Belg. 61 (1998) 228-233
    • (1998) Acta Gastroenterol. Belg. , vol.61 , pp. 228-233
    • Pol, S.1
  • 55
    • 0034948510 scopus 로고    scopus 로고
    • Efficacy and limitations of a specific immunotherapy in chronic hepatitis B
    • Pol S., et al. Efficacy and limitations of a specific immunotherapy in chronic hepatitis B. J. Hepatol. 34 (2001) 917-921
    • (2001) J. Hepatol. , vol.34 , pp. 917-921
    • Pol, S.1
  • 56
    • 0028081659 scopus 로고
    • Direct gene transfer in skeletal muscle: plasmid DNA-based immunization against the hepatitis B virus surface antigen
    • Davis H.L., et al. Direct gene transfer in skeletal muscle: plasmid DNA-based immunization against the hepatitis B virus surface antigen. Vaccine 12 (1994) 1503-1509
    • (1994) Vaccine , vol.12 , pp. 1503-1509
    • Davis, H.L.1
  • 57
    • 0027369829 scopus 로고
    • DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody
    • Davis H.L., et al. DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody. Hum. Mol. Genet. 2 (1993) 1847-1851
    • (1993) Hum. Mol. Genet. , vol.2 , pp. 1847-1851
    • Davis, H.L.1
  • 58
    • 0142199964 scopus 로고    scopus 로고
    • Hepatitis B DNA vaccine induces protective antibody responses in human non-responders to conventional vaccination
    • Rottinghaus S.T., et al. Hepatitis B DNA vaccine induces protective antibody responses in human non-responders to conventional vaccination. Vaccine 21 (2003) 4604-4608
    • (2003) Vaccine , vol.21 , pp. 4604-4608
    • Rottinghaus, S.T.1
  • 59
    • 0030752483 scopus 로고    scopus 로고
    • Successful nucleic acid based immunization of newborn chimpanzees against hepatitis B virus
    • Prince A.M., et al. Successful nucleic acid based immunization of newborn chimpanzees against hepatitis B virus. Vaccine 15 (1997) 916-919
    • (1997) Vaccine , vol.15 , pp. 916-919
    • Prince, A.M.1
  • 60
    • 33646352691 scopus 로고    scopus 로고
    • Attempted therapeutic immunization in a chimpanzee chronic HBV carrier with a high viral load
    • Shata M.T., et al. Attempted therapeutic immunization in a chimpanzee chronic HBV carrier with a high viral load. J. Med. Primatol. 35 (2006) 165-171
    • (2006) J. Med. Primatol. , vol.35 , pp. 165-171
    • Shata, M.T.1
  • 61
    • 33646949662 scopus 로고    scopus 로고
    • Immunogenicity of a hepatitis B DNA vaccine administered to chronic HBV carriers
    • Mancini-Bourgine M., et al. Immunogenicity of a hepatitis B DNA vaccine administered to chronic HBV carriers. Vaccine 24 (2006) 4482-4489
    • (2006) Vaccine , vol.24 , pp. 4482-4489
    • Mancini-Bourgine, M.1
  • 62
    • 34247201441 scopus 로고    scopus 로고
    • Phase I clinical evaluation of a six-plasmid multiclade HIV-1 DNA candidate vaccine
    • Catanzaro A.T., et al. Phase I clinical evaluation of a six-plasmid multiclade HIV-1 DNA candidate vaccine. Vaccine 25 (2007) 4085-4092
    • (2007) Vaccine , vol.25 , pp. 4085-4092
    • Catanzaro, A.T.1
  • 63
    • 34247144932 scopus 로고    scopus 로고
    • Safety and immunogenicity of a Gag-Pol candidate HIV-1 DNA vaccine administered by a needle-free device in HIV-1-seronegative subjects
    • Tavel J.A., et al. Safety and immunogenicity of a Gag-Pol candidate HIV-1 DNA vaccine administered by a needle-free device in HIV-1-seronegative subjects. J. Acquir. Immune Defic. Syndr. 44 (2007) 601-605
    • (2007) J. Acquir. Immune Defic. Syndr. , vol.44 , pp. 601-605
    • Tavel, J.A.1
  • 64
    • 33845412550 scopus 로고    scopus 로고
    • Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 DNA candidate vaccine
    • Graham B.S., et al. Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 DNA candidate vaccine. J. Infect. Dis. 194 (2006) 1650-1660
    • (2006) J. Infect. Dis. , vol.194 , pp. 1650-1660
    • Graham, B.S.1
  • 65
    • 33645937646 scopus 로고    scopus 로고
    • The mechanism of naked DNA uptake and expression
    • Wolff J.A., and Budker V. The mechanism of naked DNA uptake and expression. Adv. Genet. 54 (2005) 3-20
    • (2005) Adv. Genet. , vol.54 , pp. 3-20
    • Wolff, J.A.1    Budker, V.2
  • 66
    • 1942537809 scopus 로고    scopus 로고
    • Hydroporation as the mechanism of hydrodynamic delivery
    • Zhang G., et al. Hydroporation as the mechanism of hydrodynamic delivery. Gene Ther. 11 (2004) 675-682
    • (2004) Gene Ther. , vol.11 , pp. 675-682
    • Zhang, G.1
  • 67
    • 0029982850 scopus 로고    scopus 로고
    • DNA vaccine for hepatitis B: evidence for immunogenicity in chimpanzees and comparison with other vaccines
    • Davis H.L., et al. DNA vaccine for hepatitis B: evidence for immunogenicity in chimpanzees and comparison with other vaccines. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 7213-7218
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 7213-7218
    • Davis, H.L.1
  • 68
    • 17344369213 scopus 로고    scopus 로고
    • Genetic immunization of chimpanzees chronically infected with the hepatitis B virus, using a recombinant retroviral vector encoding the hepatitis B virus core antigen
    • Sallberg M., et al. Genetic immunization of chimpanzees chronically infected with the hepatitis B virus, using a recombinant retroviral vector encoding the hepatitis B virus core antigen. Hum. Gene Ther. 9 (1998) 1719-1729
    • (1998) Hum. Gene Ther. , vol.9 , pp. 1719-1729
    • Sallberg, M.1
  • 69
    • 0000590610 scopus 로고    scopus 로고
    • Profound suppression of hepatitis B virus replication with lamivudine
    • Lai C.L., and Yuen M.F. Profound suppression of hepatitis B virus replication with lamivudine. J. Med. Virol. 61 (2000) 367-373
    • (2000) J. Med. Virol. , vol.61 , pp. 367-373
    • Lai, C.L.1    Yuen, M.F.2
  • 70
    • 0037234233 scopus 로고    scopus 로고
    • Priming of cytotoxic T cell responses to exogenous hepatitis B virus core antigen is B cell dependent
    • Lazdina U., et al. Priming of cytotoxic T cell responses to exogenous hepatitis B virus core antigen is B cell dependent. J. Gen. Virol. 84 Pt 1 (2003) 139-146
    • (2003) J. Gen. Virol. , vol.84 , Issue.PART 1 , pp. 139-146
    • Lazdina, U.1
  • 71
    • 0034979137 scopus 로고    scopus 로고
    • Molecular basis for the interaction of the hepatitis B virus core antigen with the surface immunoglobulin receptor on naive B cells
    • Lazdina U., et al. Molecular basis for the interaction of the hepatitis B virus core antigen with the surface immunoglobulin receptor on naive B cells. J. Virol. 75 (2001) 6367-6374
    • (2001) J. Virol. , vol.75 , pp. 6367-6374
    • Lazdina, U.1
  • 72
    • 0031474161 scopus 로고    scopus 로고
    • Role of B cells in antigen presentation of the hepatitis B core
    • Milich D.R., et al. Role of B cells in antigen presentation of the hepatitis B core. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 14648-14653
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 14648-14653
    • Milich, D.R.1
  • 73
    • 0037094095 scopus 로고    scopus 로고
    • Priming Th1 immunity to viral core particles is facilitated by trace amounts of RNA bound to its arginine-rich domain
    • Riedl P., et al. Priming Th1 immunity to viral core particles is facilitated by trace amounts of RNA bound to its arginine-rich domain. J. Immunol. 168 (2002) 4951-4959
    • (2002) J. Immunol. , vol.168 , pp. 4951-4959
    • Riedl, P.1
  • 74
    • 27144545320 scopus 로고    scopus 로고
    • Combinatorial approach to hepadnavirus-like particle vaccine design
    • Billaud J.N., et al. Combinatorial approach to hepadnavirus-like particle vaccine design. J. Virol. 79 (2005) 13656-13666
    • (2005) J. Virol. , vol.79 , pp. 13656-13666
    • Billaud, J.N.1
  • 75
    • 33846240816 scopus 로고    scopus 로고
    • Advantages to the use of rodent hepadnavirus core proteins as vaccine platforms
    • Billaud J.N., et al. Advantages to the use of rodent hepadnavirus core proteins as vaccine platforms. Vaccine 25 (2007) 1593-1606
    • (2007) Vaccine , vol.25 , pp. 1593-1606
    • Billaud, J.N.1
  • 76
    • 0036986329 scopus 로고    scopus 로고
    • A malaria vaccine candidate based on a hepatitis B virus core platform
    • Sallberg M., et al. A malaria vaccine candidate based on a hepatitis B virus core platform. Intervirology 45 (2002) 350-361
    • (2002) Intervirology , vol.45 , pp. 350-361
    • Sallberg, M.1
  • 77
    • 7044254906 scopus 로고    scopus 로고
    • Phase I testing of a malaria vaccine composed of hepatitis B virus core particles expressing Plasmodium falciparum circumsporozoite epitopes
    • Nardin E.H., et al. Phase I testing of a malaria vaccine composed of hepatitis B virus core particles expressing Plasmodium falciparum circumsporozoite epitopes. Infect. Immun. 72 (2004) 6519-6527
    • (2004) Infect. Immun. , vol.72 , pp. 6519-6527
    • Nardin, E.H.1
  • 78
    • 21144480904 scopus 로고    scopus 로고
    • Safety and enhanced immunogenicity of a hepatitis B core particle Plasmodium falciparum malaria vaccine formulated in adjuvant Montanide ISA 720 in a phase I trial
    • Oliveira G.A., et al. Safety and enhanced immunogenicity of a hepatitis B core particle Plasmodium falciparum malaria vaccine formulated in adjuvant Montanide ISA 720 in a phase I trial. Infect. Immun. 73 (2005) 3587-3597
    • (2005) Infect. Immun. , vol.73 , pp. 3587-3597
    • Oliveira, G.A.1
  • 79
    • 0029913027 scopus 로고    scopus 로고
    • DNA immunization induces antibody and cytotoxic T cell responses to hepatitis B core antigen in H-2b mice
    • Kuhober A., et al. DNA immunization induces antibody and cytotoxic T cell responses to hepatitis B core antigen in H-2b mice. J. Immunol. 156 (1996) 3687-3695
    • (1996) J. Immunol. , vol.156 , pp. 3687-3695
    • Kuhober, A.1
  • 80
    • 1842299314 scopus 로고    scopus 로고
    • Characterization of humoral and CD4+ cellular responses after genetic immunization with retroviral vectors expressing different forms of the hepatitis B virus core and e antigens
    • Sallberg M., et al. Characterization of humoral and CD4+ cellular responses after genetic immunization with retroviral vectors expressing different forms of the hepatitis B virus core and e antigens. J. Virol. 71 (1997) 5295-5303
    • (1997) J. Virol. , vol.71 , pp. 5295-5303
    • Sallberg, M.1
  • 81
    • 1842369628 scopus 로고    scopus 로고
    • Characterization of CD8+ cytotoxic T-lymphocyte responses after genetic immunization with retrovirus vectors expressing different forms of the hepatitis B virus core and e antigens
    • Townsend K., et al. Characterization of CD8+ cytotoxic T-lymphocyte responses after genetic immunization with retrovirus vectors expressing different forms of the hepatitis B virus core and e antigens. J. Virol. 71 (1997) 3365-3374
    • (1997) J. Virol. , vol.71 , pp. 3365-3374
    • Townsend, K.1
  • 82
    • 34249911224 scopus 로고    scopus 로고
    • Immunogenicity of hybrid DNA vaccines expressing hepatitis B core particles carrying human and simian immunodeficiency virus epitopes in mice and rhesus macaques
    • Fuller D.H., et al. Immunogenicity of hybrid DNA vaccines expressing hepatitis B core particles carrying human and simian immunodeficiency virus epitopes in mice and rhesus macaques. Virology 364 (2007) 245-255
    • (2007) Virology , vol.364 , pp. 245-255
    • Fuller, D.H.1
  • 83
    • 0036206523 scopus 로고    scopus 로고
    • Cross-presentation of virus-like particles by skin-derived CD8(-) dendritic cells: a dispensable role for TAP
    • Ruedl C., et al. Cross-presentation of virus-like particles by skin-derived CD8(-) dendritic cells: a dispensable role for TAP. Eur. J. Immunol. 32 (2002) 818-825
    • (2002) Eur. J. Immunol. , vol.32 , pp. 818-825
    • Ruedl, C.1
  • 84
    • 33344479476 scopus 로고    scopus 로고
    • Rapid, high-level production of hepatitis B core antigen in plant leaf and its immunogenicity in mice
    • Huang Z., et al. Rapid, high-level production of hepatitis B core antigen in plant leaf and its immunogenicity in mice. Vaccine 24 (2006) 2506-2513
    • (2006) Vaccine , vol.24 , pp. 2506-2513
    • Huang, Z.1
  • 85
    • 10844266556 scopus 로고    scopus 로고
    • Generation of murine CTL by a hepatitis B virus-specific peptide and evaluation of the adjuvant effect of heat shock protein glycoprotein 96 and its terminal fragments
    • Li H., et al. Generation of murine CTL by a hepatitis B virus-specific peptide and evaluation of the adjuvant effect of heat shock protein glycoprotein 96 and its terminal fragments. J. Immunol. 174 (2005) 195-204
    • (2005) J. Immunol. , vol.174 , pp. 195-204
    • Li, H.1
  • 86
    • 0032769963 scopus 로고    scopus 로고
    • A pilot study of the CY-1899 T-cell vaccine in subjects chronically infected with hepatitis B virus. The CY1899 T Cell Vaccine Study Group
    • Heathcote J., et al. A pilot study of the CY-1899 T-cell vaccine in subjects chronically infected with hepatitis B virus. The CY1899 T Cell Vaccine Study Group. Hepatology 30 (1999) 531-536
    • (1999) Hepatology , vol.30 , pp. 531-536
    • Heathcote, J.1
  • 87
    • 0034849593 scopus 로고    scopus 로고
    • Protection against woodchuck hepatitis virus (WHV) infection by gene gun coimmunization with WHV core and interleukin-12
    • Garcia-Navarro R., et al. Protection against woodchuck hepatitis virus (WHV) infection by gene gun coimmunization with WHV core and interleukin-12. J. Virol. 75 (2001) 9068-9076
    • (2001) J. Virol. , vol.75 , pp. 9068-9076
    • Garcia-Navarro, R.1
  • 88
    • 0031060105 scopus 로고    scopus 로고
    • Characterization of T-cell response to woodchuck hepatitis virus core protein and protection of woodchucks from infection by immunization with peptides containing a T-cell epitope
    • Menne S., et al. Characterization of T-cell response to woodchuck hepatitis virus core protein and protection of woodchucks from infection by immunization with peptides containing a T-cell epitope. J. Virol. 71 (1997) 65-74
    • (1997) J. Virol. , vol.71 , pp. 65-74
    • Menne, S.1
  • 89
    • 0027177152 scopus 로고
    • Immunization with recombinant woodchuck hepatitis virus nucleocapsid antigen or hepatitis B virus nucleocapsid antigen protects woodchucks from woodchuck hepatitis virus infection
    • Schodel F., et al. Immunization with recombinant woodchuck hepatitis virus nucleocapsid antigen or hepatitis B virus nucleocapsid antigen protects woodchucks from woodchuck hepatitis virus infection. Vaccine 11 (1993) 624-628
    • (1993) Vaccine , vol.11 , pp. 624-628
    • Schodel, F.1
  • 90
    • 0032889271 scopus 로고    scopus 로고
    • Immunization of woodchucks with plasmids expressing woodchuck hepatitis virus (WHV) core antigen and surface antigen suppresses WHV infection
    • Lu M., et al. Immunization of woodchucks with plasmids expressing woodchuck hepatitis virus (WHV) core antigen and surface antigen suppresses WHV infection. J. Virol. 73 (1999) 281-289
    • (1999) J. Virol. , vol.73 , pp. 281-289
    • Lu, M.1
  • 91
    • 33745852568 scopus 로고    scopus 로고
    • DNA vaccines expressing the duck hepatitis B virus surface proteins lead to reduced numbers of infected hepatocytes and protect ducks against the development of chronic infection in a virus dose-dependent manner
    • Miller D.S., et al. DNA vaccines expressing the duck hepatitis B virus surface proteins lead to reduced numbers of infected hepatocytes and protect ducks against the development of chronic infection in a virus dose-dependent manner. Virology 351 (2006) 159-169
    • (2006) Virology , vol.351 , pp. 159-169
    • Miller, D.S.1
  • 92
    • 0031964789 scopus 로고    scopus 로고
    • Protective efficacy of DNA vaccines against duck hepatitis B virus infection
    • Triyatni M., et al. Protective efficacy of DNA vaccines against duck hepatitis B virus infection. J. Virol. 72 (1998) 84-94
    • (1998) J. Virol. , vol.72 , pp. 84-94
    • Triyatni, M.1
  • 93
    • 0041767448 scopus 로고    scopus 로고
    • Entecavir therapy combined with DNA vaccination for persistent duck hepatitis B virus infection
    • Foster W.K., et al. Entecavir therapy combined with DNA vaccination for persistent duck hepatitis B virus infection. Antimicrob. Agents Chemother. 47 (2003) 2624-2635
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 2624-2635
    • Foster, W.K.1
  • 94
    • 0029130068 scopus 로고
    • High-level hepatitis B virus replication in transgenic mice
    • Guidotti L.G., et al. High-level hepatitis B virus replication in transgenic mice. J. Virol. 69 (1995) 6158-6169
    • (1995) J. Virol. , vol.69 , pp. 6158-6169
    • Guidotti, L.G.1
  • 95
    • 0028295478 scopus 로고
    • Extrathymic expression of the intracellular hepatitis B core antigen results in T cell tolerance in transgenic mice
    • Milich D.R., et al. Extrathymic expression of the intracellular hepatitis B core antigen results in T cell tolerance in transgenic mice. J. Immunol. 152 (1994) 455-466
    • (1994) J. Immunol. , vol.152 , pp. 455-466
    • Milich, D.R.1
  • 96
    • 0036158719 scopus 로고    scopus 로고
    • Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus
    • Lerat H., et al. Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology 122 (2002) 352-365
    • (2002) Gastroenterology , vol.122 , pp. 352-365
    • Lerat, H.1
  • 97
    • 0031712813 scopus 로고    scopus 로고
    • The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice
    • Moriya K., et al. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat. Med. 4 (1998) 1065-1067
    • (1998) Nat. Med. , vol.4 , pp. 1065-1067
    • Moriya, K.1
  • 98
    • 28844440938 scopus 로고    scopus 로고
    • In vivo clearance of hepatitis C virus nonstructural 3/4A-expressing hepatocytes by DNA vaccine-primed cytotoxic T lymphocytes
    • Ahlen G., et al. In vivo clearance of hepatitis C virus nonstructural 3/4A-expressing hepatocytes by DNA vaccine-primed cytotoxic T lymphocytes. J. Infect. Dis. 192 (2005) 2112-2116
    • (2005) J. Infect. Dis. , vol.192 , pp. 2112-2116
    • Ahlen, G.1
  • 99
    • 0037108818 scopus 로고    scopus 로고
    • Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection
    • Yang P.L., et al. Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 13825-13830
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 13825-13830
    • Yang, P.L.1
  • 100
    • 0033166561 scopus 로고    scopus 로고
    • High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA
    • Zhang G., et al. High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum. Gene Ther. 10 (1999) 1735-1737
    • (1999) Hum. Gene Ther. , vol.10 , pp. 1735-1737
    • Zhang, G.1
  • 101
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infection
    • Barber D.L., et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439 (2006) 682-687
    • (2006) Nature , vol.439 , pp. 682-687
    • Barber, D.L.1
  • 102
    • 33748947326 scopus 로고    scopus 로고
    • PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
    • Day C.L., et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 443 (2006) 350-354
    • (2006) Nature , vol.443 , pp. 350-354
    • Day, C.L.1
  • 103
    • 0036337681 scopus 로고    scopus 로고
    • Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins: implications for immunotherapy of persistent viral infections
    • Kakimi K., et al. Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins: implications for immunotherapy of persistent viral infections. J. Virol. 76 (2002) 8609-8620
    • (2002) J. Virol. , vol.76 , pp. 8609-8620
    • Kakimi, K.1
  • 104
    • 33644862356 scopus 로고    scopus 로고
    • Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
    • Lindenbach B.D., et al. Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 3805-3809
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 3805-3809
    • Lindenbach, B.D.1
  • 105
    • 17944379233 scopus 로고    scopus 로고
    • Hepatitis C virus replication in mice with chimeric human livers
    • Mercer D.F., et al. Hepatitis C virus replication in mice with chimeric human livers. Nat. Med. 7 (2001) 927-933
    • (2001) Nat. Med. , vol.7 , pp. 927-933
    • Mercer, D.F.1
  • 106
    • 16244415868 scopus 로고    scopus 로고
    • Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera
    • Meuleman P., et al. Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera. Hepatology 41 (2005) 847-856
    • (2005) Hepatology , vol.41 , pp. 847-856
    • Meuleman, P.1
  • 107
    • 38049083122 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge
    • Law M., et al. Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge. Nat. Med. 14 (2007) 25-27
    • (2007) Nat. Med. , vol.14 , pp. 25-27
    • Law, M.1
  • 108
    • 0142178211 scopus 로고    scopus 로고
    • HCV persistence and immune evasion in the absence of memory T cell help
    • Grakoui A., et al. HCV persistence and immune evasion in the absence of memory T cell help. Science 302 (2003) 659-662
    • (2003) Science , vol.302 , pp. 659-662
    • Grakoui, A.1
  • 109
    • 0038543543 scopus 로고    scopus 로고
    • Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection
    • Shoukry N.H., et al. Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection. J. Exp. Med. 197 (2003) 1645-1655
    • (2003) J. Exp. Med. , vol.197 , pp. 1645-1655
    • Shoukry, N.H.1
  • 110
    • 33847067210 scopus 로고    scopus 로고
    • Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C
    • Kaplan D.E., et al. Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C. Gastroenterology 132 (2007) 654-666
    • (2007) Gastroenterology , vol.132 , pp. 654-666
    • Kaplan, D.E.1
  • 111
    • 0028114164 scopus 로고
    • Hepatitis C infection in patients with primary hypogammaglobulinemia after treatment with contaminated immune globulin
    • Bjoro K., et al. Hepatitis C infection in patients with primary hypogammaglobulinemia after treatment with contaminated immune globulin. N. Engl. J. Med. 331 (1994) 1607-1611
    • (1994) N. Engl. J. Med. , vol.331 , pp. 1607-1611
    • Bjoro, K.1
  • 112
    • 33847015308 scopus 로고    scopus 로고
    • Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo
    • von Hahn T., et al. Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo. Gastroenterology 132 (2007) 667-678
    • (2007) Gastroenterology , vol.132 , pp. 667-678
    • von Hahn, T.1
  • 113
    • 34347253229 scopus 로고    scopus 로고
    • Hepatitis C virus epitope-specific neutralizing antibodies in Igs prepared from human plasma
    • Zhang P., et al. Hepatitis C virus epitope-specific neutralizing antibodies in Igs prepared from human plasma. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 8449-8454
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 8449-8454
    • Zhang, P.1
  • 114
    • 0027442136 scopus 로고
    • Characterization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia viruses
    • Ralston R., et al. Characterization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia viruses. J. Virol. 67 (1993) 6753-6761
    • (1993) J. Virol. , vol.67 , pp. 6753-6761
    • Ralston, R.1
  • 115
    • 0028147612 scopus 로고
    • Vaccination of chimpanzees against infection by the hepatitis C virus
    • Choo Q.L., et al. Vaccination of chimpanzees against infection by the hepatitis C virus. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 1294-1298
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 1294-1298
    • Choo, Q.L.1
  • 116
    • 23944452579 scopus 로고    scopus 로고
    • Prospects for a vaccine against the hepatitis C virus
    • Houghton M., and Abrignani S. Prospects for a vaccine against the hepatitis C virus. Nature 436 (2005) 961-966
    • (2005) Nature , vol.436 , pp. 961-966
    • Houghton, M.1    Abrignani, S.2
  • 117
    • 0033958695 scopus 로고    scopus 로고
    • Immune responses to hepatitis C virus structural and nonstructural proteins induced by plasmid DNA immunizations
    • Gordon E.J., et al. Immune responses to hepatitis C virus structural and nonstructural proteins induced by plasmid DNA immunizations. J. Infect. Dis. 181 (2000) 42-50
    • (2000) J. Infect. Dis. , vol.181 , pp. 42-50
    • Gordon, E.J.1
  • 118
    • 0030271494 scopus 로고    scopus 로고
    • Evaluation of hepatitis C virus protein epitopes for vaccine development
    • Koshy R., and Inchauspe G. Evaluation of hepatitis C virus protein epitopes for vaccine development. Trends Biotechnol. 14 (1996) 364-369
    • (1996) Trends Biotechnol. , vol.14 , pp. 364-369
    • Koshy, R.1    Inchauspe, G.2
  • 119
    • 0029156764 scopus 로고
    • Immune responses to plasmid DNA encoding the hepatitis C virus core protein
    • Lagging L.M., et al. Immune responses to plasmid DNA encoding the hepatitis C virus core protein. J. Virol. 69 (1995) 5859-5863
    • (1995) J. Virol. , vol.69 , pp. 5859-5863
    • Lagging, L.M.1
  • 120
    • 0029844635 scopus 로고    scopus 로고
    • Immunogenicity and antigenicity of the ATPase/helicase domain of the hepatitis C virus non-structural 3 protein
    • Sallberg M., et al. Immunogenicity and antigenicity of the ATPase/helicase domain of the hepatitis C virus non-structural 3 protein. J. Gen. Virol. 77 Pt 11 (1996) 2721-2728
    • (1996) J. Gen. Virol. , vol.77 , Issue.PART 11 , pp. 2721-2728
    • Sallberg, M.1
  • 121
    • 0029971032 scopus 로고    scopus 로고
    • Expression and immune response to hepatitis C virus core DNA-based vaccine constructs
    • Tokushige K., et al. Expression and immune response to hepatitis C virus core DNA-based vaccine constructs. Hepatology 24 (1996) 14-20
    • (1996) Hepatology , vol.24 , pp. 14-20
    • Tokushige, K.1
  • 122
    • 0030685837 scopus 로고    scopus 로고
    • Immune responses to the hepatitis C virus NS4A protein are profoundly influenced by the combination of the viral genotype and the host major histocompatibility complex
    • Zhang Z.X., et al. Immune responses to the hepatitis C virus NS4A protein are profoundly influenced by the combination of the viral genotype and the host major histocompatibility complex. J. Gen. Virol. 78 Pt 11 (1997) 2735-2746
    • (1997) J. Gen. Virol. , vol.78 , Issue.PART 11 , pp. 2735-2746
    • Zhang, Z.X.1
  • 123
    • 0032212215 scopus 로고    scopus 로고
    • Genetic immunization generates cellular and humoral immune responses against the nonstructural proteins of the hepatitis C virus in a murine model
    • Encke J., et al. Genetic immunization generates cellular and humoral immune responses against the nonstructural proteins of the hepatitis C virus in a murine model. J. Immunol. 161 (1998) 4917-4923
    • (1998) J. Immunol. , vol.161 , pp. 4917-4923
    • Encke, J.1
  • 124
    • 0032077308 scopus 로고    scopus 로고
    • Differential cellular and humoral immune responses to HCV core and HBV envelope proteins after genetic immunizations using chimeric constructs
    • Geissler M., et al. Differential cellular and humoral immune responses to HCV core and HBV envelope proteins after genetic immunizations using chimeric constructs. Vaccine 16 (1998) 857-867
    • (1998) Vaccine , vol.16 , pp. 857-867
    • Geissler, M.1
  • 125
    • 0031627502 scopus 로고    scopus 로고
    • Immune responses against hepatitis C virus structural proteins following genetic immunisation
    • Inchauspe G., et al. Immune responses against hepatitis C virus structural proteins following genetic immunisation. Dev. Biol. Stand. 92 (1998) 163-168
    • (1998) Dev. Biol. Stand. , vol.92 , pp. 163-168
    • Inchauspe, G.1
  • 126
    • 0034994396 scopus 로고    scopus 로고
    • Humoral and CD4(+) T helper (Th) cell responses to the hepatitis C virus non-structural 3 (NS3) protein: NS3 primes Th1-like responses more effectively as a DNA-based immunogen than as a recombinant protein
    • Lazdina U., et al. Humoral and CD4(+) T helper (Th) cell responses to the hepatitis C virus non-structural 3 (NS3) protein: NS3 primes Th1-like responses more effectively as a DNA-based immunogen than as a recombinant protein. J. Gen. Virol. 82 Pt 6 (2001) 1299-1308
    • (2001) J. Gen. Virol. , vol.82 , Issue.PART 6 , pp. 1299-1308
    • Lazdina, U.1
  • 127
    • 0029084640 scopus 로고
    • DNA-based immunization with chimeric vectors for the induction of immune responses against the hepatitis C virus nucleocapsid
    • Major M.E., et al. DNA-based immunization with chimeric vectors for the induction of immune responses against the hepatitis C virus nucleocapsid. J. Virol. 69 (1995) 5798-5805
    • (1995) J. Virol. , vol.69 , pp. 5798-5805
    • Major, M.E.1
  • 128
    • 0037213842 scopus 로고    scopus 로고
    • DNA immunization with hepatitis C virus (HCV) polycistronic genes or immunization by HCV DNA priming-recombinant canarypox virus boosting induces immune responses and protection from recombinant HCV-vaccinia virus infection in HLA-A2.1-transgenic mice
    • Pancholi P., et al. DNA immunization with hepatitis C virus (HCV) polycistronic genes or immunization by HCV DNA priming-recombinant canarypox virus boosting induces immune responses and protection from recombinant HCV-vaccinia virus infection in HLA-A2.1-transgenic mice. J. Virol. 77 (2003) 382-390
    • (2003) J. Virol. , vol.77 , pp. 382-390
    • Pancholi, P.1
  • 129
    • 0036166630 scopus 로고    scopus 로고
    • Hepatitis C virus non-structural protein 3-specific cellular immune responses following single or combined immunization with DNA or recombinant Semliki Forest virus particles
    • Brinster C., et al. Hepatitis C virus non-structural protein 3-specific cellular immune responses following single or combined immunization with DNA or recombinant Semliki Forest virus particles. J. Gen. Virol. 83 Pt 2 (2002) 369-381
    • (2002) J. Gen. Virol. , vol.83 , Issue.PART 2 , pp. 369-381
    • Brinster, C.1
  • 130
    • 0035192083 scopus 로고    scopus 로고
    • Different hepatitis C virus nonstructural protein 3 (Ns3)-DNA-expressing vaccines induce in HLA-A2.1 transgenic mice stable cytotoxic T lymphocytes that target one major epitope
    • Brinster C., et al. Different hepatitis C virus nonstructural protein 3 (Ns3)-DNA-expressing vaccines induce in HLA-A2.1 transgenic mice stable cytotoxic T lymphocytes that target one major epitope. Hepatology 34 (2001) 1206-1217
    • (2001) Hepatology , vol.34 , pp. 1206-1217
    • Brinster, C.1
  • 131
    • 1842581995 scopus 로고    scopus 로고
    • Codon optimization and mRNA amplification effectively enhances the immunogenicity of the hepatitis C virus nonstructural 3/4A gene
    • Frelin L., et al. Codon optimization and mRNA amplification effectively enhances the immunogenicity of the hepatitis C virus nonstructural 3/4A gene. Gene Ther. 11 (2004) 522-533
    • (2004) Gene Ther. , vol.11 , pp. 522-533
    • Frelin, L.1
  • 132
    • 0038066406 scopus 로고    scopus 로고
    • Low dose and gene gun immunization with a hepatitis C virus nonstructural (NS) 3 DNA-based vaccine containing NS4A inhibit NS3/4A-expressing tumors in vivo
    • Frelin L., et al. Low dose and gene gun immunization with a hepatitis C virus nonstructural (NS) 3 DNA-based vaccine containing NS4A inhibit NS3/4A-expressing tumors in vivo. Gene Ther. 10 (2003) 686-699
    • (2003) Gene Ther. , vol.10 , pp. 686-699
    • Frelin, L.1
  • 133
    • 33750796905 scopus 로고    scopus 로고
    • Modulation of the immune response induced by gene electrotransfer of a hepatitis C virus DNA vaccine in nonhuman primates
    • Capone S., et al. Modulation of the immune response induced by gene electrotransfer of a hepatitis C virus DNA vaccine in nonhuman primates. J. Immunol. 177 (2006) 7462-7471
    • (2006) J. Immunol. , vol.177 , pp. 7462-7471
    • Capone, S.1
  • 134
    • 32244435842 scopus 로고    scopus 로고
    • A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees
    • Folgori A., et al. A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees. Nat. Med. 12 (2006) 190-197
    • (2006) Nat. Med. , vol.12 , pp. 190-197
    • Folgori, A.1
  • 135
    • 0023766227 scopus 로고
    • Competition between unrelated peptides recognized by H-2-Kd restricted T cells
    • Pala P., et al. Competition between unrelated peptides recognized by H-2-Kd restricted T cells. J. Immunol. 141 (1988) 2289-2294
    • (1988) J. Immunol. , vol.141 , pp. 2289-2294
    • Pala, P.1
  • 136
    • 0036569390 scopus 로고    scopus 로고
    • Competition between CTL narrows the immune response induced by prime-boost vaccination protocols
    • Palmowski M.J., et al. Competition between CTL narrows the immune response induced by prime-boost vaccination protocols. J. Immunol. 168 (2002) 4391-4398
    • (2002) J. Immunol. , vol.168 , pp. 4391-4398
    • Palmowski, M.J.1
  • 137
    • 0030752480 scopus 로고    scopus 로고
    • Nucleic acid vaccination with HIV regulatory genes: a combination of HIV-1 genes in separate plasmids induces strong immune responses
    • Hinkula J., et al. Nucleic acid vaccination with HIV regulatory genes: a combination of HIV-1 genes in separate plasmids induces strong immune responses. Vaccine 15 (1997) 874-878
    • (1997) Vaccine , vol.15 , pp. 874-878
    • Hinkula, J.1
  • 138
    • 34547434301 scopus 로고    scopus 로고
    • Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells
    • Cheng G., et al. Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 9035-9040
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 9035-9040
    • Cheng, G.1
  • 139
    • 34748832365 scopus 로고    scopus 로고
    • An accelerated vaccine schedule with a poly-antigenic hepatitis C virus MVA-based candidate vaccine induces potent, long lasting and in vivo cross-reactive T cell responses
    • Fournillier A., et al. An accelerated vaccine schedule with a poly-antigenic hepatitis C virus MVA-based candidate vaccine induces potent, long lasting and in vivo cross-reactive T cell responses. Vaccine 25 (2007) 7339-7353
    • (2007) Vaccine , vol.25 , pp. 7339-7353
    • Fournillier, A.1
  • 140
    • 12144286264 scopus 로고    scopus 로고
    • Intrahepatic hepatitis C virus RNA quantification in microdissected hepatocytes
    • Vona G., et al. Intrahepatic hepatitis C virus RNA quantification in microdissected hepatocytes. J. Hepatol. 40 (2004) 682-688
    • (2004) J. Hepatol. , vol.40 , pp. 682-688
    • Vona, G.1
  • 141
    • 0032169470 scopus 로고    scopus 로고
    • Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B
    • Boni C., et al. Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B. J. Clin. Invest. 102 (1998) 968-975
    • (1998) J. Clin. Invest. , vol.102 , pp. 968-975
    • Boni, C.1
  • 142
    • 33847406557 scopus 로고    scopus 로고
    • PD-1:PD-L1 interactions contribute to the functional suppression of virus-specific CD8+ T lymphocytes in the liver
    • Maier H., et al. PD-1:PD-L1 interactions contribute to the functional suppression of virus-specific CD8+ T lymphocytes in the liver. J. Immunol. 178 (2007) 2714-2720
    • (2007) J. Immunol. , vol.178 , pp. 2714-2720
    • Maier, H.1
  • 143
    • 33750691709 scopus 로고    scopus 로고
    • PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion
    • Urbani S., et al. PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion. J. Virol. 80 (2006) 11398-11403
    • (2006) J. Virol. , vol.80 , pp. 11398-11403
    • Urbani, S.1
  • 144
    • 15444375498 scopus 로고    scopus 로고
    • Heterologous T cell immunity in severe hepatitis C virus infection
    • Urbani S., et al. Heterologous T cell immunity in severe hepatitis C virus infection. J. Exp. Med. 201 (2005) 675-680
    • (2005) J. Exp. Med. , vol.201 , pp. 675-680
    • Urbani, S.1
  • 145
    • 11844306534 scopus 로고    scopus 로고
    • In vivo immunization by vaccine therapy following virus suppression by lamivudine: a novel approach for treating patients with chronic hepatitis B
    • Horiike N., et al. In vivo immunization by vaccine therapy following virus suppression by lamivudine: a novel approach for treating patients with chronic hepatitis B. J. Clin. Virol. 32 2 (2005) 156-161
    • (2005) J. Clin. Virol. , vol.32 , Issue.2 , pp. 156-161
    • Horiike, N.1
  • 146
    • 3242794286 scopus 로고    scopus 로고
    • Efficacy of hepatitis B vaccination and interferon-alpha-2b combination therapy versus interferon-alpha-2b monotherapy in children with chronic hepatitis B
    • Helvaci M., et al. Efficacy of hepatitis B vaccination and interferon-alpha-2b combination therapy versus interferon-alpha-2b monotherapy in children with chronic hepatitis B. J. Gastroenterol. Hepatol. 19 7 (2004) 785-791
    • (2004) J. Gastroenterol. Hepatol. , vol.19 , Issue.7 , pp. 785-791
    • Helvaci, M.1
  • 147
    • 0041657605 scopus 로고    scopus 로고
    • Specific hepatitis B vaccine therapy in inactive HBsAg carriers: a randomized controlled trial
    • Yalcin K., et al. Specific hepatitis B vaccine therapy in inactive HBsAg carriers: a randomized controlled trial. Infection 31 4 (2003) 221-225
    • (2003) Infection , vol.31 , Issue.4 , pp. 221-225
    • Yalcin, K.1
  • 148
    • 0141455257 scopus 로고    scopus 로고
    • The lack of effect of therapeutic vaccination with a pre-S2/S HBV vaccine in the immune tolerant phase of chronic HBV infection
    • Yalcin K., et al. The lack of effect of therapeutic vaccination with a pre-S2/S HBV vaccine in the immune tolerant phase of chronic HBV infection. J. Clin. Gastroenterol. 37 4 (2003) 330-335
    • (2003) J. Clin. Gastroenterol. , vol.37 , Issue.4 , pp. 330-335
    • Yalcin, K.1
  • 149
    • 0037019913 scopus 로고    scopus 로고
    • Immunological monitoring during therapeutic vaccination as a prerequisite for the design of new effective therapies: induction of a vaccine-specific CD4+ T-cell proliferative response in chronic hepatitis B carriers
    • Jung M.C., et al. Immunological monitoring during therapeutic vaccination as a prerequisite for the design of new effective therapies: induction of a vaccine-specific CD4+ T-cell proliferative response in chronic hepatitis B carriers. Vaccine 20 29-30 (2002) 3598-3612
    • (2002) Vaccine , vol.20 , Issue.29-30 , pp. 3598-3612
    • Jung, M.C.1
  • 150
    • 0036200712 scopus 로고    scopus 로고
    • Clinical and immunological efficacy of intradermal vaccine plus lamivudine with or without interleukin-2 in patients with chronic hepatitis B
    • Dahmen A., et al. Clinical and immunological efficacy of intradermal vaccine plus lamivudine with or without interleukin-2 in patients with chronic hepatitis B. J. Med. Virol. 66 4 (2002) 452-460
    • (2002) J. Med. Virol. , vol.66 , Issue.4 , pp. 452-460
    • Dahmen, A.1
  • 151
    • 0034948510 scopus 로고    scopus 로고
    • Efficacy and limitations of a specific immunotherapy in chronic hepatitis B
    • Pol S., et al. Efficacy and limitations of a specific immunotherapy in chronic hepatitis B. J. Hepatol. 34 6 (2001) 917-921
    • (2001) J. Hepatol. , vol.34 , Issue.6 , pp. 917-921
    • Pol, S.1
  • 152
    • 0033050827 scopus 로고    scopus 로고
    • Specific vaccine therapy in chronic hepatitis B: induction of T cell proliferative responses specific for envelope antigens
    • Couillin I., et al. Specific vaccine therapy in chronic hepatitis B: induction of T cell proliferative responses specific for envelope antigens. J. Infect. Dis. 180 1 (1999) 15-26
    • (1999) J. Infect. Dis. , vol.180 , Issue.1 , pp. 15-26
    • Couillin, I.1
  • 153
    • 0142151747 scopus 로고    scopus 로고
    • A pilot study of therapeutic vaccination with envelope protein E1 in 35 patients with chronic hepatitis C
    • Nevens F., et al. A pilot study of therapeutic vaccination with envelope protein E1 in 35 patients with chronic hepatitis C. Hepatology 38 5 (2003) 1289-1296
    • (2003) Hepatology , vol.38 , Issue.5 , pp. 1289-1296
    • Nevens, F.1
  • 154
    • 33646144429 scopus 로고    scopus 로고
    • Immunogenicity and safety of a novel therapeutic hepatitis C virus (HCV) peptide vaccine: a randomized, placebo controlled trial for dose optimization in 128 healthy subjects
    • Firbas C., et al. Immunogenicity and safety of a novel therapeutic hepatitis C virus (HCV) peptide vaccine: a randomized, placebo controlled trial for dose optimization in 128 healthy subjects. Vaccine 24 20 (2006) 4343-4353
    • (2006) Vaccine , vol.24 , Issue.20 , pp. 4343-4353
    • Firbas, C.1
  • 155
    • 3843137346 scopus 로고    scopus 로고
    • A candidate vaccine based on the hepatitis C E1 protein: tolerability and immunogenicity in healthy volunteers
    • Leroux-Roels G., et al. A candidate vaccine based on the hepatitis C E1 protein: tolerability and immunogenicity in healthy volunteers. Vaccine 22 23-24 (2004) 3080-3086
    • (2004) Vaccine , vol.22 , Issue.23-24 , pp. 3080-3086
    • Leroux-Roels, G.1


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